Neuroplastic effects of transcranial direct current stimulation on painful symptoms reduction in chronic hepatitis C: A phase II randomized, double blind, sham controlled trial

Frontiers in Neuroscience

Volumn 9, Issue JAN, 2016, Pages

  Brietzke, Aline P ^a   Rozisky, Joanna R ^a   Dussan Sarria, Jairo A ^a   Deitos, Alicia ^a   Laste, Gabriela ^a   Hoppe, Priscila F T ^a   Muller, Suzana ^a   Torres, Iraci L S ^a   Alvares da Silva, Mário R ^a   de Amorim, Rivadavio F B ^b   Fregni, Felipe ^b   Caumo, Wolnei ^a  

^a HOSPITAL DE CLÍNICAS DE PORTO ALEGRE   (Brazil)

^b and Red Sox Foundation and Massachusetts General Hospital Home Base Program   (United States)

Author keywords

Chronic pain; Hepatitis C; Hepatitis C virus; PEG IFN; Transcranial direct current stimulation

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; PEGINTERFERON; PROTEINASE INHIBITOR; RIBAVIRIN;

ADULT; ANALGESIA; ARTICLE; CHRONIC HEPATITIS C; CLINICAL ARTICLE; CLINICAL EFFECTIVENESS; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; INTENTION TO TREAT ANALYSIS; MALE; MOTOR CORTEX; NERVE CELL PLASTICITY; OUTCOME ASSESSMENT; PAIN; PAIN ASSESSMENT; PHASE 2 CLINICAL TRIAL; PRESSURE PAIN THRESHOLD; PROTEIN BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL; TRANSCRANIAL DIRECT CURRENT STIMULATION; TREATMENT DURATION; TREATMENT OUTCOME; VISUAL ANALOG SCALE;

EID: 84958061683     PISSN: 16624548     EISSN: 1662453X     Source Type: Journal    
DOI: 10.3389/fnins.2015.00498     Document Type: Article

References (51)

1. Antal, A., Brepohl, N., Poreisz, C., Boros, K., Csifcsak, G., and Paulus, W. (2008). Transcranial direct current stimulation over somatosensory cortex decreases experimentally induced acute pain perception. Clin. J. Pain 24, 56-63. doi: 10.1097/AJP.0b013e318157233b.
2. Babor, T. F., de la Fuente, J. R., Saunders, J., and Grant, M. (1989). AUDIT: The Alcohol Use Disorders Identification Test: Guidelines for Use in Primary Health Care. Geneva: World Health Organization.
3. Barnett, A. G., van der Pols, J. C., and Dobson, A. J. (2005). Regression to the mean: what it is and how to deal with it. Int. J. Epidemiol. 34, 215-220. doi: 10.1093/ije/dyh299.
4. Benedetti, F., Mayberg, H. S., Wager, T. D., Stohler, C. S., and Zubieta, J. K. (2005). Neurobiological mechanisms of the placebo effect. J. Neurosci. 25, 10390-10402. doi: 10.1523/JNEUROSCI.3458-05.2005.
5. Boggio, P. S., Zaghi, S., and Fregni, F. (2009). Modulation of emotions associated with images of human pain using anodal transcranial direct current stimulation (tDCS). Neuropsychologia 47, 212-217. doi: 10.1016/j.neuropsychologia.2008.07.022.
6. Borckardt, J. J., Romagnuolo, J., Reeves, S. T., Madan, A., Frohman, H., Beam, W., et al. (2011). Feasibility, safety, and effectiveness of transcranial direct current stimulation for decreasing post-ERCP pain: a randomized, sham-controlled, pilot study. Gastrointest. Endosc. 73, 1158-1164. doi: 10.1016/j.gie.2011.01.050.
7. Caumo, W., Torres, F., Moreira, N. L. Jr. Auzani, J. A., Monteiro, C. A., Londero, G., et al. (2013). The clinical impact of preoperative melatonin on postoperative outcomes in patients undergoing abdominal hysterectomy. Anesth. Analg. 105, 1263-1271. doi: 10.1213/01.ane.0000282834.78456.90.
8. Chassot, M., Dussan-Sarria, J. A., Sehn, F. C., Deitos, A., de Souza, A., Vercelino, R., et al. (2015). Electroacupuncture analgesia is associated with increased serum brain-derived neurotrophic factor in chronic tension-type headache: a randomized, sham controlled, crossover trial. BMC Complement. Altern. Med. 15:144. doi: 10.1186/s12906-015-0664-x.
9. Dall'Agnol, L., Medeiros, L. F., Torres, I. L., Deitos, A., Brietzke, A., Laste, G., et al. (2014). Repetitive transcranial magnetic stimulation increases the corticospinal inhibition and the brain-derived neurotrophic factor in chronic myofascial pain syndrome: an explanatory double-blinded, randomized, sham-controlled trial. J. Pain. 15, 845-855. doi: 10.1016/j.jpain.2014.05.001.
10. Dasilva, A. F., Mendonca, M. E., Zaghi, S., Lopes, M., Dossantos, M. F., Spierings, E. L., et al. (2012). tDCS-induced analgesia and electrical fields in pain-related neural networks in chronic migraine. Headache 52, 1283-1295. doi: 10.1111/j.1526-4610.2012.02141.x.
11. Dieckhöfer, A., Waberski, T. D., Nitsche, M., Paulus, W., Buchner, H., and Gobbelé, R. (2006). Transcranial direct current stimulation applied over the somatosensory cortex-differential effect on low and high frequency SEPs. Clin. Neurophysiol. 117, 2221-2227. doi: 10.1016/j.clinph.2006.07.136.
12. EASL (2015). EASL recommendations on treatment of hepatitis C. J. Hepatol. 63, 199-236. doi: 10.1016/j.jhep.2015.03.025.
13. Fagerlund, A. J., Hansen, O. A., and Aslaksen, P. M. (2015). Transcranial direct current stimulation as a treatment for patients with fibromyalgia: a randomized controlled trial. Pain 156, 62-71. doi: 10.1016/j.pain.0000000000000006.
14. Fenton, B. W., Palmieri, P. A., Boggio, P., Fanning, J., and Fregni, F. (2009). A preliminary study of transcranial direct current stimulation for the treatment of refractory chronic pelvic pain. Brain Stimul. 2, 103-107. doi: 10.1016/j.brs.2008.09.009.
15. Fregni, F., Boggio, P. S., Lima, M. C., Ferreira, M. J., Wagner, T., Rigonatti, S. P., et al. (2006a). A sham-controlled, phase II trial of transcranial direct current stimulation for the treatment of central pain in traumatic spinal cord injury. Pain 122, 197-209. doi: 10.1016/j.pain.2006.02.023.
16. Fregni, F., Boggio, P. S., Nitsche, M., Bermpoh, F., Antal, A., Feredoes, E., et al. (2005). Anodal transcranial direct current stimulation of prefrontal cortex enhances working memory. Exp. Brain Res. 166, 23-30. doi: 10.1007/s00221-005-2334-6.
17. Fregni, F., Gimenes, R., Valle, A. C., Ferreira, M. J., Rocha, R. R., Natalle, L., et al. (2006b). A randomized, sham-controlled, proof of principle study of transcranial direct current stimulation for the treatment of pain in fibromyalgia. Arthritis Rheum. 54, 3988-3998. doi: 10.1002/art.22195.
18. Garcia-Larrea, L., and Peyron, R. (2007). Motor cortex stimulation for neuropathic pain: from phenomenology to mechanisms. Neuroimage 37(Suppl. 1), S71-S79. doi: 10.1016/j.neuroimage.2007.05.062.
19. Genoud, C., Knott, G. W., Sakata, K., Lu, B., and Welker, E. (2004). Altered synapse formation in the adult somatosensory cortex of brain-derived neurotrophic factor heterozygote mice. J. Neurosci. 24, 2394-2400. doi: 10.1523/JNEUROSCI.4040-03.2004.
20. Hansen, N., Obermann, M., Poitz, F., Holle, D., Diener, H. C., Antal, A., et al. (2010). Modulation of human trigeminal and extracranial nociceptive processing by transcranial direct current stimulation of the motor cortex. Cephalalgia 31, 661-670. doi: 10.1177/0333102410390394.
21. Huckans, M., Fuller, B., Wheaton, V., Jaehnert, S., Ellis, C., Kolessar, M., et al. (2015). A longitudinal study evaluating the effects of interferon-alpha therapy on cognitive and psychiatric function in adults with chronic hepatitis C. J. Psychosom. Res. 78, 184-192. doi: 10.1016/j.jpsychores.2014.07.020.
22. Kaipper, M. B., Chachamovich, E., Hidalgo, M. P., Torres, I. L., and Caumo, W. (2010). Evaluation of the structure of Brazilian State-Trait Anxiety Inventory using a Rasch psychometric approach. J. Psychosom. Res. 68, 223-233. doi: 10.1016/j.jpsychores.2009.09.013.
23. Kenis, G., Prickaerts, J., van Os, J., Koek, G. H., Robaeys, G., Steinbusch, H. W., et al. (2011). Depressive symptoms following interferon-α therapy: mediated by immune-et al. Induced reductions in brain-derived neurotrophic factor? Int. J. Neuropsychopharmacol. 14, 247-253. doi: 10.1017/S1461145710000830.
24. Knotkova, H., Rosedale, M., Strauss, S. M., Horne, J., Soto, E., Cruciani, R. A., et al. (2012). Using transcranial direct current stimulation to treat depression in HIV-infected persons: the outcomes of a feasibility study. Front. Psychiatry 3:59. doi: 10.3389/fpsyt.2012.00059.
25. Kohli, A., Shaffer, A., Sherman, A., and Kottilil, S. (2014). Treatment of hepatitis C: a systematic review. J. Am. Med. Assoc. 312, 631-640. doi: 10.1001/jama.2014.7085.
26. Kokkotou, E., Conboy, L. A., Ziogas, D. C., Quilty, M. T., Kelley, J. M., Davis, R. B., et al. (2010). Serum correlates of the placebo effect in irritable bowel syndrome. Neurogastroenterol. Motil. 22, 285-e81. doi: 10.1111/j.1365-2982.2009.01440.x.
27. Kumru, H., Soler, D., Vidal, J., Navarro, X., Tormos, J. M., and Pascual-Leone, A. (2013). The effects of transcranial direct current stimulation with visual illusion in neuropathic pain due to spinal cord injury: an evoked potentials and quantitative thermal testing study. Eur. J. Pain. 17, 55-66. doi: 10.1002/j.1532-2149.2012.00167.x.
28. Lindenberg, R., Renga, V., Zhu, L. L., Nair, D., and Schlaug, G. (2010). Bihemispheric brain stimulation facilitates motor recovery in chronic stroke patients. Neurology 75, 2176-2184. doi: 10.1212/WNL.0b013e318202013a.
29. Loftis, J. M., and Hauser, P. (2004). The phenomenology and treatment of interferon-induced depression. J. Affect. Disord. 15, 175-190. doi: 10.1016/j.jad.2004.04.002.
30. Louie, K. S., St Laurent, S., Forssen, U. M., Mundy, L. M., and Pimenta, J. M. (2012). The high comorbidity burden of the hepatitis C virus infected population in the United States. BMC Infect. Dis. 12:86. doi: 10.1186/1471-2334-12-86.
31. Middel, B., and van Sonderen, E. (2002). Statistical significant change versus relevant or important change in (quasi) experimental design: some conceptual and methodological problems in estimating magnitude of intervention-related change in health services research. Int. J. Integr. Care 2:e15.
32. Nitsche, M. A., Doemkes, S., Karaköse, T., Antal, A., Liebetanz, D., Lang, N., et al. (2007).Shaping the effects of transcranial direct current stimulation ofthe human motor cortex. J. Neurophysiol. 97, 3109-3117. doi: 10.1152/jn.01312.2006.
33. Nitsche, M. A., and Paulus, W. (2000). Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation. J. Physiol. 527, 633-639. doi: 10.1111/j.1469-7793.2000.t01-1-00633.x.
34. Par, G., Szereday, L., Berki, T., Palinkas, L., Halasz, M., Miseta, A., et al. (2013). Increased baseline proinflammatory cytokine production in chronic hepatitis C patients with rapid virological response to peginterferon plus ribavirin. PLoS ONE 8:e67770. doi: 10.1371/journal.pone.0067770.
35. Polanía, R., Nitsche, M. A., and Paulus, W. (2011). Modulating functional connectivity patterns and topological functional organization of the human brain with transcranial direct current stimulation. Hum. Brain Mapp. 32, 1236-1249. doi: 10.1002/hbm.21104.
36. Quan, N., and Banks, W. A. (2007). Brain-immune communication pathways. Brain Behav. Immun. 21, 727-735. doi: 10.1016/j.bbi.2007.05.005.
37. Raison, C. L., Borisov, A. S., Majer, M., Drake, D. F., Pagnoni, G., Woolwine, B. J., et al. (2009). Activation of central nervous system inflammatory pathways by interferonalpha: relationship to monoamines and depression. Biol. Psychiatry 65, 296-303. doi: 10.1016/j.biopsych.2008.08.010.
38. Sakrajai, P., Janyacharoen, T., Jensen, M. P., Sawanyawisuth, K., Auvichayapat, N., Tunkamnerdthai, O., et al. (2014). Pain reduction in myofascial pain syndrome by anodal transcranial direct current stimulation combined with standard treatment: a randomized controlled study. Clin. J. Pain 30, 1076-1083. doi: 10.1097/AJP.0000000000000069.
39. Savli, H., Gulkac, M. D., and Esen, N. (2004). The effect of stimulated microglia conditioned media on BDNF gene expression of striatal astrocytes: quantification by real-time PCR. Int. J. Neurosci. 114, 1601-1612. doi: 10.1080/00207450490476138.
40. Schinder, A. F., and Poo, M. (2000). The neurotrophin hypothesis for synaptic plasticity. Trends Neurosci. 23, 639-645. doi: 10.1016/S0166-2236(00)01672-6.
41. Schwertner, A., Conceição Dos Santos, C. C., Costa, G. D., Deitos, A., de Souza, A., de Souza, I. C., et al. (2013). Efficacy of melatonin in the treatment of endometriosis: a phase II, randomized, double-blind, placebo-controlled trial. Pain 154, 874-881. doi: 10.1016/j.pain.2013.02.025.
42. Sehn, F., Chachamovich, E., Vidor, L. P., Dall-Agnol, L., de Souza, I. C., Torres, I. L., et al. (2012). Cross-cultural adaptation and validation of the Brazilian Portuguese version of the pain catastrophizing scale. Pain Med. 13, 1425-1435. doi: 10.1111/j.1526-4637.2012.01492.x.
43. Souto, G., Borges, I. C., Goes, B. T., de Mendonça, M. E., Gonçalves, R. G., Garcia, L. B., et al. (2014). Effects of tDCS-induced motor cortex modulation on pain in HTLV-1: a blind randomized clinical trial. Clin. J. Pain 30, 809-815. doi: 10.1097/AJP.0000000000000037.
44. Valle, A., Roizenblatt, S., Botte, S., Zaghi, S., Riberto, M., Tufik, S., et al. (2009). Efficacy of anodal transcranial direct current stimulation (tDCS) for the treatment of fibromyalgia: results of a randomized, sham-controlled longitudinal clinical trial. J. Pain Manag. 2, 353-361.
45. Vidor, L. P., Torres, I. L., Custódio de Souza, I. C., Fregni, F., and Caumo, W. (2012). Analgesic and sedative effects of melatonin in temporomandibular disorders: a double-blind, randomized, parallel-group, placebo-controlled study. J. Pain Symptom Manage. 46, 422-432. doi: 10.1016/j.jpainsymman.2012.08.019.
46. Wagner, T., Valero-Cabre, A., and Pascual-Leone, A. (2007). Noninvasive human brain stimulation. Annu. Rev. Biomed. Eng. 9, 527-565. doi: 10.1146/annurev.bioeng.9.061206.133100.
47. Warmenhoven, F., van Rijswijk, E., Engels, Y., Kan, C., Prins, J., van Weel, C., et al. (2012). The Beck Depression Inventory (BDI-II) and a single screening question as screening tools for depressive disorder in Dutch advanced cancer patients. Support Care Cancer 20, 319-324. doi: 10.1007/s00520-010-1082-8.
48. Wechsler, M. E., Kelley, J. M., Boyd, I. O., Dutile, S., Marigowda, G., Kirsch, I., et al. (2011). Active albuterol or placebo, sham acupuncture, or no intervention in asthma. N. Engl. J. Med. 365, 119-126. doi: 10.1056/NEJMoa1103319.
49. Xanthos, D. N., and Sandkühler, J. (2014). Neurogenic neuroinflammation: inflammatory CNS reactions in response to neuronal activity. Nat. Rev. Neurosci. 15, 43-53. doi: 10.1038/nrn3617.
50. Zanette, S. A., Dussan-Sarria, J. A., Souza, A., Deitos, A., Torres, I. L., and Caumo, W. (2014). Higher serum S100B and BDNF levels are correlated with a lower pressure-pain threshold in fibromyalgia. Mol. Pain. 8;10:46. doi: 10.1186/1744-8069-10-46.
51. Zhanga, S., Rusta, G., Cardarellib, K., Felizzolac, J., Fransuad, M., and Stringer, H. G. Jr. (2015). Adherence to highly active antiretroviral therapy impact on clinical and economic outcomes for Medicaid enrollees with human immunodeficiency virus and hepatitis C coinfection. AIDS Care. 27, 829-835. doi: 10.1080/09540121.2015.1021745.