Nasal IL-4+CXCR5+CD4+ T follicular helper cell counts correlate with local IgE production in eosinophilic nasal polyps

Journal of Allergy and Clinical Immunology

Volumn 137, Issue 2, 2016, Pages 462-473

  Zhang, Ya Na ^a,b   Song, Jia ^a   Wang, Hai ^a   Wang, Heng ^a   Zeng, Ming ^a   Zhai, Guan Ting ^a   Ma, Jin ^a   Li, Zhi Yong ^a   Liao, Bo ^a   Wang, Bao Feng ^a   Zhen, Zhen ^a,c   Wang, Nan ^a   Cao, Ping Ping ^a   Lin, Peng ^b   Ning, Qin ^a   Liu, Zheng ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b TIANJIN FIRST CENTRAL HOSPITAL   (China)

^c PEKING UNIVERSITY FIRST HOSPITAL   (China)

Author keywords

B cell; ectopic lymphoid structure; eosinophil; IgE; IL 4; nasal polyp; T follicular helper cell

Indexed keywords

CD4 ANTIGEN; CHEMOKINE RECEPTOR CXCR5; GAMMA INTERFERON; IMMUNOGLOBULIN A; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2; IMMUNOGLOBULIN G3; IMMUNOGLOBULIN G4; INTERLEUKIN 17; INTERLEUKIN 21; INTERLEUKIN 4; PROGRAMMED DEATH 1 RECEPTOR; PROTEIN BCL 6; BIOLOGICAL MARKER;

ARTICLE; B LYMPHOCYTE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; EOSINOPHILIC NASAL POLYP; FLOW CYTOMETRY; GERMINAL CENTER; HELPER CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOGLOBULIN PRODUCTION; IMMUNOHISTOCHEMISTRY; LYMPHOID CELL; NOSE POLYP; PHENOTYPE; PLASMA CELL; PRIORITY JOURNAL; T LYMPHOCYTE SUBPOPULATION; TONSIL; ANTIBODY PRODUCTION; BIOSYNTHESIS; EOSINOPHILIA; IMMUNOLOGY; IMMUNOPHENOTYPING; LYMPHOCYTE COUNT; METABOLISM; NASAL POLYPS; NOSE MUCOSA; PATHOLOGY;

ANTIBODY FORMATION; B-LYMPHOCYTES; BIOMARKERS; EOSINOPHILIA; HUMANS; IMMUNOGLOBULIN E; IMMUNOPHENOTYPING; INTERLEUKIN-4; LYMPHOCYTE COUNT; NASAL MUCOSA; NASAL POLYPS; PHENOTYPE; RECEPTORS, CXCR5; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, HELPER-INDUCER;

EID: 84957963500     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2015.07.025     Document Type: Article

References (31)

1. W.J. Fokkens, V.J. Lund, J. Mullol, C. Bachert, I. Alobid, F. Baroody, and et al. European position paper on rhinosinusitis and nasal polyps 2012 Rhinol Suppl 23 2012 1 299
2. P.P. Cao, H.B. Li, B.F. Wang, S.B. Wang, X.J. You, Y.H. Cui, and et al. Distinct immunopathologic characteristics of various types of chronic rhinosinusitis in adult Chinese J Allergy Clin Immunol 124 2009 478 484
3. C. Bachert, P. Gavaert, G. Holtappels, S.G. Johansson, and P. Van Cauwenberge Total and specific IgE in nasal polyps is related to local eosinophilic inflammation J Allergy Clin Immunol 107 2001 607 614
4. P.P. Cao, Y.N. Zhang, B. Liao, J. Ma, B.F. Wang, H. Wang, and et al. Increased local IgE production induced by common aeroallergens and phenotypic alteration of mast cells in Chinese eosinophilic, but not non-eosinophilic, chronic rhinosinusitis with nasal polyps Clin Exp Allergy 44 2014 690 700
5. P. Gevaert, K.T. Nouri-Aria, H. Wu, C.E. Harper, P. Takhar, D.J. Fear, and et al. Local receptor revision and class switching to IgE in chronic rhinosinusitis with nasal polyps Allergy 68 2013 55 63
6. D. Mechtcheriakova, Y. Sobanov, G. Holtappels, E. Bajna, M. Svoboda, M. Jaritz, and et al. Activation-induced cytidine deaminase (AID)-associated multigene signature to assess impact of AID in etiology of diseases with inflammatory component PLoS One 6 2011 e25611
7. M. Chen, Z. Guo, W. Ju, B. Ryffel, X. He, and S.G. Zheng The development and function of follicular helper T cells in immune responses Cell Mol Immunol 9 2012 375 379
8. N. Fazilleau, L. Mark, L.J. McHeyzer-Williams, and M.G. McHeyzer-Williams Follicular helper T cells: lineage and location Immunity 30 2009 324 335
9. C.S. Ma, and E.K. Deenick Human T follicular helper (Tfh) cells and disease Immunol Cell Biol 92 2014 64 71
10. S.G. Tangye, C.S. Ma, R. Brink, and E.K. Deenick The good, the bad and the ugly - TFH cells in human health and disease Nat Rev Immunol 13 2013 412 426
11. M. Lindqvist, J. van Lunzen, D.Z. Soghoian, B.D. Kuhl, S. Ranasinghe, G. Kranias, and et al. Expansion of HIV-specific T follicular helper cells in chronic HIV infection J Clin Invest 122 2012 3271 3280
12. + T cells indicate Tfh cell activity and promote antibody responses upon antigen reexposure Immunity 39 2013 770 781
13. R. Morita, N. Schmitt, S.E. Bentebibel, R. Ranganathan, L. Bourdery, G. Zurawski, and et al. Human blood CXCR5(+)CD4(+) T cells are counterparts of T follicular cells and contain specific subsets that differentially support antibody secretion Immunity 34 2011 108 121
14. M. Locci, C. Havenar-Daughton, E. Landais, J. Wu, M.A. Kroenke, C.L. Arlehamn, and et al. Human circulating PD-1+CXCR3-CXCR5+ memory Tfh cells are highly functional and correlate with broadly neutralizing HIV antibody responses Immunity 39 2013 758 769
15. N. Schmitt, S.E. Bentebibel, and H. Ueno Phenotype and functions of memory Tfh cells in human blood Trends Immunol 35 2014 436 442
16. + follicular helper T cell infiltration predicts breast cancer survival J Clin Invest 123 2013 2873 2892
17. Y. Chu, F. Wang, M. Zhou, L. Chen, and Y. Lu A preliminary study on the characterization of follicular helper T (Tfh) cells in rheumatoid arthritis synovium Acta Histochem 116 2014 539 543
18. F. Mazerolles, C. Picard, S. Kracker, A. Fischer, and A. Durandy Blood CD4+CD45RO+CXCR5+ T cells are decreased but partially functional in signal transducer and activator of transcription 3 deficiency J Allergy Clin Immunol 131 2013 1146 1156
19. S.E. Bentebibel, N. Schmitt, J. Banchereau, and H. Ueno Human tonsil B-cell lymphoma 6 (BCL6)-expressing CD4+ T-cell subset specialized for B-cell help outside germinal centers Proc Natl Acad Sci U S A 108 2011 E488 E497
20. K.E. Hulse, J.E. Norton, L. Suh, Q. Zhong, M. Mahdavinia, P. Simon, and et al. Chronic rhinosinusitis with nasal polyps is characterized by B-cell inflammation and EBV-induced protein 2 expression J Allergy Clin Immunol 131 2013 1075 1083
21. M. Dullaers, R. De Bruyne, F. Ramadani, H.J. Gould, P. Gevaert, and B.N. Lambrecht The who, where, and when of IgE in allergic airway disease J Allergy Clin Immunol 129 2012 635 645
22. M. Vicario, C. Blanchard, K.F. Stringer, M.H. Collins, M.K. Mingler, A. Ahrens, and et al. Local B cells and IgE production in the oesophageal mucosa in eosinophilic oesophagitis Gut 59 2010 12 20
23. S. Crotty T follicular helper cell differentiation, function, and roles in disease Immunity 41 2014 529 542
24. C. Le Coz, A. Joublin, J.L. Pasquali, A.S. Korganow, H. Dumortier, and F. Monneaux Circulating TFH subset distribution is strongly affected in lupus patients with an active disease PLoS One 8 2013 e75319
25. A. Kato, A. Peters, L. Suh, R. Carter, K.E. Harris, R. Chandra, and et al. Evidence of a role for B cell-activating factor of the TNF family in the pathogenesis of chronic rhinosinusitis with nasal polyps J Allergy Clin Immunol 121 2008 1385 1392
26. B.K. Tan, Q.Z. Li, L. Suh, A. Kato, D.B. Conley, R.K. Chandra, and et al. Evidence for intranasal antinuclear autoantibodies in patients with chronic rhinosinusitis with nasal polyps J Allergy Clin Immunol 128 2011 1198 1206
27. L.L. Shi, J. Song, P. Xiong, P.P. Cao, B. Liao, J. Ma, and et al. Disease-specific T-helper cell polarizing function of lesional dendritic cells in different types of chronic rhinosinusitis with nasal polyps Am J Respir Crit Care Med 190 2014 628 638
28. I. Wollenberg, A. Agua-Doce, A. Hernández, C. Almeida, V.G. Oliveira, J. Faro, and et al. Regulation of the germinal center reaction by Foxp3+ follicular regulatory T cells J Immunol 187 2011 4553 4560
29. M.A. Linterman, W. Pierson, S.K. Lee, A. Kallies, S. Kawamoto, T.F. Rayner, and et al. Foxp3+ follicular regulatory T cells control the germinal center response Nat Med 17 2011 975 982
30. C.G. Vinuesa, S. Fagarasan, and C. Dong New territory for T follicular helper cells Immunity 39 2013 417 420
31. A. Ballesteros-Tato, and T.D. Randall Priming of T follicular helper cells by dendritic cells Immunol Cell Biol 92 2014 22 27