Intrinsic network connectivity abnormalities in HIV-infected individuals over age 60

Journal of NeuroVirology

Volumn 22, Issue 1, 2016, Pages 80-87

  Guha, Anika ^a   Wang, Liang ^a   Tanenbaum, Aaron ^a   Esmaeili Firidouni, Pardis ^b   Wendelken, Lauren A ^b   Busovaca, Edgar ^b   Clifford, Katherine ^b   Desai, Akash ^b   Ances, Beau M ^a,c   Valcour, Victor ^b  

^a WASHINGTON UNIVERSITY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c WASHINGTON UNIVERSITY IN ST LOUIS   (United States)

Author keywords

Cognition; Functional MRI; HIV; Network connectivity

Indexed keywords

VIRUS RNA; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT;

ADULT; ARTICLE; BRAIN FUNCTION; COGNITION; CONNECTOME; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; HIV ASSOCIATED DEMENTIA; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MAJOR CLINICAL STUDY; MALE; NEUROPSYCHOLOGY; PRIORITY JOURNAL; RESTING STATE NETWORK; SALIENCE NETWORK; VIRUS LOAD; AGED; ANTAGONISTS AND INHIBITORS; BLOOD; BRAIN; CASE CONTROL STUDY; CD4 LYMPHOCYTE COUNT; CD4+ T LYMPHOCYTE; COGNITION DISORDERS; COMPLICATION; DRUG EFFECTS; FUNCTIONAL NEUROIMAGING; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HIV INFECTIONS; MIDDLE AGED; NERVE CELL NETWORK; NEUROPSYCHOLOGICAL TEST; PATHOLOGY; PATHOPHYSIOLOGY; VIROLOGY;

AGED; ANTI-HIV AGENTS; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; BRAIN; CASE-CONTROL STUDIES; CD4 LYMPHOCYTE COUNT; CD4-POSITIVE T-LYMPHOCYTES; COGNITION DISORDERS; FEMALE; FUNCTIONAL NEUROIMAGING; HIV INFECTIONS; HUMANS; MALE; MIDDLE AGED; NERVE NET; NEUROPSYCHOLOGICAL TESTS; RNA, VIRAL; VIRAL LOAD;

EID: 84957849991     PISSN: 13550284     EISSN: 15382443     Source Type: Journal    
DOI: 10.1007/s13365-015-0370-y     Document Type: Article

References (37)

1. Andrews-Hanna JR, Snyder AZ, Vincent JL, Lustig C, Head D, Raichle ME, Buckner RL (2007) Disruption of large-scale brain systems in advanced aging. Neuron 56(5):924–935
2. Antinori A, Arendt G, Becker JT, Brew BJ, Byrd DA, Cherner M, Clifford DB, Cinque P, Epstein LG, Goodkin K, Gisslen M, Grant I, Heaton RK, Joseph J, Marder K, Marra CM, McArthur JC, Nunn M, Price RW, Pulliam L, Robertson KR, Sacktor N, Valcour V, Wojna VE (2007) Updated research nosology for HIV-associated neurocognitive disorders. Neurology 69(18):1789–1799
3. Brier MR, Thomas JB, Snyder AZ, Benzinger TL, Zhang D, Raichle ME, Holtzman DM, Morris JC, Ances BM (2012) Loss of intranetwork and internetwork resting state functional connections with Alzheimer’s disease progression. J Neurosci 32(26):8890–8899
4. Brier MR, Thomas JB, Snyder AZ, Wang L, Fagan AM, Benzinger T, Morris JC, Ances BM (2014) Unrecognized preclinical Alzheimer disease confounds rs-fcMRI studies of normal aging. Neurology 83(18):1613–1619
5. Brooks JT, Buchacz K, Gebo KA, Mermin J (2012) HIV infection and older Americans: the public health perspective. Am J Public Health 102(8):1516–1526
6. Chiao S, Rosen HJ, Nicolas K, Wendelken LA, Alcantar O, Rankin KP, Miller B, Valcour V (2013) Deficits in self-awareness impact the diagnosis of asymptomatic neurocognitive impairment in HIV. AIDS Res Hum Retrovir 29(6):949–956
7. Clifford DB, Ances BM (2013) HIV-associated neurocognitive disorder. Lancet Infect Dis 13(11):976–986
8. Eden A, Fuchs D, Hagberg L, Nilsson S, Spudich S, Svennerholm B, Price RW, Gisslen M (2010) HIV-1 viral escape in cerebrospinal fluid of subjects on suppressive antiretroviral treatment. J Infect Dis 202(12):1819–1825
9. Geerligs L, Renken RJ, Saliasi E, Maurits NM and Lorist MM (2014) “A brain-wide study of age-related changes in functional connectivity.” Cereb Cortex
10. Glisky EL (2007) Changes in cognitive function in human aging. Brain aging: models, methods, and mechanisms. D. R. Riddle. Boca Raton (FL)
11. Hacker CD, Laumann TO, Szrama NP, Baldassarre A, Snyder AZ, Leuthardt EC, Corbetta M (2013) Resting state network estimation in individual subjects. Neuroimage 82:616–633
12. Heaton RK, Franklin DR, Ellis RJ, McCutchan JA, Letendre SL, Leblanc S, Corkran SH, Duarte NA, Clifford DB, Woods SP, Collier AC, Marra CM, Morgello S, Mindt MR, Taylor MJ, Marcotte TD, Atkinson JH, Wolfson T, Gelman BB, McArthur JC, Simpson DM, Abramson I, Gamst A, Fennema-Notestine C, Jernigan TL, Wong J, Grant I (2011) HIV-associated neurocognitive disorders before and during the era of combination antiretroviral therapy: differences in rates, nature, and predictors. J Neurovirol 17(1):3–16
13. Hedden T, Mormino EC, Amariglio RE, Younger AP, Schultz AP, Becker JA, Buckner RL, Johnson KA, Sperling RA, Rentz DM (2012) Cognitive profile of amyloid burden and white matter hyperintensities in cognitively normal older adults. J Neurosci 32(46):16233–16242
14. High KP, Brennan-Ing M, Clifford DB, Cohen MH, Currier J, Deeks SG, Deren S, Effros RB, Gebo K, Goronzy JJ, Justice AC, Landay A, Levin J, Miotti PG, Munk RJ, Nass H, Rinaldo CR Jr, Shlipak MG, Tracy R, Valcour V, Vance DE, Walston JD, Volberding P (2012) “HIV and aging: state of knowledge and areas of critical need for research. A report to the NIH Office of AIDS Research by the HIV and Aging Working Group.”. J Acquir Immune Defic Syndr 60(Suppl 1):S1–18
15. Jahanshad N, Valcour VG, Nir TM, Kohannim O, Busovaca E, Nicolas K and Thompson P (2012). “Disrupted brain networks in the aging HIV+ population.” Brain Connect
16. Kaul M (2009) HIV-1 associated dementia: update on pathological mechanisms and therapeutic approaches. Curr Opin Neurol 22(3):315–320
17. Morgan EE, Iudicello JE, Weber E, Duarte NA, Riggs PK, Delano-Wood L, Ellis R, Grant I, Woods SP (2012) Synergistic effects of HIV infection and older age on daily functioning. J Acquir Immune Defic Syndr 61(3):341–348
18. Nightingale S, Winston A, Letendre S, Michael BD, McArthur JC, Khoo S, Solomon T (2014) Controversies in HIV-associated neurocognitive disorders. Lancet Neurol 13(11):1139–1151
19. Nir TM, Jahanshad N, Busovaca E, Wendelken L, Nicolas K, Thompson PM and Valcour VG (2013) “Mapping white matter integrity in elderly people with HIV.” Hum Brain Mapp
20. Ortega M, Brier MR, Ances BM (2015) Effects of HIV and combination antiretroviral therapy on cortico-striatal functional connectivity. AIDS 29(6):703–712
21. Pathai S, Bajillan H, Landay AL, High KP (2014) Is HIV a model of accelerated or accentuated aging? J Gerontol A Biol Sci Med Sci 69(7):833–842
22. Power JD, Barnes KA, Snyder AZ, Schlaggar BL, Petersen SE (2012) Spurious but systematic correlations in functional connectivity MRI networks arise from subject motion. Neuroimage 59(3):2142–2154
23. Power JD, Mitra A, Laumann TO, Snyder AZ, Schlaggar BL, Petersen SE (2014) Methods to detect, characterize, and remove motion artifact in resting state fMRI. Neuroimage 84:320–341
24. Saad ZS, Reynolds RC, Jo HJ, Gotts SJ, Chen G, Martin A, Cox RW (2013) Correcting brain-wide correlation differences in resting-state FMRI. Brain Connect 3(4):339–352
25. Sacktor N, Skolasky R, Selnes OA, Watters M, Poff P, Shiramizu B, Shikuma C, Valcour V (2007) Neuropsychological test profile differences between young and old human immunodeficiency virus-positive individuals. J Neurovirol 13(3):203–209
26. Schulte T, Muller-Oehring EM, Sullivan EV, Pfefferbaum A (2011) Disruption of emotion and conflict processing in HIV infection with and without alcoholism comorbidity. J Int Neuropsychol Soc 17(3):537–550
27. Seeley WW, Crawford RK, Zhou J, Miller BL, Greicius MD (2009) Neurodegenerative diseases target large-scale human brain networks. Neuron 62(1):42–52
28. Shulman GL, Pope DL, Astafiev SV, McAvoy MP, Snyder AZ, Corbetta M (2010) Right hemisphere dominance during spatial selective attention and target detection occurs outside the dorsal frontoparietal network. J Neurosci 30(10):3640–3651
29. Smyser CD, Inder TE, Shimony JS, Hill JE, Degnan AJ, Snyder AZ, Neil JJ (2010) Longitudinal analysis of neural network development in preterm infants. Cereb Cortex 20(12):2852–2862
30. Thomas JB, Brier MR, Ortega M, Benzinger TL, Ances BM (2015) Weighted brain networks in disease: centrality and entropy in human immunodeficiency virus and aging. Neurobiol Aging 36(1):401–412
31. Valcour V, Chalermchai T, Sailasuta N, Marovich M, Lerdlum S, Suttichom D, Suwanwela NC, Jagodzinski L, Michael N, Spudich S, van Griensven F, de Souza M, Kim J, Ananworanich J (2012) “Central nervous system viral invasion and inflammation during acute HIV infection.”. J Infect Dis 206(2):275–282
32. Vance DE, Fazeli PL, Gakumo CA (2013) The impact of neuropsychological performance on everyday functioning between older and younger adults with and without HIV. J Assoc Nurses AIDS Care 24(2):112–125
33. Wang L, Roe CM, Snyder AZ, Brier MR, Thomas JB, Xiong C, Benzinger TL, Morris JC, Ances BM (2012) Alzheimer disease family history impacts resting state functional connectivity. Ann Neurol 72(4):571–577
34. Woods SP, Moore DJ, Weber E, Grant I (2009) Cognitive neuropsychology of HIV-associated neurocognitive disorders. Neuropsychol Rev 19(2):152–168
35. Wright PW, Heaps JM, Shimony JS, Thomas JB, Ances BM (2012) The effects of HIV and combination antiretroviral therapy on white matter integrity. AIDS 26(12):1501–1508
36. Yao Y, Lu WL, Xu B, Li CB, Lin CP, Waxman D, Feng JF (2013) The increase of the functional entropy of the human brain with age. Sci Rep 3:2853
37. Zhang D, Raichle ME (2010) Disease and the brain’s dark energy. Nat Rev Neurol 6(1):15–28