Mental health and gender dysphoria: A review of the literature

International Review of Psychiatry

Volumn 28, Issue 1, 2016, Pages 44-57

  Dhejne, Cecilia ^a   Van Vlerken, Roy ^b   Heylens, Gunter ^c   Arcelus, Jon ^d,e  

^a KAROLINSKA INSTITUTE   (Sweden)

^b VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^c GHENT UNIVERSITY HOSPITAL   (Belgium)

^d Nottingham Centre for Gender Dysphoria   (United Kingdom)

^e UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

anxiety; depression; Gender dysphoria; mental health; psychiatric disorders; transsexualism

Indexed keywords

ANXIETY DISORDER; AVOIDANT PERSONALITY DISORDER; BIPOLAR DISORDER; CLINICAL ASSESSMENT; DEPRESSION; DISEASE SEVERITY; GENDER BIAS; GENDER CONFIRMING MEDICAL INTERVENTION; GENDER DYSPHORIA; HEALTH SERVICE; HUMAN; MEDICAL CARE; MENTAL HEALTH; MORBIDITY; MULTICENTER STUDY (TOPIC); ONSET AGE; PARANOIA; PREVALENCE; PRIORITY JOURNAL; REVIEW; RISK FACTOR; SCHIZOPHRENIA; SEX DIFFERENCE; SUICIDE ATTEMPT; SYSTEMATIC REVIEW; TRANSGENDER; TREATMENT OUTCOME; VULNERABLE POPULATION; COMPLICATION; CROSS-SECTIONAL STUDY; FEMALE; LONGITUDINAL STUDY; MALE; MENTAL DISEASE; PSYCHOLOGY;

CROSS-SECTIONAL STUDIES; FEMALE; GENDER DYSPHORIA; HUMANS; LONGITUDINAL STUDIES; MALE; MENTAL DISORDERS; PSYCHOPATHOLOGY; TRANSGENDER PERSONS;

EID: 84957704161     PISSN: 09540261     EISSN: 13691627     Source Type: Journal    
DOI: 10.3109/09540261.2015.1115753     Document Type: Review

References (70)

1. American Psychiatric Association. (1987). Diagnostic and Statistical Manual of Mental Disorders (3rd ed. rev.). Washington, DC: APA.
2. American Psychiatric Association. (1994). Diagnostic and Statistical Manual of Mental Disorders (4th ed.). Washington, DC: APA.
3. American Psychiatric Association. (2000). Diagnostic and Statistical Manual of Mental Disorders (4th ed., text rev.). Washington, DC: APA.
4. American Psychiatric Association. (2013). Diagnostic and Statistical Manual of Mental Disorders (5th ed.). Arlington, VA: APA.
5. Arcelus, J., Bouman, W. P., Van De Noortgate, W., Claes, L., Witcomb, G. L., & Fernandez-Aranda, F. (2015). Systematic review and meta-analysis of prevalence studies in transsexualism. European Psychiatry 30 (6), 807-815.
6. Auer, M. K., Höhne, N., Bazzara-Castro, M. A., Pfister, H., Fuss, J., Stalla, G. K,. Ising, M. (2013). Psychopathological profiles in transsexuals and the challenge of their special status among the sexes. PLoS One, 8 (10), e78469.
7. Bandini, E., Fisher, AD., Ricca, J., Meriggiola, M. C., Jannini, E. A., Manieri, C., Maggi, M. (2011). Childhood maltreatment in subjects with male-to-female gender identity disorder. International Journal of Impotence research, 23, 276-285.
8. Bauer, G. R., Scheim, A. I., Pyne, J., Travers, R., & Hammond, R. (2015). Intervenable factors associated with suicide risk in transgender persons: A respondent driven sampling study in Ontario, Canada. BMC Public Health, 15, 525.
9. Bazargan, M., & Galvan, F. (2012). Perceived discrimination and depression among low-income Latina male-to-female transgender women. BMC Public Health, 12, 663-671.
10. Bockting, W. O., Miner, M. H., Swinburne Romine, R. E., Hamiltion, A., & Coleman E. (2013). Stigma, mental health, and resilience in an online sample of the US transgender population. American Journal of Public Health, 5, 943-995.
11. Clements-Nolle, K., Marx, R., & Katz, M. (2006). Attempted suicide among transgender persons: The influence of gender-based discrimination and victimization. Journal of Homosexuality, 3, 53-69.
12. Coleman, E., Bockting, W., Botzer, M., Cohen-Kettenis, P., DeCuypere, G., Feldman, J., Zucker, K. (2012). Standards of care for the health of transsexual, transgender, and gender-nonconforming people, version 7. International Journal of Transgenderism, 13, 165-232.
13. Colizzi, M., Costa, R., Pace, V., & Todarello, O. (2013). Hormonal treatment reduces psychobiological distress in gender identity disorder, independently of the attachment style. Journal of Sexual Medicine, 10 (12), 3049-3058.
14. Colizzi, M., Costa, R., & Todarello, O. (2014). Transsexual patients' psychiatric comorbidity and positive effect of cross-sex hormonal treatment on mental health: Results from a longitudinal study. Psychoneuroendocrinology, 39, 65-73.
15. Colizzi, M., Costa, R., & Todarello, O. (2015). Dissociative symptoms in individuals with gender dysphoria: Is the elevated prevalence real? Psychiatry Research, 226, 173-180.
16. Colton Meier, S., Pardo, S. T., & Labuski, C. (2013). Measures of clinical health among female-to-male transgender persons as a function of sexual orientation. Archives of Sexual Behavior, 42, 463-474.
17. Claes, L., Bouman, W. P., Witcomb, G., Thurston, M., & Arcelus, J. (2015). Non-suicidal self-injury in transsexualism: Associations with psychological symptoms, victimization, interpersonal functioning and perceived social support. Journal of Sexual Medicine, 12 (1), 168-179.
18. Davey, A., Bouman, W. P., Meyer, C., & Arcelus, J. (2015). Interpersonal functioning among individuals with gender dysphoria. Journal of Clinical Psychology, 71 (12), 1173-1185.
19. Davey, A., Bouman, W. P., Arcelus, J., & Meyer, C. (2014). Social support and psychological well-being in gender dysphoria: A comparison of patients with matched controls. Journal of Sexual Medicine, 11, 2976-2985.
20. De Cuypere, G., Jannes, C., & Rubens, R. (1995). Psychosocial functioning of transsexuals in Belgium. Acta Psychiatrica Scandinavica, 91, 180-184.
21. De Cuypere, G., Elaut, E., Heylens, G., Van Maele, G., Selvaggi, G., T'Sjoen, G., Monstrey, S. (2006). Long-term follow up: Psychosocial outcome of Belgian transsexuals after sex reassignment surgery. Sexologies, 15, 126-133.
22. Derogatis, L. R., & Unger, R. (2010). Symptom Checklist-90-Revised. In Weiner, I. B. & Craighead, W. E. (Eds). Corsini Encyclopedia of Psychology,. 4th edition. Hoboken, NJ: John Wiley & Sons.
23. Dhejne, C., Lichtenstein, P., Boman, M., Johansson, A. L., Langstrom, N., & Landen, M. (2011). Long-term follow-up of transsexual persons undergoing sex reassignment surgery: Cohort study in Sweden. PLoS One, 6, e16885.
24. Drescher, J., Cohen-Kettenis, P., & Winter, S. (2012). Minding the body: Situating gender identity diagnoses in the ICD-11. International Review of Psychiatry, 24 (6), 568-577.
25. Duisin, D., Batinic, B., Barisic, J., Djordjevic, M. L., Vujovic, S., & Bizic, M. (2014). Personality disorders in persons with gender identity disorder. The Scientific World Journal, 809058.
26. Factor, R. J., & Rothblum, E. D. (2007). A study of transgender adults and their non-transgender siblings on demographic characteristics, social support, and experience of violence. Journal of LGBT Health Research, 3, 11-30.
27. First, M. B., Spitzer, R. L., Gibbon M., and Williams, J. B. W. (2002). Structured Clinical Interview for DSM-IV-TR Axis I Disorders, Research Version, Patient Edition. (SCID-I/P),. New York: Biometrics Research, New York State Psychiatric Institute.
28. Fisher, A. D., Bandini, E., Casale, H., Ferrucio, N., Meriggiola, M. C., Gualerzi, A., Maggi, M. (2013). Sociodemographic and clinical features of gender identity disorder: An Italian multicentric evaluation. Journal of Sexual Medicine, 10, 408-419.
29. Fisher, A. D., Castellini, G., Bandini, E., Casale, H., Fanni, E., Benni, L., Rellini, A. H. (2014). Cross-sex hormonal treatment and body uneasiness in individuals with gender dysphoria. Journal of Sexual Medicine, 11, 709-719.
30. Gehring, D., & Knudson, G. (2005). Prevalence of childhood trauma in a clinical population of transsexual people. International Journal of Transgenderism, 8, 23-30.
31. Gomez-Gil, E., Trilla, A., Salamero, M., Godas, T., & Valdes, M. (2009). Sociodemographic, clinical, and psychiatric characteristics of transsexuals from Spain. Archives of Sexual Behavior, 38, 378-392.
32. Gomez-Gil, E., Vidal-Hagemeijer, A., & Salamero, M. (2008). MMPI-2 characteristics of transsexuals requesting sex reassignment: Comparison of patients in prehormonal and presurgical phases. Journal of Personality Assessment, 90, 368-374.
33. GÓmez-Gil, E., Zubiaurre-Elorza, L., Esteva, I., Guillamon, A., GodÁs, T., Cruz Almaraz, M., Salamero M. (2012). Hormone-treated transsexuals report less social distress, anxiety and depression. Psychoneuroendocrinology, 37, 662-670.
34. Gooren, L. j., Sunkaew, T., Giltay, E. J., & Guadamuz, T. E. (2015). Cross-sex hormone use functional health and mental-being among transgender men (Toms) and Transgender women (Kathoeys) in Thailand. Culture, Health & Sexuality, 1, 92-103.
35. Gorin-Lazard, A., Baumstarck, K., Boyer, L., Maquigneau, A., Gebleux, S., Penochet, J. C., Bonierbale, M. (2012). Is hormonal therapy associated with better quality of life in transsexuals? A cross sectional study. Journal of Sexual Medicine, 9, 531-541.
36. Gorin-Lazard, A., Baumstarck, K., Boyer, L., Maquigneau, A., Penochet, J. C. Pringuey, D., Auquier, P. (2013). Hormonal therapy is associated with better self-esteem, mood and quality of life in transsexuals. Journal of Nervous and Mental Disease, 201, 996-1000.
37. Haraldsen, I. R., & Dahl, A. A. (2000). Symptom profiles of gender dysphoric patients of transsexual type compared to patients with personality disorders and healthy adults. Acta Psychiatrica Scandinavica, 102, 276-281.
38. Hepp, U., Kraemer, B., Schnyder, U., Miller, N., & Delsignore, A. (2005). Psychiatric comorbidity in gender identity disorder. Journal of Psychosomatic Research, 58, 259-261.
39. Heylens, G., Elaut, E., Kreukels, B. P., Paap, M. C., Cerwenka, S., Richter-Appelt, H., De Cuypere, G. (2014a). Psychiatric characteristics in transsexual individuals: Multicenter study in four European countries. British Journal of Psychiatry, 204, 151-156.
40. Heylens G., Verroken C., De Cock S., T'sjoen G., & De Cuypere G. (2014b). Effects of different steps in gender reassignment therapy on psychopathology: A prospective study of persons with a gender identity disorder. Journal of Sexual Medicine, 11, 119-126.
41. Hoshiai, M., Matsumoto, Y., Sato, T., Ohnishi, M., Okabe, N., Kishimoto, Y., Kuroda, S. (2010). Psychosomatic comorbidity among patients with gender identity disorder. Psychiatry Clinical Neurosciences, 64, 514-519.
42. Johansson, A., Sundbom, E., Hojerback, T., & Bodlund, O. (2010). A five-year follow-up study of Swedish adults with gender identity disorder. Archives of Sexual Behavior, 39, 1429-1437.
43. Judge, C., O'Donovan, C., Callaghan, G., Gaoatswe, G., O'Shea, D. (2014). Gender dysphoria-prevalence and co-morbidities in an irish adult population. Frontiers in Endocrinology, 5, 87.
44. Kersting A., Reutemann, M., Gast, U., Ohrmann, P., Suslow, T., Michael, N., & Arolot, V. (2003). Dissociative disorders and traumatic childhood experiences in transsexuals. Journal of Nervous and Mental Disease, 191, 182-189.
45. Kim, T. S., Cheon, Y. H., Pae C. U., Kim, J. J., Lee, C. U., Lee, S. J., Lee, C. (2006). Psychological burdens are associated with young male transsexuals in Korea. Psychiatry and Clinical Neurosciences, 60, 417-421.
46. Kreukels, B. P., Haraldsen, I. R., De Cuypere, G., Richter-Appelt, H., Gijs, L., & Cohen-Kettenis, P. T. (2012). A European network for the investigation of gender incongruence: The ENIGI initiative. European Psychiatry, 27, 445-450.
47. Landén, M., Wålinder, J. & Lundstrom, B. (1998). Clinical characteristics of a total cohort of female and male applicants for sex reassignment: A descriptive study. Acta Psychiatrica Scandinavica, 97, 189-194.
48. Lawrence, A. & Zucker, K. (2012) Gender identity disorders. In M. Hersen & D. Beidel (Eds.), Adult psychopathology and diagnosis, (6th ed., pp. 601-635). London: Wiley.
49. Lev, A. I. (2009). The ten tasks of the mental health provider: Recommendations for revision of the world professional association for transgender health's standards of care. International Journal of Transgenderism, 11, 74-99.
50. Lothstein, L. M. (1984). Psychological testing with transsexuals: A 30-year review. Journal Personality Assessment, 48, 500-507.
51. Madeddu, F., Prunas, A., & Hartmann, D. (2009). Prevalence of Axis II Disorders in a sample of clients undertaking psychiatric evaluation for sex reassignment surgery. Psychiatric Quarterly, 80, 261-267.
52. Mazaheri Meybodi, A., Hajebi, A., & Ghanbari Jolfaie, A. (2014a). Psychiatric Axis I Comorbidities among patients with gender dysphoria. Psychiatry Journal, 971814.
53. Mazaheri Meybodi, A., Hajebi, A., & Ghanbari Jolfaie, A. (2014b). The frequency of personality disorders in patients with gender identity disorder. Medical Journal of the Islamic Republic of Iran, 28, 90.
54. Meyer-Bahlburg, H. F. (2010). From mental disorder to iatrogenic hypogonadism: Dilemmas in conceptualizing gender identity variants as psychiatric conditions. Archive of Sexual Behavior, 39, 461-476.
55. Miach, P. P., Berah, E. F., Butcher, J. N., & Rouse, S. (2000). Utility of the MMPI-2 in assessing gender dysphoric patients. Journal of Personality Assessment, 75, 268-279.
56. Nuttbrock, L., Bockting, W., Rosenblum, A., Hwahng, S., Manson, M., Macri, M., & Becker, J. (2014). Gender abuse, depressive symptoms and substance use among transgender women: A 3-year prospective study. American Journal of Public Health, 11, 2199-2266.
57. Nuttbrock, L., Bockting, W., Rosenblum, A., Manson, M., Macri, M., & Becker, J. (2011). Gender identity conflict/ affirmation and major depression across the life course of transgender women. International Journal of Transgenderism, 13, 91-1034.
58. Pimenoff, V., & Pfäfflin, F. (2011). Transsexualism: Treatment outcome of compliant and noncompliant patients. International Journal of Transgenderism, 13, 37-44.
59. Richards, C., Arcelus, J., Barrett, J., Bouman, WP., Lenihan, P, Lorimer, S., Murjan, S., & Seal, L. (2015). Trans is not a disorder-but should still receive funding. Sexual and Relationship Therapy, 30, 309-313.
60. Rotondi, N. K. (2011). Depression in trans people: A review of the risk factors. International Journal of Transgenderism, 13, 104-116.
61. Ruppin, U., & Pfafflin, F. (2015). Long-Term Follow-Up of Adults with Gender Identity Disorder. Archive of Sexual Behavior. 1321-1329.
62. Selvaggi, G., & Giordiano, S. (2014). The role of mental health professionals in gender reassignment surgeries: Unjust discrimination or responsible care? Aesthtetic Plastic Surgery, 38, 1177-1183.
63. Simon, L., Zsolt, U., Fogd, D., & Czobor P. (2011). Dysfunctional core beliefs, perceived parenting and psychopathology in gender identity disorder: A comparison of male-to-female, female-to-male transsexual and nontranssexual control subject. Journal of Behavior Therapy and Experimental Psychiatry, 5, 38-45.
64. Slabbekoorn, D., Goozen, S. H. V., Gooren, L. J., & Cohen-Kettenis, P. T. (2001). Effects of cross-sex hormone treatment on emotionality in transsexuals. International Journal of Transgenderism, 5 (3), 2-18.
65. Smith, Y. L., van Goosen, S. H., & Cohen-Kettenis, P. T. (2001). Adolescents with gender identity disorder who were accepted or rejected for sex reassignment surgery: A prospective follow-up study. Journal of the American Academy of Child and Adolescent Psychiatry, 40, 472-481.
66. Smith, Y. L., van Goosen, S. H., Kuiper, A. J., & Cohen-Kettenis, P. T. (2005). Transsexual subtypes: Clinical and theoretical significance. Psychiatry Research, 137, 151-160.
67. Udeze, B., Abdelmawla, N., Khoosal, D., & Terry, T. (2008). Psychological functions in male-to-female transsexual people before and after surgery. Sexual and Relationship Therapy, 23, 141-145.
68. Weyers, S., Elaut, E., De Sutter, P., Gerris, J., T'Sjoen, G., Heylens, G., Verstraelen, H. (2009). Long-term assessment of the physical, mental, and sexual health among transsexual women. Journal of Sexual Medicine, 6 (3), 752-760
69. World Health Organization. (1992). Manual of the International Statistical Classification of Diseases, Injuries, and Causes of Death, Tenth Revision, Geneva: Author.
70. Zubiaurre-Elorza, L., Junque, C., Gomez-Gil, E., Segovia, S., Carrillo, B., Rametti, G., & Guillamon, A. (2013). Cortical thickness in untreated transsexuals. Cerebral Cortex, 23, 2855-2862.