Unique distribution of aromatase in the human brain: In vivo studies with PET and [N-methyl-11C]vorozole

Synapse

Volumn 64, Issue 11, 2010, Pages 801-807

  Biegon, Anat ^a   Kim, Sung Won ^b   Alexoff, David L ^a   Jayne, Millard ^a   Carter, Pauline ^a   Hubbard, Barbara ^a   King, Payton ^a   Logan, Jean ^a   Muench, Lisa ^b   Pareto, Deborah ^c   Schlyer, David ^a   Shea, Colleen ^a   Telang, Frank ^a   Wang, Gene Jack ^a,d   Xu, Youwen ^a   Fowler, Joanna S ^a,d,e  

^a BROOKHAVEN NATIONAL LABORATORY   (United States)

^b NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

^c BIOMATERIALES Y NANOMEDICINA CIBER BBN   (Spain)

^d MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^e STONY BROOK UNIVERSITY   (United States)

Author keywords

Androgens; Estrogen; Imaging; Steroidogenesis; Testosterone

Indexed keywords

[N METHYL 11C]VOROZOLE; AROMATASE; AROMATASE INHIBITOR; LETROZOLE; UNCLASSIFIED DRUG;

ADULT; AMYGDALOID NUCLEUS; ARTICLE; BRAIN; BRAIN REGION; CEREBELLUM; DISTRIBUTION VOLUME; DRUG BLOOD LEVEL; DRUG SPECIFICITY; FEMALE; HUMAN; HUMAN EXPERIMENT; IN VIVO STUDY; KINETICS; MALE; MEDULLA OBLONGATA; MENSTRUAL CYCLE; METABOLITE; NORMAL HUMAN; NUCLEUS ACCUMBENS; OCCIPITAL CORTEX; PONS; POSITRON EMISSION TOMOGRAPHY; PREOPTIC AREA; PRIORITY JOURNAL; PUTAMEN; RADIATION DOSE DISTRIBUTION; TEMPORAL CORTEX; THALAMUS; WHITE MATTER;

ADULT; AROMATASE; AROMATASE INHIBITORS; BRAIN; BRAIN MAPPING; FEMALE; HUMANS; MALE; POSITRON-EMISSION TOMOGRAPHY; PROTEIN BINDING; RADIOPHARMACEUTICALS; TISSUE DISTRIBUTION; TRIAZOLES; YOUNG ADULT;

EID: 78149479235     PISSN: 08874476     EISSN: 10982396     Source Type: Journal    
DOI: 10.1002/syn.20791     Document Type: Article

References (42)

1. Abdelgadir SE, Resko JA, Ojeda SR, Lephart ED, McPhaul MJ, Roselli CE. 1994. Androgens regulate aromatase cytochrome P450 messenger ribonucleic acid in rat brain. Endocrinology 135: 395-401.
2. Alexoff DL, Shea C, Wolf AP, Fowler JS, King P, Gatley SJ, Schlyer DJ. 1995. Plasma input function determination for PET using a commercial laboratory robot. Nucl Med Biol 22: 893-904.
3. Biegon A, Kim, S-W, Logan J, Hooker JM, Muench L, Fowler JS. 2010. Nicotine blocks brain estrogen synthase (aromatase): In vivo PET studies in female baboons. Biol Psychiatry. Feb 24 Epub ahead of print.
4. Brailoiu E, Dun SL, Brailoiu GC, Mizuo K, Sklar LA, Oprea TI, Prossnitz ER, Dun NJ. 2007. Distribution and characterization of estrogen receptor G protein-coupled receptor 30 in the rat central nervous system. J Endocrinol 193: 311-321.
5. Budzar A, Howell A. 2001. Advances in aromatase inhibition: Clinical efficacy and tolerability in the treatment of breast cancer. Clin Cancer Res 7: 2620-2635.
6. Bulun SE, Simpson ER. 2008. Aromatase expression in women's cancers. Adv Exp Med Biol 630: 112-132.
7. Cohen MH, Johnson JR, Li N, Chen G, Pazdur R. 2002. Approval summary: Letrozole in the treatment of postmenopausal women with advanced breast cancer. Clin Cancer Res 8: 665-669.
8. Danielson PB. 2002. The cytochrome P450 superfamily: Biochemistry, evolution and drug metabolism in humans. Curr Drug Metab 3: 561-597.
9. Fedele L, Somigliana E, Frontino G, Benaglia L, Vigano P. 2008. New drugs in development for the treatment of endometriosis. Expert Opin Investig Drugs 17: 1187-1202.
10. Garcia-Segura LM. 2008. Aromatase in the brain: Not just for reproduction anymore J Neuroendocrinol 20: 705-712.
11. Golovine K, Schwerin M, Vanselow J. 2003. Three different promoters control expression of the aromatase cytochrome p450 gene (cyp19) in mouse gonads and brain. Biol Reprod 68: 978-984.
12. Gunn RN, Gunn SR, Cunningham VJ. 2001. Positron emission tomography compartmental models. J Cereb Blood Flow Metab 21: 635-652.
13. Hartgens F, Kuipers H. 2004. Effects of androgenic-anabolic steroids in athletes. Sports Med 34: 513-554.
14. Hiltunen M, Iivonen S, Soininen H. 2006. Aromatase enzyme and Alzheimer's disease. Minerva Endocrinol 31: 61-73.
15. Innis RB, Cunningham VJ, Delforge J, Fujita M, Giedde A, Gunn RN, Holden J, Houle S, Huang SC, Ichise M, Lida H, Ito H, Kimura Y, Koeppe RA, Knudsen GM, Knuuti J, Lammertsma AA, Laruelle M, Logan J, Maguire RP, Mintun MA, Morris ED, Parsey R, Price JC, Slifstein M, Sossi V, Suhara T, Votaw JR, Wong DF, Carson RE. 2007. Consensus nomenclature for in vivo imaging of reversibly binding radioligands. J Cereb Blood Flow Metab 27: 1533-1539.
16. Ishunina TA, van Beurden D, van der Meulen G, Unmehopa UA, Hol EM, Huitinga I, Swaab DF. 2005. Diminished aromatase immunoreactivity in the hypothalamus, but not in the basal forebrain nuclei in Alzheimer's disease. Neurobiol Aging 26: 173-194.
17. Iveson TJ, Smith IE, Ahern J, Smithers DA, Trunet PF, Dowsett M. 1993. Phase I study of the oral nonsteroidal aromatase inhibitor CGS 20267 in healthy postmenopausal women. J Clin Endocrinol Metab 77: 324-331.
18. Jones ME, Boon WC, Proietto J, Simpson ER. 2006. Of mice and men: The evolving phenotype of aromatase deficiency. Trends Endocrinol Metab 17: 55-64.
19. Kil KE, Biegon A, Ding YS, Fischer A, Ferrieri RA, Kim SW, Pareto D, Schueller MJ, Fowler JS. 2009. Synthesis and PET studies of [(11)C-cyano]letrozole (Femara), an aromatase inhibitor drug. Nucl Med Biol 36: 215-223.
20. Kim SW, Biegon A, Katsamanis Z, Erlich CW, Hooker JM, Shea C, Muench L, Xu Y, King P, Alexoff D, Fowler JS. 2009. Reinvestigation of the synthesis and evaluation of [N-methyl-11C]vorozole, a radiotracer targeting cytochrome P450 aromatase. Nucl Med Biol 36: 323-334.
21. Lidström P, Bonasera TA, Kirilovas D, Lindblom B, Lu L, Bergström E, Bergström M, Westlin J-E, Långström B. 1998. Synthesis, in vivo rhesus monkey biodistribution and in vitro evaluation of a 11C-labelled potent aromatase inhibitor: [N-methyl-11C]vorozole. Nucl Med Biol 25: 497-501.
22. Liu T, Xu D, Ashe J, Bushara K. 2008. Specificity of inferior olive response to stimulus timing. J Neurophysiol 100: 1557-1561.
23. Logan J. 2003. A review of graphical methods for tracer studies and strategies to reduce bias. Nucl Med Biol 30: 833-844.
24. Miceli V, Cervello M, Azzolina A, Montalto G, Calabrò M, Carruba G. 2009. Aromatase and amphiregulin are correspondingly expressed in human liver cancer cells. Ann N Y Acad Sci 1155: 252-256.
25. Österlund MK, Gustafsson JA, Keller E, Hurd YL. 2000. Estrogen receptor beta (ERbeta) messenger ribonucleic acid (mRNA) expression within the human forebrain: Distinct distribution pattern to ERalpha mRNA. J Clin Endocrinol Metab 85: 3840-3846.
26. Österlund MK, Yasmin L, Hurd YL. 2001. Estrogen receptors in the human forebrain and the relation to neuropsychiatric disorders. Prog Neurobiol 64: 251-267.
27. Press W, Flannery B, Teukolsky S, Vetterline W. 1990. Numerical recipes in C: The art of scientific computing. Cambridge: Cambridge University Press.
28. Qiu J, Ronnekleiv OK, Kelly MJ. 2008. Modulation of hypothalamic neuronal activity through a novel G-protein-coupled estrogen membrane receptor. Steroids 73: 985-991.
29. Roselli CE. 2007. Brain aromatase: Roles in reproduction and neuroprotection. J Steroid Biochem Mol Biol 106: 143-150.
30. Roselli CE, Resko JA. 2001. Cytochrome P450 aromatase (CYP19) in the non-human primate brain: Distribution, regulation, and functional significance. J Steroid Biochem Mol Biol 79: 247-253.
31. Roselli CE, Ellinwood WE, Resko JA. 1984. Regulation of brain aromatase activity in rats. Endocrinology 114: 192-200.
32. Roselli CE, Klosterman S, Resko JA. 2001. Anatomic relationships between aromatase and androgen receptor mRNA expression in the hypothalamus and amygdala of adult male cynomolgus monkeys. J Comp Neurol 439: 208-223.
33. Sasano H, Takahashi K, Satoh F, Nagura H, Harada N. 1998. Aromatase in the human central nervous system. Clin Endocrinol 48: 325-329.
34. Saldahana CJ, Duncan KA, Walters BJ. 2009. Neuroprotective actions of brain aromatase. Front Neuroendocrinol 30: 106-118.
35. Simpson ER, Clyne C, Rubin G, Boon WC, Robertson K, Britt K, Speed C, Jones M. 2002. Aromatase-A brief overview. Annu Rev Physiol 64: 93-127.
36. Steckelbroeck S, Heidrich DD, Stoffel-Wagner B, Hans VHJ, Schramm J, Bidlingmaier F, Klingmüller D. 1999. Characterization of aromatase cytochrome P450 activity in the human temporal lobe. J Clin Endocrinol Metab 84: 2795-2801.
37. Stoffel-Wagner B, Watzka M, Schramm J, Bidlingmaier F Klingmüller D. 1999. Expression of CYP19 (aromatase) mRNA in different areas of the human brain. J Steroid Biochem Mol Biol 70: 237-241.
38. Takahashi K, Bergström M, Frändberg P, Vesström E-L, Watanabe Y, Långström B. 2006. Imaging of aromatase distribution in rat and rhesus monkey brains with [11C]vorozole. Nucl Med Biol 33: 599-605.
39. Toran-Allerand CD. 2009. Minireview: A plethora of estrogen receptors in the brain: Where will it end? Endocrinology 145: 1069-1074.
40. Vanden Bossche H, Willemsens G, Roels I, Bellens D, Moereels H, Coene M-C, Le Jeune L, Lauwers W, Janssen PAJ. 1990. R76713 and enantiomers: Selective nonsteroidal inhibitors of the cytochrome P450-dependent oestrogen synthesis. Biochem Pharmacol 40: 1707-1718.
41. Ward R, Arend I. 2007. An object-based frame of reference within the human pulvinar. Brain 130: 2462-2469.
42. Wu MV, Manoli DS, Fraser EJ, Coats JK, Tollkuhn J, Honda S, Harada N, Shah NM. 2009. Estrogen masculinizes neural pathways and sex-specific behaviors. Cell 139: 61-72.