Discovery of Pyrophosphate Diesters as Tunable, Soluble, and Bioorthogonal Linkers for Site-Specific Antibody-Drug Conjugates

Journal of the American Chemical Society

Volumn 138, Issue 4, 2016, Pages 1430-1445

  Kern, Jeffrey C ^a   Cancilla, Mark ^b   Dooney, Deborah ^b   Kwasnjuk, Kristen ^b   Zhang, Rena ^b   Beaumont, Maribel ^b   Figueroa, Isabel ^b   Hsieh, SuChun ^b   Liang, Linda ^b   Tomazela, Daniela ^b   Zhang, Jeffrey ^b   Brandish, Philip E ^c   Palmieri, Anthony ^c   Stivers, Peter ^c   Cheng, Mangeng ^b   Feng, Guo ^b   Geda, Prasanthi ^b   Shah, Sanjiv ^b   Beck, Andrew ^d   Bresson, Damien ^d   Firdos, Juhi ^d   Gately, Dennis ^d   Knudsen, Nick ^d   Manibusan, Anthony ^d   Schultz, Peter G ^d   Sun, Ying ^d   Garbaccio, Robert M ^a   more..

^a Global Chemistry Manufacturing and Controls   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

^c Partners Res and Educ Prog   (United States)

^d AMBRX INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CULTURE; ESTERS; HORMONES; PLASMA STABILITY;

ANTIBODY-DRUG CONJUGATES; GLUCOCORTICOID RECEPTOR; MECHANISTIC STUDIES; ORTHOGONAL PROPERTY; PROOF OF CONCEPT; PYROPHOSPHATE ESTERS; SOLUBLE PHOSPHATES; TARGETED DELIVERY;

ANTIBODIES;

ANTIBODY CONJUGATE; ANTIBODY DRUG CONJUGATE; BUDESONIDE; DEXAMETHASONE; DEXAMETHASONE SODIUM PHOSPHATE; FLUTICASONE PROPIONATE; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; MESSENGER RNA; ORGANOPHOSPHATE; PYROPHOSPHORIC ACID DERIVATIVE; UNCLASSIFIED DRUG; ESTER;

ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; EC50; HUMAN; HUMAN CELL; IMMUNOCOMPETENT CELL; IN VITRO STUDY;

DIPHOSPHATES; ESTERS; GLUCOCORTICOIDS; IMMUNOCONJUGATES;

EID: 84957563041     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/jacs.5b12547     Document Type: Article

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