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Volumn 196, Issue 3, 2016, Pages 963-977

Molecular mechanisms of airway hyperresponsiveness in a murine model of steroid-resistant airway inflammation

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 13; INTERLEUKIN 17; STAT6 PROTEIN; TRANSCRIPTOME;

EID: 84957717353     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1501531     Document Type: Article
Times cited : (44)

References (55)
  • 1
    • 84856845581 scopus 로고    scopus 로고
    • Severe asthma: From characteristics to phenotypes to endo-types
    • Wenzel, S. 2012. Severe asthma: from characteristics to phenotypes to endo-types. Clin. Exp. Allergy 42: 650-658.
    • (2012) Clin. Exp. Allergy , vol.42 , pp. 650-658
    • Wenzel, S.1
  • 2
    • 84874378125 scopus 로고    scopus 로고
    • A global perspective in asthma: From pheno-type to endotype
    • Xie, M., and S. E. Wenzel. 2013. A global perspective in asthma: from pheno-type to endotype. Chin. Med. J. (Engl.) 126: 166-174.
    • (2013) Chin. Med. J. (Engl.) , vol.126 , pp. 166-174
    • Xie, M.1    Wenzel, S.E.2
  • 5
    • 80054906310 scopus 로고    scopus 로고
    • T(H)17 cells in asthma and inflammation
    • Aujla, S. J., and J. F. Alcorn. 2011. T(H)17 cells in asthma and inflammation. Biochim. Biophys. Acta 1810: 1066-1079.
    • (2011) Biochim. Biophys. Acta , vol.1810 , pp. 1066-1079
    • Aujla, S.J.1    Alcorn, J.F.2
  • 6
    • 20844455261 scopus 로고    scopus 로고
    • Comparison of IL-17 production by helper T cells among atopic and nonatopic asthmatics and control subjects
    • Hashimoto, T., K. Akiyama, N. Kobayashi, and A. Mori. 2005. Comparison of IL-17 production by helper T cells among atopic and nonatopic asthmatics and control subjects. Int. Arch. Allergy Immunol. 137(Suppl. 1): 51-54.
    • (2005) Int. Arch. Allergy Immunol. , vol.137 , pp. 51-54
    • Hashimoto, T.1    Akiyama, K.2    Kobayashi, N.3    Mori, A.4
  • 8
    • 77953913216 scopus 로고    scopus 로고
    • Increased serum IL-17 is an independent risk factor for severe asthma
    • Agache, I., C. Ciobanu, C. Agache, and M. Anghel. 2010. Increased serum IL-17 is an independent risk factor for severe asthma. Respir. Med. 104: 1131-1137.
    • (2010) Respir. Med. , vol.104 , pp. 1131-1137
    • Agache, I.1    Ciobanu, C.2    Agache, C.3    Anghel, M.4
  • 9
    • 0037636682 scopus 로고    scopus 로고
    • Interleukin-17 in sputum correlates with airway hyperresponsiveness to methacholine
    • Barczyk, A., W. Pierzchala, and E. Sozan-ska. 2003. Interleukin-17 in sputum correlates with airway hyperresponsiveness to methacholine. Respir. Med. 97: 726-733.
    • (2003) Respir. Med. , vol.97 , pp. 726-733
    • Barczyk, A.1    Pierzchala, W.2    Sozan-Ska, E.3
  • 11
    • 33645059692 scopus 로고    scopus 로고
    • Evaluation of airway inflammation by quantitative Th1/Th2 cytokine mRNA measurement in sputum of asthma patients
    • Truyen, E., L. Coteur, E. Dilissen, L. Overbergh, L. J. Dupont, J. L. Ceuppens, and D. M. Bullens. 2006. Evaluation of airway inflammation by quantitative Th1/Th2 cytokine mRNA measurement in sputum of asthma patients. Thorax 61: 202-208.
    • (2006) Thorax , vol.61 , pp. 202-208
    • Truyen, E.1    Coteur, L.2    Dilissen, E.3    Overbergh, L.4    Dupont, L.J.5    Ceuppens, J.L.6    Bullens, D.M.7
  • 12
    • 77956266532 scopus 로고    scopus 로고
    • The polymorphism of IL-17 G-152A was associated with childhood asthma and bacterial colonization of the hypopharynx in Bron-chiolitis
    • Chen, J., Y. Deng, J. Zhao, Z. Luo, W. Peng, J. Yang, L. Ren, L. Wang, Z. Fu, X. Yang, and E. Liu. 2010. The polymorphism of IL-17 G-152A was associated with childhood asthma and bacterial colonization of the hypopharynx in bron-chiolitis. J. Clin. Immunol. 30: 539-545.
    • (2010) J. Clin. Immunol. , vol.30 , pp. 539-545
    • Chen, J.1    Deng, Y.2    Zhao, J.3    Luo, Z.4    Peng, W.5    Yang, J.6    Ren, L.7    Wang, L.8    Fu, Z.9    Yang, X.10    Liu, E.11
  • 13
    • 84861781096 scopus 로고    scopus 로고
    • Association between polymorphisms in cytokine genes IL-17A and IL-17F and development of allergic rhinitis and comorbid asthma in Chinese subjects
    • Wang, M., Y. Zhang, D. Han, and L. Zhang. 2012. Association between polymorphisms in cytokine genes IL-17A and IL-17F and development of allergic rhinitis and comorbid asthma in Chinese subjects. Hum. Immunol. 73: 647-653.
    • (2012) Hum. Immunol. , vol.73 , pp. 647-653
    • Wang, M.1    Zhang, Y.2    Han, D.3    Zhang, L.4
  • 15
    • 14644435711 scopus 로고    scopus 로고
    • IL-13 R130Q, a common variant associated with allergy and asthma, enhances effector mechanisms essential for human allergic inflammation
    • Vladich, F. D., S. M. Brazille, D. Stern, M. L. Peck, R. Ghittoni, and D. Vercelli. 2005. IL-13 R130Q, a common variant associated with allergy and asthma, enhances effector mechanisms essential for human allergic inflammation. J. Clin. Invest. 115: 747-754.
    • (2005) J. Clin. Invest. , vol.115 , pp. 747-754
    • Vladich, F.D.1    Brazille, S.M.2    Stern, D.3    Peck, M.L.4    Ghittoni, R.5    Vercelli, D.6
  • 19
    • 0037377608 scopus 로고    scopus 로고
    • Measuring lung function in mice: The phe-notyping uncertainty principle
    • Bates, J. H., and C. G. Irvin. 2003. Measuring lung function in mice: the phe-notyping uncertainty principle. J. Appl. Physiol. 94: 1297-1306.
    • (2003) J. Appl. Physiol. , vol.94 , pp. 1297-1306
    • Bates, J.H.1    Irvin, C.G.2
  • 22
    • 44649131954 scopus 로고    scopus 로고
    • Potentiation of IL-19 expression in airway epithelia by IL-17A and IL-4/IL-13: Important implications in asthma
    • 1421.e1-3
    • Huang, F., S. Wachi, P. Thai, A. Loukoianov, K. H. Tan, R. M. Forteza, and R. Wu. 2008. Potentiation of IL-19 expression in airway epithelia by IL-17A and IL-4/IL-13: important implications in asthma. J. Allergy Clin. Immunol. 121: 1415-1421, 1421.e1-3.
    • (2008) J. Allergy Clin. Immunol. , vol.121 , pp. 1415-1421
    • Huang, F.1    Wachi, S.2    Thai, P.3    Loukoianov, A.4    Tan, K.H.5    Forteza, R.M.6    Wu, R.7
  • 24
    • 84885456137 scopus 로고    scopus 로고
    • IL-33 markedly activates murine eo-sinophils by an NF-kB-dependent mechanism differentially dependent upon an IL-4-driven autoinflammatory loop
    • Bouffi, C., M. Rochman, C. B. Zust, E. M. Stucke, A. Kartashov, P. C. Fulkerson, A. Barski, and M. E. Rothenberg. 2013. IL-33 markedly activates murine eo-sinophils by an NF-kB-dependent mechanism differentially dependent upon an IL-4-driven autoinflammatory loop. J. Immunol. 191: 4317-4325.
    • (2013) J. Immunol. , vol.191 , pp. 4317-4325
    • Bouffi, C.1    Rochman, M.2    Zust, C.B.3    Stucke, E.M.4    Kartashov, A.5    Fulkerson, P.C.6    Barski, A.7    Rothenberg, M.E.8
  • 26
    • 5044251100 scopus 로고    scopus 로고
    • STAT6-mediated signaling in Th2-dependent allergic asthma: Critical role for the development of eosinophilia, airway hyper-responsiveness and mucus hypersecretion, distinct from its role in Th2 differentiation
    • Hoshino, A., T. Tsuji, J. Matsuzaki, T. Jinushi, S. Ashino, T. Teramura, K. Chamoto, Y. Tanaka, Y. Asakura, T. Sakurai, et al. 2004. STAT6-mediated signaling in Th2-dependent allergic asthma: critical role for the development of eosinophilia, airway hyper-responsiveness and mucus hypersecretion, distinct from its role in Th2 differentiation. Int. Immunol. 16: 1497-1505.
    • (2004) Int. Immunol. , vol.16 , pp. 1497-1505
    • Hoshino, A.1    Tsuji, T.2    Matsuzaki, J.3    Jinushi, T.4    Ashino, S.5    Teramura, T.6    Chamoto, K.7    Tanaka, Y.8    Asakura, Y.9    Sakurai, T.10
  • 27
    • 9644262463 scopus 로고    scopus 로고
    • Signaling pathways in Th2 development
    • Mowen, K. A., and L. H. Glimcher. 2004. Signaling pathways in Th2 development. Immunol. Rev. 202: 203-222.
    • (2004) Immunol. Rev. , vol.202 , pp. 203-222
    • Mowen, K.A.1    Glimcher, L.H.2
  • 28
    • 38149091442 scopus 로고    scopus 로고
    • Targeting TNF - Alpha: A novel therapeutic approach for asthma
    • quiz 11-12
    • Brightling, C., M. Berry, and Y. Amrani. 2008. Targeting TNF - Alpha: a novel therapeutic approach for asthma. J. Allergy Clin. Immunol. 121: 5-10, quiz 11-12.
    • (2008) J. Allergy Clin. Immunol. , vol.121 , pp. 5-10
    • Brightling, C.1    Berry, M.2    Amrani, Y.3
  • 29
    • 77956955243 scopus 로고    scopus 로고
    • Complement-mediated regulation of the IL-17A axis is a central genetic determinant of the severity of experimental allergic asthma
    • Lajoie, S., I. P. Lewkowich, Y. Suzuki, J. R. Clark, A. A. Sproles, K. Dienger, A. L. Budelsky, and M. Wills-Karp. 2010. Complement-mediated regulation of the IL-17A axis is a central genetic determinant of the severity of experimental allergic asthma. Nat. Immunol. 11: 928-935.
    • (2010) Nat. Immunol. , vol.11 , pp. 928-935
    • Lajoie, S.1    Lewkowich, I.P.2    Suzuki, Y.3    Clark, J.R.4    Sproles, A.A.5    Dienger, K.6    Budelsky, A.L.7    Wills-Karp, M.8
  • 31
    • 0035340763 scopus 로고    scopus 로고
    • A murine IL-4 receptor antagonist that inhibits IL-4 - And IL-13-induced responses prevents antigen-induced airway eosinophilia and airway hyperresponsiveness
    • Tomkinson, A., C. Duez, G. Cieslewicz, J. C. Pratt, A. Joetham, M. C. Shanafelt, R. Gundel, and E. W. Gelfand. 2001. A murine IL-4 receptor antagonist that inhibits IL-4 - And IL-13-induced responses prevents antigen-induced airway eosinophilia and airway hyperresponsiveness. J. Immunol. 166: 5792-5800.
    • (2001) J. Immunol. , vol.166 , pp. 5792-5800
    • Tomkinson, A.1    Duez, C.2    Cieslewicz, G.3    Pratt, J.C.4    Joetham, A.5    Shanafelt, M.C.6    Gundel, R.7    Gelfand, E.W.8
  • 32
    • 35348909044 scopus 로고    scopus 로고
    • Effect of an interleukin-4 variant on late phase asthmatic response to allergen challenge in asthmatic patients: Results of two phase 2a studies
    • Wenzel, S., D. Wilbraham, R. Fuller, E. B. Getz, and M. Longphre. 2007. Effect of an interleukin-4 variant on late phase asthmatic response to allergen challenge in asthmatic patients: results of two phase 2a studies. Lancet 370: 1422-1431.
    • (2007) Lancet , vol.370 , pp. 1422-1431
    • Wenzel, S.1    Wilbraham, D.2    Fuller, R.3    Getz, E.B.4    Longphre, M.5
  • 37
    • 84890026323 scopus 로고    scopus 로고
    • Randomized, double-blind, placebo-controlled study of brodalumab, a human anti-IL-17 receptor monoclonal antibody, in moderate to severe asthma
    • Busse, W. W., S. Holgate, E. Kerwin, Y. Chon, J. Feng, J. Lin, and S. L. Lin. 2013. Randomized, double-blind, placebo-controlled study of brodalumab, a human anti-IL-17 receptor monoclonal antibody, in moderate to severe asthma. Am. J. Respir. Crit. Care Med. 188: 1294-1302.
    • (2013) Am. J. Respir. Crit. Care Med. , vol.188 , pp. 1294-1302
    • Busse, W.W.1    Holgate, S.2    Kerwin, E.3    Chon, Y.4    Feng, J.5    Lin, J.6    Lin, S.L.7
  • 38
    • 68849084891 scopus 로고    scopus 로고
    • Structure and signalling in the IL-17 receptor family
    • Gaffen, S. L. 2009. Structure and signalling in the IL-17 receptor family. Nat. Rev. Immunol. 9: 556-567.
    • (2009) Nat. Rev. Immunol. , vol.9 , pp. 556-567
    • Gaffen, S.L.1
  • 39
    • 0035877106 scopus 로고    scopus 로고
    • Stat6 is necessary and sufficient for IL-4's role in Th2 differentiation and cell expansion
    • Zhu, J., L. Guo, C. J. Watson, J. Hu-Li, and W. E. Paul. 2001. Stat6 is necessary and sufficient for IL-4's role in Th2 differentiation and cell expansion. J. Immunol. 166: 7276-7281.
    • (2001) J. Immunol. , vol.166 , pp. 7276-7281
    • Zhu, J.1    Guo, L.2    Watson, C.J.3    Hu-Li, J.4    Paul, W.E.5
  • 41
    • 44449167278 scopus 로고    scopus 로고
    • Distinct roles for IL-13 and IL-4 via IL-13 receptor alpha1 and the type II IL-4 receptor in asthma pathogenesis
    • Munitz, A., E. B. Brandt, M. Mingler, F. D. Finkelman, and M. E. Rothenberg. 2008. Distinct roles for IL-13 and IL-4 via IL-13 receptor alpha1 and the type II IL-4 receptor in asthma pathogenesis. Proc. Natl. Acad. Sci. USA 105: 7240-7245.
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 7240-7245
    • Munitz, A.1    Brandt, E.B.2    Mingler, M.3    Finkelman, F.D.4    Rothenberg, M.E.5
  • 42
    • 0032482159 scopus 로고    scopus 로고
    • Abrogation of bronchial eosinophilic inflammation and airway hyperreactivity in signal transducers and activators of transcription (STAT)6-deficient mice
    • Akimoto, T., F. Numata, M. Tamura, Y. Takata, N. Higashida, T. Takashi, K. Takeda, and S. Akira. 1998. Abrogation of bronchial eosinophilic inflammation and airway hyperreactivity in signal transducers and activators of transcription (STAT)6-deficient mice. J. Exp. Med. 187: 1537-1542.
    • (1998) J. Exp. Med. , vol.187 , pp. 1537-1542
    • Akimoto, T.1    Numata, F.2    Tamura, M.3    Takata, Y.4    Higashida, N.5    Takashi, T.6    Takeda, K.7    Akira, S.8
  • 43
    • 0032536837 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription factor 6 (Stat6)-deficient mice are protected from antigen-induced airway hyperresponsiveness and mucus production
    • Kuperman, D., B. Schofield, M. Wills-Karp, and M. J. Grusby. 1998. Signal transducer and activator of transcription factor 6 (Stat6)-deficient mice are protected from antigen-induced airway hyperresponsiveness and mucus production. J. Exp. Med. 187: 939-948.
    • (1998) J. Exp. Med. , vol.187 , pp. 939-948
    • Kuperman, D.1    Schofield, B.2    Wills-Karp, M.3    Grusby, M.J.4
  • 45
    • 0036344597 scopus 로고    scopus 로고
    • Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma
    • Kuperman, D. A., X. Huang, L. L. Koth, G. H. Chang, G. M. Dolganov, Z. Zhu, J. A. Elias, D. Sheppard, and D. J. Erle. 2002. Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma. Nat. Med. 8: 885-889.
    • (2002) Nat. Med. , vol.8 , pp. 885-889
    • Kuperman, D.A.1    Huang, X.2    Koth, L.L.3    Chang, G.H.4    Dolganov, G.M.5    Zhu, Z.6    Elias, J.A.7    Sheppard, D.8    Erle, D.J.9
  • 46
    • 24744442575 scopus 로고    scopus 로고
    • IL-4 receptor signaling in Clara cells is required for allergen-induced mucus production
    • Kuperman, D. A., X. Huang, L. Nguyenvu, C. Hölscher, F. Brombacher, and D. J. Erle. 2005. IL-4 receptor signaling in Clara cells is required for allergen-induced mucus production. J. Immunol. 175: 3746-3752.
    • (2005) J. Immunol. , vol.175 , pp. 3746-3752
    • Kuperman, D.A.1    Huang, X.2    Nguyenvu, L.3    Hölscher, C.4    Brombacher, F.5    Erle, D.J.6
  • 51
    • 84881403233 scopus 로고    scopus 로고
    • STAT6 controls the number of regulatory T cells in vivo, thereby regulating allergic lung inflammation
    • Dorsey, N. J., S. P. Chapoval, E. P. Smith, J. Skupsky, D. W. Scott, and A. D. Keegan. 2013. STAT6 controls the number of regulatory T cells in vivo, thereby regulating allergic lung inflammation. J. Immunol. 191: 1517-1528.
    • (2013) J. Immunol. , vol.191 , pp. 1517-1528
    • Dorsey, N.J.1    Chapoval, S.P.2    Smith, E.P.3    Skupsky, J.4    Scott, D.W.5    Keegan, A.D.6
  • 52
    • 84882778526 scopus 로고    scopus 로고
    • Lung type 2 innate lymphoid cells express cysteinyl leukotriene receptor 1, which regulates TH2 cytokine production
    • Doherty, T. A., N. Khorram, S. Lund, A. K. Mehta, M. Croft, and D. H. Broide. 2013. Lung type 2 innate lymphoid cells express cysteinyl leukotriene receptor 1, which regulates TH2 cytokine production. J. Allergy Clin. Immunol. 132: 205-213.
    • (2013) J. Allergy Clin. Immunol. , vol.132 , pp. 205-213
    • Doherty, T.A.1    Khorram, N.2    Lund, S.3    Mehta, A.K.4    Croft, M.5    Broide, D.H.6
  • 53
    • 84887007017 scopus 로고    scopus 로고
    • Type 2 innate lymphoid cells constitutively express arginase-I in the naive and inflamed lung
    • Bando, J. K., J. C. Nussbaum, H. E. Liang, and R. M. Locksley. 2013. Type 2 innate lymphoid cells constitutively express arginase-I in the naive and inflamed lung. J. Leukoc. Biol. 94: 877-884.
    • (2013) J. Leukoc. Biol. , vol.94 , pp. 877-884
    • Bando, J.K.1    Nussbaum, J.C.2    Liang, H.E.3    Locksley, R.M.4


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