Sex-Steroid Hormone Manipulation Reduces Brain Response to Reward

Neuropsychopharmacology

Volumn 41, Issue 4, 2016, Pages 1057-1065

  Macoveanu, Julian ^a,b   Henningsson, Susanne ^a,b   Pinborg, Anja ^b,c   Jensen, Peter ^b   Knudsen, Gitte M ^b   Frokjaer, Vibe G ^b   Siebner, Hartwig R ^a,c  

^a HVIDOVRE HOSPITAL   (Denmark)

^b University of Copenhagen   (Denmark)

^c Mental Health Center Glostrup   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ESTRADIOL; GONADORELIN AGONIST; PLACEBO; PROGESTERONE; SEX HORMONE; TESTOSTERONE; GONADORELIN;

ADULT; AMYGDALOID NUCLEUS; ARTICLE; BRAIN FUNCTION; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATIONAL STUDY; DEPRESSION; DOUBLE BLIND PROCEDURE; ELECTROENCEPHALOGRAM; ESTRADIOL BLOOD LEVEL; FEMALE; FOLLICULAR PHASE; FOLLOW UP; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HAMILTON DEPRESSION RATING SCALE; HUMAN; MOOD DISORDER; NERVE POTENTIAL; PRIORITY JOURNAL; PROGESTERONE BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL; REWARD; TESTOSTERONE BLOOD LEVEL; AGONISTS; AMYGDALA; BLOOD; BRAIN CORTEX; BRAIN MAPPING; DECISION MAKING; DRUG EFFECTS; GAMBLING; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOPHYSIOLOGY; PHYSIOLOGY; RISK; YOUNG ADULT;

ADULT; AMYGDALA; BRAIN MAPPING; CEREBRAL CORTEX; CHOICE BEHAVIOR; DEPRESSION; DOUBLE-BLIND METHOD; ESTRADIOL; FEMALE; GAMBLING; GONADAL STEROID HORMONES; GONADOTROPIN-RELEASING HORMONE; HUMANS; MAGNETIC RESONANCE IMAGING; PROGESTERONE; REWARD; RISK; TESTOSTERONE; YOUNG ADULT;

EID: 84957439734     PISSN: 0893133X     EISSN: 1740634X     Source Type: Journal    
DOI: 10.1038/npp.2015.236     Document Type: Article

References (44)

1. Amanatkar HR, Chibnall JT, Seo B-W, Manepalli JN, Grossberg GT (2014). Impact of exogenous testosterone on mood: A systematic review and meta-Analysis of randomized placebo-controlled trials. Ann Clin Psychiatry 26: 19-32.
2. Barth C, Villringer A, Sacher J (2015). Sex hormones affect neurotransmitters and shape the adult female brain during hormonal transition periods. Front Neurosci 9: 37.
3. Bayer J, Bandurski P, Sommer T (2013). Differential modulation of activity related to the anticipation of monetary gains and losses across the menstrual cycle. Eur J Neurosci 38: 3519-3526.
4. Bayer J, Schultz H, Gamer M, Sommer T (2014). Menstrual-cycle dependent fluctuations in ovarian hormones affect emotional memory. Neurobiol Learn Mem 110: 55-63.
5. Biegon A, Kim SW, Alexoff DL, Jayne M, Carter P, Hubbard B et al (2010). Unique distribution of aromatase in the human brain: in vivo studies with PET and [N-methyl-11C]vorozole. Synapse 64: 801-807.
6. Brummelte S, Galea LA (2010). Depression during pregnancy and postpartum: contribution of stress and ovarian hormones. Prog Neuropsychopharmacol Biol Psychiatry 34: 766-776.
7. Clark DA, Beck AT, Beck JS (1994). Symptom differences in major depression, dysthymia, panic disorder, and generalized anxiety disorder. Am J Psychiatry 151: 205-209.
8. Clark L, Bechara A, Damasio H, Aitken MR, Sahakian BJ, Robbins TW (2008). Differential effects of insular and ventromedial prefrontal cortex lesions on risky decision-making. Brain 131: 1311-1322.
9. Critchley HD, Mathias CJ, Dolan RJ (2001). Neural activity in the human brain relating to uncertainty and arousal during anticipation. Neuron 29: 537-545.
10. Dreher J-C, Schmidt PJ, Kohn P, Furman D, Rubinow D, Berman KF (2007). Menstrual cycle phase modulates reward-related neural function in women. Proc Natl Acad Sci USA 104: 2465-2470.
11. Fitzgerald PB, Laird AR, Maller J, Daskalakis ZJ (2008). A metaanalytic study of changes in brain activation in depression. Hum Brain Mapp 29: 683-695.
12. Freeman EW, Sammel MD, Lin H, Nelson DB (2006). Associations of hormones and menopausal status with depressed mood in women with no history of depression. Arch Gen Psychiatry 73: 375-382.
13. Freeman EW, Sammel MD, Liu L, Gracia CR, Nelson DB, Hollander L (2004). Hormones and menopausal status as predictors of depression in women in transition to menopause. Arch Gen Psychiatry 61: 62-70.
14. Frokjaer VG, Pinborg A, Holst KK, Overgaard A, Henningsson S, Heede M et al (2015). Role of serotonin transporter changes in depressive responses to sex-steroid hormone manipulation: A positron emission tomography study. Biol Psychiatry (e-pub ahead of print 27 April 2015).
15. Fu CHY, Williams SCR, Cleare AJ, Brammer MJ, Walsh ND, Kim J et al (2004). Attenuation of the neural response to sad faces in major depression by antidepressant treatment: A prospective, event-related functional magnetic resonance imaging study. Arch Gen Psychiatry 61: 877-889.
16. Gingnell M, Morell A, Bannbers E, Wikström J, Sundström Poromaa I (2012). Menstrual cycle effects on amygdala reactivity to emotional stimulation in premenstrual dysphoric disorder. Horm Behav 62: 400-406.
17. Goldstein JM, Jerram M, Poldrack R, Ahern T, Kennedy DN, Seidman LJ et al (2005). Hormonal cycle modulates arousal circuitry in women using functional magnetic resonance imaging. J Neurosci 25: 9309-9316.
18. Gottfried JA, ODoherty J, Dolan RJ (2003). Encoding predictive reward value in human amygdala and orbitofrontal cortex. Science 301: 1104-1107.
19. Hamilton M (1980). Rating depressive patients. J Clin Psychiatry 41: 21-24.
20. Höfer P, Lanzenberger R, Kasper S (2013). Testosterone in the brain: neuroimaging findings and the potential role for neuropsychopharmacology. Eur Neuropsychopharmacol 23: 79-88.
21. Holland PC, Gallagher M (2004). Amygdala-frontal interactions and reward expectancy. Curr Opin Neurobiol 14: 148-155.
22. Keedwell PA, Andrew C, Williams SC, Brammer MJ, Phillips ML (2005). The neural correlates of anhedonia in major depressive disorder. Biol Psychiatry 58: 843-853.
23. Kuhnen CM, Knutson B (2005). The neural basis of financial risk taking. Neuron 47: 763-770.
24. Leppänen JM (2006). Emotional information processing in mood disorders: A review of behavioral and neuroimaging findings. Curr Opin Psychiatry 19: 34-39.
25. Macoveanu J, Rowe JB, Hornboll B, Elliott R, Paulson OB, Knudsen GM et al (2013a). Playing it safe but losing anyway-Serotonergic signaling of negative outcomes in dorsomedial prefrontal cortex in the context of risk-Aversion. Eur Neuropsychopharmacol 23: 919-930.
26. Macoveanu J, Rowe JB, Hornboll B, Elliott R, Paulson OB, Knudsen GM et al (2013b). Serotonin 2 A receptors contribute to the regulation of risk-Averse decisions. Neuroimage 83: 35-44.
27. Maldjian JA, Laurienti PJ, Kraft RA, Burdette JH (2003). An automated method for neuroanatomic and cytoarchitectonic atlas-based interrogation of fMRI data sets. Neuroimage 19: 1233-1239.
28. Munk-Olsen T, Laursen TM, Pedersen CB, Mors O, Mortensen PB (2006). New parents and mental disorders: A population-based register study. JAMA 296: 2582-2589.
29. Murray EA (2007). The amygdala, reward and emotion. Trends Cogn Sci 11: 489-497.
30. ODoherty JP (2004). Reward representations and reward-related learning in the human brain: insights from neuroimaging. Curr Opin Neurobiol 14: 769-776.
31. Ossewaarde L, Hermans EJ, van Wingen GA, Kooijman SC, Johansson I-M, Bäckström T et al (2010). Neural mechanisms underlying changes in stress-sensitivity across the menstrual cycle. Psychoneuroendocrinology 35: 47-55.
32. Oulis P, Masdrakis VG, Markianos M (2014). Testosterone and dehydroepiandrosterone sulfate in female anxious and nonanxious major depression. Int J Psychiatry Clin Pr 18: 21-24.
33. Peper JS, Koolschijn PC, Crone EA (2013). Development of risk taking: Contributions from adolescent testosterone and the orbito-frontal cortex. J Cogn Neurosci 25: 2141-2150.
34. Preuschoff K, Quartz SR, Bossaerts P (2008). Human insula activation reflects risk prediction errors as well as risk. J Neurosci 28: 2745-2752.
35. Sliz D, Hayley S (2012). Major depressive disorder and alterations in insular cortical activity: A review of current functional magnetic imaging research. Front Hum Neurosci 6: 323.
36. Snaith P (1993). Anhedonia: A neglected symptom of psychopathology. Psychol Med 23: 957-966.
37. Studer B, Apergis-Schoute AM, Robbins TW, Clark L (2012). What are the odds? The neural correlates of active choice during gambling. Front Neurosci 6: 46.
38. Stuhrmann A, Dohm K, Kugel H, Zwanzger P, Redlich R, Grotegerd D et al (2013). Mood-congruent amygdala responses to subliminally presented facial expressions in major depression: Associations with anhedonia. J Psychiatry Neurosci 38: 249-258.
39. Toffoletto S, Lanzenberger R, Gingnell M, Sundström-Poromaa I, Comasco E (2014). Emotional and cognitive functional imaging of estrogen and progesterone effects in the female human brain: A systematic review. Psychoneuroendocrinology 50C: 28-52.
40. Tzourio-Mazoyer N, Landeau B, Papathanassiou D, Crivello F, Etard O, Delcroix N et al (2002). Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain. Neuroimage 15: 273-289.
41. Victor TA, Furey ML, Fromm SJ, Ohman A, Drevets WC (2010). Relationship between amygdala responses to masked faces and mood state and treatment in major depressive disorder. Arch Gen Psychiatry 67: 1128-1138.
42. Vrieze E, Pizzagalli DA, Demyttenaere K, Hompes T, Sienaert P, de Boer P et al (2013). Reduced reward learning predicts outcome in major depressive disorder. Biol Psychiatry 73: 639-645.
43. van Wingen G, Mattern C, Verkes RJ, Buitelaar J, Fernández G (2010). Testosterone reduces amygdala-orbitofrontal cortex coupling. Psychoneuroendocrinology 35: 105-113.
44. Zarrouf FA, Artz S, Griffith J, Sirbu C, Kommor M (2009). Testosterone and depression: systematic review and metaanalysis. J Psychiatr Pr 15: 289-305.