Liver injury from herbal, dietary, and weight loss supplements: A review

Journal of Clinical and Translational Hepatology

Volumn 3, Issue 2, 2015, Pages 93-98

  Zheng, Elizabeth X ^a   Navarro, Victor J ^a  

^a EINSTEIN MEDICAL CENTER   (United States)

Author keywords

Drug induced liver injury; Herbal and dietary supplements; Weight loss supplements

Indexed keywords

EID: 84958521541     PISSN: 22250719     EISSN: 23108819     Source Type: Journal    
DOI: 10.14218/JCTH.2015.00006     Document Type: Review

References (40)

1. Briefel RR, Johnson CL. Secular trends in dietary intake in the United States. Annu Rev Nutr 2004;24:401–431. doi: 10.1146/annurev.nutr.23.011702. 073349.
2. Bailey RL, Gahche JJ, Lentino CV, Dwyer JT, Engel JS, Thomas PR, et al. Dietary supplement use in the United States, 2003-2006. J Nutr 2011;141:261–266. doi: 10.3945/jn.110.133025.
3. Navarro VJ, Barnhart H, Bonkovsky HL, Davern T, Fontana RJ, Grant L, et al. Liver injury from herbals and dietary supplements in the U.S. Drug-Induced Liver Injury Network. Hepatology 2014;60:1399–1408. doi: 10.1002/hep. 27317.
4. Sgro C, Clinard F, Ouazir K, Chanay H, Allard C, Guilleminet C, et al. Incidence of drug-induced hepatic injuries: a French population-based study. Hepatology 2002;36:451–455. doi: 10.1053/jhep.2002.34857.
5. Björnsson ES, Bergmann OM, Björnsson HK, Kvaran RB, Olafsson S. Incidence, presentation, and outcomes in patients with drug-induced liver injury in the general population of Iceland. Gastroenterology 2013;144:1419–1425. doi: 10.1053/j.gastro.2013.02.006.
6. Benichou C. Criteria of drug-induced liver disorders: report of an international consensus meeting. J Hepatol 1990;11:272–276.
7. http://www.fda.gov/cder/livertox/clinical.pdf, accessed January 11, 2015.
8. Davern TJ, Chalasani N, Fontana RJ, Hayashi PH, Protiva P, Kleiner DE, et al. Acute hepatitis E infection accounts for some cases of suspected drug-induced liver injury. Gastroenterology 2011;141:1665–1672.e1-e9. doi: 10.1053/j. gastro.2011.07.051.
9. Danan G, Benichou C. Causality assessment of adverse reactions to drugs—I. A novel method based on the conclusions of international consensus meetings: application to drug-induced liver injuries. J Clin Epidemiol 1993;46: 1323–1330. doi: 10.1016/0895-4356(93)90101-6.
10. Maria VA, Victorino RM. Development and validation of a clinical scale for the diagnosis of drug-induced hepatitis. Hepatology 1997;26:664–669. doi: 10. 1002/hep.510260319.
11. Benichou C, Danan G, Flahault A. Causality assessment of adverse reaction to drugs –II. An original model for validation of drug causality assessment methods: case reports with positive rechallenge. J Clin Epidemiol 1993;46:1331– 1336. doi: 10.1016/0895-4356(93)90102-7.
12. Rockey DC, Seeff LB, Rochon J, Freston J, Chalasani N, Bonacini M, et al. Causality assessment in drug-induced liver injury using a structured expert opinion process: comparison to the Roussel-Uclaf causality assessment method. Hepatology 2010;51:2117–2126. doi: 10.1002/hep.23577.
13. Bonkovsky HL, Shedlofsky SI, Jones DP, LaBrecque D. Drug-induced liver injury. In: Boyer TD, Manns MP, Wright TL, eds. Zakim and Boyer's Hepatology— A Textbook of Liver Disease. 5th ed. Philadelphia: Saunders-Elsevier; 2006: 503–550.
14. Teschke R, Genthner A, Wolff A, Frenzel C, Schulze J, Eickhoff A. Herbal hepatotoxicity: analysis of cases with initially reported positive re-exposure tests. Dig Liver Dis 2014;46:264–269. doi: 10.1016/j.dld.2013.10.020.
15. Chalasani N, Fontana RJ, Bonkovsky HL, Watkins PB, Davern T, Serrano J, et al. Causes, clinical features, and outcomes from a prospective study of drug induced liver injury in the United States. Gastroenterology 2008;135:1924– 1934.e1-e4. doi: 10.1053/j.gastro.2008.09.011.
16. Navarro VJ, Barnhart HX, Bonkovsky HL. The rising burden of herbal and dietary supplement induced hepatotoxicity in the U.S.A. Program and abstracts of the 64th Annual Meeting of the American Association for the Study of Liver Diseases. November, 2013; Washington, DC. Abstract 113.
17. Flegal KM, Carroll MD, Ogden CL, Curtin LR. Prevalence and trends in obesity among US adults, 1999-2008. JAMA 2010;303:235–241. doi: 10.1001/jama. 2009.2014.
18. http://www.marketresearch.com/Marketdata-Enterprises-Inc-v416/Weight-Loss-Status-Forecast-8016030, accessed January 12, 2015.
19. Pillitteri JL, Shiffman S, Rohay JM, Harkins AM, Burton SL, Wadden TA. Use of dietary supplements for weight loss in the United States: results of a national survey. Obesity 2008;16:790–796. doi: 10.1038/oby.2007.136.
20. Dhar R, Stout CW, Link MS, Homoud MK, Weinstock J, Estes NA 3rd. Cardio-vascular toxicities of performance enhancing substances in sports. Mayo Clin Proc 2005;80:1307–1315. doi: 10.4065/80.10.1307.
21. Jones FJ, Andrews AH. Acute liver injury associated with the herbal supplement hydroxycut in a soldier deployed to Iraq. Am J Gastroenterol 2007;102: 2357–2358. doi: 10.1111/j.1572-0241.2007.01353_10.x.
22. Fong TL, Klontz KC, Canas-Coto A, Casper SJ, Durazo FA, Davern TJ 2nd, et al. Hepatotoxicity due to hydroxycut: a case series. Am J Gastroenterol 2009; 105:1561–1566. doi: 10.1038/ajg.2010.5.
23. Stevens T, Qadri A, Zein NN. Two patients with acute liver injury associated with use of the herbal weight-loss supplement hydroxycut. Ann Intern Med 2005;142:477–478. doi: 10.7326/0003-4819-142-6-200503150-00026.
24. Shim M, Saab S. Severe hepatotoxicity due to hydroxycut: A case report. Dig Dis Sci 2009;54:406–408. doi: 10.1007/s10620-008-0353-4.
25. Laczek J, Duncan M. Three cases of acute hepatitis in patients taking hydroxycut bodybuilding supplement. Am J Gastroenterol 2008;103:S143–S144.
26. Dara L, Hewett J, Lim JK. Hydroxycut hepatotoxicity: a case series and review of liver toxicity from herbal weight loss supplements. World J Gastroenterol 2008;14:6999–7004. doi: 10.3748/wjg.14.6999.
27. Kaswala D, Shah S, Patel N, Raisoni S, Swaminathan S. Hydroxycut-induced liver toxicity. Ann Med Health Sci Res 2014;4:143–145. doi: 10.4103/2141-9248.126627.
28. Roytman MM, Pörzgen P, Lee CL, Huddleston L, Kuo TT, Bryant-Greenwood P, et al. Outbreak of severe hepatitis linked to weight-loss supplement OxyELITE Pro. Am J Gastroenterol 2014;109:1296–1298. doi: 10.1038/ajg.2014.159.
29. http://www.fda.gov/iceci/enforcementactions/warningletters/2013/ucm371203. htm, accessed March 2015.
30. Foley S, Butlin E, Shields W, Lacey B. Experience with OxyElite Pro and acute liver injury in active duty service members. Dig Dis Sci 2014;59:3117–3121. doi: 10.1007/s10620-014-3221-4.
31. Galati G, Lin A, Sultan AM, O'Brien PJ. Cellular and in vivo hepatotoxicity caused by green tea phenolic acids and catechins. Free Radic Biol Med 2006;40:570–580. doi: 10.1016/j.freeradbiomed.2005.09.014.
32. Lambert JD, Kennett MJ, Sang S, Reuhl KR, Ju J, Yang CS. Hepatoxicity of high oral dose (-)-epigallocatechin-3-gallate in mice. Food Chem Toxicol 2010;48: 409–416. doi: 10.1016/j.fct.2009.10.030.
33. Kapetanovic IM, Crowell JA, Krishnaraj R, Zakharov A, Lindeblad M, Lyubimov A. Exposure and toxicity of green tea polyphenols in fasted and non-fasted dogs. Toxicology 2009;260:28–36. doi: 10.1016/j.tox.2009.03.007.
34. Triscari J, Sullivan AC. Comparative effects of (−)-hydroxycitrate and (+)-allo hydroxycitrate on acetyl CoA carboxylase and fatty acid and cholesterol synthesis in vivo. Lipids 1977;12:357–363.
35. Kim YJ, Choi MS, Park YB, Kim SR, Lee MK, Jung UJ. Garcinia Cambogia attenuates diet-induced adiposity but exacerbates hepatic collagen accumulation and inflammation. World J Gastroenterol 2013;19:4689–4701. doi: 10.3748/wjg. v19.i29.4689.
36. Han D, Matsumaru K, Rettori D, Kaplowitz N. Usnic acid-induced necrosis of cultured mouse hepatocytes: inhibition of mitochondrial function and oxidative stress. Biol Pharm 2004;63:439–451. doi:10.1016/j.bcp.2003.09.032.
37. Karmase A, Jagtap S, Bhutani KK. Anti adipogenic activity of Aegle marmelos Correa. Phytomedicine 2013;20:1267–1271. doi: 10.1016/j.phymed.2013. 07.011.
38. Fan C, Deng J, Yang Y, Liu J, Wang Y, Zhang X, et al. Multi-ingredients determination and fingerprint analysis of leaves from Ilex latifolia using ultraperformance liquid chromatography coupled with quadrupole time of light mass spectrometry. J Pharm Biomed Anal 2013;84:20–29. doi: 10.1016/j.jpba.2013.05.039.
39. Gao F, Hu Y, Fang G, Yang G, Xu Z, Dou L, et al. Recent developments in the field of the determination of constituents of TCMs in body fluids of animals and human. J Pharm Biomed 2014;87:214–260. doi: 10.1016/j.jpba.2013.04. 006.
40. Sun H, Zhang AH, Zou DX, Sun WJ, Wu XH, Wang XJ. Metabolomics coupled with pattern recognition and pathway analysis on potential biomarkers in liver injury and hepatoprotective effects of Yinchenhao. Appl Biochem Biotechnol 2014;173:857–869. doi: 10.1007/s12010-014-0903-5.