Irritability and problem behavior in Autism Spectrum Disorder: A practice pathway for pediatric primary care

Pediatrics

Volumn 137, Issue , 2016, Pages S136-S148

  McGuire, Kelly ^a,b   Fung, Lawrence K ^c   Hagopian, Louis ^d   Vasa, Roma A ^d   Mahajan, Rajneesh ^d   Bernal, Pilar ^e   Silberman, Anna E ^a   Wolfe, Audrey ^f   Coury, Daniel L ^g   Hardan, Antonio Y ^c   Veenstra VanderWeele, Jeremy ^a,h   Whitaker, Agnes H ^a  

^a NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

^b Center for Autism and Developmental Disorders   (United States)

^c STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e Children's Health Council   (United States)

^f MASSACHUSETTS GENERAL HOSPITAL   (United States)

^g NATIONWIDE CHILDREN S HOSPITAL   (United States)

^h NEW YORK PRESBYTERIAN HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARIPIPRAZOLE; PSYCHOTROPIC AGENT; RISPERIDONE;

ANXIETY DISORDER; ARTICLE; ATTENTION DEFICIT DISORDER; AUTISM; DEPRESSION; DISEASE SEVERITY; DRUG EFFICACY; DRUG SAFETY; DRUG USE; HEALTH BEHAVIOR; HEALTH CARE PERSONNEL; HUMAN; IRRITABILITY; MANIA; MEDICAL HISTORY; MENTAL STRESS; MONITORING; OBSESSIVE COMPULSIVE DISORDER; PATIENT REFERRAL; PEDIATRICS; PERSONALIZED MEDICINE; PRIMARY MEDICAL CARE; PRIORITY JOURNAL; PROBLEM BEHAVIOR; REINFORCEMENT; TREATMENT PLANNING; TREATMENT RESPONSE; ADOLESCENT; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; AUTISM SPECTRUM DISORDER; CHILD; PRACTICE GUIDELINE; PRESCHOOL CHILD; PRIMARY HEALTH CARE; PROCEDURES; PSYCHOLOGY;

ADOLESCENT; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; AUTISM SPECTRUM DISORDER; CHILD; CHILD, PRESCHOOL; HUMANS; IRRITABLE MOOD; PEDIATRICS; PRIMARY HEALTH CARE; PROBLEM BEHAVIOR;

EID: 84957827746     PISSN: 00314005     EISSN: 10984275     Source Type: Journal    
DOI: 10.1542/peds.2015-2851L     Document Type: Article

References (71)

1. American Psychiatric Association. DSM 5. Arlington, VA: American Psychiatric Association; 2013
2. Myers SM, Johnson CP; American Academy of Pediatrics Council on Children With Disabilities. Management of children with autism spectrum disorders. Pediatrics. 2007; 120(5): 1162-1182
3. Gurney JG, McPheeters ML, Davis MM. Parental report of health conditions and health care use among children with and without autism: National Survey of Children's Health. Arch Pediatr Adolesc Med. 2006; 160(8): 825-830
4. Horner RH, Carr EG, Strain PS, Todd AW, Reed HK. Problem behavior interventions for young children with autism: A research synthesis. J Autism Dev Disord. 2002; 32(5): 423-446
5. Kaat AJ, Lecavalier L, Aman MG. Validity of the Aberrant Behavior Checklist in children with autism spectrum disorder. J Autism Dev Disord. 2014; 44(5): 1103-1116
6. Aman MG. Aberrant Behavior Checklist: Current identity and future developments. Clin Exp Pharmacol. 2012; 2(3): 2161-1459
7. Mandell DS. Psychiatric hospitalization among children with autism spectrum disorders. J Autism Dev Disord. 2008; 38(6): 1059-1065
8. Bruininks RH, Hill BK, Morreau LE. Prevalence and implications of maladaptive behaviors and dual diagnosis in residential and other service programs. In: Stark JA, Menolascino FJ, Albarelli MH, Gray VC, eds. Mental Retardation and Mental Health. New York, NY: Springer; 1988: 3-29
9. Fung LK, Mahajan R, Nozzolillo A, et al Pharmacologic treatment of severe irritability and problem behaviors in autism: A systematic review and metaanalysis. Pediatrics. 2016; 137(suppl 2): E20152851L
10. Mandell DS, Morales KH, Marcus SC, Stahmer AC, Doshi J, Polsky DE. Psychotropic medication use among Medicaid-enrolled children with autism spectrum disorders. Pediatrics. 2008; 121(3). Available at: Www.pediatrics.org/cgi/content/full/121/3/e441
11. Almandil NB, Liu Y, Murray ML, Besag FM, Aitchison KJ, Wong IC. Weight gain and other metabolic adverse effects associated with atypical antipsychotic treatment of children and adolescents: A systematic review and meta-analysis. Paediatr Drugs. 2013; 15(2): 139-150
12. Haddad PM, Dursun SM. Neurological complications of psychiatric drugs: Clinical features and management. Hum Psychopharmacol. 2008; 23(suppl 1): 15-26
13. Coury D, Jones NE, Klatka K, Winklosky B, Perrin JM. Healthcare for children with autism: The Autism Treatment Network. Curr Opin Pediatr. 2009; 21(6): 828-832
14. Weiss JA, Wingsiong A, Lunsky Y. Defining crisis in families of individuals with autism spectrum disorders. Autism. 2014; 18(8): 985-995
15. Gabriels RL. Understanding behavioral and emotional issues in autism. In: Gabriels RL, Hill DE, eds. Growing Up With Autism: Working With School-Age Children and Adolescents. New York, NY: Guilford Press; 2007: 3-36
16. Volkmar F, Siegel M, Woodbury-Smith M, King B, McCracken J, State M; American Academy of Child and Adolescent Psychiatry (AACAP) Committee on Quality Issues (CQI). Practice parameter for the assessment and treatment of children and adolescents with autism spectrum disorder. J Am Acad Child Adolesc Psychiatry. 2014; 53(2): 237-257
17. Bauman ML. Medical comorbidities in autism: Challenges to diagnosis and treatment. Neurotherapeutics. 2010; 7(3): 320-327
18. Mazefsky CA, Filipink R, Lindsey J, Lubetsky MJ. Medical evaluation and comorbid psychiatric disorders. In: Lubetsky MJ, Handen BL, McGonigle JJ, eds. Autism Spectrum Disorder. New York, NY: Oxford University Press; 2011
19. Buie T, Campbell DB, Fuchs GJ III, et al. Evaluation, diagnosis, and treatment of gastrointestinal disorders in individuals with ASDs: A consensus report. Pediatrics. 2010; 125(suppl 1): S1-S18
20. Zeidán-Chuliá F, Gursoy UK, Könönen E, Gottfried C. A dental look at the autistic patient through orofacial pain. Acta Odontol Scand. 2011; 69(4): 193-200
21. Guinchat V, Cravero C, Diaz L, et al. Acute behavioral crises in psychiatric inpatients with autism spectrum disorder (ASD): Recognition of concomitant medical or non-ASD psychiatric conditions predicts enhanced improvement. Res Dev Disabil. 2015; 38: 242-255
22. Cohen S, Conduit R, Lockley SW, Rajaratnam SM, Cornish KM. The relationship between sleep and behavior in autism spectrum disorder (ASD): A review. J Neurodev Disord. 2014; 6(1): 44
23. Malow BA, Byars K, Johnson K, et al; Sleep Committee of the Autism Treatment Network. A practice pathway for the identification, evaluation, and management of insomnia in children and adolescents with autism spectrum disorders. Pediatrics. 2012; 130(suppl 2): S106-S124
24. Rossignol DA, Frye RE. Melatonin in autism spectrum disorders: A systematic review and metaanalysis. Dev Med Child Neurol. 2011; 53(9): 783-792
25. McElhanon BO, McCracken C, Karpen S, Sharp WG. Gastrointestinal symptoms in autism spectrum disorder: A meta-analysis. Pediatrics. 2014; 133(5): 872-883
26. Mazefsky CA, Schreiber DR, Olino TM, Minshew NJ. The association between emotional and behavioral problems and gastrointestinal symptoms among children with high-functioning autism. Autism. 2014; 18(5): 493-501
27. El Achkar CM, Spence SJ. Clinical characteristics of children and young adults with co-occurring autism spectrum disorder and epilepsy. Epilepsy Behav. 2015; 47: 183-190
28. Hartley-McAndrew M, Weinstock A. Autism spectrum disorder: Correlation between aberrant behaviors, EEG abnormalities and seizures. Neurol Int. 2010; 2(1): E10
29. Hirota T, Veenstra-Vanderweele J, Hollander E, Kishi T. Antiepileptic medications in autism spectrum disorder: A systematic review and meta-analysis. J Autism Dev Disord. 2014; 44(4): 948-957
30. King BH, de Lacy N, Siegel M. Psychiatric assessment of severe presentations in autism spectrum disorders and intellectual disability. Child Adolesc Psychiatr Clin N Am. 2014; 23(1): 1-14
31. McEvoy RE, Rogers SJ, Pennington BF. Executive function and social communication deficits in young autistic children. J Child Psychol Psychiatry. 1993; 34(4): 563-578
32. McClintock K, Hall S, Oliver C. Risk markers associated with challenging behaviours in people with intellectual disabilities: A meta-analytic study. J Intellect Disabil Res. 2003; 47(pt 6): 405-416
33. Kurtz PF, Boelter EW, Jarmolowicz DP, Chin MD, Hagopian LP. An analysis of functional communication training as an empirically supported treatment for problem behavior displayed by individuals with intellectual disabilities. Res Dev Disabil. 2011; 32(6): 2935-2942
34. Wacker DP, Lee JF, Padilla Dalmau YC, et al. Conducting functional communication training via telehealth to reduce the problem behavior of young children with autism. J Dev Phys Disabil. 2013; 25(1): 35-48
35. Hutchins TL, Prelock PA. Using communication to reduce challenging behaviors in individuals with autism spectrum disorders and intellectual disability. Child Adolesc Psychiatr Clin N Am. 2014; 23(1): 41-55
36. Goh S, Whitaker A, Feldman J, et al. Teaching non-verbal children with autistic disorder to read and write: A pilot study. Int J Dev Disabil. 2013; 59(2): 95-107
37. Westcott HL, Jones DP. The abuse of disabled children. J Child Psychol Psychiatry. 1999; 40(4): 497-506
38. Mandell DS, Walrath CM, Manteuffel B, Sgro G, Pinto-Martin JA. The prevalence and correlates of abuse among children with autism served in comprehensive community-based mental health settings. Child Abuse Negl. 2005; 29(12): 1359-1372
39. Brown-Lavoie SM, Viecili MA, Weiss JA. Sexual knowledge and victimization in adults with autism spectrum disorders. J Autism Dev Disord. 2014; 44(9): 2185-2196
40. Edelson MG. Sexual abuse of children with autism: Factors that increase risk and interfere with recognition of abuse. Disabil Stud Q. 2010; 30(1)
41. Blake JJ, Lund EM, Zhou Q, Kwok OM, Benz MR. National prevalence rates of bully victimization among students with disabilities in the United States. Sch Psychol Q. 2012; 27(4): 210-222
42. Sterzing PR, Shattuck PT, Narendorf SC, Wagner M, Cooper BP. Bullying involvement and autism spectrum disorders: Prevalence and correlates of bullying involvement among adolescents with an autism spectrum disorder. Arch Pediatr Adolesc Med. 2012; 166(11): 1058-1064
43. Zeedyk SM, Rodriguez G, Tipton LA, Baker BL, Blacher J. Bullying of youth with autism spectrum disorder, intellectual disability, or typical development: Victim and parent perspectives. Res Autism Spectr Disord. 2014; 8(9): 1173-1183
44. Zaidman-Zait A, Mirenda P, Duku E, et al; Pathways in ASD Study Team. Examination of bidirectional relationships between parent stress and two types of problem behavior in children with autism spectrum disorder. J Autism Dev Disord. 2014; 44(8): 1908-1917
45. Tonge B, Brereton A, Kiomall M, Mackinnon A, King N, Rinehart N. Effects on parental mental health of an education and skills training program for parents of young children with autism: A randomized controlled trial. J Am Acad Child Adolesc Psychiatry. 2006; 45(5): 561-569
46. Brookman-Frazee L, Koegel RL. Using parent/clinician partnerships in parent education programs for children with autism. J Posit Behav Interv. 2004; 6(4): 195-213
47. Pozo P, Sarriá E. Prediction of stress in mothers of children with autism spectrum disorders. Span J Psychol. 2014; 17: E6
48. Dosen A. Integrative treatment in persons with intellectual disability and mental health problems. J Intellect Disabil Res. 2007; 51(pt 1): 66-74
49. Brosnan J, Healy O. A review of behavioral interventions for the treatment of aggression in individuals with developmental disabilities. Res Dev Disabil. 2011; 32(2): 437-446
50. Matson JL, Jang J. Treating aggression in persons with autism spectrum disorders: A review. Res Dev Disabil. 2014; 35(12): 3386-3391
51. Doehring P, Reichow B, Palka T, Phillips C, Hagopian L. Behavioral approaches to managing severe problem behaviors in children with autism spectrum and related developmental disorders: A descriptive analysis. Child Adolesc Psychiatr Clin N Am. 2014; 23(1): 25-40
52. Iwata BA, Deleon IG, Roscoe EM. Reliability and validity of the functional analysis screening tool. J Appl Behav Anal. 2013; 46(1): 271-284
53. Quinn MM, Gable RA, Rutherford RB Jr, Nelson CM, Howell KW. Addressing student problem behavior: An IEP team's introduction to functional behavioral assessment and behavior intervention plans. 1998. Available at: Http://cecp. air.org/fba/problembehavior/funcanal.pdf. Accessed May 15, 2015
54. Simonoff E, Pickles A, Charman T, Chandler S, Loucas T, Baird G. Psychiatric disorders in children with autism spectrum disorders: Prevalence, comorbidity, and associated factors in a population-derived sample. J Am Acad Child Adolesc Psychiatry. 2008; 47(8): 921-929
55. Mahajan R, Bernal MP, Panzer R, et al; Autism Speaks Autism Treatment Network Psychopharmacology Committee. Clinical practice pathways for evaluation and medication choice for attentiondeficit/hyperactivity disorder symptoms in autism spectrum disorders. Pediatrics. 2012; 130(suppl 2): S125-S138
56. Siegel M. Psychopharmacology of autism spectrum disorder: Evidence and practice. Child Adolesc Psychiatr Clin N Am. 2012; 21(4): 957-973
57. Vasa RA, Carroll LM, Nozzolillo AA, et al. A systematic review of treatments for anxiety in youth with autism spectrum disorders. J Autism Dev Disord. 2014; 44(12): 3215-3229
58. Walkup JT, Albano AM, Piacentini J, et al. Cognitive behavioral therapy, sertraline, or a combination in childhood anxiety. N Engl J Med. 2008; 359(26): 2753-2766
59. March JS, Biederman J, Wolkow R, et al. Sertraline in children and adolescents with obsessivecompulsive disorder: A multicenter randomized controlled trial. JAMA. 1998; 280(20): 1752-1756
60. March J, Silva S, Petrycki S, et al; Treatment for Adolescents With Depression Study (TADS) Team. Fluoxetine, cognitive-behavioral therapy, and their combination for adolescents with depression: Treatment for Adolescents With Depression Study (TADS) randomized controlled trial. JAMA. 2004; 292(7): 807-820
61. King BH, Hollander E, Sikich L, et al; STAART Psychopharmacology Network. Lack of efficacy of citalopram in children with autism spectrum disorders and high levels of repetitive behavior: Citalopram ineffective in children with autism. Arch Gen Psychiatry. 2009; 66(6): 583-590
62. Research Units on Pediatric Psychopharmacology Autism Network. Randomized, controlled, crossover trial of methylphenidate in pervasive developmental disorders with hyperactivity. Arch Gen Psychiatry. 2005; 62(11): 1266-1274
63. Ameis SH, Corbett-Dick P, Cole L, Correll CU. Decision making and antipsychotic medication treatment for youth with autism spectrum disorders: Applying guidelines in the real world. J Clin Psychiatry. 2013; 74(10): 1022-1024
64. Sarvet B, Gold J, Bostic JQ, et al. Improving access to mental health care for children: The Massachusetts Child Psychiatry Access Project. Pediatrics. 2010; 126(6): 1191-1200
65. Sarris M. When a psychiatric crisis hits: Children with autism in the emergency room. 2013. Available at: Www.iancommunity.org/cs/simons-simplex-community/autism-and-The-er. Accessed February 20, 2015
66. Aman MG, Singh NN, Stewart AW, Field CJ. The Aberrant Behavior Checklist: A behavior rating scale for the assessment of treatment effects. Am J Ment Defic. 1985; 89(5): 485-491
67. Pyles DA, Muniz K, Cade A, Silva R. A behavioral diagnostic paradigm for integrating behavior-analytic and psychopharmacological interventions for people with a dual diagnosis. Res Dev Disabil. 1997; 18(3): 185-214
68. Sevin JA, Bowers-Stephens C, Hamilton ML, Ford A. Integrating behavioral and pharmacological interventions in treating clients with psychiatric disorders and mental retardation. Res Dev Disabil. 2001; 22(6): 463-485
69. Wachtel LE, Hagopian LP. Psychopharmacology and applied behavioral analysis: Tandem treatment of severe problem behaviors in intellectual disability and a case series. Isr J Psychiatry Relat Sci. 2006; 43(4): 265-274
70. Hagopian LP, Caruso-Anderson ME. Integrating behavioral and pharmacological interventions for severe problem behavior displayed by children with neurogenetic and developmental disorders. In: Shapiro BK, Accardo PJ, eds. Neurobehavioral Disorders: Behavioral Issues and Their Treatment. Baltimore, MD: Paul H Brookes Publishing; 2010: 219-239
71. Minshawi NF, Hurwitz S, Morriss D, McDougle CJ. Multidisciplinary assessment and treatment of selfinjurious behavior in autism spectrum disorder and intellectual disability: Integration of psychological and biological theory and approach. J Autism Dev Disord. 2015; 45(6): 1541-1568