-
2
-
-
0037421590
-
Pharmacogenomics-drug disposition, drug targets, and side effects
-
Evans WE, McLeod HL. Pharmacogenomics-drug disposition, drug targets, and side effects. N Engl J Med 2003; 348: 538-549.
-
(2003)
N Engl J Med
, vol.348
, pp. 538-549
-
-
Evans, W.E.1
McLeod, H.L.2
-
3
-
-
84877268066
-
Commercial prospects for genomic sequencing technologies
-
Mohamed S, Syed BA. Commercial prospects for genomic sequencing technologies. Nat Rev Drug Discov 2013; 12: 341-342.
-
(2013)
Nat Rev Drug Discov
, vol.12
, pp. 341-342
-
-
Mohamed, S.1
Syed, B.A.2
-
4
-
-
84861335436
-
Pharmacogene regulatory elements: From discovery to applications
-
Smith RP, Lam ET, Markova S, Yee SW, Ahituv N. Pharmacogene regulatory elements: from discovery to applications. Genome Med 2012; 4: 45.
-
(2012)
Genome Med
, vol.4
, pp. 45
-
-
Smith, R.P.1
Lam, E.T.2
Markova, S.3
Yee, S.W.4
Ahituv, N.5
-
6
-
-
84859885816
-
Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks
-
Trapnell C, Roberts A, Goff L, Pertea G, Kim D, Kelley DR et al. Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks. Nat Protoc 2012; 7: 562-578.
-
(2012)
Nat Protoc
, vol.7
, pp. 562-578
-
-
Trapnell, C.1
Roberts, A.2
Goff, L.3
Pertea, G.4
Kim, D.5
Kelley, D.R.6
-
7
-
-
77958471357
-
Differential expression analysis for sequence count data
-
Anders S, Huber W. Differential expression analysis for sequence count data. Genome Biol 2010; 11: R106.
-
(2010)
Genome Biol
, vol.11
, pp. R106
-
-
Anders, S.1
Huber, W.2
-
8
-
-
84865527768
-
Detecting differential usage of exons from RNAseq data
-
Anders S, Reyes A, Huber W. Detecting differential usage of exons from RNAseq data. Genome Res 2012; 22: 2008-2017.
-
(2012)
Genome Res
, vol.22
, pp. 2008-2017
-
-
Anders, S.1
Reyes, A.2
Huber, W.3
-
9
-
-
78649714014
-
Analysis and design of RNA sequencing experiments for identifying isoform regulation
-
Katz Y, Wang ET, Airoldi EM, Burge CB. Analysis and design of RNA sequencing experiments for identifying isoform regulation. Nat Methods 2010; 7: 1009-1015.
-
(2010)
Nat Methods
, vol.7
, pp. 1009-1015
-
-
Katz, Y.1
Wang, E.T.2
Airoldi, E.M.3
Burge, C.B.4
-
10
-
-
79551584794
-
Conservation of an RNA regulatory map between Drosophila and mammals
-
Brooks AN, Yang L, Duff MO, Hansen KD, Park JW, Dudoit S et al. Conservation of an RNA regulatory map between Drosophila and mammals. Genome Res 2011; 21: 193-202.
-
(2011)
Genome Res
, vol.21
, pp. 193-202
-
-
Brooks, A.N.1
Yang, L.2
Duff, M.O.3
Hansen, K.D.4
Park, J.W.5
Dudoit, S.6
-
11
-
-
84880557325
-
Genomic medicine: A decade of successes, challenges, and opportunities
-
McCarthy JJ, McLeod HL, Ginsburg GS. Genomic medicine: a decade of successes, challenges, and opportunities. Sci Transl Med 2013; 5: 189sr184.
-
(2013)
Sci Transl Med
, vol.5
, pp. 189sr184
-
-
McCarthy, J.J.1
McLeod, H.L.2
Ginsburg, G.S.3
-
12
-
-
84878682420
-
The Genotype-Tissue Expression (GTEx) project
-
GTEx Consortium
-
GTEx Consortium. The Genotype-Tissue Expression (GTEx) project. Nat Genet 2013; 45: 580-585.
-
(2013)
Nat Genet
, vol.45
, pp. 580-585
-
-
-
13
-
-
84865760395
-
GENCODE: The reference human genome annotation for the ENCODE Project
-
Harrow J, Frankish A, Gonzalez JM, Tapanari E, Diekhans M, Kokocinski F et al. GENCODE: the reference human genome annotation for The ENCODE Project. Genome Res 2012; 22: 1760-1774.
-
(2012)
Genome Res
, vol.22
, pp. 1760-1774
-
-
Harrow, J.1
Frankish, A.2
Gonzalez, J.M.3
Tapanari, E.4
Diekhans, M.5
Kokocinski, F.6
-
14
-
-
0036025450
-
UGT1A1∗28 polymorphism as a determinant of irinotecan disposition and toxicity
-
Iyer L, Das S, Janisch L, Wen M, Ramirez J, Karrison T et al. UGT1A1∗28 polymorphism as a determinant of irinotecan disposition and toxicity. Pharmacogenomics J 2002; 2: 43-47.
-
(2002)
Pharmacogenomics J
, vol.2
, pp. 43-47
-
-
Iyer, L.1
Das, S.2
Janisch, L.3
Wen, M.4
Ramirez, J.5
Karrison, T.6
-
15
-
-
0036765343
-
Pharmacogenomics of human UDPglucuronosyltransferases and irinotecan toxicity
-
Tukey RH, Strassburg CP, Mackenzie PI. Pharmacogenomics of human UDPglucuronosyltransferases and irinotecan toxicity. Mol Pharmacol 2002; 62: 446-450.
-
(2002)
Mol Pharmacol
, vol.62
, pp. 446-450
-
-
Tukey, R.H.1
Strassburg, C.P.2
Mackenzie, P.I.3
-
16
-
-
84890340211
-
Common CYP2D6 polymorphisms affecting alternative splicing and transcription: Long-range haplotypes with two regulatory variants modulate CYP2D6 activity
-
Wang D, Poi MJ, Sun X, Gaedigk A, Leeder JS, Sadee W. Common CYP2D6 polymorphisms affecting alternative splicing and transcription: long-range haplotypes with two regulatory variants modulate CYP2D6 activity. Hum Mol Genet 2014; 23: 268-278.
-
(2014)
Hum Mol Genet
, vol.23
, pp. 268-278
-
-
Wang, D.1
Poi, M.J.2
Sun, X.3
Gaedigk, A.4
Leeder, J.S.5
Sadee, W.6
-
17
-
-
84862830326
-
Transcriptome landscape of the human placenta
-
Kim J, Zhao K, Jiang P, Lu ZX, Wang J, Murray JC et al. Transcriptome landscape of the human placenta. BMC Genomics 2012; 13: 115.
-
(2012)
BMC Genomics
, vol.13
, pp. 115
-
-
Kim, J.1
Zhao, K.2
Jiang, P.3
Lu, Z.X.4
Wang, J.5
Murray, J.C.6
-
18
-
-
84880181531
-
Transcriptome analyses of the human retina identify unprecedented transcript diversity and 3.5 Mb of novel transcribed sequence via significant alternative splicing and novel genes
-
Farkas MH, Grant GR, White JA, Sousa ME, Consugar MB, Pierce EA. Transcriptome analyses of the human retina identify unprecedented transcript diversity and 3.5 Mb of novel transcribed sequence via significant alternative splicing and novel genes. BMC Genomics 2013; 14: 486.
-
(2013)
BMC Genomics
, vol.14
, pp. 486
-
-
Farkas, M.H.1
Grant, G.R.2
White, J.A.3
Sousa, M.E.4
Consugar, M.B.5
Pierce, E.A.6
-
19
-
-
46249106990
-
Mapping and quantifying mammalian transcriptomes by RNA-Seq
-
Mortazavi A, Williams BA, McCue K, Schaeffer L, Wold B. Mapping and quantifying mammalian transcriptomes by RNA-Seq. Nat Methods 2008; 5: 621-628.
-
(2008)
Nat Methods
, vol.5
, pp. 621-628
-
-
Mortazavi, A.1
Williams, B.A.2
McCue, K.3
Schaeffer, L.4
Wold, B.5
-
20
-
-
84875160515
-
Model-based approaches to predict drug-drug interactions associated with hepatic uptake transporters: Preclinical, clinical and beyond
-
Barton HA, Lai Y, Goosen TC, Jones HM, El-Kattan AF, Gosset JR et al. Model-based approaches to predict drug-drug interactions associated with hepatic uptake transporters: preclinical, clinical and beyond. Expert Opin Drug Metab Toxicol 2013; 9: 459-472.
-
(2013)
Expert Opin Drug Metab Toxicol
, vol.9
, pp. 459-472
-
-
Barton, H.A.1
Lai, Y.2
Goosen, T.C.3
Jones, H.M.4
El-Kattan, A.F.5
Gosset, J.R.6
-
21
-
-
84868017737
-
Drug disposition in pathophysiological conditions
-
Gandhi A, Moorthy B, Ghose R. Drug disposition in pathophysiological conditions. Curr Drug Metab 2012; 13: 1327-1344.
-
(2012)
Curr Drug Metab
, vol.13
, pp. 1327-1344
-
-
Gandhi, A.1
Moorthy, B.2
Ghose, R.3
-
22
-
-
77951091171
-
Therapeutic implications of renal anionic drug transporters
-
Masereeuw R, Russel FG. Therapeutic implications of renal anionic drug transporters. Pharmacol Ther 2010; 126: 200-216.
-
(2010)
Pharmacol Ther
, vol.126
, pp. 200-216
-
-
Masereeuw, R.1
Russel, F.G.2
-
23
-
-
84862076531
-
Impact of drug transporter pharmacogenomics on pharmacokinetic and pharmacodynamic variability-Considerations for drug development
-
Lai Y, Varma M, Feng B, Stephens JC, Kimoto E, El-Kattan A et al. Impact of drug transporter pharmacogenomics on pharmacokinetic and pharmacodynamic variability-considerations for drug development. Expert Opin Drug Metab Toxicol 2012; 8: 723-743.
-
(2012)
Expert Opin Drug Metab Toxicol
, vol.8
, pp. 723-743
-
-
Lai, Y.1
Varma, M.2
Feng, B.3
Stephens, J.C.4
Kimoto, E.5
El-Kattan, A.6
-
24
-
-
44449101051
-
Identification of genetic variants and gene expression relationships associated with pharmacogenes in humans
-
Huang RS, Duan S, Kistner EO, Zhang W, Bleibel WK, Cox NJ et al. Identification of genetic variants and gene expression relationships associated with pharmacogenes in humans. Pharmacogenet Genomics 2008; 18: 545-549.
-
(2008)
Pharmacogenet Genomics
, vol.18
, pp. 545-549
-
-
Huang, R.S.1
Duan, S.2
Kistner, E.O.3
Zhang, W.4
Bleibel, W.K.5
Cox, N.J.6
-
25
-
-
84885864334
-
A statin-dependent QTL for GATM expression is associated with statininduced myopathy
-
Mangravite LM, Engelhardt BE, Medina MW, Smith JD, Brown CD, Chasman DI et al. A statin-dependent QTL for GATM expression is associated with statininduced myopathy. Nature 2013; 502: 377-380.
-
(2013)
Nature
, vol.502
, pp. 377-380
-
-
Mangravite, L.M.1
Engelhardt, B.E.2
Medina, M.W.3
Smith, J.D.4
Brown, C.D.5
Chasman, D.I.6
-
26
-
-
83755207567
-
Lymphoblastoid cell lines in pharmacogenomic discovery and clinical translation
-
Wheeler HE, Dolan ME. Lymphoblastoid cell lines in pharmacogenomic discovery and clinical translation. Pharmacogenomics 2012; 13: 55-70.
-
(2012)
Pharmacogenomics
, vol.13
, pp. 55-70
-
-
Wheeler, H.E.1
Dolan, M.E.2
-
27
-
-
84866611528
-
Pharmacogenomics knowledge for personalized medicine
-
Whirl-Carrillo M, McDonagh EM, Hebert JM, Gong L, Sangkuhl K, Thorn CF et al. Pharmacogenomics knowledge for personalized medicine. Clin Pharmacol Ther 2012; 92: 414-417.
-
(2012)
Clin Pharmacol Ther
, vol.92
, pp. 414-417
-
-
Whirl-Carrillo, M.1
McDonagh, E.M.2
Hebert, J.M.3
Gong, L.4
Sangkuhl, K.5
Thorn, C.F.6
-
29
-
-
34248663609
-
-
Table of Pharmacogenomic Biomarkers in Drug Labels
-
U.S. Food and Drug Admnistration (2013). Table of Pharmacogenomic Biomarkers in Drug Labels.
-
(2013)
U.S. Food and Drug Admnistration
-
-
-
30
-
-
84904718484
-
Pharmaco-MIR: Linking microRNAs and drug effects
-
Rukov JL, Wilentzik R, Jaffe I, Vinther J, Shomron N. Pharmaco-miR: linking microRNAs and drug effects. Brief Bioinform 2013; 15: 648-659.
-
(2013)
Brief Bioinform
, vol.15
, pp. 648-659
-
-
Rukov, J.L.1
Wilentzik, R.2
Jaffe, I.3
Vinther, J.4
Shomron, N.5
-
31
-
-
84876042374
-
Insolution hybrid capture of bisulfite-converted DNA for targeted bisulfite sequencing of 174 ADME genes
-
Ivanov M, Kals M, Kacevska M, Metspalu A, Ingelman-Sundberg M, Milani L. Insolution hybrid capture of bisulfite-converted DNA for targeted bisulfite sequencing of 174 ADME genes. Nucleic Acids Res 2013; 41: e72.
-
(2013)
Nucleic Acids Res
, vol.41
, pp. e72
-
-
Ivanov, M.1
Kals, M.2
Kacevska, M.3
Metspalu, A.4
Ingelman-Sundberg, M.5
Milani, L.6
-
32
-
-
84859109645
-
The limits of genome-wide methods for pharmacogenomic testing
-
Gamazon ER, Skol AD, Perera MA. The limits of genome-wide methods for pharmacogenomic testing. Pharmacogenet Genomics 2012; 22: 261-272.
-
(2012)
Pharmacogenet Genomics
, vol.22
, pp. 261-272
-
-
Gamazon, E.R.1
Skol, A.D.2
Perera, M.A.3
-
33
-
-
73549120609
-
Clinical pharmacology and pharmacogenetics in a genomics era: The DMET platform
-
Sissung TM, English BC, Venzon D, Figg WD, Deeken JF. Clinical pharmacology and pharmacogenetics in a genomics era: the DMET platform. Pharmacogenomics 2010; 11: 89-103.
-
(2010)
Pharmacogenomics
, vol.11
, pp. 89-103
-
-
Sissung, T.M.1
English, B.C.2
Venzon, D.3
Figg, W.D.4
Deeken, J.F.5
-
34
-
-
84891771466
-
The UCSC Genome Browser database: 2014 update
-
Karolchik D, Barber GP, Casper J, Clawson H, Cline MS, Diekhans M et al. The UCSC Genome Browser database: 2014 update. Nucleic Acids Res 2014; 42: D764-D770.
-
(2014)
Nucleic Acids Res
, vol.42
, pp. D764-D770
-
-
Karolchik, D.1
Barber, G.P.2
Casper, J.3
Clawson, H.4
Cline, M.S.5
Diekhans, M.6
-
35
-
-
65449136284
-
TopHat: Discovering splice junctions with RNA-Seq
-
Trapnell C, Pachter L, Salzberg SL. TopHat: discovering splice junctions with RNA-Seq. Bioinformatics 2009; 25: 1105-1111.
-
(2009)
Bioinformatics
, vol.25
, pp. 1105-1111
-
-
Trapnell, C.1
Pachter, L.2
Salzberg, S.L.3
-
36
-
-
84929001104
-
The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humans
-
Human genomics
-
Consortium GT, Human genomics. The Genotype-Tissue Expression (GTEx) pilot analysis: multitissue gene regulation in humans. Science 2015; 348: 648-660.
-
(2015)
Science
, vol.348
, pp. 648-660
-
-
Consortium, G.T.1
-
37
-
-
0034069495
-
Gene ontology: Tool for the unification of biology the Gene Ontology Consortium
-
Ashburner M, Ball CA, Blake JA, Botstein D, Butler H, Cherry JM et al. Gene ontology: tool for the unification of biology. The Gene Ontology Consortium. Nat Genet 2000; 25: 25-29.
-
(2000)
Nat Genet
, vol.25
, pp. 25-29
-
-
Ashburner, M.1
Ball, C.A.2
Blake, J.A.3
Botstein, D.4
Butler, H.5
Cherry, J.M.6
-
38
-
-
84872257350
-
Renal transporters in drug development
-
Morrissey KM, Stocker SL, Wittwer MB, Xu L, Giacomini KM. Renal transporters in drug development. Annu Rev Pharmacol Toxicol 2013; 53: 503-529.
-
(2013)
Annu Rev Pharmacol Toxicol
, vol.53
, pp. 503-529
-
-
Morrissey, K.M.1
Stocker, S.L.2
Wittwer, M.B.3
Xu, L.4
Giacomini, K.M.5
-
39
-
-
84891751622
-
The druggable genome: Evaluation of drug targets in clinical trials suggests major shifts in molecular class and indication
-
Rask-Andersen M, Masuram S, Schioth HB. The druggable genome: Evaluation of drug targets in clinical trials suggests major shifts in molecular class and indication. Annu Rev Pharmacol Toxicol 2014; 54: 9-26.
-
(2014)
Annu Rev Pharmacol Toxicol
, vol.54
, pp. 9-26
-
-
Rask-Andersen, M.1
Masuram, S.2
Schioth, H.B.3
-
41
-
-
84890369635
-
Recent genetic discoveries implicating ion channels in human cardiovascular diseases
-
George AL Jr. Recent genetic discoveries implicating ion channels in human cardiovascular diseases. Curr Opin Pharmacol 2014; 15: 47-52.
-
(2014)
Curr Opin Pharmacol
, vol.15
, pp. 47-52
-
-
George, A.L.1
-
42
-
-
77950361453
-
KCNH2 pharmacogenomics summary
-
Oshiro C, Thorn CF, Roden DM, Klein TE, Altman RB. KCNH2 pharmacogenomics summary. Pharmacogenet Genomics 2010; 20: 775-777.
-
(2010)
Pharmacogenet Genomics
, vol.20
, pp. 775-777
-
-
Oshiro, C.1
Thorn, C.F.2
Roden, D.M.3
Klein, T.E.4
Altman, R.B.5
-
43
-
-
56749098074
-
Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing
-
Pan Q, Shai O, Lee LJ, Frey BJ, Blencowe BJ. Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing. Nat Genet 2008; 40: 1413-1415.
-
(2008)
Nat Genet
, vol.40
, pp. 1413-1415
-
-
Pan, Q.1
Shai, O.2
Lee, L.J.3
Frey, B.J.4
Blencowe, B.J.5
-
44
-
-
47649124124
-
A global view of gene activity and alternative splicing by deep sequencing of the human transcriptome
-
Sultan M, Schulz MH, Richard H, Magen A, Klingenhoff A, Scherf M et al. A global view of gene activity and alternative splicing by deep sequencing of the human transcriptome. Science 2008; 321: 956-960.
-
(2008)
Science
, vol.321
, pp. 956-960
-
-
Sultan, M.1
Schulz, M.H.2
Richard, H.3
Magen, A.4
Klingenhoff, A.5
Scherf, M.6
-
45
-
-
84904008021
-
Comprehensive analysis of gene expression in human retina and supporting tissues
-
Li M, Jia C, Kazmierkiewicz KL, Bowman AS, Tian L, Liu Y et al. Comprehensive analysis of gene expression in human retina and supporting tissues. Hum Mol Genet 2014; 23: 4001-4014.
-
(2014)
Hum Mol Genet
, vol.23
, pp. 4001-4014
-
-
Li, M.1
Jia, C.2
Kazmierkiewicz, K.L.3
Bowman, A.S.4
Tian, L.5
Liu, Y.6
-
46
-
-
84876297798
-
Expression of mRNA transcripts encoding membrane transporters detected with whole transcriptome sequencing of human brain and liver
-
Webb A, Papp AC, Sanford JC, Huang K, Parvin JD, Sadee W. Expression of mRNA transcripts encoding membrane transporters detected with whole transcriptome sequencing of human brain and liver. Pharmacogenet Genomics 2013; 23: 269-278.
-
(2013)
Pharmacogenet Genomics
, vol.23
, pp. 269-278
-
-
Webb, A.1
Papp, A.C.2
Sanford, J.C.3
Huang, K.4
Parvin, J.D.5
Sadee, W.6
-
47
-
-
84893276590
-
Analysis of the human tissue-specific expression by genome-wide integration of transcriptomics and antibody-based proteomics
-
Fagerberg L, Hallstrom BM, Oksvold P, Kampf C, Djureinovic D, Odeberg J et al. Analysis of the human tissue-specific expression by genome-wide integration of transcriptomics and antibody-based proteomics. Mol Cell Proteom 2014; 13: 397-406.
-
(2014)
Mol Cell Proteom
, vol.13
, pp. 397-406
-
-
Fagerberg, L.1
Hallstrom, B.M.2
Oksvold, P.3
Kampf, C.4
Djureinovic, D.5
Odeberg, J.6
-
48
-
-
84924299302
-
The human gastrointestinal tract-specific transcriptome and proteome as defined by RNA sequencing and antibody-based profiling
-
Gremel G, Wanders A, Cedernaes J, Fagerberg L, Hallstrom B, Edlund K et al. The human gastrointestinal tract-specific transcriptome and proteome as defined by RNA sequencing and antibody-based profiling. J Gastroenterol 2014; 50: 46-57.
-
(2014)
J Gastroenterol
, vol.50
, pp. 46-57
-
-
Gremel, G.1
Wanders, A.2
Cedernaes, J.3
Fagerberg, L.4
Hallstrom, B.5
Edlund, K.6
-
49
-
-
77953938256
-
Differentiation of human adipose-derived stem cells into beating cardiomyocytes
-
Choi YS, Dusting GJ, Stubbs S, Arunothayaraj S, Han XL, Collas P et al. Differentiation of human adipose-derived stem cells into beating cardiomyocytes. J Cell Mol Med 2010; 14: 878-889.
-
(2010)
J Cell Mol Med
, vol.14
, pp. 878-889
-
-
Choi, Y.S.1
Dusting, G.J.2
Stubbs, S.3
Arunothayaraj, S.4
Han, X.L.5
Collas, P.6
-
50
-
-
1042302786
-
Spontaneous cardiomyocyte differentiation from adipose tissue stroma cells
-
Planat-Benard V, Menard C, Andre M, Puceat M, Perez A, Garcia-Verdugo JM et al. Spontaneous cardiomyocyte differentiation from adipose tissue stroma cells. Circ Res 2004; 94: 223-229.
-
(2004)
Circ Res
, vol.94
, pp. 223-229
-
-
Planat-Benard, V.1
Menard, C.2
Andre, M.3
Puceat, M.4
Perez, A.5
Garcia-Verdugo, J.M.6
-
51
-
-
0037015231
-
Drug-induced long-QT syndrome associated with a subclinical SCN5A mutation
-
Makita N, Horie M, Nakamura T, Ai T, Sasaki K, Yokoi H et al. Drug-induced long-QT syndrome associated with a subclinical SCN5A mutation. Circulation 2002; 106: 1269-1274.
-
(2002)
Circulation
, vol.106
, pp. 1269-1274
-
-
Makita, N.1
Horie, M.2
Nakamura, T.3
Ai, T.4
Sasaki, K.5
Yokoi, H.6
-
52
-
-
33947259522
-
A common SCN5A variant alters the responsiveness of human sodium channels to class i antiarrhythmic agents
-
Shuraih M, Ai T, Vatta M, Sohma Y, Merkle EM, Taylor E et al. A common SCN5A variant alters the responsiveness of human sodium channels to class I antiarrhythmic agents. J Cardiovasc Electrophysiol 2007; 18: 434-440.
-
(2007)
J Cardiovasc Electrophysiol
, vol.18
, pp. 434-440
-
-
Shuraih, M.1
Ai, T.2
Vatta, M.3
Sohma, Y.4
Merkle, E.M.5
Taylor, E.6
-
53
-
-
0037422575
-
Evidence for the widespread coupling of alternative splicing and nonsense-mediated mRNA decay in humans
-
Lewis BP, Green RE, Brenner SE. Evidence for the widespread coupling of alternative splicing and nonsense-mediated mRNA decay in humans. Proc Natl Acad Sci USA 2003; 100: 189-192.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 189-192
-
-
Lewis, B.P.1
Green, R.E.2
Brenner, S.E.3
-
54
-
-
41149136735
-
Organic anion transporter 2 (SLC22A7) is a facilitative transporter of cGMP
-
Cropp CD, Komori T, Shima JE, Urban TJ, Yee SW, More SS et al. Organic anion transporter 2 (SLC22A7) is a facilitative transporter of cGMP. Mol Pharmacol 2008; 73: 1151-1158.
-
(2008)
Mol Pharmacol
, vol.73
, pp. 1151-1158
-
-
Cropp, C.D.1
Komori, T.2
Shima, J.E.3
Urban, T.J.4
Yee, S.W.5
More, S.S.6
-
55
-
-
84873336516
-
Gene expression profiling of transporters in the solute carrier and ATP-binding cassette superfamilies in human eye substructures
-
Dahlin A, Geier E, Stocker SL, Cropp CD, Grigorenko E, Bloomer M et al. Gene expression profiling of transporters in the solute carrier and ATP-binding cassette superfamilies in human eye substructures. Mol Pharm 2013; 10: 650-663.
-
(2013)
Mol Pharm
, vol.10
, pp. 650-663
-
-
Dahlin, A.1
Geier, E.2
Stocker, S.L.3
Cropp, C.D.4
Grigorenko, E.5
Bloomer, M.6
-
56
-
-
17844378450
-
Possible involvement of organic anion transporter 2 on the interaction of theophylline with erythromycin in the human liver
-
Kobayashi Y, Sakai R, Ohshiro N, Ohbayashi M, Kohyama N, Yamamoto T. Possible involvement of organic anion transporter 2 on the interaction of theophylline with erythromycin in the human liver. Drug Metab Dispos 2005; 33: 619-622.
-
(2005)
Drug Metab Dispos
, vol.33
, pp. 619-622
-
-
Kobayashi, Y.1
Sakai, R.2
Ohshiro, N.3
Ohbayashi, M.4
Kohyama, N.5
Yamamoto, T.6
-
57
-
-
17644380567
-
Transport mechanism and substrate specificity of human organic anion transporter 2 (hOat2 [SLC22A7])
-
Kobayashi Y, Ohshiro N, Sakai R, Ohbayashi M, Kohyama N, Yamamoto T. Transport mechanism and substrate specificity of human organic anion transporter 2 (hOat2 [SLC22A7]). J Pharm Pharmacol 2005; 57: 573-578.
-
(2005)
J Pharm Pharmacol
, vol.57
, pp. 573-578
-
-
Kobayashi, Y.1
Ohshiro, N.2
Sakai, R.3
Ohbayashi, M.4
Kohyama, N.5
Yamamoto, T.6
-
58
-
-
84875211310
-
Cytochrome P450 enzymes in drug metabolism: Regulation of gene expression, enzyme activities, and impact of genetic variation
-
Zanger UM, Schwab M. Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation. Pharmacol Ther 2013; 138: 103-141.
-
(2013)
Pharmacol Ther
, vol.138
, pp. 103-141
-
-
Zanger, U.M.1
Schwab, M.2
-
60
-
-
84872338190
-
Potent human uric acid transporter 1 inhibitors: In vitro and in vivo metabolism and pharmacokinetic studies
-
Wempe MF, Lightner JW, Miller B, Iwen TJ, Rice PJ, Wakui S et al. Potent human uric acid transporter 1 inhibitors: in vitro and in vivo metabolism and pharmacokinetic studies. Drug Design Dev Ther 2012; 6: 323-339.
-
(2012)
Drug Design Dev Ther
, vol.6
, pp. 323-339
-
-
Wempe, M.F.1
Lightner, J.W.2
Miller, B.3
Iwen, T.J.4
Rice, P.J.5
Wakui, S.6
-
61
-
-
33749335282
-
The Connectivity Map: Using gene-expression signatures to connect small molecules, genes, and disease
-
Lamb J, Crawford ED, Peck D, Modell JW, Blat IC, Wrobel MJ et al. The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease. Science 2006; 313: 1929-1935.
-
(2006)
Science
, vol.313
, pp. 1929-1935
-
-
Lamb, J.1
Crawford, E.D.2
Peck, D.3
Modell, J.W.4
Blat, I.C.5
Wrobel, M.J.6
-
62
-
-
33749011163
-
The NCI60 human tumour cell line anticancer drug screen
-
Shoemaker RH. The NCI60 human tumour cell line anticancer drug screen. Nat Rev Cancer 2006; 6: 813-823.
-
(2006)
Nat Rev Cancer
, vol.6
, pp. 813-823
-
-
Shoemaker, R.H.1
-
63
-
-
77957973745
-
Chronic ethanol exposure changes dopamine D2 receptor splicing during retinoic acid-induced differentiation of human SH-SY5Y cells
-
Wernicke C, Hellmann J, Finckh U, Rommelspacher H. Chronic ethanol exposure changes dopamine D2 receptor splicing during retinoic acid-induced differentiation of human SH-SY5Y cells. Pharmacol Rep 2010; 62: 649-663.
-
(2010)
Pharmacol Rep
, vol.62
, pp. 649-663
-
-
Wernicke, C.1
Hellmann, J.2
Finckh, U.3
Rommelspacher, H.4
-
64
-
-
79955758640
-
Coordinately regulated alternative splicing of genes involved in cholesterol biosynthesis and uptake
-
Medina MW, Gao F, Naidoo D, Rudel LL, Temel RE, McDaniel AL et al. Coordinately regulated alternative splicing of genes involved in cholesterol biosynthesis and uptake. PLoS ONE 2011; 6: e19420.
-
(2011)
PLoS ONE
, vol.6
, pp. e19420
-
-
Medina, M.W.1
Gao, F.2
Naidoo, D.3
Rudel, L.L.4
Temel, R.E.5
McDaniel, A.L.6
-
65
-
-
78049239924
-
Genome-wide analysis of novel splice variants induced by topoisomerase i poisoning shows preferential occurrence in genes encoding splicing factors
-
Solier S, Barb J, Zeeberg BR, Varma S, Ryan MC, Kohn KW et al. Genome-wide analysis of novel splice variants induced by topoisomerase I poisoning shows preferential occurrence in genes encoding splicing factors. Cancer Res 2010; 70: 8055-8065.
-
(2010)
Cancer Res
, vol.70
, pp. 8055-8065
-
-
Solier, S.1
Barb, J.2
Zeeberg, B.R.3
Varma, S.4
Ryan, M.C.5
Kohn, K.W.6
-
66
-
-
84930684260
-
RNA-Sequencing Analysis of HepG2 Cells Treated with Atorvastatin
-
Stormo C, Kringen MK, Lyle R, Olstad OK, Sachse D, Berg JP et al. RNA-Sequencing Analysis of HepG2 Cells Treated with Atorvastatin. PLoS ONE 2014; 9: e105836.
-
(2014)
PLoS ONE
, vol.9
, pp. e105836
-
-
Stormo, C.1
Kringen, M.K.2
Lyle, R.3
Olstad, O.K.4
Sachse, D.5
Berg, J.P.6
-
67
-
-
84876161743
-
Paraquat modulates alternative pre-mRNA splicing by modifying the intracellular distribution of SRPK2
-
Vivarelli S, Lenzken SC, Ruepp MD, Ranzini F, Maffioletti A, Alvarez R et al. Paraquat modulates alternative pre-mRNA splicing by modifying the intracellular distribution of SRPK2. PLoS ONE 2013; 8: e61980.
-
(2013)
PLoS ONE
, vol.8
, pp. e61980
-
-
Vivarelli, S.1
Lenzken, S.C.2
Ruepp, M.D.3
Ranzini, F.4
Maffioletti, A.5
Alvarez, R.6
-
68
-
-
0037452790
-
Individuality and variation in gene expression patterns in human blood
-
Whitney AR, Diehn M, Popper SJ, Alizadeh AA, Boldrick JC, Relman DA et al. Individuality and variation in gene expression patterns in human blood. Proc Natl Acad Sci USA 2003; 100: 1896-1901.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 1896-1901
-
-
Whitney, A.R.1
Diehn, M.2
Popper, S.J.3
Alizadeh, A.A.4
Boldrick, J.C.5
Relman, D.A.6
-
69
-
-
45149108420
-
Mapping the genetic architecture of gene expression in human liver
-
Schadt EE, Molony C, Chudin E, Hao K, Yang X, Lum PY et al. Mapping the genetic architecture of gene expression in human liver. PLoS Biol 2008; 6: e107.
-
(2008)
PLoS Biol
, vol.6
, pp. e107
-
-
Schadt, E.E.1
Molony, C.2
Chudin, E.3
Hao, K.4
Yang, X.5
Lum, P.Y.6
-
70
-
-
84855906545
-
Using genome-wide association studies to identify genes important in serious adverse drug reactions
-
Daly AK. Using genome-wide association studies to identify genes important in serious adverse drug reactions. Annu Rev Pharmacol Toxicol 2012; 52: 21-35.
-
(2012)
Annu Rev Pharmacol Toxicol
, vol.52
, pp. 21-35
-
-
Daly, A.K.1
-
71
-
-
84872936239
-
Pharmacogenomics of adverse drug reactions
-
Daly AK. Pharmacogenomics of adverse drug reactions. Genome Med 2013; 5: 5.
-
(2013)
Genome Med
, vol.5
, pp. 5
-
-
Daly, A.K.1
-
72
-
-
84859974894
-
mRNA transcript diversity creates new opportunities for pharmacological intervention
-
Barrie ES, Smith RM, Sanford JC, Sadee W. mRNA transcript diversity creates new opportunities for pharmacological intervention. Mol Pharmacol 2012; 81: 620-630.
-
(2012)
Mol Pharmacol
, vol.81
, pp. 620-630
-
-
Barrie, E.S.1
Smith, R.M.2
Sanford, J.C.3
Sadee, W.4
-
73
-
-
80051567157
-
Alternative transcription exceeds alternative splicing in generating the transcriptome diversity of cerebellar development
-
Pal S, Gupta R, Kim H, Wickramasinghe P, Baubet V, Showe LC et al. Alternative transcription exceeds alternative splicing in generating the transcriptome diversity of cerebellar development. Genome Res 2011; 21: 1260-1272.
-
(2011)
Genome Res
, vol.21
, pp. 1260-1272
-
-
Pal, S.1
Gupta, R.2
Kim, H.3
Wickramasinghe, P.4
Baubet, V.5
Showe, L.C.6
|