Poly(3-Hydroxybutyrate) Production in Repeated fed-Batch with Cell Recycle Using a Medium with low Carbon Source Concentration

Applied Biochemistry and Biotechnology

Volumn 178, Issue 2, 2016, Pages 408-417

  Ienczak, Jaciane Lutz ^a   Schmidt, Mélodi ^b   Quines, Luci Kelin ^b   Zanfonato, Kellen ^b   da Cruz Pradella, José Geraldo ^a   Schmidell, Willibaldo ^b   de Aragao, Glaucia Maria Falcao ^b  

^a BRAZILIAN CENTER FOR RESEARCH IN ENERGY AND MATERIALS CNPEM   (Brazil)

^b FEDERAL UNIVERSITY OF SANTA CATARINA   (Brazil)

Author keywords

Cell recycle; Cross flow filtration; Low carbon source concentration; Poly(3 hydroxybutyrate); Repeated fed batch

Indexed keywords

CELLS; COSTS; CYTOLOGY; INDUSTRIAL MANAGEMENT; PROCESS CONTROL; PRODUCTIVITY; REAL TIME CONTROL; RECYCLING;

CELL RECYCLE; CROSS FLOW FILTRATION; FED BATCHES; LOW CARBON; POLY-3-HYDROXYBUTYRATE;

SUBSTRATES;

POLY(3 HYDROXYBUTYRIC ACID); CARBON; CULTURE MEDIUM; HYDROXYBUTYRIC ACID; POLY-BETA-HYDROXYBUTYRATE; POLYESTER;

ARTICLE; BIOMASS; CARBON SOURCE; CELL DENSITY; CONTROLLED STUDY; CUPRIAVIDUS NECATOR; FED BATCH CULTURE; NONHUMAN; OXYGEN CONSUMPTION; PROCESS CONTROL; PRODUCTIVITY; CULTURE MEDIUM; KINETICS; METABOLISM;

BIOMASS; CARBON; CULTURE MEDIA; CUPRIAVIDUS NECATOR; HYDROXYBUTYRATES; KINETICS; POLYESTERS;

EID: 84958177438     PISSN: 02732289     EISSN: 15590291     Source Type: Journal    
DOI: 10.1007/s12010-015-1883-9     Document Type: Article

References (21)

1. Anderson, A. J., & Dawes, E. A. (1990). Occurrence, metabolism, metabolic role, end industrial uses of bacterial polyhydroxyalkanoates. Microbiol Reviews, 54(4), 450–472.
2. Riesenberg, D., & Guthke, R. (1999). High-cell-density cultivation of microorganisms. Applied Microbiology and Biotechnology, 51, 422–430.
3. Ienczak, J. L., Quines, L. K., Melo, A. A., Brandellero, M., Mendes, C. R., Schmidell, W., & Aragão, G. M. F. (2011). High cell density strategy for poly(3-hydroxybutyrate) production by Cupriavidus necator. Brazilian Journal of Chemical Engineering, 28, 585–596.
4. Marangoni, C., Furigo Jr., A., & Aragão, G. M. F. (2002). Production of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) by Ralstonia eutropha in whey and inverted sugar with propionic acid feeding. Process Biochemistry, 38, 137–141.
5. Aragão, G. M. F., Schmidell, W., Ienczak, J. L., Schmidt, F. C., Dalcanton, F., Fiorese, M. L., Rodrigues, R., Deucher, R., & Marangoni, C. (2009). Preparation of polyhydroxyalkanoates from a citric residue. International Application Published Under the Patent Cooperation Treaty (PCT), WO2009/149529 A1.
6. Delgenes, J. P., Escare, M. C., Laplace, J. M., Moletta, R., & Navarro, J. M. (1998). Biological production of industrial chemicals, i.e. xylitol and ethanol, from lignocelluloses by controlled mixed culture systems. Ind. Crop Prod., 7, 101–111.
7. Santos, S. C., Rosa, P. R. F., Sakamoto, I. K., Varesche, M. B. A., & Silva, E. L. (2014). Hydrogen production from diluted and raw sugarcane vinasse under thermophilic anaerobic conditions. Interntional Journal of Hydrogen Energy, 39, 9599–9610.
8. Khanna, S., & Srivastava, A. K. (2005). Repeated fed-batch cultivation of Ralstonia eutropha for poly(β-hydroxybutyrate) production. Biotechnology Letters, 27, 1401–1403.
9. Ibrahim, M. H. A., & Steinbüchel, A. (2010). High-cell-density cyclic fed-batch fermentation of a poly(3-hydroxybutyrate)-accumulating thermophile, Chelatococcus sp. Strain MW10. Applied and Enviromental Microbiology, 76, 7890–7895.
10. Ahn, W. S., Park, S. J., & Lee, S. Y. (2001). Production of poly(3-hydroxybutyrate) from whey by cell recycle fed-batch culture of recombinant Escherichia coli. Biotechnolgy Letters., 23, 235–240.
11. Pinto, M. A., & Immanuel, C. D. (2005). Modelling and bifurcation studies os a two-stage continuous bioreactor for the production of poly-ß-hydroxybutyrate (PHB). Aiche Annual Meeting.
12. Lambrechts, T., Papantoniou, I., Sonnaert, M., Schrooten, J., & Aerts, J. M. (2014). Model-based cell number quantification using online single-oxygen sensor data for tissue engineering perfusion bioreactors. Biotechnology and Bioengineering, 111, 1982–1992.
13. Brandl, H., Gross, R. A., Lenz, R. W., & Fuller, R. C. (1998). Pseudomonas oleovorans as a source of poly(β-hydroxyalkanoates) for potential applications as biodegradable polyesters. Applied and Enviromental Microbiology, 54, 1977–1982.
14. Taguchi, H., & Humphrey, A. (1966). Dynamic measurement of the volumetric oxygen transfer coefficient in fermentation systems. Journal of Fermentation Technology, 44, 881–889.
15. Pirt, S. J. (1975). Principles of microbe and cell cultivations. Oxford: Blackwell.
16. Ryu, H. W., Hahn, S. K., Chang, Y. K., & Chang, H. N. (1997). Production of poly(3-hydroxybutyrate) by high cell density fed-batch culture of Alcaligenes eutrophus with phosphate limitation. Biotechnology and Bioengineering, 55(1), 25–32.
17. Khanna, S., & Srivastava, A. K. (2008). Continuous production of poly-β-hydroxybutyrate by high-cell-density cultivation of Wautersia eutropha. Journal of Chemical Technology & Biotechnology, 83, 799–805.
18. Shang, L., Jiang, M., & Chang, H. N. (2003). Poly(3-hydroxybutyrate) synthesis in fed-batch culture of Ralstonia eutropha with phosphate limitation under different glucose concentrations. Biotechnology Letters, 25, 1415–1419.
19. Davis, R., Duane, G., Kenny, S. T., Cerrone, F., Guzik, M. W., Babu, R. P., Casey, E., & O’Connor, K. E. (2015). High cell density cultivation of Pseudomonas putida KT2440 using glucose without the need for oxygen enriched air supply. Biotechnology and Bioengineering, 112, 725–733.
20. Atlié, A., Koller, M., Scherzer, D., Kutschera, C., Grillo-Fernandes, E., Horvat, P., Chiellini, E., & Braunegg, G. (2011). Continuous production of poly([R]-3-hydroxybutyrate) by Cupriavidus necator in a multistage bioreactor cascade. Applied and Enviromental Microbiology, 91, 295–304.
21. Cesário, M. T., Rapose, R. S., Almeida, M. C. M. D., Keulen, F. V., Ferreira, B. S., & Fonseca, M. M. R. (2014). Enhanced bioproduction of poly-3-hydroxybutyrate from wheat straw lignocellulosic hydrolysates. New Biotechnology, 31, 104–113.