Simulating hypoxia-induced acidic environment in cancer cells facilitates mobilization and redox-cycling of genomic copper by daidzein leading to pro-oxidant cell death: Implications for the sensitization of resistant hypoxic cancer cells to therapeutic challenges

BioMetals

Volumn 29, Issue 2, 2016, Pages 299-310

  Ullah, Mohammad F ^a,b   Ahmad, Aamir ^a,c   Bhat, Showket H ^b   Khan, Husain Y ^a   Zubair, Haseeb ^a   Sarkar, Fazlul H ^c   Hadi, Sheikh M ^a  

^a ALIGARH MUSLIM UNIVERSITY   (India)

^b UNIVERSITY OF TABUK   (Saudi Arabia)

^c WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cancer; Cell death; Chemoprevention; Daidzein; DNA breakage; Hypoxia

Indexed keywords

2,9 DIMETHYL 1,10 PHENANTHROLINE; ANTINEOPLASTIC AGENT; CELL DNA; COBALT CHLORIDE; COPPER; DAIDZEIN; REACTIVE OXYGEN METABOLITE; ISOFLAVONE DERIVATIVE;

ACIDIFICATION; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER CELL LINE; CANCER CELL; CELL DEATH; CELL HYPOXIA; CYTOTOXICITY; DNA STRAND BREAKAGE; DRUG MECHANISM; HUMAN; HUMAN CELL; NORMAL HUMAN; PH; SENSITIZATION; SIMULATION; TUMOR MICROENVIRONMENT; CELL PROLIFERATION; DNA CLEAVAGE; DNA DAMAGE; DRUG EFFECTS; DRUG RESISTANCE; DRUG SCREENING; HUMAN GENOME; METABOLISM; OXIDATION REDUCTION REACTION; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL HYPOXIA; CELL LINE, TUMOR; CELL PROLIFERATION; COPPER; DNA CLEAVAGE; DNA DAMAGE; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; GENOME, HUMAN; HUMANS; HYDROGEN-ION CONCENTRATION; ISOFLAVONES; OXIDATION-REDUCTION; REACTIVE OXYGEN SPECIES;

EID: 84957975045     PISSN: 09660844     EISSN: 15728773     Source Type: Journal    
DOI: 10.1007/s10534-016-9916-6     Document Type: Article

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