Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1

Journal of Medicinal Chemistry

Volumn 59, Issue 3, 2016, Pages 1140-1148

  Llona Minguez, Sabin ^a   Höglund, Andreas ^a,g   Jacques, Sylvain A ^a,h   Johansson, Lars ^a   Calderón Montaño, José Manuel ^a   Claesson, Magnus ^c   Loseva, Olga ^a   Valerie, Nicholas C K ^a   Lundbäck, Thomas ^a   Piedrafita, Javier ^f   Maga, Giovanni ^d   Crespan, Emmanuele ^d   Meijer, Laurent ^e   Burgos Morón, Estefanía ^a   Baranczewski, Pawel ^a,b   Hagbjörk, Ann Louise ^b   Svensson, Richard ^b   Wiita, Elisee ^a   Almlöf, Ingrid ^a   Visnes, Torkild ^a   Jeppsson, Fredrik ^a   Sigmundsson, Kristmundur ^a,i   Jensen, Annika Jenmalm ^a   Artursson, Per ^b   Jemth, Ann Sofie ^a   Stenmark, Pål ^c   Warpman Berglund, Ulrika ^a   Scobie, Martin ^a   Helleday, Thomas ^a   more..

^a KAROLINSKA INSTITUTE   (Sweden)

^b UPPSALA UNIVERSITY   (Sweden)

^c STOCKHOLM UNIVERSITY   (Sweden)

^d CNR   (Italy)

^e Centre de Perharidy   (France)

^f TORREY PINES INSTITUTE FOR MOLECULAR STUDIES   (United States)

^g Sprint BioScience AB   (Sweden)

^h UNIVERSITÉ DE STRASBOURG   (France)

ⁱ DUKE NUS MEDICAL SCHOOL   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

1 (4 METHOXYBENZYL) 1H BENZO[D]IMIDAZOLE; 1 (4 METHOXYBENZYL) 2 METHYL 1H BENZO[D]IMIDAZOLE; 1 (4 METHOXYBENZYL) 2 METHYL 4 NITRO 1H BENZO[D]IMIDAZOLE; 1 (4 METHOXYBENZYL) 2,5,6 TRIMETHYL 1H BENZO[D]IMIDAZOLE; 1 (4 METHOXYBENZYL) 5,6 DIMETHYL 1H BENZO[D]IMIDAZOLE; 1 BENZYL 5,6 DICHLORO 2 METHYL 4 NITRO 1H BENZO[D]IMIDAZOLE; 1 [4 (1H PYRAZOL 1 YL)BENZYL] 5,6 DICHLORO 2 METHYL 4 NITRO 1H BENZO[D]IMIDAZOLE; 1 [4 (1H PYRROL 1 YL)BENZYL] 5,6 DICHLORO 2 METHYL 4 NITRO 1H BENZO[D]IMIDAZOLE; 2,5,6 TRIMETHYL 4 NITRO 1H BENZO[D]IMIDAZOLE; 4 [(5,6 DICHLORO 2 METHYL 1H BENZO[D]IMIDAZOL 1 YL)METHYL]PHENYL]BORONIC ACID; 4 [(5,6 DICHLORO 2 METHYL 4 NITRO 1H BENZO[D]IMIDAZOL 1 YL)METHYL] 2 METHYLTHIAZOLE; 4 [(5,6 DICHLORO 2 METHYL 4 NITRO 1H BENZO[D]IMIDAZOL 1 YL)METHYL]BENZALDEHYDE; 4 [(5,6 DICHLORO 2 METHYL 4 NITRO 1H BENZO[D]IMIDAZOL 1 YL)METHYL]BENZOIC ACID; 4 [(5,6 DICHLORO 2 METHYL 4 NITRO 1H BENZO[D]IMIDAZOL 1 YL)METHYL]BENZONITRILE; 4 [(5,6 DICHLORO 2 METHYL 4 NITRO 1H BENZO[D]IMIDAZOL 1 YL)METHYL]BORONIC ACID; 4 [(5,6 DICHLORO 2 METHYL 4 NITRO 1H BENZO[D]IMIDAZOL 1 YL)METHYL]PHENYL ACETATE; 5,6 DICHLORO 1 (4 METHOXYBENZYL) 2 METHYL 1H BENZO[D]IMIDAZOLE; 5,6 DICHLORO 1 (4 METHOXYBENZYL) 2 METHYL 4 NITRO 1H BENZO[D]IMIDAZOLE; 5,6 DICHLORO 1 [(6 CHLOROPYRIDIN 3 YL)METHYL] 2 METHYL 4 NITRO 1H BENZO[D]IMIDAZOLE; 5,6 DICHLORO 1 [2 (3,5 DIMETHYL 1H PYRAZOL 4 YL)ETHYL] 2 METHYL 4 NITRO 1H BENZO[D]IMIDAZOLE; 5,6 DICHLORO 2 CYCLOPROPYL 4 NITRO 1H BENZO[D]IMIDAZOLE; 5,6 DICHLORO 2 METHYL 4 NITRO 1 PHENYL 1H BENZO[D]IMIDAZOLE; DEOXYCYTIDINE TRIPHOSPHATE; DEOXYCYTIDINE TRIPHOSPHATE PYROPHOSPHATASE 1; HYDROLASE INHIBITOR; METHYL 4 [(5,6 DICHLORO 2 METHYL 4 NITRO 1H BENZO[D]IMIDAZOL 1 YL)METHYL]BENZOATE; UNCLASSIFIED DRUG; UNINDEXED DRUG; [4 [(5,6 DICHLORO 2 CYCLOPROPYL 4 NITRO 1H BENZO[D]IMIDAZOL 1YL)METHYL]PHENYL]BORONIC ACID; [4 [(5,6 DIFLUORO 2 METHYL 4 NITRO 1H BENZO[D]IMIDAZOL 1 YL)METHYL]PHENYL]BORONIC ACID; [4 [[4 NITRO 2 (TRIFLUOROMETHYL) 1H BENZO[D]IMIDAZOL 1 YL]METHYL]PHENYL]BORONIC ACID; DCTP PYROPHOSPHATASE; ENZYME INHIBITOR; INORGANIC PYROPHOSPHATASE; LIGAND;

ACYLATION; ALKYLATION; ARTICLE; ARYLATION; CANCER STEM CELL; CELL MEMBRANE PERMEABILITY; DRUG CYTOTOXICITY; DRUG HALF LIFE; DRUG POTENCY; DRUG SOLUBILITY; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; IN VIVO STUDY; LEUKEMIA CELL; MOUSE; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG DEVELOPMENT; HL-60 CELL LINE; METABOLISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DISCOVERY; ENZYME INHIBITORS; HL-60 CELLS; HUMANS; LIGANDS; MOLECULAR STRUCTURE; PYROPHOSPHATASES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84958231153     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/acs.jmedchem.5b01741     Document Type: Article

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