Analgesic and sedative effects of melatonin in temporomandibular disorders: A double-blind, randomized, parallel-group, placebo-controlled study

Journal of Pain and Symptom Management

Volumn 46, Issue 3, 2013, Pages 422-432

  Vidor, Liliane Pinto ^c   Torres, Iraci L S ^b,c   De Souza, Izabel Cristina Custodio ^a   Fregni, Felipe ^d   Caumo, Wolnei ^a,b,c,e  

^a Clinics Hospital of Porto Alegre   (Brazil)

^b Institute of Basic Health Sciences   (United States)

^c FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^d MASSACHUSETTS GENERAL HOSPITAL   (United States)

^e BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

Clinical Trial; Melatonin; Myofascial Pain; Pain Threshold; Temporomandibular Pain

Indexed keywords

ANALGESIC AGENT; CODEINE; CYCLOBENZAPRINE; DIPYRONE; IBUPROFEN; MELATONIN; ORPHENADRINE; PARACETAMOL; PLACEBO;

ADULT; ANALGESIC ACTIVITY; ARTICLE; BECK DEPRESSION INVENTORY; CLINICAL ARTICLE; CLINICAL ASSESSMENT; COMORBIDITY; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DISEASE PREDISPOSITION; DOUBLE BLIND PROCEDURE; FEMALE; FIBROMYALGIA; HUMAN; JAW DISEASE; JAW PAIN; LANGUAGE DISABILITY; MYOFASCIAL PAIN; NEUROPATHIC PAIN; NUCLEAR MAGNETIC RESONANCE IMAGING; OSTEOARTHRITIS; PAIN; PAIN ASSESSMENT; PAIN THRESHOLD; PITTSBURGH SLEEP QUALITY INDEX; PRESSURE PAIN; PSYCHOLOGIC TEST; RANDOMIZED CONTROLLED TRIAL; REGULATORY MECHANISM; RHEUMATOID ARTHRITIS; SLEEP DISORDER; SLEEP PARAMETERS; SLEEP PATTERN; SLEEP QUALITY; SLEEP WAKING CYCLE; STATE TRAIT ANXIETY INVENTORY; TEMPOROMANDIBULAR JOINT; VISUAL ANALOG SCALE;

CLINICAL TRIAL; MELATONIN; MYOFASCIAL PAIN; PAIN THRESHOLD; TEMPOROMANDIBULAR PAIN;

ADULT; ANALGESICS, NON-NARCOTIC; CENTRAL NERVOUS SYSTEM DEPRESSANTS; DOUBLE-BLIND METHOD; FEMALE; HUMANS; HYPNOTICS AND SEDATIVES; MELATONIN; PAIN; PAIN MEASUREMENT; PLACEBO EFFECT; SLEEP INITIATION AND MAINTENANCE DISORDERS; TEMPOROMANDIBULAR JOINT DYSFUNCTION SYNDROME; TREATMENT OUTCOME;

EID: 84888638570     PISSN: 08853924     EISSN: 18736513     Source Type: Journal    
DOI: 10.1016/j.jpainsymman.2012.08.019     Document Type: Article

References (48)

1. Macfarlane TV, Glenny AM, Worthington HV. Systematic review of population-based epidemiological studies of orofacial pain. J Dent 2001;29: 451e467.
2. Dworkin SF, LeResche L. Research diagnostic criteria for temporomandibular disorders: Review, criteria, examinations and specifications, critique. J Craniomandib Disord 1992;6:301e355.
3. Truelove EL, Sommers EE, LeResche L, Dworkin SF, Von Korff M. Clinical diagnostic criteria for TMD. New classification permits multiple diagnoses. J Am Dent Assoc 1992;123:47e54.
4. Riley JL, Benson MB, Gremillion HA, et al. Sleep disturbance in orofacial pain patients: Painrelated or emotional distress? Cranio 2001;19: 106e113.
5. Moldofsky H. Management of sleep disorders in fibromyalgia. Rheum Dis Clin North Am 2002;28: 353e365.
6. Plesh O, Curtis D, Levine J, McCall WD Jr. Amitriptyline treatment of chronic pain in patients with temporomandibular disorders. J Oral Rehabil 2000;27:834e841.
7. Bendtsen L, Jensen R. Amitriptyline reduces myofascial tenderness in patients with chronic tensiontype headache. Cephalalgia 2000;20:603e610.
8. Tofferi JK, Jackson JL, O?Malley PG. Treatment of fibromyalgia with cyclobenzaprine: A meta-analysis. Arthritis Rheum 2004;51:9e13.
9. Browning R, Jackson JL, O?Malley PG. Cyclobenzaprine and back pain: A meta-analysis. Arch Intern Med 2001;161:1613e1620.
10. Szabadi E. Drugs for sleep disorders: mechanisms and therapeutic prospects. Br J Clin Pharmacol 2006;61:761e766.
11. Citera G, Arias MA, Maldonado-Cocco JA. The effect of melatonin in patients with fibromyalgia: A pilot study. Clin Rheumatol 2000;19:9e13.
12. Acuna-Castroviejo D, Escames G, Reiter RJ. Melatonin therapy in fibromyalgia. J Pineal Res 2006;40: 98e99.
13. Hussain SA, Al-Khalifa II, Jasim NA, Gorial FI. Adjuvant use of melatonin for treatment of fibromyalgia. J Pineal Res 2011;50:267e271.
14. Reiter RJ, Acuña-Castroviejo D, Tan DX. Melatonin therapy in fibromyalgia. Curr Pain Headache Rep 2007;11:339e342.
15. Ambriz-Tututi M, Granados-Soto V. Oral and spinal melatonin reduces tactile allodynia in rats via activation of MT2 and opioid receptors. Pain 2007;132:273e280.
16. Esposito E, Paterniti I, Mazzon E, Bramanti P, Cuzzocrea S. Melatonin reduces hyperalgesia associated with inflammation. J Pineal Res 2010;49: 321e331.
17. Barrett T, Kent S, Voudouris N. Does melatonin modulate beta-endorphin, corticosterone, and pain threshold? Life Sci 2000;66:467e476.
18. Bennett RM. The rational management of fibromyalgia patients. Rheum Dis Clin North Am 2002; 28:181e199.
19. Mahdi AA, Fatima G, Das SK, Verma NS. Abnormality of circadian rhythm of serum melatonin and other biochemical parameters in fibromyalgia syndrome. Indian J Biochem Biophys 2011;48:82e87.
20. Wikner J, Hirsch U, Wetterberg L, Rojdmark S. Fibromyalgiada syndrome with decreased nocturnal melatonin secretion. Clin Endocrinol 1998;49: 179e183.
21. Korszun A, Sackett-Lundeen L, Papadopoulos E, et al. Melatonin levels in women with fibromyalgia and chronic fatigue syndrome. J Rheumatol 1999; 26:2675e2680.
22. Press J, Phillip M, Neumann L, et al. Normal melatonin levels in patients with fibromyalgia syndrome. J Rheumatol 1998;25:551e555.
23. Caumo W, Levandovski R, Hidalgo MP. Preoperative anxiolytic effect of melatonin and clonidine on postoperative pain and morphine consumption in patients undergoing abdominal hysterectomy: A double-blind, randomized, placebo-controlled study. J Pain 2009;10:100e108.
24. Klupi-nska G, Poplawski T, Drzewoski J, et al. Therapeutic effect of melatonin in patients with functional dyspepsia. J Clin Gastroenterol 2007;41: 270e274.
25. Song GH, Leng PH, Gwee KA, Moochhala SM, Ho KY. Melatonin improves abdominal pain in irritable bowel syndrome patients who have sleep disturbances: A randomized, double blind, placebo controlled study. Gut 2005;54:1402e1407.
26. International RDC/TMD Consortium: A Designated Network of the International Association for Dental Research. Available from http://www.rdctmdinternational. org/. Accessed March 6, 2011.
27. John MT, Dworkin SF, Mancl LA. Reliability of clinical temporomandibular disorder diagnoses. Pain 2005;118:61e69.
28. Dao TT, Lavigne GJ, Feine JS, Tanguay R, Lund JP. Power and sample size calculations for clinical trials of myofascial pain of jaw muscles. J Dent Res 1991;70:118e122.
29. Cannella KAS. Another decision to evaluate: Choice of standardized mean difference effect size estimator. Sixth International Cochrane Colloquium. Baltimore, MD; 1998.
30. Caumo W, Torres F, Moreira NL Jr, et al. The clinical impact of preoperative melatonin on postoperative outcomes in patients undergoing abdominal hysterectomy. Anesth Analg 2007;105: 1263e1271.
31. Rufiange M, Dumont M, Lachapelle P. Correlating retinal function with melatonin secretion in subjects with an early or late circadian phase. Invest Ophthalmol Vis Sci 2002;43:2491e2499.
32. Gorenstein C, Andrade L. Validation of a Portuguese version of the Beck Depression Inventory and the State-Trait anxiety Inventory in Brazilian subjects. Braz J Med Biol Res 1996;29:453e457.
33. Buysse DJ, Reynolds CF, Monk TH, Berman SR, Kupfer DJ. The Pittsburgh Sleep Quality Index: A new instrument for psychiatric practice and research. Psychiatry Res 1989;28:193e213.
34. Kaipper MB, Chachamovich E, Hidalgo MP, Torres IL, Caumo W. Evaluation of the structure of Brazilian State-Trait Anxiety Inventory using a Rasch psychometric approach. J Psychosom Res 2010;68:223e233.
35. Scott J, Huskisson EC. Graphic representation of pain. Pain 1976;2:175e184.
36. Fisher AA. Pressure Threshold Meter: its use for quantification of tender spots. Arch Phys Med Rehabil 1986;67:836e838.
37. Diggle PJ, Liang KY, Zeger SL. Analysis of longitudinal data. Oxford, UK: Clarendon Press, 1994.
38. Morgan PJ, Barret P, Howell E, Helliwell R. Melatonin receptors: localization, molecular pharmacology and physiological significance. Neurochem Int 1994;24:101e146.
39. Laurido C, Pelissie T, Soto-Moyano R, et al. Effect of melatonin on rat spinal cord nociceptive transmission. Neuroreport 2002;13:89e91.
40. Wu FS, Yang YC, Tsai JJ. Noncompetitive inhibition of the glycine receptor-mediated current by melatonin in cultured neurons. Brain Res 2000; 881:208e211.
41. Cuzzocrea S, Tan DX, Costantino G, et al. The protective role of endogenous melatonin in carrageenan induced pleurisy in the rat. FASEB J 1999; 13:1930e1938.
42. Haack M, Scott-Sutherland J, Santangelo G, et al. Pain sensitivity and modulation in primary insomnia. Eur J Pain 2012;16:522e533.
43. Smith MT, Haythornthwaite JA. How do sleep disturbance and chronic pain inter-relate? Insights from the longitudinal and cognitive-behavioral clinical trials literature. Sleep Med Rev 2004;8:119e132.
44. Acũna-Castroviejo D, Escames G, Mac?́as M, et al. Cell protective role of melatonin in the brain. J Pineal Res 1995;19:57e63.
45. Fleshner M, Nguyen KT, Cotter CS, Watkins LR, Maier SF. Acute stressor exposure both suppresses acquired immunity and potentiates innate immunity. Am J Physiol 1998;275:R870eR878.
46. Couto-Moraes R, Palermo-Neto J, Markus RP. The immune-pineal axis: stress as a modulator of pineal gland function. Ann N Y Acad Sci 2009;1153: 193e202.
47. Brebner K, Hayley S, Zacharko R, Merali Z, Anisman H. Synergistic effects of interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha: Central monoamine, corticosterone, and behavioral variations. Neuropsychopharmacology 2000;22: 566e580.
48. Verhagen AP, de Vet HC, de Bie RA, et al. The Delphi list: A criteria list for quality assessment of randomized clinical trials for conducting systematic reviews developed by Delphi consensus. J Clin Epidemiol 1998;51:1235e1241.