Continuous production of poly-β-hydroxybutyrate by high-cell-density cultivation of Wautersia eutropha

Journal of Chemical Technology and Biotechnology

Volumn 83, Issue 6, 2008, Pages 799-805

  Khanna, Shilpi ^a   Srivastava, Ashok K ^a  

^a INDIAN INSTITUTE OF TECHNOLOGY DELHI   (India)

Author keywords

Continuous cultivation; High cell density; Steady state; Wautersia eutropha

Indexed keywords

BIODEGRADABLE POLYMERS; BIOMASS; BIOTECHNOLOGY; PRODUCTION;

CONTINUOUS CULTIVATION; HIGH CELL DENSITY; POLYHYDROXYBUTYRATE;

CELL CULTURE;

POLY(3 HYDROXYBUTYRIC ACID);

BIODEGRADABLE POLYMERS; BIOMASS; BIOTECHNOLOGY; CELL CULTURE; PRODUCTION;

ARTICLE; BATCH REACTOR; BIOMASS DISTRIBUTION; CELL DENSITY; CONCENTRATION PROCESS; CONTINUOUS FERMENTATION; CONTROLLED STUDY; CUPRIAVIDUS NECATOR; DILUTION; FED BATCH CULTURE; FERMENTATION MEDIUM; NONHUMAN; POLYMER PRODUCTION; SPECIES CULTIVATION; STEADY STATE;

CUPRIAVIDUS NECATOR;

EID: 44649094016     PISSN: 02682575     EISSN: 10974660     Source Type: Journal    
DOI: 10.1002/jctb.1868     Document Type: Article

References (23)

1. Khanna S and Srivastava AK, Recent advances in microbial polyhydroxyalkanoates. Process Biochem 40:609-619 (2005).
2. Reddy CSK, Kalia VC and Rashmi CR, Polyhydroxyalkanoates: an overview. Bioresource Technol 87:137-146 (2003).
3. Steinbuchel A and FuchtenbuschB, Bacterial and other biological systems for polyester production. Trends Biotechnol 16:419-427 (1998).
4. Omar S, Rayes A, Eqaab A, Voß I and Steinbuchel A, Optimization of cell growth and poly(3-hydroxybutyrate) accumulation on date syrup by a Bacillus megaterium strain. Biotechnol Lett 23:1119-1123 (2001).
5. Khanna S and Srivastava AK, Statistical media optimization studies for growth and PHB production by Ralstonia eutropha. Process Biochem 40:2173-2182 (2005).
6. Grothe E and Chisti Y, Poly(β-hydroxybutyric acid) thermoplastic production by Alcaligenes latus: behavior of fed-batch cultures. Bioprocess Biosyst Eng 22:441-449 (2000).
7. Kim BS, Production of medium chain length polyhydroxyalkanoates by fed-batch culture of Pseudomonas oleovorans. Biotechnol Lett 24:125-130 (2002).
8. Patwardhan PR and Srivastava AK, Model-based fed-batch cultivation of R. eutropha for enhanced biopolymer production. Biochem Eng J 20:21-28 (2004).
9. Khanna S and Srivastava AK, Computer simulated fed-batch cultivation for over production of PHB: a comparison of simultaneous and alternate feeding of carbon and nitrogen. Biochem Eng J 27:197-203 (2006).
10. Khanna S and Srivastava AK, Model based nitrogen and carbon feeding for over production of poly(β-hydroxybutyrate) by Ralstonia eutropha. Enzyme Microb Technol 39:1145-1151 (2006).
11. Preusting H, van Houten R, Hoers A, Keol van Langenberhe E, Favre Bulle O and Witholt B, High cell density cultivation of Pseudomonas oleovorans: growth and production of poly(3-hydroxyalkanoates) in two-liquid phase batch and fed-batch systems. Biotechnol Bioeng 41:550-556 (1993).
12. Preusting H, Kingma J and Witholt B, Physiology and polyester formation of Pseudomonas oleovorans in continuous two-phase-liquid cultures. Enzyme Microb Technol 13:770-780 (1991).
13. Koyama N and Doi Y, Continuous production of poly(3-hydroxybutyrate- co-3-hydroxyvalerate) by Alcaligenes eutrophus. Biotechnol Lett 17:281-284 (1995).
14. Kellerhals MB, Hazenberg W and Witholt B, High cell density fermentations of Pseudomonas oleovorans for the production of mcl-PHAs in two-liquid phase media. Enzyme Microb Technol 24:111-116 (1999).
15. Zinn M, Weilenmann H-U, Hany R, Schmid M and Egli T, Tailored synthesis of poly([R]-3-hydroxybutyrate-co-3-hydroxyvalerate) (PHB/HV) in Ralstonia eutropha DSM 428. Acta Biotechnol 23: 309-316 (2003).
16. Miller GL, Use of dinitrosalicylic acid reagent for determination of reducing sugar. Anal Chem 31:426-428 (1959).
17. Horwitz W, AOAC, Official Methods of Analysis. Association of Official Analytical Chemists, Washington, DC (1980).
18. Riis V and Mai W, Gas chromatographic determination of poly-β-hydroxybutyric acid in microbial biomass after hydrochloric acid propanolysis, J Chromatogr 445:285-289 (1988).
19. Khanna S and Srivastava AK, A simple structured mathematical model for biopolymer (PHB) production. Biotechnol Prog 21:830-838 (2005).
20. + levels on poly(β-hydroxybutyrate) production and growth in a continuous culture of Alcaligenes eutrophus. Biotechnol Prog 12:234-239 (1996).
21. Dominguez H, Nunez MJ, Chamy R and Lema JM, Determination of kinetic parameters of fermentation processes by a continuous unsteady-state method: application to the alcoholic fermentation of D-xylose by Pichia stipitis. Biotechnol Bioeng 41:1129-1132 (1993).
22. Ramsay BA, Saracovan I, Ramsay JA and Marchessault RH, Continuous production of long-side-chain poly-β-hydroxyalkanoates by Pseudomonas oleovorans. Appl Environ Microbiol 57:625-629 (1991).
23. Huijberts GNM and Eggink G, Production of PHA by Pseudomonas putida KT2442 in continuous cultures. Appl Microbiol Biotechnol 46 :233-239 (1996).