Effects of oral supplementation of iron on hepcidin blood concentrations among non-anaemic female blood donors: A randomized controlled trial

Vox Sanguinis

Volumn 110, Issue 2, 2016, Pages 166-171

  Waldvogel, S ^a   Rochat, B ^b   Peduzzi, D ^b   Vaucher, P ^c   Tissot, J D ^d   Favrat, B ^b,c  

^a GENEVA UNIVERSITY HOSPITALS   (Switzerland)

^b LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^c UNIVERSITY CENTER OF LEGAL MEDICINE   (Switzerland)

^d Blood Transfusion Service of the Swiss Red Cross   (Switzerland)

Author keywords

Blood donation; Ferritin; Hepcidin; Iron deficiency; Oral iron

Indexed keywords

FERRITIN; FERROUS SULFATE; HEMOGLOBIN; HEPCIDIN; BIOLOGICAL MARKER; IRON; IRON INTAKE;

ADULT; ARTICLE; CONTROLLED STUDY; DIET SUPPLEMENTATION; DRUG EFFECT; FEMALE; FERRITIN BLOOD LEVEL; HEMOGLOBIN BLOOD LEVEL; HUMAN; IRON DEFICIENCY; MASS SPECTROMETRY; PREMENOPAUSE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TREATMENT RESPONSE; ADMINISTRATION AND DOSAGE; ADOLESCENT; BLOOD; BLOOD DONOR; DRUG EFFECTS; IRON INTAKE; MIDDLE AGED; ORAL DRUG ADMINISTRATION; PHARMACOLOGY;

ADMINISTRATION, ORAL; ADOLESCENT; ADULT; BIOMARKERS; BLOOD DONORS; FEMALE; HEMOGLOBINS; HEPCIDINS; HUMANS; IRON; IRON, DIETARY; MIDDLE AGED;

EID: 84958641846     PISSN: 00429007     EISSN: 14230410     Source Type: Journal    
DOI: 10.1111/vox.12348     Document Type: Article

References (22)

1. Nicolas G, Bennoun M, Devaux I, et al.: Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice. Proc Natl Acad Sci USA 2001; 98:8780-8785
2. Nemeth E, Tuttle MS, Powelson J, et al.: Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science 2004; 306:2090-2093
3. Pak M, Lopez MA, Gabayan V, et al.: Suppression of hepcidin during anemia requires erythropoietic activity. Blood 2006; 108:3730-3735
4. Kautz L, Jung G, Valore EV, et al.: Identification of erythroferrone as an erythroid regulator of iron metabolism. Nat Genet 2014; 46:678-684
5. Galan P, Yoon HC, Preziosi P, et al.: Determining factors in the iron status of adult women in the SU.VI.MAX study. Supplementation en Vitamines et Mineraux Antioxydants. Eur J Clin Nutr 1998; 52:383-388
6. Cable RG, Glynn SA, Kiss JE, et al.: Iron deficiency in blood donors: analysis of enrollment data from the REDS-II Donor Iron Status Evaluation (RISE) study. Transfusion 2011; 51:511-522
7. Verdon F, Burnand B, Stubi CL, et al.: Iron supplementation for unexplained fatigue in non-anaemic women: double blind randomised placebo controlled trial. BMJ 2003; 326:1124
8. Murray-Kolb LE, Beard JL: Iron treatment normalizes cognitive functioning in young women. Am J Clin Nutr 2007; 85:778-787
9. Brownlie T, Utermohlen V, Hinton PS, et al.: Tissue iron deficiency without anemia impairs adaptation in endurance capacity after aerobic training in previously untrained women. Am J Clin Nutr 2004; 79:437-443
10. Roughead ZK, Hunt JR: Adaptation in iron absorption: iron supplementation reduces nonheme-iron but not heme-iron absorption from food. Am J Clin Nutr 2000; 72:982-989
11. Kroot JJ, van Herwaarden AE, Tjalsma H, et al.: Second round robin for plasma hepcidin methods: first steps toward harmonization. Am J Hematol 2012; 87:977-983
12. Bregman DB, Morris D, Koch TA, et al.: Hepcidin levels predict nonresponsiveness to oral iron therapy in patients with iron deficiency anemia. Am J Hematol 2013; 88:97-101
13. Mast AE, Schlumpf KS, Wright DJ, et al.: Hepcidin level predicts hemoglobin concentration in individuals undergoing repeated phlebotomy. Haematologica 2013; 98:1324-1330
14. Waldvogel S, Pedrazzini B, Vaucher P, et al.: Clinical evaluation of iron treatment efficiency among non-anemic but iron-deficient female blood donors: a randomized controlled trial. BMC Med 2012; 10:8
15. Pedrazzini B, Waldvogel S, Cornuz J, et al.: The impact of iron supplementation efficiency in female blood donors with a decreased ferritin level and no anaemia. Rationale and design of a randomised controlled trial: a study protocol. Trials 2009; 10:4
16. Ganz T, Olbina G, Girelli D, et al.: Immunoassay for human serum hepcidin. Blood 2008; 112:4292-4297
17. Rochat B, Peduzzi D, McMullen J, et al.: Validation of hepcidin quantification in plasma using LC-HRMS and discovery of a new hepcidin isoform. Bioanalysis 2013; 5:2509-2520
18. Mazur A, Feillet-Coudray C, Romier B, et al.: Dietary iron regulates hepatic hepcidin 1 and 2 mRNAs in mice. Metabolism 2003; 52:1229-1231
19. Berglund S, Lonnerdal B, Westrup B, et al.: Effects of iron supplementation on serum hepcidin and serum erythropoietin in low-birth-weight infants. Am J Clin Nutr 2011; 94:1553-1561
20. Papanikolaou G, Tzilianos M, Christakis JI, et al.: Hepcidin in iron overload disorders. Blood 2005; 105:4103-4105
21. Guyatt GH, Oxman AD, Ali M, et al.: Laboratory diagnosis of iron-deficiency anemia: an overview. J Gen Intern Med 1992; 7:145-153
22. Rushton DH, Barth JH: What is the evidence for gender differences in ferritin and haemoglobin? Crit Rev Oncol Hematol 2010; 73:1-9