Baicalin attenuates high fat diet-induced insulin resistance and ectopic fat storage in skeletal muscle, through modulating the protein kinase B/Glycogen synthase kinase 3 beta pathway

Chinese Journal of Natural Medicines

Volumn 14, Issue 1, 2016, Pages 48-55

  Xi, You Li ^a,b   Li, Hong Xia ^a   Chen, Chen ^c   Liu, Ya Qun ^a   Lv, Hong Mei ^a   Dong, Shi Qi ^a   Luo, Er Fei ^a   Gu, Ming Bo ^a   Liu, Hua ^a,c  

^a MEDICAL SCHOOL OF SOUTHEAST UNIVERSITY   (China)

^b THE AFFILIATED DRUM TOWER HOSPITAL OF NANJING UNIVERSITY MEDICAL SCHOOL   (China)

^c SOUTHEAST UNIVERSITY   (China)

Author keywords

Baicalin; Glycogen synthase kinase 3 beta; Insulin resistance; Protein kinase B; Skeletal muscle ectopic fat storage

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; BAICALIN; GLUCOSE; GLYCOGEN SYNTHASE KINASE 3BETA; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INSULIN; PROTEIN KINASE B; FLAVONOID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DRUG MEGADOSE; GLUCOSE BLOOD LEVEL; GLUCOSE INTOLERANCE; GLUCOSE TOLERANCE; GLUCOSE TOLERANCE TEST; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; INSULIN SENSITIVITY; INSULIN TOLERANCE TEST; LIPID DIET; LIPID STORAGE; LIPOGENESIS; MALE; MOUSE; NONHUMAN; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; THERAPY EFFECT; TREATMENT DURATION; ADIPOSE TISSUE; ANIMAL; C57BL MOUSE; METABOLISM; PHYSIOLOGY;

ACETYL-COA CARBOXYLASE; ADIPOSE TISSUE; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; DIET, HIGH-FAT; FLAVONOIDS; GLYCOGEN SYNTHASE KINASE 3 BETA; INSULIN RESISTANCE; MALE; MICE; MICE, INBRED C57BL; MUSCLE, SKELETAL; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION;

EID: 84957698474     PISSN: 20956975     EISSN: 18755364     Source Type: Journal    
DOI: 10.3724/SP.J.1009.2016.00048     Document Type: Article

References (25)

1. Suh JM, Jonker JW, Ahmadian M, et al. Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer [J]. Nature 2014, 513(7518):436-439.
2. Mizgier ML, Casas M, Contreras-Ferrat A, et al. Potential role of skeletal muscle glucose metabolism on the regulation of insulin secretion [J]. Obes Rev 2014, 15(7):587-597.
3. Hage Hassan R, Bourron O, Hajduch E Defect of insulin signal in peripheral tissues: Important role of ceramide [J]. World J Diabetes 2014, 5(3):244-257.
4. Huang WH, Lee AR, Yang CH Antioxidative and anti- inflammatory activities of polyhydroxyflavonoids of Scutellaria baicalensis GEORGI [J]. Biosci Biotechnol Biochem 2006, 70(10):2371-2380.
5. Li HB, Chen F Isolation and purification of baicalein, wogonin and oroxylin A from the medicinal plant Scutellaria baicalensis by high-speed counter-current chromatography [J]. J Chromatogr A 2005, 1074(1-2):107-110.
6. Waisundara VY, Siu SY, Hsu A, et al. Baicalin upregulates the genetic expression of antioxidant enzymes in Type-2 diabetic Goto-Kakizaki rats [J]. Life Sci 2011, 88(23-24):1016-1025.
7. Pu P, Wang XA, Salim M, et al. Baicalein, a natural product, selectively activating AMPKalpha(2) and ameliorates metabolic disorder in diet-induced mice [J]. Mol Cell Endocrinol 2012, 362(1-2):128-138.
8. De Lange P, Moreno M, Silvestri E, et al. Fuel economy in food-deprived skeletal muscle: signaling pathways and regulatory mechanisms [J]. FASEB J 2007, 21(13):3431-3441.
9. Glund S, Schoelch C, Thomas L, et al. Inhibition of acetyl- CoA carboxylase 2 enhances skeletal muscle fatty acid oxidation and improves whole-body glucose homeostasis in db/db mice [J]. Diabetologia 2012, 55(7):2044-2053.
10. Badin PM, Vila IK, Louche K, et al. High-fat diet-mediated lipotoxicity and insulin resistance is related to impaired lipase expression in mouse skeletal muscle [J]. Endocrinology 2013, 154(4):1444-1453.
11. Zhang BB, Zhou G, Li C AMPK: an emerging drug target for diabetes and the metabolic syndrome [J]. Cell Metab 2009, 9(5):407-416.
12. Bray GA Medical consequences of obesity [J]. J Clin Endocrinol Metab 2004, 89(6):2583-2589.
13. Kelley DE, Goodpaster BH, Storlien L Muscle triglyceride and insulin resistance [J]. Annu Rev Nutr 2002, 22:325-346.
14. Frosig C, Jensen TE, Jeppesen J, et al. AMPK and insulin action-responses to ageing and high fat diet [J]. PLoS One 2013, 8(5):e62338.
15. Min W, Liu X, Qian Q, et al. Effects of baicalin against UVA- induced photoaging in skin fibroblasts [J]. Am J Chin Med 2014, 42(3):709-727.
16. Lixuan Z, Jingcheng D, Wenqin Y, et al. Baicalin attenuates inflammation by inhibiting NF-kappaB activation in cigarette smoke induced inflammatory models [J]. Pulm Pharmacol Ther 2010, 23(5):411-419.
17. Zhu J, Wang J, Sheng Y, et al. Baicalin improves survival in a murine model of polymicrobial sepsis via suppressing inflammatory response and lymphocyte apoptosis [J]. PLoS One 2012, 7(5):e35523.
18. Liu SZ, Deng YX, Chen B, et al. Antihyperglycemic effect of the traditional Chinese scutellaria-coptis herb couple and its main components in streptozotocin-induced diabetic rats [J]. J Ethnopharmacol 2013, 145(2):490-498.
19. Shen HY, Wu XD Improvement effect of baicalin on dexamethasone-induced insulin resistance of rat adipocyte [J]. Chin J Clin Pharmacol Ther 2011, 16(3):263-269.
20. Snel M, Jonker JT, Schoones J, et al. Ectopic fat and insulin resistance: pathophysiology and effect of diet and lifestyle interventions [J]. Int J Endocrinol 2012, 2012:983814.
21. Rector RS, Thyfault JP, Laye MJ, et al. Cessation of daily exercise dramatically alters precursors of hepatic steatosis in Otsuka Long-Evans Tokushima Fatty (OLETF) rats [J]. J Physiol 2008, 586(pt17):4241-4249.
22. Kahn BB, Alquier T, Carling D, et al. AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism [J]. Cell Metab 2005, 1(1):15-25.
23. Samuel VT, Shulman GI Mechanisms for insulin resistance: common threads and missing links [J]. Cell 2012, 148(5):852-871.
24. Erion DM, Shulman GI Diacylglycerol-mediated insulin resistance [J]. Nat Med 2010, 16(4):400-402.
25. Doble BW, Woodgett JR GSK-3: tricks of the trade for a multi-tasking kinase [J]. J Cell Sci 2003, 116(Pt 7):1175-1186.