High Infiltration of Tumor-Associated Macrophages Influences Poor Prognosis in Human Gastric Cancer Patients, Associates with the Phenomenon of EMT

Medicine (United States)

Volumn 95, Issue 6, 2016, Pages

  Zhang, Jia ^a   Yan, Yan ^a   Yang, Ya ^a   Wang, Li ^a   Li, Min ^a   Wang, Jizhao ^a   Liu, Xu ^a   Duan, Xiaoyi ^a   Wang, Jiansheng ^a  

^a THE FIRST AFFILIATED HOSPITAL OF XI AN JIAOTONG UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CHLORDANE; UVOMORULIN; VIMENTIN;

ADULT; AGED; ARTICLE; CANCER PROGNOSIS; CANCER STAGING; CANCER TISSUE; CELL INFILTRATION; EPITHELIAL MESENCHYMAL TRANSITION; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; METASTASIS; OVERALL SURVIVAL; PRIORITY JOURNAL; PROTEIN EXPRESSION; STOMACH CANCER; SURVIVAL RATE; TUMOR ASSOCIATED LEUKOCYTE; TUMOR DIFFERENTIATION; MACROPHAGE; MIDDLE AGED; MORTALITY; PATHOLOGY; PROGNOSIS; STOMACH TUMOR; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; EPITHELIAL-MESENCHYMAL TRANSITION; FEMALE; HUMANS; MACROPHAGES; MALE; MIDDLE AGED; PROGNOSIS; STOMACH NEOPLASMS; SURVIVAL RATE;

EID: 84958260911     PISSN: 00257974     EISSN: 15365964     Source Type: Journal    
DOI: 10.1097/MD.0000000000002636     Document Type: Article

References (27)

1. Torre LA, Bray F, Siegel RL, et al. Global cancer statistics, 2012. CA. 2015;65:87-108
2. Catalano V, Labianca R, Beretta GD, et al. Gastric cancer. Crit Rev Oncol/Hematol. 2009;71:127-164
3. Singh A, Settleman J. EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer. Oncogene. 2010;29:4741-4751
4. Yoon CH, Kim MJ, Lee H, et al. PTTG1 oncogene promotes tumor malignancy via epithelial to mesenchymal transition and expansion of cancer stem cell population. J Biol Chem. 2012;287:19516-19527
5. Huang J, Xiao D, Li G, et al. EphA2 promotes epithelialmesenchymal transition through the Wnt/beta-catenin pathway in gastric cancer cells. Oncogene. 2014;33:2737-2747
6. Thiery JP, Acloque H, Huang RY, et al. Epithelial-mesenchymal transitions in development and disease. Cell. 2009;139:871-890
7. Klymkowsky MW, Savagner P. Epithelial-mesenchymal transition: a cancer researchers conceptual friend and foe. Am J Pathol. 2009;174:1588-1593
8. Savagner P. The epithelial-mesenchymal transition (EMT) phenomenon. Ann Oncol. 2010;21(Suppl 7):vii89-vii92
9. Allavena P, Sica A, Solinas G, et al. The inflammatory microenvironment in tumor progression: the role of tumor-Associated macrophages. Crit Rev Oncol/Hematol. 2008;66:1-9
10. Condeelis J, Pollard JW. Macrophages: obligate partners for tumor cell migration, invasion, and metastasis. Cell. 2006;124:263-266
11. Joyce JA, Pollard JW. Microenvironmental regulation of metastasis. Nat Rev Cancer. 2009;9:239-252
12. Quail DF, Joyce JA. Microenvironmental regulation of tumor progression and metastasis. Nat Med. 2013;19:1423-1437
13. Qian BZ, Pollard JW. Macrophage diversity enhances tumor progression and metastasis. Cell. 2010;141:39-51
14. Ohta M, Kitadai Y, Tanaka S, et al. Monocyte chemoattractant protein-1 expression correlates with macrophage infiltration and tumor vascularity in human gastric carcinomas. Int J Oncol. 2003;22:773-778
15. Ishigami S, Natsugoe S, Tokuda K, et al. Tumor-Associated macrophage (TAM) infiltration in gastric cancer. Anticancer Res. 2003;23 (5a):4079-4083
16. Fan QM, Jing YY, Yu GF, et al. Tumor-Associated macrophages promote cancer stem cell-like properties via transforming growth factor-beta1-induced epithelial-mesenchymal transition in hepatocellular carcinoma. Cancer Lett. 2014;352:160-168
17. Lee CH, Liu SY, Chou KC, et al. Tumor-Associated macrophages promote oral cancer progression through activation of the Axl signaling pathway. Ann Surg Oncol. 2014;21:1031-1037
18. Mak KK, Wu AT, Lee WH, et al. Pterostilbene, a bioactive component of blueberries, suppresses the generation of breast cancer stem cells within tumor microenvironment and metastasis via modulating NF-kappaB/microRNA 448 circuit. Mol Nutr Food Res. 2013;57:1123-1134
19. Liu CY, Xu JY, Shi XY, et al. M2-polarized tumor-Associated macrophages promoted epithelial-mesenchymal transition in pancreatic cancer cells, partially through TLR4/IL-10 signaling pathway. Lab Invest. 2013;93:844-854
20. Edge S, Compton BD, Fritz CC, et al. AJCC Cancer Staging Handbook. New York: Springer; 2010
21. Ma J, Liu L, Che G, et al. The M1 form of tumor-Associated macrophages in non-small cell lung cancer is positively associated with survival time. BMC Cancer. 2010;10:112
22. Go Y, Tanaka H, Tokumoto M, et al. Tumor-Associated macrophages extend along lymphatic flow in the pre-metastatic lymph nodes of human gastric cancer. Annal Surg Oncol. 2016;23(Suppl 2): 230-235
23. Zhang H, Wang X, Shen Z, et al. Infiltration of diametrically polarized macrophages predicts overall survival of patients with gastric cancer after surgical resection. Gastric Cancer. 2015;18: 740-750
24. Lin CN, Wang CJ, Chao YJ, et al. The significance of the co-existence of osteopontin and tumor-Associated macrophages in gastric cancer progression. BMC Cancer. 2015;15:128
25. Wu MH, Lee WJ, Hua KT, et al. Macrophage infiltration induces gastric cancer invasiveness by activating the beta-catenin pathway. PloS One. 2015;10:e0134122
26. Wu H, Xu JB, He YL, et al. Tumor-Associated macrophages promote angiogenesis and lymphangiogenesis of gastric cancer. J Surg Oncol. 2012;106:462-468
27. Yang Y, Li M, Yan Y, et al. Expression of RAP1B is associated with poor prognosis and promotes an aggressive phenotype in gastric cancer. Oncol Rep. 2015;34:2385-2394