MeCP2 SUMOylation rescues Mecp2-mutant-induced behavioural deficits in a mouse model of Rett syndrome

Nature Communications

Volumn 7, Issue , 2016, Pages

  Tai, Derek J C ^a   Liu, Yen C ^a,b   Hsu, Wei L ^a   Ma, Yun L ^a   Cheng, Sin J ^a,c   Liu, Shau Y ^a   Lee, Eminy H Y ^a  

^a INSTITUTE OF BIOMEDICAL SCIENCES   (Taiwan)

^b NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^c ACADEMIA SINICA   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

BCO2 PROTEIN; BRAIN DERIVED NEUROTROPHIC FACTOR; CORTICOTROPIN RELEASING FACTOR; CRE RECOMBINASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; DEXAMETHASONE; E2 PROTEIN; GLYCOPROTEIN E1; LYSINE; MESSENGER RNA; METHYL CPG BINDING PROTEIN 2; MX1 PROTEIN; OLR640 PROTEIN; PROTEIN; PROTEIN INHIBITOR OF ACTIVATED STAT1; SENTRIN SPECIFIC PROTEASE 1; SMALL INTERFERING RNA; SOMATOMEDIN B; SOMATOMEDIN C; UNCLASSIFIED DRUG; WNT5B PROTEIN; WNT6 PROTEIN; MECP2 PROTEIN, MOUSE; PROTEIN INHIBITOR OF ACTIVATED STAT;

BRAIN; GENE EXPRESSION; MEMORY; MOLECULAR ANALYSIS; MUTATION; NEUROLOGY; PROTEIN; RODENT;

ADULT; AGED; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; COGNITIVE DEFECT; CONTROLLED STUDY; DNA BINDING; DOWN REGULATION; EMBRYO; EXCITATORY POSTSYNAPTIC POTENTIAL; FEAR; FEMALE; GENE EXPRESSION REGULATION; GENE INACTIVATION; GENE MUTATION; GENE OVEREXPRESSION; GENETIC TRANSDUCTION; GENETIC TRANSFECTION; HEK293 CELL LINE; HIPPOCAMPAL CA1 REGION; HIPPOCAMPAL NEURONAL CULTURE; HIPPOCAMPUS; HUMAN; HUMAN CELL; IN VITRO STUDY; LOCOMOTION; MALE; MEMORY CONSOLIDATION; MOLECULAR WEIGHT; MOUSE; NERVE CELL; NERVE CELL PLASTICITY; NONHUMAN; PROTEIN ANALYSIS; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN SECRETION; RAT; RETT SYNDROME; SIGNAL TRANSDUCTION; SNIFFING; SOCIAL INTERACTION; SUMOYLATION; TRANSCRIPTION REGULATION; UBIQUITINATION; UPREGULATION; ANIMAL; ANIMAL BEHAVIOR; DISEASE MODEL; EXPLORATORY BEHAVIOR; GENE VECTOR; GENETICS; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; LEARNING; LENTIVIRINAE; MEMORY; METABOLISM; MUTATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SITE DIRECTED MUTAGENESIS; SOCIAL BEHAVIOR; SPRAGUE DAWLEY RAT; WESTERN BLOTTING;

MUS; RATTUS;

ANIMALS; BEHAVIOR, ANIMAL; BLOTTING, WESTERN; CA1 REGION, HIPPOCAMPAL; DISEASE MODELS, ANIMAL; EXPLORATORY BEHAVIOR; FEAR; GENE KNOCKOUT TECHNIQUES; GENETIC VECTORS; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; IN VITRO TECHNIQUES; LEARNING; LENTIVIRUS; MEMORY; METHYL-CPG-BINDING PROTEIN 2; MICE; MUTAGENESIS, SITE-DIRECTED; MUTATION; NEURONAL PLASTICITY; NEURONS; PROTEIN INHIBITORS OF ACTIVATED STAT; RATS; RATS, SPRAGUE-DAWLEY; RETT SYNDROME; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SOCIAL BEHAVIOR; SUMOYLATION;

EID: 84957601291     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms10552     Document Type: Article

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