Antidepressant, antioxidant and neurotrophic properties of the standardized extract of Cocos nucifera husk fiber in mice

Journal of Natural Medicines

Volumn 70, Issue 3, 2016, Pages 510-521

  Lima, Eliane Brito Cortez ^a   de Sousa, Caren Nádia Soares ^a   Vasconcelos, Germana Silva ^a   Meneses, Lucas Nascimento ^a   e Silva Pereira, Yuri Freitas ^a   Ximenes, Naiara Coelho ^a   Santos Júnior, Manuel Alves ^a   Matos, Natália Castelo Branco ^a   Brito, Rayanne ^a   Miron, Diogo ^a   Leal, Luzia Kalyne Almeida Moreira ^a   Macêdo, Danielle ^a   Vasconcelos, Silvânia Maria Mendes ^a  

^a FEDERAL UNIVERSITY OF CEARÁ   (Brazil)

Author keywords

BDNF; Behavioral test; Cocos nucifera; Oxidative stress; Phenols

Indexed keywords

ALPHA TOCOPHEROL; ANTIDEPRESSANT AGENT; ANTIOXIDANT; BRAIN DERIVED NEUROTROPHIC FACTOR; CATECHIN; CHLOROGENIC ACID; COCOS NUCIFERA EXTRACT; DIAZEPAM; MALONALDEHYDE; PLANT EXTRACT; UNCLASSIFIED DRUG;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIDEPRESSANT ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; BRAIN REGION; CONTROLLED STUDY; CORPUS STRIATUM; DEPRESSION; DRUG DOSE COMPARISON; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG RESPONSE; FORCED SWIM TEST; HIPPOCAMPUS; MALE; MOUSE; NONHUMAN; OPEN FIELD TEST; PREFRONTAL CORTEX; PROTEIN DETERMINATION; TAIL SUSPENSION TEST; ANIMAL; ANIMAL BEHAVIOR; CHEMISTRY; COCONUT; DISEASE MODEL; DRUG EFFECTS; ISOLATION AND PURIFICATION; METABOLISM; OXIDATIVE STRESS;

ANIMALS; ANTIDEPRESSIVE AGENTS; ANTIOXIDANTS; BEHAVIOR, ANIMAL; BRAIN-DERIVED NEUROTROPHIC FACTOR; COCOS; CORPUS STRIATUM; DISEASE MODELS, ANIMAL; HIPPOCAMPUS; MALE; MICE; OXIDATIVE STRESS; PLANT EXTRACTS; PREFRONTAL CORTEX;

EID: 84957648925     PISSN: 13403443     EISSN: 18610293     Source Type: Journal    
DOI: 10.1007/s11418-016-0970-8     Document Type: Article

References (90)

1. World Health Organization (2008) The global burden of disease: 2004 update. World Health Organization, Geneva, p 146
2. Kessler R, Berglund P, Demler O, Jin R, Koretz D, Merikangas K, Rush A, Walters E, Wang P (2003) The epidemiology of major depressive disorder: results from the National Comorbidity Survey Replication (NCS-R). J Am Med Assoc 289:3095–3105
3. Kessler R (2012) The costs of depression. Psychiatr Clin North Am 35:1–14
4. Rush A, Trivedi M, Wisniewski S, Nierenberg A, Stewart J, Warden D, Niederehe G, Thase M, Lavori P, Lebowitz B, McGrath P, Rosenbaum J, Sackeim H, Kupfer D, Luther J, Fava M (2006) Acute and longer-term outcomes in depressed outpatients requiring one or several treatment steps: a STAR*D report. Am J Psychiatry 163:1905–1917
5. Bajpai A, Verma A, Srivastava M, Srivastava R (2014) Oxidative stress and major depression. J Clin Diagn Res 8:CC04–CC07
6. Palta P, Samuel L, Miller E, Szanton S (2014) Depression and oxidative stress: results from a meta-analysis of observational studies. Psychosom Med 76:12–19
7. Kumar B, Kuhad A, Chopra K (2011) Neuropsychopharmacological effect of sesamol in unpredictable chronic mild stress model of depression: behavioral and biochemical evidences. Psychopharmacology 214:819–828
8. Zhang X, Yao J (2013) Oxidative stress and therapeutic implications in psychiatric disorders. Prog Neuropsychopharmacol Biol Psychiatry 46:197–199
9. Duman R, Voleti B (2012) Signaling pathways underlying the pathophysiology and treatment of depression: novel mechanisms for rapid-acting agents. Trends Neurosci 35:47–56
10. Che Y, Zhou Z, Shu Y, Zhai C, Zhu Y, Gong S, Cui Y, Wang J (2015) Chronic unpredictable stress impairs endogenous antioxidant defense in rat brain. Neurosci Lett 584:208–213
11. Bilici M, Efe H, Koroglu M, Uydu H, Bekaroglu M, Deger O (2001) Antioxidative enzyme activities and lipid peroxidation in major depression: alterations by antidepressant treatments. J Affect Disord 64:43–51
12. Autry A, Monteggia L (2012) Brain-derived neurotrophic factor and neuropsychiatric disorders. Pharmacol Rev 64:238–258
13. Wolkowitz O, Wolf J, Shelly W, Rosser R, Burke H, Lerner G, Reus V, Nelson J, Epel E, Mellon S (2011) Serum BDNF levels before treatment predict SSRI response in depression. Prog Neuropsychopharmacol Biol Psychiatry 35:1623–1630
14. Mao Q, Huang Z, Zhong X, Xian X, Ip S (2014) Brain-derived neurotrophic factor signalling mediates the antidepressant-like effect of piperine in chronically stressed mice. Behav Brain Res 26:140–145
15. Liu Y, Jia G, Gou L, Sun L, Fu X, Lan N, Li S, Yin X (2013) Antidepressant-like effects of tea polyphenols on mouse model of chronic unpredictable mild stress. Pharmacol Biochem Behav 104:27–32
16. Bocchio-Chiavetto L, Bagnardi V, Zanardini R, Molteni R, Nielsen M, Placentino A, Giovannini C, Rillosi L, Ventriglia M, Riva MA, Gennarelli M (2010) Serum and plasma BDNF levels in major depression: a replication study and meta-analyses. World J Biol Psychiatry 11:763–773
17. Fernandes B, Berk M, Turck C, Steiner J, Gonçalves C (2014) Decreased peripheral brain-derived neurotrophic factor levels are a biomarker of disease activity in major psychiatric disorders: a comparative meta-analysis. Mol Psychiatry 19:750–751
18. Citó M, Silva M, Santos L, Fernandes M, Melo F, Aguiar J, Lopes I, Sousa P, Vasconcelos S, Macêdo D, Sousa F (2015) Antidepressant-like effect of Hoodia gordonii in a forced swimming test in mice: evidence for involvement of the monoaminergic system. Braz J Med Biol Res 48:57–64
19. Gaire B, Lim D (2014) Antidepressant effects of Radix et Caulis Acanthopanacis Santicosi extracts on rat models with depression in terms of immobile behavior. J Tradit Chin Med 34:317–323
20. De Sousa F, Oliveira I, Silva M, de Melo C, Santiago V, de Castro Chaves R, Fernandes M, Gutierrez S, Vasconcelos S, Macêdo D, Barbosa Filho J (2014) Involvement of monoaminergic system in the antidepressant-like effect of riparin I from Aniba riparia (Nees) Mez (Lauraceae) in mice. Fundam Clin Pharmacol 28:95–103
21. Do Amaral J, Silva M, de Aquino Neto M, Moura B, de Carvalho A, Vasconcelos P, Barbosa Filho J, Gutierrez S, Vasconcelos S, Macêdo D, de Sousa F (2013) Antidepressant-like effect of bis-eugenol in the mice forced swimming test: evidence for the involvement of the monoaminergic system. Fundam Clin Pharmacol 27:471–482
22. Esquenazi D, Wigg M, Miranda M, Rodrigues H, Tostes J, Rozental S, Alviano C (2002) Antimicrobial and antiviral activities of polyphenolics from Cocos nucifera Linn. (Palmae) husk fiber extract. Res in Microbiol 153:647–652
23. Costa C, Bevilaqua C, Morais S, Camurça-Vasconcelos A, Maciel M, Braga R, Oliveira L (2010) Anthelmintic activity of Cocos nucifera L. on intestinal nematodes of mice. Res in Vet Sci 88:101–103
24. Mendonça-Filho R, Rodrigues I, Alviano D, Santos A, Soares R, Alviano C, Lopes A, Rosa Mdo S (2004) Leishmanicidal activity of polyphenolic-rich extract from husk fiber of Cocos nucifera Linn. (Palmae). Res Microbiol 155:136–143
25. Koschek P, Alviano D, Alviano C, Gattass C (2007) The husk fiber of Cocos nucifera L. (Palmae) is a source of anti-neoplastic activity. Braz J Med Biol Res 40:1339–1343
26. Calzada F, Mulia Y, Contrera T (2007) Effect of Mexican medicinal plant used to treat trichomoniasis on Trichomonas vaginalis trophozoites. J Ethnopharmacol 113:248–251
27. Akinyele T, Okoh O, Akinpelu D, Okoh A (2011) In-vitro antibacterial properties of crude aqueous and n-hexane extracts of the husk of Cocos nucifera. Molecules 16:2135–2145
28. Silva R, Oliveira e Silva D, Fontes H, Alviano C, Fernandes P, Alviano D (2013) Anti-inflammatory, antioxidant, and antimicrobial activities of Cocos nucifera var. typica. BMC Complement Altern Med 13:107
29. Lima E, Sousa C, Meneses L, Ximenes N, Santos Júnior M, Vasconcelos G, Lima N, Patrocínio M, Macedo D, Vasconcelos S (2015) Cocos nucifera (L.) (Arecaceae): a phytochemical and pharmacological review. Braz J Med Biol Res 48:953–964. doi:10.1590/1414-431X20154773
30. Folin O, Ciocalteu V (1927) On tyrosine and tryptophane determinations in proteins. J Biol Chem 73:627–650
31. Wootton-Beard PC, Moran A, Ryan L (2011) Stability of the total antioxidant capacity and total polyphenol content of 23 commercially available vegetable juices before and after in vitro digestion measured by FRAP, DPPH, ABTS and Folin-Ciocalteu methods. Food Res Intern 44:217–224
32. Archer J (1973) Tests for emotionality in rats and mice: a review. Anim Behav 21:205–235
33. Porsolt R, Anton G, Blavet N, Jalfre M (1978) Behavioural despair in rats: a new model sensitive to antidepressant treatments. Eur J Pharmacol 47:379–391
34. Steru L, Chermat R, Thierry B, Simon P (1985) The tail suspension test: a new method for screening antidepressants in mice. Psychopharmacology 85:367–370
35. Green L, Tannenbaum S, Goldman P (1981) Nitrate synthesis in the germfree and conventional rat. Science 212:56–58
36. Huong N, Matsumoto K, Kasai R, Yamasaki K, Watanabe H (1998) In vitro antioxidant activity of Vietnamese ginseng saponin and its components. Biol Pharm Bull 21:978–981
37. Maehly A, Chance B (1954) The assay catalases and peroxidases. Methods Biochem Anal 1:357–359
38. Chance B, Maehly A (1955) Assay catalases and peroxidases. Methods Enzymol 2:764–768
39. Lowry H, Rosebrough N, Farr A, Randall R (1951) Protein measurements with the follin phenol reagent. J Biol Chem 193:265–275
40. Vasconcelos A, Oliveira I, Vidal L, Rodrigues G, Gutierrez S, Barbosa-Filho J, Vasconcelos S, de França Fonteles M, Gaspar D, de Sousa F (2015) Subchronic administration of riparin III induces antidepressive-like effects and increases BDNF levels in the mouse hippocampus. Fundam Clin Pharmacol 29:394–403
41. Citó M, Silva M, Santos L, Fernandes M, Melo F, Aguiar J, Lopes I, Sousa P, Vasconcelos S, Macêdo D, Sousa F (2015) Antidepressant-like effect of Hoodia gordonii in a forced swimming test in mice: evidence for involvement of the monoaminergic system. Braz J Med Biol 48:57–64
42. Herrera-Ruiz M, García-Beltrán Y, Mora S, Díaz-Véliz G, Viana G, Tortoriello J, Ramírez G (2006) Antidepressant and anxiolytic effects of hydroalcoholic extract from Salvia elegans. J Ethnopharmacol 107:53–58
43. De Boer A, Gaillard P (2007) Drug targeting to the brain. Annu Rev Pharmacol Toxicol 47:323–355
44. Németh K, Plumb G, Berrin J, Juge N, Jacob R, Naim H, Williamson G, Swallow D, Kroon P (2003) Deglycosylation by small intestinal epithelial cell beta-glucosidases is a critical step in the absorption and metabolism of dietary flavonoid glycosides in humans. Eur J Nutr 4:29–42
45. Youdim K, Dobbie M, Kuhnle G, Proteggente A, Abbott N, Rice-Evans C (2003) Interaction between flavonoids and the blood-brain barrier: in vitro studies. J Neurochem 85:180–192
46. Youdim K, Shukitt-Hale B, Joseph J (2004) Flavonoids and the brain: interactions at the blood–brain barrier and their physiological effects on the central nervous system. Free Radic Biol Med 37:1683–1693
47. Wu L, Zhang Q, Zhang X, Lv C, Li J, Yuan Y, Yin F (2012) Pharmacokinetics and blood-brain barrier penetration of (+)-catechin and (−)-epicatechin in rats by microdialysis sampling coupled to high-performance liquid chromatography with chemiluminescence detection. J Agric Food Chem 60:9377–9383
48. Waldmeier P (1987) Amine oxidases and their endogenous substrates (with special reference to monoamine oxidase and the brain). J Neural Transm Suppl 23:55–72
49. Takeda H, Tsuji M, Miyamoto J, Masuya J, Iimori M, Matsumiya T (2003) Caffeic acid produces antidepressive- and/or anxiolytic-like effects through indirect modulation of the alpha 1A-adrenoceptor system in mice. NeuroReport 14:1067–1070
50. Gonthier M, Verny M, Besson C, Rémésy C, Scalbert A (2003) Chlorogenic acid bioavailability largely depends on its metabolism by the gut microflora in rats. J Nutr 133:1853–1859
51. Takuma K, Baba A, Matsuda T (2004) Astrocyte apoptosis: implications for neuroprotection. Prog Neurobiol 72:111–127
52. Maes M, Galecki P, Chang Y, Berk M (2011) A review on the oxidative and nitrosative stress (O&NS) pathways in major depression and their possible contribution to the(neuro)degenerative processes in that illness. Prog Neuropsychopharmacol Biol Psychiatry 35:676–692
53. Ng F, Berk M, Dean O, Bush A (2008) Oxidative stress in psychiatric disorders: evidence base and therapeutic implications. Int J Neuropsychopharmacol 11:851–876
54. Kovács P, Juránek I, Stankovicová T, Svec P (1996) Lipid peroxidation during acute stress. Pharmazie 51:51–53
55. Cumurcu B, Ozyurt H, Etikan I, Demir S, Karlidag R (2009) Total antioxidant capacity and total oxidant status in patients with major depression: impact of antidepressant treatment. Psychiatry Clin Neurosci 63:639–645
56. Silva M, de Sousa C, Gomes P, de Oliveira G, Araújo F, Ximenes N, da Silva J, Silva Vasconcelos G, Leal L, Macêdo D, Vasconcelos S (2016) Evidence for protective effect of lipoic acid and desvenlafaxine on oxidative stress in a model depression in mice. Prog Neuropsychopharmacol Biol Psychiatry 64:142–148
57. Michel T, Camara S, Tatschner T (2010) Increased xanthine oxidase in the thalamus and putamen in depression. World J Biol Psychiatry 11:314–320
58. Essa M, Vijayan R, Castellano-Gonzalez G, Memon M, Braidy N, Guillemin G (2012) Neuroprotective effect of natural products against Alzheimer’s disease. Neurochem Res 37:1829–1842
59. Monte A, de Souza G, McIntyre R, Soczynska J, dos Santos J, Cordeiro R, Ribeiro BM, de Lucena D, Vasconcelos S, de Sousa F, Carvalho A, Macêdo D (2013) Prevention and reversal of ketamine-induced schizophrenia related behavior by minocycline in mice: possible involvement of antioxidant and nitrergic pathways. J Psychopharmacol 27:1032–1043
60. da Silva F, do Carmo de Oliveira Citó M, da Silva M, Moura B, de Aquino Neto M, Feitosa M, de Castro Chaves R, Macedo D, de Vasconcelos S, de França Fonteles M, Desousa F (2010) Behavioral alterations and pro-oxidant effect of a single ketamine administration to mice. Brain Res Bull 83:9–15
61. Celikbilek A, Gocmen A, Tanik N, Yaras N, Yargicoglu P, Gumuslu S (2014) Serum lipid peroxidation markers are correlated with those in brain samples in different stress models. Acta Neuropsychiatr 26:51–57
62. Gümüştaş K, Meta Güzeyli F, Atükeren P, Sanus G, Kemerdere R, Tanriverdi T, Kaynar M (2007) The effects of vitamin E on lipid peroxidation, nitric oxide production and superoxide dismutase expression in hyperglycemic rats with cerebral ischemia-reperfusion injury. Turk Neurosurg 17:78–82
63. Garg R, Kumar A (2008) Possible role of citalopram and desipramine against sleep deprivation-induced anxiety like-behavior alterations and oxidative damage in mice. Indian J Exp Biol 46:770–776
64. Freudenberg F, Alttoa A, Reif A (2015) Neuronal nitric oxide synthase (NOS1) and its adaptor, NOS1AP, as a genetic risk factors for psychiatric disorders. Genes Brain Behav 14:46–63
65. Okumura T, Kishi T, Okochi T, Ikeda M, Kitajima T, Yamanouchi Y, Kinoshita Y, Kawashima K, Tsunoka T, Inada T, Ozaki N, Iwata N (2010) Genetic association analysis of functional polymorphisms in neuronal nitric oxide synthase 1 gene (NOS1) and mood disorders and fluvoxamine response in major depressive disorder in the Japanese population. Neuropsychobiology 61:57–63
66. Galecki P, Maes M, Florkowski A, Lewinski A, Galecka E, Bienkiewicz M, Szemraj J (2011) Association between inducible and neuronal nitric oxide synthase polymorphisms and recurrent depressive disorder. J Affect Disord 129:175–182
67. Kim Y, Paik J, Lee S, Yoon D, Han C, Lee B (2006) Increased plasma nitric oxide level associated with suicide attempt in depressive patients. Prog Neuropsychopharmacol Biol Psychiatry 30:1091–1096
68. Chrapko W, Jurasz P, Radomski M, Lara N, Archer S, Le Mellédo J (2004) Decreased platelet nitric oxide synthase activity and plasma nitric oxide metabolites in major depressive disorder. Biol Psychiatry 56:129–134
69. Rachkauskas G (1998) The level of lipid peroxidation and the function of the antioxidant system in different forms of schizophrenia. Lik Sprava 5:92–93
70. Wang C, Wu H, Jing X, Meng Q, Liu B, Zhang H, Gao G (2012) Oxidative parameters in the rat brain of chronic mild stress model for depression: relation to anhedonia-like responses. J Membr Biol 245:675–681
71. Matés J, Sánchez-Jiménez F (1999) Antioxidant enzymes and their implications in pathophysiologic processes. Front Biosci 4:339–345
72. Murakami S, Imbe H, Morikawa Y, Kubo C, Senba E (2005) Chronic stress, as well as acute stress, reduces BDNF mRNA expression in the rat hippocampus but less robustly. Neurosci Res 53:129–139
73. Yulug˘ B, Ozan E, Gönül A, Kilic E (2009) Brain-derived neurotrophic factor, stress and depression: a mini-review. Brain Res Bull 78:267–269
74. Van der Kolk N, Speelman A, van Nimwegen M, Kessels R, IntHout J, Hakobjan M, Munneke M, Bloem B, van de Warrenburg B (2015) BDNF polymorphism associates with decline in set shifting in Parkinson’s disease. Neurobiol Aging 36:1605–1606
75. Duman RS (2004) Role of neurotrophic factors in the etiology and treatment of mood disorders. NeuroMol Med 5:11–25
76. Mello B, Monte A, McIntyre R, Soczynska J, Custódio C, Cordeiro R, Chaves J, Vasconcelos S, Nobre H Jr, Florenço de Sousa F, Hyphantis T, Carvalho A, Macêdo D (2013) Effects of doxycycline on depressive-like behavior in mice after lipopolysaccharide (LPS) administration. J Psychiatr Res 47:1521–1529
77. Cai S, Huang S, Hao W (2015) New hypothesis and treatment targets of depression: an integrated view of key findings. Neurosci Bull 31:61–74
78. Cryan J, Valentino R, Lucki I (2005) Assessing substrates underlying the behavioral effects of antidepressants using the modified rat forced swimming test. Neurosci Biobehav Rev 29:547–569
79. Krishnan V, Nestler E (2008) The molecular neurobiology of depression. Nature 455:894–902
80. Castrén E, Võikar V, Rantamäki T (2007) Role of neurotrophic factors in depression. Curr Opin Pharmacol 7:18–21
81. Dwivedi Y (2013) Involvement of brain-derived neurotrophic factor in late-life depression. Am J Geriatr Psychiatr 21:433–449
82. Hellweg R, Ziegenhorn A, Heuser I, Deuschle M (2008) Serum concentrations of nerve growth factor and brain-derived neurotrophic factor in depressed patients before and after antidepressant treatment. Pharmacopsychiatry 41:66–71
83. Numakawa T (2014) Possible protective action of neurotrophic factors and natural compounds against common neurodegenerative diseases. Neural Regen Res 9:1506–1508
84. Roohbakhsh A, Parhiz H, Soltani F, Rezaee R, Iranshahi M (2014) Neuropharmacological properties and pharmacokinetics of the citrus flavonoids hesperidin and hesperetin—a mini-review. Life Sci 113:1–6
85. Donato F, de Gomes M, Goes A, Filho C, Del Fabbro L, Antunes M, Souza L, Boeira S, Jesse C (2014) Hesperidin exerts antidepressant-like effects in acute and chronic treatments in mice: possible role of l-arginine-NO-cGMP pathway and BDNF levels. Brain Res Bull 104:19–26
86. Souza L, de Gomes M, Goes A, Del Fabbro L, Filho C, Boeira S, Jesse C (2013) Evidence for the involvement of the serotonergic 5-HT1A receptors in the antidepressant-like effect caused by hesperidin in mice. Prog Neuropsychopharmacol 40:103–109
87. Stringer T, Guerrieri D, Vivar C, Van Praag H (2015) Plant-derived flavanol (−) epicatechin mitigates anxiety in association with elevated hippocampal monoamine and BDNF levels, but does not influence pattern separation in mice. Transl Psychiatry 6:493
88. Zheng M, Fan Y, Shi D, Liu C (2013) Antidepressant-like effect of flavonoids extracted from Apocynum venetum leaves on brain monoamine levels and dopaminergic system. J Ethnopharmacol 147:108–113
89. Takeda H, Tsuji M, Inazu M, Egashira T, Matsumiya T (2002) Rosmarinic acid and caffeic acid produce antidepressive-like effect in the forced swimming test in mice. Eur J Pharmacol 449:261–267
90. Sato Y, Itagaki S, Kurokawa T, Ogura J, Kobayashi M, Hirano T, Sugawara M, Iseki K (2011) In vitro and in vivo antioxidant properties of chlorogenic acid and caffeic acid. Int J Pharm 403:136–138