Biological modeling of mucus to modulate mucus barriers

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 310, Issue 4, 2016, Pages G225-G227

  Desseyn, Jean Luc ^a   Gouyer, Valérie ^a   Gottrand, Frédéric ^a  

^a UNIVERSITÉ DE LILLE   (France)

Author keywords

Gelling mucin; Mucin CYS domain; Mucosal barrier; Mucus; Transgenic mouse

Indexed keywords

MUCIN; MUCIN 2;

ARTICLE; BACTERIAL TRANSLOCATION; CACHEXIA; CHRONIC LIVER DISEASE; CITROBACTER RODENTIUM; FEEDING; GLYCOSYLATION; INFECTION; INTESTINE MUCOSA; INTESTINE OBSTRUCTION; LACTOBACILLUS; MOUSE; MUCOSA INFLAMMATION; MUCUS; MUCUS SECRETION; NONHUMAN; PRIORITY JOURNAL; TRANSGENIC MOUSE; YEAST; ANIMAL; IMMUNOLOGY; INTESTINE FLORA; METABOLISM; PHYSIOLOGY; TIGHT JUNCTION;

ANIMALS; GASTROINTESTINAL MICROBIOME; INTESTINAL MUCOSA; MUCIN-2; MUCUS; TIGHT JUNCTIONS;

EID: 84958544752     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00274.2015     Document Type: Article

References (36)

1. Bäckström M, Ambort D, Thomsson E, Johansson MEV, Hansson GC. Increased understanding of the biochemistry and biosynthesis of MUC2 and other gel-forming mucins through the recombinant expression of their protein domains. Mol Biotechnol 54: 250–256, 2013.
2. Bansil R, Stanley E, LaMont JT. Mucin biophysics. Annu Rev Physiol 57: 635–657, 1995.
3. Bansil R, Turner BS. Mucin structure, aggregation, physiological functions and biomedical applications. Curr Opin Colloid Interface Sci 11: 164–170, 2006.
4. Becker C, Neurath MF, Wirtz S. The intestinal microbiota in inflammatory bowel disease. ILAR J 56: 192–204, 2015.
5. Bermúdez-Humarán LG, Aubry C, Motta JP, Deraison C, Steidler L, Vergnolle N, Chatel JM, Langella P. Engineering lactococci and lactobacilli for human health. Curr Opin Microbiol 16: 278–283, 2013.
6. Borges S, Silva J, Teixeira P. The role of lactobacilli and probiotics in maintaining vaginal health. Arch Gynecol Obstet 289: 479–489, 2014.
7. Bromberg LE, Barr DP. Self-association of mucin. Biomacromolecules 1: 325–334, 2000.
8. Brunelli R, Papi M, Arcovito G, Bompiani A, Castagnola M, Parasassi T, Sampaolese B, Vincenzoni F, De Spirito M. Globular structure of human ovulatory cervical mucus. FASEB J 21: 3872–3876, 2007.
9. Camilleri M, Murphy R, Chadwick VS. Dose-related effects of chenodeoxycholic acid in the rabbit colon. Dig Dis Sci 25: 433–438, 1980.
10. Cao X, Bansil R, Bhaskar KR, Turner BS, LaMont JT, Niu N, Afdhal NH. pH-dependent conformational change of gastric mucin leads to sol-gel transition. Biophys J 76: 1250–1258, 1999.
11. Chen Y, Zhao YH, Kalaslavadi TB, Hamati E, Nehrke K, Le AD, Ann DK, Wu R. Genome-wide search and identification of a novel gel-forming mucin MUC19/Muc19 in glandular tissues. Am J Respir Cell Mol Biol 30: 155–165, 2004.
12. De Waele JJ. Rational use of antimicrobials in patients with severe acute pancreatitis. Semin Respir Crit Care Med 32: 174–180, 2011.
13. Desseyn JL. Mucin CYS domains are ancient and highly conserved modules that evolved in concert. Mol Phylogenet Evol 52: 284–292, 2009.
14. Gouyer V, Dubuquoy L, Robbe-Masselot C, Neut C, Singer E, Plet S, Geboes K, Desreumaux P, Gottrand F, Desseyn JL. Delivery of a mucin domain enriched in cysteine residues strengthens the intestinal mucous barrier. Sci Rep 5: 9577, 2015.
15. Johansson MEV, Gustafsson JK, Holmen-Larsson J, Jabbar KS, Xia L, Xu H, Ghishan FK, Carvalho FA, Gewirtz AT, Sjovall H, Hansson GC. Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis. Gut 63: 281–291, 2014.
16. Johansson MEV, Sjovall H, Hansson GC, Sjövall H, Hansson GC. The gastrointestinal mucus system in health and disease. Nat Rev Gastroenterol Hepatol 10: 352–361, 2013.
17. Kaiko GE, Stappenbeck TS. Host-microbe interactions shaping the gastrointestinal environment. Trends Immunol 35: 538–548, 2014.
18. Kelly T, Buxbaum J. Gastrointestinal manifestations of cystic fibrosis. Dig Dis Sci 60: 1903–1913, 2015.
19. Khor B, Gardet A, Xavier RJ. Genetics and pathogenesis of inflammatory bowel disease. Nature 474: 307–317, 2011.
20. Klinkspoor JH, Mok KS, Van Klinken BJ, Tytgat GN, Lee SP, Groen AK. Mucin secretion by the human colon cell line LS174T is regulated by bile salts. Glycobiology 9: 13–19, 1999.
21. Knoop KA, McDonald KG, Kulkarni DH, Newberry RD. Antibiotics promote inflammation through the translocation of native commensal colonic bacteria. Gut 2015 Jun 4. doi: 10.1136/gutjnl-2014-309059. [Epub ahead of print].
22. Lai SK, Wang YY, Wirtz D, Hanes J. Micro- and macrorheology of mucus. Adv Drug Deliv Rev 61: 86–100, 2009.
23. Lee HY, Crawley S, Hokari R, Kwon S, Kim YS. Bile acid regulates MUC2 transcription in colon cancer cells via positive EGFR/PKC/Ras/ ERK/CREB, PI3K/Akt/IkappaB/NF-kappaB and p38/MSK1/CREB pathways and negative JNK/c-Jun/AP-1 pathway. Int J Oncol 36: 941–953, 2010.
24. Liévin-Le Moal V, Servin AL. Anti-infective activities of lactobacillus strains in the human intestinal microbiota: from probiotics to gastrointestinal anti-infectious biotherapeutic agents. Clin Microbiol Rev 27: 167–199, 2014.
25. Madzak C, Gaillardin C, Beckerich JM. Heterologous protein expression and secretion in the non-conventional yeast Yarrowia lipolytica: a review. J Biotechnol 109: 63–81, 2004.
26. Pavlidis P, Powell N, Vincent RP, Ehrlich D, Bjarnason I, Hayee B. Systematic review: bile acids and intestinal inflammation-luminal aggressors or regulators of mucosal defence? Aliment Pharmacol Ther 42: 802–817, 2015.
27. Perez-Vilar J, Boucher RC. Reevaluating gel-forming mucins’ roles in cystic fibrosis lung disease. Free Radic Biol Med 37: 1564–1577, 2004.
28. Ridley C, Kouvatsos N, Raynal BD, Howard M, Collins RF, Desseyn JL, Jowitt TA, Baldock C, Davis CW, Hardingham TE, Thornton DJ. Assembly of the respiratory mucin MUC5B: a new model for a gelforming Mucin. J Biol Chem 289: 16409–16420, 2014.
29. Sampson TR, Weiss DS. Exploiting CRISPR/Cas systems for biotechnology. Bioessays 36: 34–38, 2014.
30. Schietroma M, Pessia B, Carlei F, Cecilia EM, De Santis G, Amicucci G. Laparoscopic versus open colorectal surgery for colon cancer: the effect of surgical trauma on the bacterial translocation. A prospective randomized study. Am J Surg 210: 263–269, 2015.
31. Schnabl B, Brenner DA. Interactions between the intestinal microbiome and liver diseases. Gastroenterology 146: 1513–1524, 2014.
32. Shekels LL, Lyftogt CT, Ho SB. Bile acid-induced alterations of mucin production in differentiated human colon cancer cell lines. Int J Biochem Cell Biol 28: 193–201, 1996.
33. Swank GM, Deitch EA. Role of the gut in multiple organ failure: bacterial translocation and permeability changes. World J Surg 20: 411–417, 1996.
34. Valque H, Gouyer V, Husson MO, Gottrand F, Desseyn JL. Abnormal expression of Muc5b in Cftr-null mice and in mammary tumors of MMTV-ras mice. Histochem Cell Biol 136: 699–708, 2011.
35. van Vliet MJ, Harmsen HJM, de Bont ESJM, Tissing WJE. The role of intestinal microbiota in the development and severity of chemotherapyinduced mucositis. PLoS Pathog 6: e1000879, 2010.
36. Zhang K, Hornef MW, Dupont A. The intestinal epithelium as guardian of gut barrier integrity. Cell Microbiol 17: 1561–1569, 2015.