Is cardiac and hepatic iron status assessed by MRI T2* associated with left ventricular function in patients with idiopathic cardiomyopathy?

Heart and Vessels

Volumn 31, Issue 12, 2016, Pages 1950-1959

  Kanzaki, Yumiko ^a   Yuki, Masako ^a   Yamamura, Ken ichiro ^a   Narumi, Yoshifumi ^a   Ishizaka, Nobukazu ^a  

^a OSAKA MEDICAL COLLEGE   (Japan)

Author keywords

Cardiomyopathy; Hemoglobin; Iron; Magnetic resonance imaging; T2*

Indexed keywords

HEMOGLOBIN; IRON;

ADULT; AGE; ARTICLE; CARDIAC IMAGING; CARDIOMYOPATHY; CONGESTIVE CARDIOMYOPATHY; CONTROLLED STUDY; FEMALE; GENDER; HEART FUNCTION; HEART LEFT VENTRICLE EJECTION FRACTION; HEART LEFT VENTRICLE FUNCTION; HEART SEPTUM; HUMAN; HYPERTROPHIC CARDIOMYOPATHY; IDIOPATHIC CARDIOMYOPATHY; KIDNEY FUNCTION; MAJOR CLINICAL STUDY; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; AGED; CARDIAC MUSCLE; CHEMISTRY; CINE MAGNETIC RESONANCE IMAGING; COMPARATIVE STUDY; CROSS-SECTIONAL STUDY; DIAGNOSTIC IMAGING; HEART; HEART STROKE VOLUME; LIVER; METABOLISM; MIDDLE AGED; PATHOPHYSIOLOGY; PREDICTIVE VALUE; PROCEDURES; RETROSPECTIVE STUDY;

ADULT; AGED; CARDIOMYOPATHY, DILATED; CARDIOMYOPATHY, HYPERTROPHIC; CROSS-SECTIONAL STUDIES; FEMALE; HEART; HUMANS; IRON; LIVER; MAGNETIC RESONANCE IMAGING, CINE; MALE; MIDDLE AGED; MYOCARDIUM; PREDICTIVE VALUE OF TESTS; RETROSPECTIVE STUDIES; STROKE VOLUME; VENTRICULAR FUNCTION, LEFT;

EID: 84958759861     PISSN: 09108327     EISSN: 16152573     Source Type: Journal    
DOI: 10.1007/s00380-016-0814-1     Document Type: Article

References (42)

1. Cohen-Solal A, Leclercq C, Deray G, Lasocki S, Zambrowski JJ, Mebazaa A, de Groote P, Damy T, Galinier M (2014) Iron deficiency: an emerging therapeutic target in heart failure. Heart 100:1414–1420
2. Hentze MW, Muckenthaler MU, Andrews NC (2004) Balancing acts: molecular control of mammalian iron metabolism. Cell 117:285–297
3. Berdoukas V, Coates TD, Cabantchik ZI (2015) Iron and oxidative stress in cardiomyopathy in thalassemia. Free Radic Biol Med 88(Pt A):3–9
4. Olivieri NF, Nathan DG, MacMillan JH, Wayne AS, Liu PP, McGee A, Martin M, Koren G, Cohen AR (1994) Survival in medically treated patients with homozygous beta-thalassemia. N Engl J Med 331:574–578
5. Gao X, Campian JL, Qian M, Sun XF, Eaton JW (2009) Mitochondrial DNA damage in iron overload. J Biol Chem 284:4767–4775
6. Eguchi A, Naito Y, Iwasaku T, Okuhara Y, Morisawa D, Sawada H, Nishimura K, Oboshi M, Fujii K, Mano T, Masuyama T, Hirotani S (2015) Association of dietary iron restriction with left ventricular remodeling after myocardial infarction in mice. Heart Vessels. doi:10.1007/s00380-00014-00621-00385
7. Nabeta T, Inomata T, Iida Y, Ikeda Y, Iwamoto M, Ishii S, Sato T, Watanabe I, Naruke T, Shinagawa H, Koitabashi T, Takeuchi I, Nishii M, Inoue Y, Izumi T (2014) Baseline cardiac magnetic resonance imaging versus baseline endomyocardial biopsy for the prediction of left ventricular reverse remodeling and prognosis in response to therapy in patients with idiopathic dilated cardiomyopathy. Heart Vessels 29:784–792
8. Kobashigawa JA (2015) Cardiac magnetic resonance: is it time to replace the endomyocardial biopsy to detect heart transplant rejection? J Heart Lung Transplant 34:631–633
9. Ramazzotti A, Pepe A, Positano V, Rossi G, De Marchi D, Brizi MG, Luciani A, Midiri M, Sallustio G, Valeri G, Caruso V, Centra M, Cianciulli P, De Sanctis V, Maggio A, Lombardi M (2009) Multicenter validation of the magnetic resonance T2* technique for segmental and global quantification of myocardial iron. J Magn Reson Imaging 30:62–68
10. Anderson LJ, Holden S, Davis B, Prescott E, Charrier CC, Bunce NH, Firmin DN, Wonke B, Porter J, Walker JM, Pennell DJ (2001) Cardiovascular T2-star (T2*) magnetic resonance for the early diagnosis of myocardial iron overload. Eur Heart J 22:2171–2179
11. Pascal L, Beyne-Rauzy O, Brechignac S, Marechaux S, Vassilieff D, Ernst O, Berthon C, Gyan E, Gourin MP, Dreyfus F, Fenaux P, Rose C (2013) Cardiac iron overload assessed by T2* magnetic resonance imaging and cardiac function in regularly transfused myelodysplastic syndrome patients. Br J Haematol 162:413–415
12. Moussavi F, Ghasabeh MA, Roodpeyma S, Alavi S, Shakiba M, Gheiratmand R, Omidghaemi M (2014) Optimal method for early detection of cardiac disorders in thalassemia major patients: magnetic resonance imaging or echocardiography? Blood Res 49:182–186
13. Nagao M, Matsuo Y, Kamitani T, Yonezawa M, Yamasaki Y, Kawanami S, Abe K, Mukai Y, Higo T, Yabuuchi H, Takemura A, Yoshiura T, Sunagawa K, Honda H (2014) Quantification of myocardial iron deficiency in nonischemic heart failure by cardiac T2* magnetic resonance imaging. Am J Cardiol 113:1024–1030
14. Maron BJ, Rowin EJ, Casey SA, Link MS, Lesser JR, Chan RH, Garberich RF, Udelson JE, Maron MS (2015) Hypertrophic cardiomyopathy in adulthood associated with low cardiovascular mortality with contemporary management strategies. J Am Coll Cardiol 65:1915–1928
15. Richardson P, McKenna W, Bristow M, Maisch B, Mautner B, O’Connell J, Olsen E, Thiene G, Goodwin J, Gyarfas I, Martin I, Nordet P (1996) Report of the 1995 World Health Organization/International Society and Federation of Cardiology Task Force on the definition and classification of cardiomyopathies. Circulation 93:841–842
16. Reeder SB, Faranesh AZ, Boxerman JL, McVeigh ER (1998) In vivo measurement of T*2 and field inhomogeneity maps in the human heart at 1.5 T. Magn Reson Med 39:988–998
17. Matsuo S, Imai E, Horio M, Yasuda Y, Tomita K, Nitta K, Yamagata K, Tomino Y, Yokoyama H, Hishida A (2009) Revised equations for estimated GFR from serum creatinine in Japan. Am J Kidney Dis 53:982–992
18. Brittenham GM, Badman DG (2003) Noninvasive measurement of iron: report of an NIDDK workshop. Blood 101:15–19
19. Passen EL, Rodriguez ER, Neumann A, Tan CD, Parrillo JE (1996) Images in cardiovascular medicine. Cardiac hemochromatosis. Circulation 94:2302–2303
20. Nichols-Vinueza DX, White MT, Powell AJ, Banka P, Neufeld EJ (2014) MRI guided iron assessment and oral chelator use improve iron status in thalassemia major patients. Am J Hematol 89:684–688
21. Gandon Y, Olivie D, Guyader D, Aube C, Oberti F, Sebille V, Deugnier Y (2004) Non-invasive assessment of hepatic iron stores by MRI. Lancet 363:357–362
22. Ernst O, Thuret I, Petit P, Ameur F, Loundou AD, de Kerviler E, Izzillo R, Willig AL, Pascal L, Verlhac S, Mordon S, Fenaux P, Rose C (2013) Iron overload of hematological origin: validation of a screening procedure for cardiac overload by MRI in routine clinical practice. Diagn Interv Imaging 94:601–608
23. Ellingson AM, Nagel TM, Polly DW, Ellermann J, Nuckley DJ (2014) Quantitative T2* (T2 star) relaxation times predict site specific proteoglycan content and residual mechanics of the intervertebral disc throughout degeneration. J Orthop Res 32:1083–1089
24. Yamamoto D, Suzuki M, Yakushijin A, Yamanaka K, Kohno T, Haraigawa T, Uemura S, Enomoto D, Honda K (2012) Analysis of microvascular injury using T2^* cardiac magnetic resonance imaging in two patients with reperfused acute myocardial infarction. J Cardiol (Japanese) 7:199–205
25. Lotan CS, Bouchard A, Cranney GB, Bishop SP, Pohost GM (1992) Assessment of postreperfusion myocardial hemorrhage using proton NMR imaging at 1.5 T. Circulation 86:1018–1025
26. Eghbali A, Taherahmadi H, Shahbazi M, Bagheri B, Ebrahimi L (2014) Association between serum ferritin level, cardiac and hepatic T2-star MRI in patients with major beta-thalassemia. Iran J Ped Hematol Oncol 4:17–21
27. Mavrogeni S (2012) Comparison of myocardial and hepatic iron loading, assessed by MRI T2*, in patients with myelodysplastic syndromes, thalassaemia major and controls. Blood Transfus 10:237–240
28. Quatre A, Jacquier A, Petit P, Giorgi R, Thuret I (2014) MRI monitoring of myocardial iron overload: use of cardiac MRI combined with hepatic MRI in a cohort of multi-transfused patients with thalassaemia. Diagn Interv Imaging 95:1065–1069
29. Wood JC (2008) Cardiac iron across different transfusion-dependent diseases. Blood Rev 22(Suppl 2):S14–S21
30. Lindenfeld J (2005) Prevalence of anemia and effects on mortality in patients with heart failure. Am Heart J 149:391–401
31. Go AS, Yang J, Ackerson LM, Lepper K, Robbins S, Massie BM, Shlipak MG (2006) Hemoglobin level, chronic kidney disease, and the risks of death and hospitalization in adults with chronic heart failure: the Anemia in Chronic Heart Failure: outcomes and Resource Utilization (ANCHOR) Study. Circulation 113:2713–2723
32. Qian C, Wei B, Ding J, Wu H, Wang Y (2015) The efficacy and safety of iron supplementation in patients with heart failure and iron deficiency: a systematic review and meta-analysis. Can J Cardiol. doi:10.1016/j.cjca.2015.06.009
33. Maeder MT, Khammy O, dos Remedios C, Kaye DM (2011) Myocardial and systemic iron depletion in heart failure implications for anemia accompanying heart failure. J Am Coll Cardiol 58:474–480
34. Leszek P, Sochanowicz B, Szperl M, Kolsut P, Brzoska K, Piotrowski W, Rywik TM, Danko B, Polkowska-Motrenko H, Rozanski JM, Kruszewski M (2012) Myocardial iron homeostasis in advanced chronic heart failure patients. Int J Cardiol 159:47–52
35. Kumfu S, Chattipakorn S, Srichairatanakool S, Settakorn J, Fucharoen S, Chattipakorn N (2011) T-type calcium channel as a portal of iron uptake into cardiomyocytes of beta-thalassemic mice. Eur J Haematol 86:156–166
36. Wijarnpreecha K, Kumfu S, Chattipakorn SC, Chattipakorn N (2015) Cardiomyopathy associated with iron overload: how does iron enter myocytes and what are the implications for pharmacological therapy? Hemoglobin 39:9–17
37. 2+ regulation in chronic rat heart failure. J Physiol Sci 60:85–94
38. Naito Y, Tsujino T, Fujimori Y, Sawada H, Akahori H, Hirotani S, Ohyanagi M, Masuyama T (2011) Impaired expression of duodenal iron transporters in Dahl salt-sensitive heart failure rats. J Hypertens 29:741–748
39. Kajimoto K, Sato N, Takano T (2015) Association of anemia and renal dysfunction with in-hospital mortality among patients hospitalized for acute heart failure syndromes with preserved or reduced ejection fraction. Eur Heart J Acute Cardiovasc Care. doi:10.1177/2048872615593387
40. Gunawardena S, Dunlap ME (2012) Anemia and iron deficiency in heart failure. Curr Heart Fail Rep 9:319–327
41. van Veldhuisen DJ, Anker SD, Ponikowski P, Macdougall IC (2011) Anemia and iron deficiency in heart failure: mechanisms and therapeutic approaches. Nat Rev Cardiol 8:485–493
42. Qian C, Wei B, Ding J, Wu H, Wang Y (2015) The efficacy and safety of iron supplementation in patients with heart failure and iron deficiency: a systematic review and meta-analysis. Can J Cardiol. doi:10.1016/j.cjca.2015.1006.1009