Discovery of cahuitamycins as biofilm inhibitors derived from a convergent biosynthetic pathway

Nature Communications

Volumn 7, Issue , 2016, Pages

  Park, Sung Ryeol ^a   Tripathi, Ashootosh ^a   Wu, Jianfeng ^a   Schultz, Pamela J ^a   Yim, Isaiah ^a,e   McQuade, Thomas J ^a   Yu, Fengan ^a   Arevang, Carl Johan ^a,f   Mensah, Abraham Y ^a,g   Tamayo Castillo, Giselle ^b,c   Xi, Chuanwu ^a   Sherman, David H ^a,d  

^a UNIVERSITY OF MICHIGAN   (United States)

^b INSTITUTO NACIONAL DE BIODIVERSIDAD   (Costa Rica)

^c UNIVERSIDAD DE COSTA RICA   (Costa Rica)

^d UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^e NATIONAL CANCER INSTITUTE   (United States)

^f KAROLINSKA INSTITUTE   (Sweden)

^g KWAME NKRUMAH UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Ghana)

Author keywords

[No Author keywords available]

Indexed keywords

ACYL CARRIER PROTEIN; ACYLTRANSFERASE; ALANINE DERIVATIVE; ANTIBIOTIC AGENT; ASPARTIC ACID DERIVATIVE; BACTERIAL EXTRACT; BENZOIC ACID DERIVATIVE; CAHUITAMYCIN A; CAHUITAMYCIN B; CAHUITAMYCIN C; CAHUITAMYCIN D; CAHUITAMYCIN DERIVATIVE; CAHUITAMYCIN E; CATECHOL METHYLTRANSFERASE; DEFEROXAMINE; EDETIC ACID; HYDROLYASE; IRON; METHYLTRANSFERASE; NONRIBOSOMAL PEPTIDE SYNTHETASE; ORNITHINE; RIBOSOME PROTEIN; SERINE; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; BACTERIAL PROTEIN; CAHUITAMYCIN A PROTEIN, STREPTOMYCES GANDOCAENSIS; CAHUITAMYCIN B PROTEIN, STREPTOMYCES GANDOCAENSIS; CAHUITAMYCIN C PROTEIN, STREPTOMYCES GANDOCAENSIS; OLIGOPEPTIDE;

ANTIBIOTIC RESISTANCE; BACTERIUM; BIOCHEMISTRY; BIOFILM; GENE EXPRESSION; INHIBITOR; ORGANIC COMPOUND; PHYSIOLOGY;

ACINETOBACTER BAUMANNII; ADENYLATION; ANTIBIOTIC BIOSYNTHESIS; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GROWTH; BACTERIAL STRAIN; BIOFILM; BIOLOGICAL ACTIVITY; CELL ENGINEERING; COMPUTER MODEL; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYCLIZATION; DRUG DETERMINATION; DRUG ISOLATION; DRUG POTENCY; DRUG PURIFICATION; GENE CLUSTER; GENE INSERTION; GENE LOCUS; GENETIC ANALYSIS; GROWTH INHIBITION; HETERONUCLEAR MULTIPLE BOND CORRELATION; HIGH THROUGHPUT SCREENING; IC50; IN VITRO STUDY; IRON CHELATION; IRON TRANSPORT; MOLECULAR STABILITY; MUTAGENESIS; NONHUMAN; PHARMACOPHORE; POINT MUTATION; PROTEIN PROCESSING; RIBOSOME; STEREOCHEMISTRY; STREPTOMYCES; STREPTOMYCES GANDOCAENSIS; BIOSYNTHESIS; DRUG EFFECTS; PHYSIOLOGY;

ACINETOBACTER BAUMANNII; STREPTOMYCES;

ACINETOBACTER BAUMANNII; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BIOFILMS; BIOSYNTHETIC PATHWAYS; HIGH-THROUGHPUT SCREENING ASSAYS; OLIGOPEPTIDES; STREPTOMYCES;

EID: 84958568345     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms10710     Document Type: Article

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