메뉴 건너뛰기




Volumn 23, Issue 3, 2013, Pages 516-524

Scleroderma dermal fibroblasts overexpress vascular endothelial growth factor due to autocrine transforming growth factor β signaling

Author keywords

Angiogenesis; Extracellular matrix; Fibrosis

Indexed keywords

MESSENGER RNA; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; VASCULOTROPIN;

EID: 84877726032     PISSN: 14397595     EISSN: 14397609     Source Type: Journal    
DOI: 10.1007/s10165-012-0698-6     Document Type: Article
Times cited : (22)

References (39)
  • 1
    • 0025210095 scopus 로고
    • Fibroblast-matrix interactions and their role in the pathogenesis of fibrosis
    • 2406813 1:STN:280:DyaK3c7mtFaksQ%3D%3D
    • Mauch C, Kreig T. Fibroblast-matrix interactions and their role in the pathogenesis of fibrosis. Rheum Dis Clin North Am. 1990;16:93-107.
    • (1990) Rheum Dis Clin North Am , vol.16 , pp. 93-107
    • Mauch, C.1    Kreig, T.2
  • 2
    • 0024887547 scopus 로고
    • Immunologic aspects of scleroderma
    • 2702049 10.1097/00002281-198901040-00011 1:STN:280:DyaK3M%2FgtFGqsg%3D%3D
    • Korn JH. Immunologic aspects of scleroderma. Curr Opin Rheumatol. 1989;1:479-84.
    • (1989) Curr Opin Rheumatol , vol.1 , pp. 479-484
    • Korn, J.H.1
  • 3
    • 0026955930 scopus 로고
    • Altered regulation of collagen metabolism in scleroderma fibroblasts grown within three-dimensional collagen gels
    • 1365320 10.1111/j.1600-0625.1992.tb00187.x 1:CAS:528:DyaK3sXitlWmu70%3D
    • Mauch C, Kozlowska E, Eckes B, Krieg T. Altered regulation of collagen metabolism in scleroderma fibroblasts grown within three-dimensional collagen gels. Exp Dermatol. 1992;1:185-90.
    • (1992) Exp Dermatol , vol.1 , pp. 185-190
    • Mauch, C.1    Kozlowska, E.2    Eckes, B.3    Krieg, T.4
  • 4
    • 0029765057 scopus 로고    scopus 로고
    • Heterogeneity of collagen synthesis in normal and systemic sclerosis skin fibroblasts. Increased proportion of high collagen-producing cells in systemic sclerosis fibroblasts
    • 8702442 10.1002/art.1780390811 1:STN:280:DyaK28zitVagtA%3D%3D
    • Jelaska A, Arakawa M, Broketa G, Korn JH. Heterogeneity of collagen synthesis in normal and systemic sclerosis skin fibroblasts. Increased proportion of high collagen-producing cells in systemic sclerosis fibroblasts. Arthritis Rheum. 1996;39:1338-46.
    • (1996) Arthritis Rheum , vol.39 , pp. 1338-1346
    • Jelaska, A.1    Arakawa, M.2    Broketa, G.3    Korn, J.H.4
  • 5
    • 25444501226 scopus 로고    scopus 로고
    • Involvement of alphavbeta5 integrin-mediated activation of latent transforming growth factor beta1 in autocrine transforming growth factor beta signaling in systemic sclerosis fibroblasts
    • 16142753 10.1002/art.21246 1:CAS:528:DC%2BD2MXhtFeltrnF
    • Asano Y, Ihn H, Yamane K, Jinnin M, Mimura Y, Tamaki K. Involvement of alphavbeta5 integrin-mediated activation of latent transforming growth factor beta1 in autocrine transforming growth factor beta signaling in systemic sclerosis fibroblasts. Arthritis Rheum. 2005;52:2897-905.
    • (2005) Arthritis Rheum , vol.52 , pp. 2897-2905
    • Asano, Y.1    Ihn, H.2    Yamane, K.3    Jinnin, M.4    Mimura, Y.5    Tamaki, K.6
  • 6
    • 0025222517 scopus 로고
    • The transforming growth factor-beta family
    • 2177343 10.1146/annurev.cb.06.110190.003121
    • Massagué J. The transforming growth factor-beta family. Annu Rev Cell Biol. 1990;6:597-641.
    • (1990) Annu Rev Cell Biol , vol.6 , pp. 597-641
    • Massagué, J.1
  • 7
    • 0024323330 scopus 로고
    • A strategy for determining the pathogenesis of systemic sclerosis. Is transforming growth factor beta the answer?
    • 2665755 1:STN:280:DyaL1Mzit1CjtA%3D%3D
    • Leroy EC, Smith EA, Kahaleh MB, Trojanowska M, Silver RM. A strategy for determining the pathogenesis of systemic sclerosis. Is transforming growth factor beta the answer? Arthritis Rheum. 1989;32:817-25.
    • (1989) Arthritis Rheum , vol.32 , pp. 817-825
    • Leroy, E.C.1    Smith, E.A.2    Kahaleh, M.B.3    Trojanowska, M.4    Silver, R.M.5
  • 8
    • 85047692249 scopus 로고    scopus 로고
    • Impaired Smad7-Smurf-mediated negative regulation of TGF-beta signaling in scleroderma fibroblasts
    • 14722617 1:CAS:528:DC%2BD2cXmsVyqsg%3D%3D
    • Asano Y, Ihn H, Yamane K, Kubo M, Tamaki K. Impaired Smad7-Smurf-mediated negative regulation of TGF-beta signaling in scleroderma fibroblasts. J Clin Invest. 2004;113:253-64.
    • (2004) J Clin Invest , vol.113 , pp. 253-264
    • Asano, Y.1    Ihn, H.2    Yamane, K.3    Kubo, M.4    Tamaki, K.5
  • 9
    • 33144458448 scopus 로고    scopus 로고
    • Increased expression of integrin alphavbeta5 induces the myofibroblastic differentiation of dermal fibroblasts
    • 16436664 10.2353/ajpath.2006.041306 1:CAS:528:DC%2BD28Xhs1agurY%3D
    • Asano Y, Ihn H, Yamane K, Jinnin M, Tamaki K. Increased expression of integrin alphavbeta5 induces the myofibroblastic differentiation of dermal fibroblasts. Am J Pathol. 2006;168:499-510.
    • (2006) Am J Pathol , vol.168 , pp. 499-510
    • Asano, Y.1    Ihn, H.2    Yamane, K.3    Jinnin, M.4    Tamaki, K.5
  • 10
    • 0016302998 scopus 로고
    • Increased collagen synthesis by scleroderma skin fibroblasts in vitro: A possible defect in the regulation or activation of the scleroderma fibroblast
    • 4430718 10.1172/JCI107827 1:CAS:528:DyaE2cXlsV2ktr4%3D
    • LeRoy EC. Increased collagen synthesis by scleroderma skin fibroblasts in vitro: a possible defect in the regulation or activation of the scleroderma fibroblast. J Clin Invest. 1974;54:880-9.
    • (1974) J Clin Invest , vol.54 , pp. 880-889
    • Leroy, E.C.1
  • 11
    • 0022493764 scopus 로고
    • Co-ordinate increase in the expression of type i and type III collagen genes in progressive systemic sclerosis fibroblasts
    • 3800922 1:CAS:528:DyaL28XkslOjsLc%3D
    • Jimenez SA, Feldman G, Bashey RI, Bienkowski R, Rosenbloom J. Co-ordinate increase in the expression of type I and type III collagen genes in progressive systemic sclerosis fibroblasts. Biochem J. 1986;237:837-43.
    • (1986) Biochem J , vol.237 , pp. 837-843
    • Jimenez, S.A.1    Feldman, G.2    Bashey, R.I.3    Bienkowski, R.4    Rosenbloom, J.5
  • 12
    • 0038004796 scopus 로고    scopus 로고
    • Expression and regulation of intracellular SMAD signaling in scleroderma skin fibroblasts
    • 12847691 10.1002/art.11157 1:CAS:528:DC%2BD3sXmtFartb4%3D
    • Mori Y, Chen SJ, Varga J. Expression and regulation of intracellular SMAD signaling in scleroderma skin fibroblasts. Arthritis Rheum. 2003;48:1964-78.
    • (2003) Arthritis Rheum , vol.48 , pp. 1964-1978
    • Mori, Y.1    Chen, S.J.2    Varga, J.3
  • 13
    • 2442640271 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase is involved in alpha2(I) collagen gene expression in normal and scleroderma fibroblasts
    • 15153536 1:CAS:528:DC%2BD2cXktFSku70%3D
    • Asano Y, Ihn H, Yamane K, Jinnin M, Mimura Y, Tamaki K. Phosphatidylinositol 3-kinase is involved in alpha2(I) collagen gene expression in normal and scleroderma fibroblasts. J Immunol. 2004;172:7123-35.
    • (2004) J Immunol , vol.172 , pp. 7123-7135
    • Asano, Y.1    Ihn, H.2    Yamane, K.3    Jinnin, M.4    Mimura, Y.5    Tamaki, K.6
  • 14
    • 0026666859 scopus 로고
    • Direct demonstration of transcriptional activation of collagen gene expression in systemic sclerosis fibroblasts: Insensitivity to TGF beta 1 stimulation
    • 1520334 10.1016/S0006-291X(05)81456-1 1:CAS:528:DyaK3sXltVCn
    • Kikuchi K, Hartl CW, Smith EA, LeRoy EC, Trojanowska M. Direct demonstration of transcriptional activation of collagen gene expression in systemic sclerosis fibroblasts: insensitivity to TGF beta 1 stimulation. Biochem Biophys Res Commun. 1992;187:45-50.
    • (1992) Biochem Biophys Res Commun , vol.187 , pp. 45-50
    • Kikuchi, K.1    Hartl, C.W.2    Smith, E.A.3    Leroy, E.C.4    Trojanowska, M.5
  • 15
    • 0035089825 scopus 로고    scopus 로고
    • Blockade of endogenous transforming growth factor beta signaling prevents up-regulated collagen synthesis in scleroderma fibroblasts: Association with increased expression of transforming growth factor beta receptors
    • 11229480 10.1002/1529-0131(200102)44:2<474: AID-ANR67>3.0.CO;2-# 1:CAS:528:DC%2BD3MXitlCgu74%3D
    • Ihn H, Yamane K, Kubo M, Tamaki K. Blockade of endogenous transforming growth factor beta signaling prevents up-regulated collagen synthesis in scleroderma fibroblasts: association with increased expression of transforming growth factor beta receptors. Arthritis Rheum. 2001;44:474-80.
    • (2001) Arthritis Rheum , vol.44 , pp. 474-480
    • Ihn, H.1    Yamane, K.2    Kubo, M.3    Tamaki, K.4
  • 16
    • 33645949405 scopus 로고    scopus 로고
    • Potential regulatory elements of the constitutive up-regulated alpha2(I) collagen gene in scleroderma dermal fibroblasts
    • 16564026 10.1016/j.bbrc.2006.03.037 1:CAS:528:DC%2BD28XjtFGjtro%3D
    • Jinnin M, Ihn H, Mimura Y, Asano Y, Tamaki K. Potential regulatory elements of the constitutive up-regulated alpha2(I) collagen gene in scleroderma dermal fibroblasts. Biochem Biophys Res Commun. 2006;343:904-9.
    • (2006) Biochem Biophys Res Commun , vol.343 , pp. 904-909
    • Jinnin, M.1    Ihn, H.2    Mimura, Y.3    Asano, Y.4    Tamaki, K.5
  • 17
    • 16644395747 scopus 로고    scopus 로고
    • The role of VEGF in the regulation of physiological and pathological angiogenesis
    • Ferrara N. The role of VEGF in the regulation of physiological and pathological angiogenesis. EXS 2005;94:209-31.
    • (2005) EXS , vol.94 , pp. 209-231
    • Ferrara, N.1
  • 18
    • 33344474964 scopus 로고    scopus 로고
    • Signal transduction by VEGF receptors in regulation of angiogenesis and lymphangiogenesis
    • 16336962 10.1016/j.yexcr.2005.11.012 1:CAS:528:DC%2BD28XhvVWltbo%3D
    • Shibuya M, Claesson-Welsh L. Signal transduction by VEGF receptors in regulation of angiogenesis and lymphangiogenesis. Exp Cell Res. 2006;312:549-60.
    • (2006) Exp Cell Res , vol.312 , pp. 549-560
    • Shibuya, M.1    Claesson-Welsh, L.2
  • 19
    • 0032435446 scopus 로고    scopus 로고
    • Serum concentrations of vascular endothelial growth factor in collagen diseases
    • Kikuchi K, Kubo M, Kadono T, Yazawa N, Ihn H, Tamaki K. Serum concentrations of vascular endothelial growth factor in collagen diseases. Br J Dermatol 1998;139:1049-51
    • (1998) Br J Dermatol , vol.139 , pp. 1049-1051
    • Kikuchi, K.1    Kubo, M.2    Kadono, T.3    Yazawa, N.4    Ihn, H.5    Tamaki, K.6
  • 20
    • 0038166874 scopus 로고    scopus 로고
    • Elevated vascular endothelial growth factor in systemic sclerosis
    • 12858453 1:CAS:528:DC%2BD3sXmtFSqsLs%3D
    • Choi JJ, Min DJ, Cho ML, Min SY, Kim SJ, Lee SS, et al. Elevated vascular endothelial growth factor in systemic sclerosis. J Rheumatol. 2003;30:1529-33.
    • (2003) J Rheumatol , vol.30 , pp. 1529-1533
    • Choi, J.J.1    Min, D.J.2    Cho, M.L.3    Min, S.Y.4    Kim, S.J.5    Lee, S.S.6
  • 21
    • 66649101854 scopus 로고    scopus 로고
    • Serum VEGF levels are related to the presence of pulmonary arterial hypertension in systemic sclerosis
    • 19426547 10.1186/1471-2466-9-18
    • Papaioannou AI, Zakynthinos E, Kostikas K, Kiropoulos T, Koutsokera A, Ziogas A, et al. Serum VEGF levels are related to the presence of pulmonary arterial hypertension in systemic sclerosis. BMC Pulm Med. 2009;9:18.
    • (2009) BMC Pulm Med , vol.9 , pp. 18
    • Papaioannou, A.I.1    Zakynthinos, E.2    Kostikas, K.3    Kiropoulos, T.4    Koutsokera, A.5    Ziogas, A.6
  • 22
    • 3142670517 scopus 로고    scopus 로고
    • Uncontrolled expression of vascular endothelial growth factor and its receptors leads to insufficient skin angiogenesis in patients with systemic sclerosis
    • 15178641 10.1161/01.RES.0000134644.89917.96 1:CAS:528: DC%2BD2cXlt1Cru7Y%3D
    • Distler O, Distler JH, Scheid A, Acker T, Hirth A, Rethage J, et al. Uncontrolled expression of vascular endothelial growth factor and its receptors leads to insufficient skin angiogenesis in patients with systemic sclerosis. Circ Res. 2004;95:109-16.
    • (2004) Circ Res , vol.95 , pp. 109-116
    • Distler, O.1    Distler, J.H.2    Scheid, A.3    Acker, T.4    Hirth, A.5    Rethage, J.6
  • 23
    • 30744438818 scopus 로고    scopus 로고
    • The differential expression of VEGF, VEGFR-2, and GLUT-1 proteins in disease subtypes of systemic sclerosis
    • 16426919 10.1016/j.humpath.2005.10.007 1:CAS:528:DC%2BD28XlvVKqug%3D%3D
    • Davies CA, Jeziorska M, Freemont AJ, Herrick AL. The differential expression of VEGF, VEGFR-2, and GLUT-1 proteins in disease subtypes of systemic sclerosis. Hum Pathol. 2006;37:190-7.
    • (2006) Hum Pathol , vol.37 , pp. 190-197
    • Davies, C.A.1    Jeziorska, M.2    Freemont, A.J.3    Herrick, A.L.4
  • 24
    • 0030870170 scopus 로고    scopus 로고
    • Oncostatin M stimulates transcription of the human alpha2(I) collagen gene via the Sp1/Sp3-binding site
    • 9305936 10.1074/jbc.272.39.24666 1:CAS:528:DyaK2sXmsFamtL8%3D
    • Ihn H, LeRoy EC, Trojanowska M. Oncostatin M stimulates transcription of the human alpha2(I) collagen gene via the Sp1/Sp3-binding site. J Biol Chem. 1997;272:24666-72.
    • (1997) J Biol Chem , vol.272 , pp. 24666-24672
    • Ihn, H.1    Leroy, E.C.2    Trojanowska, M.3
  • 25
    • 77949821778 scopus 로고    scopus 로고
    • Basic fibroblast growth factor stimulates the proliferation of human dermal fibroblasts via the ERK1/2 and JNK pathways
    • 19995368 10.1111/j.1365-2133.2009.09581.x 1:CAS:528:DC%2BC3cXlvVWhtLw%3D
    • Makino T, Jinnin M, Muchemwa FC, Fukushima S, Kogushi-Nishi H, Moriya C, et al. Basic fibroblast growth factor stimulates the proliferation of human dermal fibroblasts via the ERK1/2 and JNK pathways. Br J Dermatol. 2010;162:717-23.
    • (2010) Br J Dermatol , vol.162 , pp. 717-723
    • Makino, T.1    Jinnin, M.2    Muchemwa, F.C.3    Fukushima, S.4    Kogushi-Nishi, H.5    Moriya, C.6
  • 26
    • 77249170182 scopus 로고    scopus 로고
    • Up-regulated type i collagen expression by the inhibition of Rac1 signaling pathway in human dermal fibroblasts
    • 20102701 10.1016/j.bbrc.2010.01.090 1:CAS:528:DC%2BC3cXis1aktbs%3D
    • Igata T, Jinnin M, Makino T, Moriya C, Muchemwa FC, Ishihara T, et al. Up-regulated type I collagen expression by the inhibition of Rac1 signaling pathway in human dermal fibroblasts. Biochem Biophys Res Commun. 2010;393:101-5.
    • (2010) Biochem Biophys Res Commun , vol.393 , pp. 101-105
    • Igata, T.1    Jinnin, M.2    Makino, T.3    Moriya, C.4    Muchemwa, F.C.5    Ishihara, T.6
  • 27
    • 84860330745 scopus 로고    scopus 로고
    • Impaired IL-17 signaling pathway contributes to the increased collagen expression in scleroderma fibroblasts
    • 22403442 10.4049/jimmunol.1100591 1:CAS:528:DC%2BC38XltFKhtrY%3D
    • Nakashima T, Jinnin M, Yamane K, Honda N, Kajihara I, Makino T, et al. Impaired IL-17 signaling pathway contributes to the increased collagen expression in scleroderma fibroblasts. J Immunol. 2012;188:3573-83.
    • (2012) J Immunol , vol.188 , pp. 3573-3583
    • Nakashima, T.1    Jinnin, M.2    Yamane, K.3    Honda, N.4    Kajihara, I.5    Makino, T.6
  • 28
    • 0037024416 scopus 로고    scopus 로고
    • A comparison of serum and plasma levels of vascular endothelial growth factor during the menstrual cycle in healthy female volunteers
    • 12087467 10.1038/sj.bjc.6600322 1:CAS:528:DC%2BD38XkvVait78%3D
    • McIlhenny C, George WD, Doughty JC. A comparison of serum and plasma levels of vascular endothelial growth factor during the menstrual cycle in healthy female volunteers. Br J Cancer. 2002;86:1786-9.
    • (2002) Br J Cancer , vol.86 , pp. 1786-1789
    • McIlhenny, C.1    George, W.D.2    Doughty, J.C.3
  • 29
    • 0034608799 scopus 로고    scopus 로고
    • A distinct nuclear localization signal in the N terminus of Smad 3 determines its ligand-induced nuclear translocation
    • 10884415 10.1073/pnas.97.14.7853 1:CAS:528:DC%2BD3cXkvFCntbs%3D
    • Xiao Z, Liu X, Henis YI, Lodish HF. A distinct nuclear localization signal in the N terminus of Smad 3 determines its ligand-induced nuclear translocation. Proc Natl Acad Sci USA. 2000;97:7853-8.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 7853-7858
    • Xiao, Z.1    Liu, X.2    Henis, Y.I.3    Lodish, H.F.4
  • 30
    • 0037016689 scopus 로고    scopus 로고
    • C-myc is a downstream target of the Smad pathway
    • 11689553 10.1074/jbc.M104170200 1:CAS:528:DC%2BD38XjslGrsg%3D%3D
    • Yagi K, Furuhashi M, Aoki H, Goto D, Kuwano H, Sugamura K, et al. c-myc is a downstream target of the Smad pathway. J Biol Chem. 2002;277:854-61.
    • (2002) J Biol Chem , vol.277 , pp. 854-861
    • Yagi, K.1    Furuhashi, M.2    Aoki, H.3    Goto, D.4    Kuwano, H.5    Sugamura, K.6
  • 31
    • 33746141265 scopus 로고    scopus 로고
    • Involvement of alphavbeta5 integrin in the establishment of autocrine TGF-beta signaling in dermal fibroblasts derived from localized scleroderma
    • 16675963 10.1038/sj.jid.5700331 1:CAS:528:DC%2BD28XmvFamsrk%3D
    • Asano Y, Ihn H, Jinnin M, Mimura Y, Tamaki K. Involvement of alphavbeta5 integrin in the establishment of autocrine TGF-beta signaling in dermal fibroblasts derived from localized scleroderma. J Invest Dermatol. 2006;126:1761-9.
    • (2006) J Invest Dermatol , vol.126 , pp. 1761-1769
    • Asano, Y.1    Ihn, H.2    Jinnin, M.3    Mimura, Y.4    Tamaki, K.5
  • 32
    • 0032101178 scopus 로고    scopus 로고
    • Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene
    • 9606191 10.1093/emboj/17.11.3091 1:CAS:528:DyaK1cXjvFegtb0%3D
    • Dennler S, Itoh S, Vivien D, ten Dijke P, Huet S, Gauthier JM. Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene. EMBO J. 1998;17:3091-100.
    • (1998) EMBO J , vol.17 , pp. 3091-3100
    • Dennler, S.1    Itoh, S.2    Vivien, D.3    Ten Dijke, P.4    Huet, S.5    Gauthier, J.M.6
  • 33
    • 0032921867 scopus 로고    scopus 로고
    • Stimulation of type i collagen transcription in human skin fibroblasts by TGF-beta: Involvement of Smad 3
    • 9886263 10.1046/j.1523-1747.1999.00477.x 1:CAS:528:DyaK1MXjvFWitA%3D%3D
    • Chen SJ, Yuan W, Mori Y, Levenson A, Trojanowska M, Varga J. Stimulation of type I collagen transcription in human skin fibroblasts by TGF-beta: involvement of Smad 3. J Invest Dermatol. 1999;112:49-57.
    • (1999) J Invest Dermatol , vol.112 , pp. 49-57
    • Chen, S.J.1    Yuan, W.2    Mori, Y.3    Levenson, A.4    Trojanowska, M.5    Varga, J.6
  • 35
    • 31544442502 scopus 로고    scopus 로고
    • Constitutively phosphorylated Smad3 interacts with Sp1 and p300 in scleroderma fibroblasts
    • 16319104 10.1093/rheumatology/kei124 1:CAS:528:DC%2BD28XmslyqsQ%3D%3D
    • Ihn H, Yamane K, Asano Y, Jinnin M, Tamaki K. Constitutively phosphorylated Smad3 interacts with Sp1 and p300 in scleroderma fibroblasts. Rheumatology. 2006;45:157-65.
    • (2006) Rheumatology , vol.45 , pp. 157-165
    • Ihn, H.1    Yamane, K.2    Asano, Y.3    Jinnin, M.4    Tamaki, K.5
  • 36
    • 40349085655 scopus 로고    scopus 로고
    • Vascular disease in scleroderma: Angiogenesis and vascular repair
    • 18329533 10.1016/j.rdc.2007.12.006
    • Mulligan-Kehoe MJ, Simons M. Vascular disease in scleroderma: angiogenesis and vascular repair. Rheum Dis Clin North Am. 2008;34:73-9.
    • (2008) Rheum Dis Clin North Am , vol.34 , pp. 73-79
    • Mulligan-Kehoe, M.J.1    Simons, M.2
  • 37
    • 0029905937 scopus 로고    scopus 로고
    • Systemic sclerosis. A vascular perspective
    • 8923590 10.1016/S0889-857X(05)70295-7 1:STN:280:DyaK2s%2Fot1enug%3D%3D
    • LeRoy EC. Systemic sclerosis. A vascular perspective. Rheum Dis Clin North Am. 1996;22:675-94.
    • (1996) Rheum Dis Clin North Am , vol.22 , pp. 675-694
    • Leroy, E.C.1
  • 38
    • 34248137400 scopus 로고    scopus 로고
    • Vascular endothelial growth factor can signal through platelet-derived growth factor receptors
    • 17470632 10.1083/jcb.200608093 1:CAS:528:DC%2BD2sXltF2gt70%3D
    • Ball SG, Shuttleworth CA, Kielty CM. Vascular endothelial growth factor can signal through platelet-derived growth factor receptors. J Cell Biol. 2007;177:489-500.
    • (2007) J Cell Biol , vol.177 , pp. 489-500
    • Ball, S.G.1    Shuttleworth, C.A.2    Kielty, C.M.3
  • 39
    • 0031057091 scopus 로고    scopus 로고
    • Hypoxia regulates the expression of vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) and its receptors in human skin
    • 9036922 10.1111/1523-1747.ep12286453 1:CAS:528:DyaK2sXhvVCjtrc%3D
    • Detmar M, Brown LF, Berse B, Jackman RW, Elicker BM, Dvorak HF, et al. Hypoxia regulates the expression of vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) and its receptors in human skin. J Invest Dermatol. 1997;108:263-8.
    • (1997) J Invest Dermatol , vol.108 , pp. 263-268
    • Detmar, M.1    Brown, L.F.2    Berse, B.3    Jackman, R.W.4    Elicker, B.M.5    Dvorak, H.F.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.