메뉴 건너뛰기




Volumn 60, Issue , 2016, Pages 160-165

Sphingosine-1-phosphate and estrogen signaling in breast cancer

Author keywords

Breast cancer; Estradiol; FTY720 Fingolimod; Sphingosine kinase; Sphingosine 1 phosphate

Indexed keywords

ESTROGEN; LYSOPHOSPHOLIPID; PHOSPHOTRANSFERASE; SPHINGOSINE; SPHINGOSINE 1-PHOSPHATE; SPHINGOSINE KINASE;

EID: 84958755243     PISSN: 22124926     EISSN: None     Source Type: Book Series    
DOI: 10.1016/j.jbior.2015.09.006     Document Type: Review
Times cited : (39)

References (46)
  • 1
    • 77953923379 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2
    • Alvarez S.E., Harikumar K.B., Hait N.C., Allegood J., Strub G.M., Kim E.Y., et al. Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2. Nature 2010, 465:1084-1088.
    • (2010) Nature , vol.465 , pp. 1084-1088
    • Alvarez, S.E.1    Harikumar, K.B.2    Hait, N.C.3    Allegood, J.4    Strub, G.M.5    Kim, E.Y.6
  • 2
    • 79959498910 scopus 로고    scopus 로고
    • Pharmacological inhibition of sphingosine kinase isoforms alters estrogen receptor signaling in human breast cancer
    • Antoon J.W., Meacham W.D., Bratton M.R., Slaughter E.M., Rhodes L.V., Ashe H.B., et al. Pharmacological inhibition of sphingosine kinase isoforms alters estrogen receptor signaling in human breast cancer. J. Mol. Endocrinol. 2011, 46:205-216.
    • (2011) J. Mol. Endocrinol. , vol.46 , pp. 205-216
    • Antoon, J.W.1    Meacham, W.D.2    Bratton, M.R.3    Slaughter, E.M.4    Rhodes, L.V.5    Ashe, H.B.6
  • 3
    • 79953314461 scopus 로고    scopus 로고
    • Targeting NFkB mediated breast cancer chemoresistance through selective inhibition of sphingosine kinase-2
    • Antoon J.W., White M.D., Slaughter E.M., Driver J.L., Khalili H.S., Elliott S., et al. Targeting NFkB mediated breast cancer chemoresistance through selective inhibition of sphingosine kinase-2. Cancer Biol. Ther. 2011, 11:678-689.
    • (2011) Cancer Biol. Ther. , vol.11 , pp. 678-689
    • Antoon, J.W.1    White, M.D.2    Slaughter, E.M.3    Driver, J.L.4    Khalili, H.S.5    Elliott, S.6
  • 4
    • 84874653875 scopus 로고    scopus 로고
    • Molecularly targeted therapies for metastatic triple-negative breast cancer
    • Bayraktar S., Gluck S. Molecularly targeted therapies for metastatic triple-negative breast cancer. Breast Cancer Res. Treat. 2013, 138:21-35.
    • (2013) Breast Cancer Res. Treat. , vol.138 , pp. 21-35
    • Bayraktar, S.1    Gluck, S.2
  • 6
    • 84906274282 scopus 로고    scopus 로고
    • SPHK1 regulates proliferation and survival responses in triple-negative breast cancer
    • Datta A., Loo S.Y., Huang B., Wong L., Tan S.S., Tan T.Z., et al. SPHK1 regulates proliferation and survival responses in triple-negative breast cancer. Oncotarget 2014, 5:5920-5933.
    • (2014) Oncotarget , vol.5 , pp. 5920-5933
    • Datta, A.1    Loo, S.Y.2    Huang, B.3    Wong, L.4    Tan, S.S.5    Tan, T.Z.6
  • 7
    • 85203363507 scopus 로고    scopus 로고
    • Relevance of breast cancer hormone receptors and other factors to the efficacy of adjuvant tamoxifen: patient-level meta-analysis of randomised trials
    • Davies C., Godwin J., Gray R., Clarke M., Cutter D., Darby S., et al. Relevance of breast cancer hormone receptors and other factors to the efficacy of adjuvant tamoxifen: patient-level meta-analysis of randomised trials. Lancet 2011, 378:771-784.
    • (2011) Lancet , vol.378 , pp. 771-784
    • Davies, C.1    Godwin, J.2    Gray, R.3    Clarke, M.4    Cutter, D.5    Darby, S.6
  • 8
    • 84861399789 scopus 로고    scopus 로고
    • S1PR1-STAT3 signaling is crucial for myeloid cell colonization at future metastatic sites
    • Deng J., Liu Y., Lee H., Herrmann A., Zhang W., Zhang C., et al. S1PR1-STAT3 signaling is crucial for myeloid cell colonization at future metastatic sites. Cancer Cell 2012, 21:642-654.
    • (2012) Cancer Cell , vol.21 , pp. 642-654
    • Deng, J.1    Liu, Y.2    Lee, H.3    Herrmann, A.4    Zhang, W.5    Zhang, C.6
  • 9
    • 84973537724 scopus 로고    scopus 로고
    • Spinster 2, a sphingosine-1-phosphate transporter, plays a critical role in inflammatory and autoimmune diseases
    • (in press)
    • Donoviel M.S., Hait N.C., Ramachandran S., Maceyka M., Takabe K., Milstien S., et al. Spinster 2, a sphingosine-1-phosphate transporter, plays a critical role in inflammatory and autoimmune diseases. FASEB J. 2015, (in press).
    • (2015) FASEB J.
    • Donoviel, M.S.1    Hait, N.C.2    Ramachandran, S.3    Maceyka, M.4    Takabe, K.5    Milstien, S.6
  • 10
    • 34347238583 scopus 로고    scopus 로고
    • Activation of the novel estrogen receptor G protein-coupled receptor 30 (GPR30) at the plasma membrane
    • Filardo E., Quinn J., Pang Y., Graeber C., Shaw S., Dong J., et al. Activation of the novel estrogen receptor G protein-coupled receptor 30 (GPR30) at the plasma membrane. Endocrinology 2007, 148:3236-3245.
    • (2007) Endocrinology , vol.148 , pp. 3236-3245
    • Filardo, E.1    Quinn, J.2    Pang, Y.3    Graeber, C.4    Shaw, S.5    Dong, J.6
  • 11
    • 69949113620 scopus 로고    scopus 로고
    • Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate
    • Hait N.C., Allegood J., Maceyka M., Strub G.M., Harikumar K.B., Singh S.K., et al. Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate. Science 2009, 325:1254-1257.
    • (2009) Science , vol.325 , pp. 1254-1257
    • Hait, N.C.1    Allegood, J.2    Maceyka, M.3    Strub, G.M.4    Harikumar, K.B.5    Singh, S.K.6
  • 12
    • 84991010539 scopus 로고    scopus 로고
    • The phosphorylated prodrug FTY720 is a histone deacetylase inhibitor that reactivates ERalpha expression and enhances hormonal therapy for breast cancer
    • Hait N.C., Avni D., Yamada A., Nagahashi M., Aoyagi T., Aoki H., et al. The phosphorylated prodrug FTY720 is a histone deacetylase inhibitor that reactivates ERalpha expression and enhances hormonal therapy for breast cancer. Oncogenesis 2015, 4:e156.
    • (2015) Oncogenesis , vol.4 , pp. e156
    • Hait, N.C.1    Avni, D.2    Yamada, A.3    Nagahashi, M.4    Aoyagi, T.5    Aoki, H.6
  • 13
    • 38549152194 scopus 로고    scopus 로고
    • Principles of bioactive lipid signalling: lessons from sphingolipids
    • Hannun Y.A., Obeid L.M. Principles of bioactive lipid signalling: lessons from sphingolipids. Nat. Rev. Mol. Cell Biol. 2008, 9:139-150.
    • (2008) Nat. Rev. Mol. Cell Biol. , vol.9 , pp. 139-150
    • Hannun, Y.A.1    Obeid, L.M.2
  • 14
    • 0035793866 scopus 로고    scopus 로고
    • Role of the sphingosine-1-phosphate receptor EDG-1 in PDGF-induced cell motility
    • Hobson J.P., Rosenfeldt H.M., Barak L.S., Olivera A., Poulton S., Caron M.G., et al. Role of the sphingosine-1-phosphate receptor EDG-1 in PDGF-induced cell motility. Science 2001, 291:1800-1803.
    • (2001) Science , vol.291 , pp. 1800-1803
    • Hobson, J.P.1    Rosenfeldt, H.M.2    Barak, L.S.3    Olivera, A.4    Poulton, S.5    Caron, M.G.6
  • 15
    • 78649982367 scopus 로고    scopus 로고
    • STAT3-induced S1PR1 expression is crucial for persistent STAT3 activation in tumors
    • Lee H., Deng J., Kujawski M., Yang C., Liu Y., Herrmann A., et al. STAT3-induced S1PR1 expression is crucial for persistent STAT3 activation in tumors. Nat. Med. 2010, 16:1421-1428.
    • (2010) Nat. Med. , vol.16 , pp. 1421-1428
    • Lee, H.1    Deng, J.2    Kujawski, M.3    Yang, C.4    Liu, Y.5    Herrmann, A.6
  • 16
    • 84872406787 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate links persistent STAT3 activation, chronic intestinal inflammation, and development of colitis-associated cancer
    • Liang J., Nagahashi M., Kim E.Y., Harikumar K.B., Yamada A., Huang W.C., et al. Sphingosine-1-phosphate links persistent STAT3 activation, chronic intestinal inflammation, and development of colitis-associated cancer. Cancer Cell 2013, 23:107-120.
    • (2013) Cancer Cell , vol.23 , pp. 107-120
    • Liang, J.1    Nagahashi, M.2    Kim, E.Y.3    Harikumar, K.B.4    Yamada, A.5    Huang, W.C.6
  • 17
    • 84874255475 scopus 로고    scopus 로고
    • Biological characterization of 3-(2-amino-ethyl)-5-[3-(4-butoxyl-phenyl)-propylidene]-thiazolidine-2,4-dione (K145) as a selective sphingosine Kinase-2 inhibitor and anticancer Agent
    • Liu K., Guo T.L., Hait N.C., Allegood J., Parikh H.I., Xu W., et al. Biological characterization of 3-(2-amino-ethyl)-5-[3-(4-butoxyl-phenyl)-propylidene]-thiazolidine-2,4-dione (K145) as a selective sphingosine Kinase-2 inhibitor and anticancer Agent. Plos One 2013, 8:e56471.
    • (2013) Plos One , vol.8 , pp. e56471
    • Liu, K.1    Guo, T.L.2    Hait, N.C.3    Allegood, J.4    Parikh, H.I.5    Xu, W.6
  • 18
    • 84865159639 scopus 로고    scopus 로고
    • S1PR1 is an effective target to block STAT3 signaling in activated B cell-like diffuse large B-cell lymphoma
    • Liu Y., Deng J., Wang L., Lee H., Armstrong B., Scuto A., et al. S1PR1 is an effective target to block STAT3 signaling in activated B cell-like diffuse large B-cell lymphoma. Blood 2012, 120:1458-1465.
    • (2012) Blood , vol.120 , pp. 1458-1465
    • Liu, Y.1    Deng, J.2    Wang, L.3    Lee, H.4    Armstrong, B.5    Scuto, A.6
  • 19
    • 84901936622 scopus 로고    scopus 로고
    • Sphingolipid metabolites in inflammatory disease
    • Maceyka M., Spiegel S. Sphingolipid metabolites in inflammatory disease. Nature 2014, 510:58-67.
    • (2014) Nature , vol.510 , pp. 58-67
    • Maceyka, M.1    Spiegel, S.2
  • 21
    • 33846066888 scopus 로고    scopus 로고
    • Estrogen signaling multiple pathways to impact gene transcription
    • Marino M., Galluzzo P., Ascenzi P. Estrogen signaling multiple pathways to impact gene transcription. Curr. Genomics 2006, 7:497-508.
    • (2006) Curr. Genomics , vol.7 , pp. 497-508
    • Marino, M.1    Galluzzo, P.2    Ascenzi, P.3
  • 22
    • 84894114392 scopus 로고    scopus 로고
    • Inhibition of insulin-like growth factor-binding protein-3 signaling through sphingosine kinase-1 sensitizes triple-negative breast cancer cells to EGF receptor blockade
    • Martin J.L., de Silva H.C., Lin M.Z., Scott C.D., Baxter R.C. Inhibition of insulin-like growth factor-binding protein-3 signaling through sphingosine kinase-1 sensitizes triple-negative breast cancer cells to EGF receptor blockade. Mol. Cancer Ther. 2014, 13:316-328.
    • (2014) Mol. Cancer Ther. , vol.13 , pp. 316-328
    • Martin, J.L.1    de Silva, H.C.2    Lin, M.Z.3    Scott, C.D.4    Baxter, R.C.5
  • 23
    • 0037204724 scopus 로고    scopus 로고
    • Connections and regulation of the human estrogen receptor
    • McDonnell D.P., Norris J.D. Connections and regulation of the human estrogen receptor. Science 2002, 296:1642-1644.
    • (2002) Science , vol.296 , pp. 1642-1644
    • McDonnell, D.P.1    Norris, J.D.2
  • 25
    • 84863057277 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate produced by sphingosine kinase 1 promotes breast cancer progression by stimulating angiogenesis and lymphangiogenesis
    • Nagahashi M., Ramachandran S., Kim E.Y., Allegood J.C., Rashid O.M., Yamada A., et al. Sphingosine-1-phosphate produced by sphingosine kinase 1 promotes breast cancer progression by stimulating angiogenesis and lymphangiogenesis. Cancer Res. 2012, 72:726-735.
    • (2012) Cancer Res. , vol.72 , pp. 726-735
    • Nagahashi, M.1    Ramachandran, S.2    Kim, E.Y.3    Allegood, J.C.4    Rashid, O.M.5    Yamada, A.6
  • 26
    • 0036436697 scopus 로고    scopus 로고
    • Sphingosine kinase type 1 promotes estrogen-dependent tumorigenesis of breast cancer MCF-7 cells
    • Nava V.E., Hobson J.P., Murthy S., Milstien S., Spiegel S. Sphingosine kinase type 1 promotes estrogen-dependent tumorigenesis of breast cancer MCF-7 cells. Exp. Cell Res. 2002, 281:115-127.
    • (2002) Exp. Cell Res. , vol.281 , pp. 115-127
    • Nava, V.E.1    Hobson, J.P.2    Murthy, S.3    Milstien, S.4    Spiegel, S.5
  • 27
    • 84927913180 scopus 로고    scopus 로고
    • Revisiting the sphingolipid rheostat: evolving concepts in cancer therapy
    • Newton J., Lima S., Maceyka M., Spiegel S. Revisiting the sphingolipid rheostat: evolving concepts in cancer therapy. Exp. Cell Res. 2015, 333:195-200.
    • (2015) Exp. Cell Res. , vol.333 , pp. 195-200
    • Newton, J.1    Lima, S.2    Maceyka, M.3    Spiegel, S.4
  • 29
    • 84931085758 scopus 로고    scopus 로고
    • Binding of the sphingolipid S1P to hTERT stabilizes telomerase at the nuclear periphery by allosterically mimicking protein phosphorylation
    • Panneer Selvam S., De Palma R.M., Oaks J.J., Oleinik N., Peterson Y.K., Stahelin R.V., et al. Binding of the sphingolipid S1P to hTERT stabilizes telomerase at the nuclear periphery by allosterically mimicking protein phosphorylation. Sci. Signal. 2015, 8:ra58.
    • (2015) Sci. Signal. , vol.8 , pp. ra58
    • Panneer Selvam, S.1    De Palma, R.M.2    Oaks, J.J.3    Oleinik, N.4    Peterson, Y.K.5    Stahelin, R.V.6
  • 30
    • 84893415078 scopus 로고    scopus 로고
    • The role of sphingosine 1-phosphate in inflammation and cancer
    • Pyne N.J., Ohotski J., Bittman R., Pyne S. The role of sphingosine 1-phosphate in inflammation and cancer. Adv. Biol. Regul. 2014, 54:121-129.
    • (2014) Adv. Biol. Regul. , vol.54 , pp. 121-129
    • Pyne, N.J.1    Ohotski, J.2    Bittman, R.3    Pyne, S.4
  • 32
    • 80053259864 scopus 로고    scopus 로고
    • Sphingolipid-based drugs selectively kill cancer cells by down-regulating nutrient transporter proteins
    • Romero Rosales K., Singh G., Wu K., Chen J., Janes M.R., Lilly M.B., et al. Sphingolipid-based drugs selectively kill cancer cells by down-regulating nutrient transporter proteins. Biochem. J. 2011, 439:299-311.
    • (2011) Biochem. J. , vol.439 , pp. 299-311
    • Romero Rosales, K.1    Singh, G.2    Wu, K.3    Chen, J.4    Janes, M.R.5    Lilly, M.B.6
  • 33
    • 52949143502 scopus 로고    scopus 로고
    • Microarray analysis of altered sphingolipid metabolism reveals prognostic significance of sphingosine kinase 1 in breast cancer
    • Ruckhaberle E., Rody A., Engels K., Gaetje R., von Minckwitz G., Schiffmann S., et al. Microarray analysis of altered sphingolipid metabolism reveals prognostic significance of sphingosine kinase 1 in breast cancer. Breast Cancer Res. Treat. 2008, 112:41-52.
    • (2008) Breast Cancer Res. Treat. , vol.112 , pp. 41-52
    • Ruckhaberle, E.1    Rody, A.2    Engels, K.3    Gaetje, R.4    von Minckwitz, G.5    Schiffmann, S.6
  • 34
    • 84862883653 scopus 로고    scopus 로고
    • Role of estrogen receptor signaling in breast cancer metastasis
    • Saha Roy S., Vadlamudi R.K. Role of estrogen receptor signaling in breast cancer metastasis. Int. J. Breast Cancer 2012, 2012:654698.
    • (2012) Int. J. Breast Cancer , vol.2012 , pp. 654698
    • Saha Roy, S.1    Vadlamudi, R.K.2
  • 35
    • 84920856216 scopus 로고    scopus 로고
    • Roles and regulation of neutral sphingomyelinase-2 in cellular and pathological processes
    • Shamseddine A.A., Airola M.V., Hannun Y.A. Roles and regulation of neutral sphingomyelinase-2 in cellular and pathological processes. Adv. Biol. Regul. 2015, 57:24-41.
    • (2015) Adv. Biol. Regul. , vol.57 , pp. 24-41
    • Shamseddine, A.A.1    Airola, M.V.2    Hannun, Y.A.3
  • 36
    • 79551648970 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate produced by sphingosine kinase 2 in mitochondria interacts with prohibitin 2 to regulate complex IV assembly and respiration
    • Strub G.M., Paillard M., Liang J., Gomez L., Allegood J.C., Hait N.C., et al. Sphingosine-1-phosphate produced by sphingosine kinase 2 in mitochondria interacts with prohibitin 2 to regulate complex IV assembly and respiration. FASEB J. 2011, 25:600-612.
    • (2011) FASEB J. , vol.25 , pp. 600-612
    • Strub, G.M.1    Paillard, M.2    Liang, J.3    Gomez, L.4    Allegood, J.C.5    Hait, N.C.6
  • 37
    • 84894315496 scopus 로고    scopus 로고
    • Role of sphingolipids in oestrogen signalling in breast cancer cells: an update
    • Sukocheva O., Wadham C. Role of sphingolipids in oestrogen signalling in breast cancer cells: an update. J. Endocrinol. 2014, 220:R25-R35.
    • (2014) J. Endocrinol. , vol.220 , pp. R25-R35
    • Sukocheva, O.1    Wadham, C.2
  • 38
    • 33646117016 scopus 로고    scopus 로고
    • Estrogen transactivates EGFR via the sphingosine 1-phosphate receptor Edg-3: the role of sphingosine kinase-1
    • Sukocheva O., Wadham C., Holmes A., Albanese N., Verrier E., Feng F., et al. Estrogen transactivates EGFR via the sphingosine 1-phosphate receptor Edg-3: the role of sphingosine kinase-1. J. Cell Biol. 2006, 173:301-310.
    • (2006) J. Cell Biol. , vol.173 , pp. 301-310
    • Sukocheva, O.1    Wadham, C.2    Holmes, A.3    Albanese, N.4    Verrier, E.5    Feng, F.6
  • 39
    • 84875519602 scopus 로고    scopus 로고
    • Estrogen defines the dynamics and destination of transactivated EGF receptor in breast cancer cells: role of S1P(3) receptor and Cdc42
    • Sukocheva O., Wadham C., Xia P. Estrogen defines the dynamics and destination of transactivated EGF receptor in breast cancer cells: role of S1P(3) receptor and Cdc42. Exp. Cell Res. 2013, 319:455-465.
    • (2013) Exp. Cell Res. , vol.319 , pp. 455-465
    • Sukocheva, O.1    Wadham, C.2    Xia, P.3
  • 40
    • 70349333252 scopus 로고    scopus 로고
    • Restoring endocrine response in breast cancer cells by inhibition of the sphingosine kinase-1 signaling pathway
    • Sukocheva O., Wang L., Verrier E., Vadas M.A., Xia P. Restoring endocrine response in breast cancer cells by inhibition of the sphingosine kinase-1 signaling pathway. Endocrinology 2009, 150:4484-4492.
    • (2009) Endocrinology , vol.150 , pp. 4484-4492
    • Sukocheva, O.1    Wang, L.2    Verrier, E.3    Vadas, M.A.4    Xia, P.5
  • 41
    • 77951214876 scopus 로고    scopus 로고
    • Estradiol induces export of sphingosine 1-phosphate from breast cancer cells via ABCC1 and ABCG2
    • Takabe K., Kim R.H., Allegood J.C., Mitra P., Ramachandran S., Nagahashi M., et al. Estradiol induces export of sphingosine 1-phosphate from breast cancer cells via ABCC1 and ABCG2. J. Biol. Chem. 2010, 285:10477-10486.
    • (2010) J. Biol. Chem. , vol.285 , pp. 10477-10486
    • Takabe, K.1    Kim, R.H.2    Allegood, J.C.3    Mitra, P.4    Ramachandran, S.5    Nagahashi, M.6
  • 42
    • 46949104885 scopus 로고    scopus 로고
    • "Inside-out" signaling of sphingosine-1-phosphate: therapeutic targets
    • Takabe K., Paugh S.W., Milstien S., Spiegel S. "Inside-out" signaling of sphingosine-1-phosphate: therapeutic targets. Pharmacol. Rev. 2008, 60:181-195.
    • (2008) Pharmacol. Rev. , vol.60 , pp. 181-195
    • Takabe, K.1    Paugh, S.W.2    Milstien, S.3    Spiegel, S.4
  • 43
    • 84901930134 scopus 로고    scopus 로고
    • Export of sphingosine-1-phosphate and cancer progression
    • Takabe K., Spiegel S. Export of sphingosine-1-phosphate and cancer progression. J. Lipid Res. 2014, 9:1839-1846.
    • (2014) J. Lipid Res. , vol.9 , pp. 1839-1846
    • Takabe, K.1    Spiegel, S.2
  • 44
    • 84903272599 scopus 로고    scopus 로고
    • Evolving concepts in cancer therapy through targeting sphingolipid metabolism
    • Truman J.P., Garcia-Barros M., Obeid L.M., Hannun Y.A. Evolving concepts in cancer therapy through targeting sphingolipid metabolism. Biochim. Biophys. Acta 2014, 1841:1174-1188.
    • (2014) Biochim. Biophys. Acta , vol.1841 , pp. 1174-1188
    • Truman, J.P.1    Garcia-Barros, M.2    Obeid, L.M.3    Hannun, Y.A.4
  • 45
    • 78149348826 scopus 로고    scopus 로고
    • High expression of sphingosine 1-phosphate receptors, S1P1 and S1P3, sphingosine kinase 1, and extracellular signal-regulated kinase-1/2 is associated with development of tamoxifen resistance in estrogen receptor-positive breast cancer patients
    • Watson C., Long J.S., Orange C., Tannahill C.L., Mallon E., McGlynn L.M., et al. High expression of sphingosine 1-phosphate receptors, S1P1 and S1P3, sphingosine kinase 1, and extracellular signal-regulated kinase-1/2 is associated with development of tamoxifen resistance in estrogen receptor-positive breast cancer patients. Am. J. Pathol. 2010, 177:2205-2215.
    • (2010) Am. J. Pathol. , vol.177 , pp. 2205-2215
    • Watson, C.1    Long, J.S.2    Orange, C.3    Tannahill, C.L.4    Mallon, E.5    McGlynn, L.M.6
  • 46
    • 84873673109 scopus 로고    scopus 로고
    • The roles of sphingosine kinases 1 and 2 in regulating the Warburg effect in prostate cancer cells
    • Watson D.G., Tonelli F., Alossaimi M., Williamson L., Chan E., Gorshkova I., et al. The roles of sphingosine kinases 1 and 2 in regulating the Warburg effect in prostate cancer cells. Cell Signal. 2013, 25:1011-1017.
    • (2013) Cell Signal. , vol.25 , pp. 1011-1017
    • Watson, D.G.1    Tonelli, F.2    Alossaimi, M.3    Williamson, L.4    Chan, E.5    Gorshkova, I.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.