Nailfold videocapillaroscopy and serum VEGF levels in scleroderma are associated with internal organ involvement

Autoimmunity Highlights

Volumn 7, Issue 1, 2016, Pages 1-9

  De Santis, Maria ^a   Ceribelli, Angela ^a,b   Cavaciocchi, Francesca ^a   Crotti, Chiara ^a   Massarotti, Marco ^a   Belloli, Laura ^a,c   Marasini, Bianca ^a   Isailovic, Natasa ^a   Generali, Elena ^a   Selmi, Carlo ^a,b  

^a HUMANITAS CLINICAL AND RESEARCH CENTER   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

^c OSPEDALE NIGUARDA CA GRANDA   (Italy)

Author keywords

Autoimmunity; Biomarkers; Endothelium; Personalized medicine; Systemic sclerosis

Indexed keywords

C REACTIVE PROTEIN; CARBON MONOXIDE; CENTROMERE ANTIBODY; COMPLEMENT COMPONENT C3; COMPLEMENT COMPONENT C4; SCL 70 ANTIBODY; VASCULOTROPIN;

ADULT; AGED; ARTICLE; BLOOD CELL COUNT; BLOOD LEVEL; CAPILLAROSCOPY; CAPILLARY DENSITY; CLINICAL ARTICLE; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE DURATION; DISEASE SEVERITY; ECHOCARDIOGRAPHY; ENZYME LINKED IMMUNOSORBENT ASSAY; ESOPHAGOSCOPY; FEMALE; HUMAN; IMMUNOPRECIPITATION; INTERSTITIAL LUNG DISEASE; LUNG FUNCTION TEST; MALE; MANOMETRY; NAILFOLD VIDEOCAPILLAROSCOPY; PRIORITY JOURNAL; SCLERODERMA; URINALYSIS; VASCULAR DISEASE;

EID: 84958257592     PISSN: 20380305     EISSN: 20383274     Source Type: Journal    
DOI: 10.1007/s13317-016-0077-y     Document Type: Article

References (32)

1. De Santis M, Selmi C (2015) The autoinflammatory side of systemic sclerosis. Isr Med Assoc J 17(1):47–49
2. Selmi C, Feghali-Bostwick CA, Lleo A, Lombardi SA, De Santis M, Cavaciocchi F, Zammataro L, Mitchell MM, Lasalle JM, Medsger T Jr, Gershwin ME (2012) X chromosome gene methylation in peripheral lymphocytes from monozygotic twins discordant for scleroderma. Clin Exp Immunol 169(3):253–262. doi:10.1111/j.1365-2249.2012.04621.x
3. Bogdanos DP, Smyk DS, Rigopoulou EI, Mytilinaiou MG, Heneghan MA, Selmi C, Gershwin ME (2012) Twin studies in autoimmune disease: genetics, gender and environment. J Autoimmun 38(2–3):J156–J169. doi:10.1016/j.jaut.2011.11.003
4. Selmi C, Invernizzi P, Gershwin ME (2006) The X chromosome and systemic sclerosis. Curr Opin Rheumatol 18(6):601–605. doi:10.1097/01.bor.0000245718.56770.a4
5. Selmi C, Brunetta E, Raimondo MG, Meroni PL (2012) The X chromosome and the sex ratio of autoimmunity. Autoimmun Rev 11(6–7):A531–A537. doi:10.1016/j.autrev.2011.11.024
6. Selmi C, Ceribelli A, Generali E, Scire CA, Alborghetti F, Colloredo G, Porrati L, Achenza MI, De Santis M, Cavaciocchi F, Massarotti M, Isailovic N, Paleari V, Invernizzi P, Matthias T, Zucchi A, Meroni PL (2016) Serum antinuclear and extractable nuclear antigen antibody prevalence and associated morbidity and mortality in the general population over 15 years. Autoimmun Rev 15(2):162–166. doi:10.1016/j.autrev.2015.10.007
7. van den Hoogen F, Khanna D, Fransen J, Johnson SR, Baron M, Tyndall A, Matucci-Cerinic M, Naden RP, Medsger TA Jr, Carreira PE, Riemekasten G, Clements PJ, Denton CP, Distler O, Allanore Y, Furst DE, Gabrielli A, Mayes MD, van Laar JM, Seibold JR, Czirjak L, Steen VD, Inanc M, Kowal-Bielecka O, Muller-Ladner U, Valentini G, Veale DJ, Vonk MC, Walker UA, Chung L, Collier DH, Csuka ME, Fessler BJ, Guiducci S, Herrick A, Hsu VM, Jimenez S, Kahaleh B, Merkel PA, Sierakowski S, Silver RM, Simms RW, Varga J, Pope JE (2013) 2013 classification criteria for systemic sclerosis: an American College of Rheumatology/European League against Rheumatism collaborative initiative. Arthritis Rheum 65(11):2737–2747. doi:10.1002/art.38098
8. Cutolo M, Pizzorni C, Tuccio M, Burroni A, Craviotto C, Basso M, Seriolo B, Sulli A (2004) Nailfold videocapillaroscopic patterns and serum autoantibodies in systemic sclerosis. Rheumatology (Oxford) 43(6):719–726. doi:10.1093/rheumatology/keh156
9. Sebastiani M, Manfredi A, Colaci M, D’Amico R, Malagoli V, Giuggioli D, Ferri C (2009) Capillaroscopic skin ulcer risk index: a new prognostic tool for digital skin ulcer development in systemic sclerosis patients. Arthritis Rheum 61(5):688–694. doi:10.1002/art.24394
10. Maurer B, Distler A, Suliman YA, Gay RE, Michel BA, Gay S, Distler JH, Distler O (2014) Vascular endothelial growth factor aggravates fibrosis and vasculopathy in experimental models of systemic sclerosis. Ann Rheum Dis 73(10):1880–1887. doi:10.1136/annrheumdis-2013-203535
11. Manetti M, Guiducci S, Romano E, Ceccarelli C, Bellando-Randone S, Conforti ML, Ibba-Manneschi L, Matucci-Cerinic M (2011) Overexpression of VEGF165b, an inhibitory splice variant of vascular endothelial growth factor, leads to insufficient angiogenesis in patients with systemic sclerosis. Circ Res 109(3):e14–e26. doi:10.1161/CIRCRESAHA.111.242057
12. Bielecki M, Kowal K, Lapinska A, Chwiesko-Minarowska S, Chyczewski L, Kowal-Bielecka O (2011) Peripheral blood mononuclear cells from patients with systemic sclerosis spontaneously secrete increased amounts of vascular endothelial growth factor (VEGF) already in the early stage of the disease. Adv Med Sci 56(2):255–263. doi:10.2478/v10039-011-0025-z
13. Kajihara I, Jinnin M, Honda N, Makino K, Makino T, Masuguchi S, Sakai K, Fukushima S, Inoue Y, Ihn H (2013) Scleroderma dermal fibroblasts overexpress vascular endothelial growth factor due to autocrine transforming growth factor beta signaling. Mod Rheumatol 23(3):516–524. doi:10.1007/s10165-012-0698-6
14. Solanilla A, Villeneuve J, Auguste P, Hugues M, Alioum A, Lepreux S, Ducroix JP, Duhaut P, Conri C, Viallard JF, Nurden AT, Constans J, Ripoche J (2009) The transport of high amounts of vascular endothelial growth factor by blood platelets underlines their potential contribution in systemic sclerosis angiogenesis. Rheumatology (Oxford) 48(9):1036–1044. doi:10.1093/rheumatology/kep154
15. Alivernini S, De Santis M, Tolusso B, Mannocci A, Bosello SL, Peluso G, Pinnelli M, D’Antona G, La Torre G, Ferraccioli G (2009) Skin ulcers in systemic sclerosis: determinants of presence and predictive factors of healing. J Am Acad Dermatol 60(3):426–435. doi:10.1016/j.jaad.2008.11.025
16. Valentini G, Medsger TA Jr, Silman AJ, Bombardieri S (2003) Conclusion and identification of the core set of variables to be used in clinical investigations. Clin Exp Rheumatol 21(3 Suppl 29):S47–S48
17. De Santis M, Bosello S, La Torre G, Capuano A, Tolusso B, Pagliari G, Pistelli R, Danza FM, Zoli A, Ferraccioli G (2005) Functional, radiological and biological markers of alveolitis and infections of the lower respiratory tract in patients with systemic sclerosis. Respir Res 6:96. doi:10.1186/1465-9921-6-96
18. De Santis M, Inzitari R, Bosello SL, Peluso G, Fanali C, Iavarone F, Zizzo G, Bocci M, Cabras T, Messana I, Fuso L, Varone F, Pagliari G, Castagnola M, Ferraccioli G (2011) Beta-thymosins and interstitial lung disease: study of a scleroderma cohort with a 1-year follow-up. Respir Res 12:22. doi:10.1186/1465-9921-12-22
19. De Santis M, Bosello SL, Peluso G, Pinnelli M, Alivernini S, Zizzo G, Bocci M, Capacci A, La Torre G, Mannocci A, Pagliari G, Varone F, Pistelli R, Danza FM, Ferraccioli G (2012) Bronchoalveolar lavage fluid and progression of scleroderma interstitial lung disease. Clin Respir J 6(1):9–17. doi:10.1111/j.1752-699X.2010.00228.x
20. Yamasaki Y, Narain S, Hernandez L, Barker T, Ikeda K, Segal MS, Richards HB, Chan EK, Reeves WH, Satoh M (2006) Autoantibodies against the replication protein A complex in systemic lupus erythematosus and other autoimmune diseases. Arthritis Res Ther 8(4):R111. doi:10.1186/ar2000
21. Ceribelli A, Cavazzana I, Franceschini F, Airo P, Tincani A, Cattaneo R, Pauley BA, Chan EK, Satoh M (2010) Anti-Th/To are common antinucleolar autoantibodies in Italian patients with scleroderma. J Rheumatol 37(10):2071–2075. doi:10.3899/jrheum.100316
22. Cavazzana I, Fredi M, Selmi C, Tincani A, Franceschini F (2015) The clinical and histological spectrum of idiopathic inflammatory myopathies. Clin Rev Allergy Immunol. doi:10.1007/s12016-015-8517-4
23. Cavagna L, Nuno L, Scire CA, Govoni M, Longo FJ, Franceschini F, Neri R, Castaneda S, Sifuentes Giraldo WA, Caporali R, Iannone F, Fusaro E, Paolazzi G, Pellerito R, Schwarting A, Saketkoo LA, Ortego-Centeno N, Quartuccio L, Bartoloni E, Specker C, Pina Murcia T, La Corte R, Furini F, Foschi V, Bachiller Corral J, Airo P, Cavazzana I, Martinez-Barrio J, Hinojosa M, Giannini M, Barsotti S, Menke J, Triantafyllias K, Vitetta R, Russo A, Bogliolo L, Bajocchi G, Bravi E, Barausse G, Bortolotti R, Selmi C, Parisi S, Salaffi F, Montecucco C, Gonzalez-Gay MA, Group AC (2016) Serum Jo-1 autoantibody and isolated arthritis in the antisynthetase syndrome: review of the literature and report of the experience of AENEAS Collaborative Group. Clin Rev Allergy Immunol. doi:10.1007/s12016-016-8528-9
24. Cavagna L, Nuno L, Scire CA, Govoni M, Longo FJ, Franceschini F, Neri R, Castaneda S, Giraldo WA, Caporali R, Iannone F, Fusaro E, Paolazzi G, Pellerito R, Schwarting A, Saketkoo LA, Ortego-Centeno N, Quartuccio L, Bartoloni E, Specker C, Murcia TP, La Corte R, Furini F, Foschi V, Corral JB, Airo P, Cavazzana I, Martinez-Barrio J, Hinojosa M, Giannini M, Barsotti S, Menke J, Triantafyllias K, Vitetta R, Russo A, Bajocchi G, Bravi E, Barausse G, Bortolotti R, Selmi C, Parisi S, Montecucco C, Gonzalez-Gay MA, group Ac (2015) Clinical spectrum time course in anti Jo-1 positive antisynthetase syndrome: results from an International Retrospective Multicenter Study. Medicine (Baltimore) 94(32):e1144. doi:10.1097/MD.0000000000001144
25. Karvinen H, Pasanen E, Rissanen TT, Korpisalo P, Vahakangas E, Jazwa A, Giacca M, Yla-Herttuala S (2011) Long-term VEGF-A expression promotes aberrant angiogenesis and fibrosis in skeletal muscle. Gene Ther 18(12):1166–1172. doi:10.1038/gt.2011.66
26. Distler O, Del Rosso A, Giacomelli R, Cipriani P, Conforti ML, Guiducci S, Gay RE, Michel BA, Bruhlmann P, Muller-Ladner U, Gay S, Matucci-Cerinic M (2002) Angiogenic and angiostatic factors in systemic sclerosis: increased levels of vascular endothelial growth factor are a feature of the earliest disease stages and are associated with the absence of fingertip ulcers. Arthritis Res 4(6):R11
27. Bournia VK, Vlachoyiannopoulos PG, Selmi C, Moutsopoulos HM, Gershwin ME (2009) Recent advances in the treatment of systemic sclerosis. Clin Rev Allergy Immunol 36(2–3):176–200. doi:10.1007/s12016-008-8114-x
28. Bosello S, De Santis M, Lama G, Spano C, Angelucci C, Tolusso B, Sica G, Ferraccioli G (2010) B cell depletion in diffuse progressive systemic sclerosis: safety, skin score modification and IL-6 modulation in an up to thirty-6 months follow-up open-label trial. Arthritis Res Ther 12(2):R54. doi:10.1186/ar2965
29. De Santis M, Bosello SL, Capoluongo E, Inzitari R, Peluso G, Lulli P, Zizzo G, Bocci M, Tolusso B, Zuppi C, Castagnola M, Ferraccioli G (2012) A vascular endothelial growth factor deficiency characterises scleroderma lung disease. Ann Rheum Dis 71(9):1461–1465. doi:10.1136/annrheumdis-2011-200657
30. Kaner RJ, Crystal RG (2001) Compartmentalization of vascular endothelial growth factor to the epithelial surface of the human lung. Mol Med 7(4):240–246
31. Meyer KC, Cardoni A, Xiang ZZ (2000) Vascular endothelial growth factor in bronchoalveolar lavage from normal subjects and patients with diffuse parenchymal lung disease. J Lab Clin Med 135(4):332–338. doi:10.1067/mlc.2000.105618
32. De Franceschi L, Bosello S, Scambi C, Biasi D, De Santis M, Caramaschi P, Peluso G, La Verde V, Bambara LM, Ferraccioli G (2011) Proteome analysis of biological fluids from autoimmune-rheumatological disorders. Proteom Clin Appl 5(1–2):78–89. doi:10.1002/prca.201000069