Pilot randomized trials in pediatric critical care: A systematic review

Pediatric Critical Care Medicine

Volumn 16, Issue 7, 2015, Pages e239-e244

  Duffett, Mark ^a   Choong, Karen ^a   Hartling, Lisa ^b   Menon, Kusum ^c   Thabane, Lehana ^a   Cook, Deborah J ^a  

^a MCMASTER UNIVERSITY   (Canada)

^b UNIVERSITY OF ALBERTA   (Canada)

^c UNIVERSITY OF OTTAWA   (Canada)

Author keywords

pediatric critical care; pediatric intensive care; pilot trial; randomized controlled trial; systematic review

Indexed keywords

CEFEPIME; CEFTAZIDIME; CLONIDINE; EXENDIN 4; FENTANYL; FLUCONAZOLE; GAMMA LINOLENIC ACID; GLUTAMINE; HETASTARCH; HYDROCORTISONE; ICOSAPENTAENOIC ACID; ILOPROST; ITRACONAZOLE; LEVOSIMENDAN; MAGNESIUM SULFATE; MILRINONE; NESIRITIDE; NITRIC OXIDE; PALIVIZUMAB; PLACEBO; PROBIOTIC AGENT; REMIFENTANIL; RINGER LACTATE SOLUTION; SURFACTANT; VASOPRESSIN;

ANALGESIA; BRONCHIOLITIS; CANDIDEMIA; CHILD; CONGESTIVE CARDIOMYOPATHY; DATA BASE; DENGUE; HEART ARREST; HUMAN; HYPERGLYCEMIA; HYPOTENSION; HYPOXEMIA; INFECTION; INTENSIVE CARE; INTRACRANIAL HYPERTENSION; PEDIATRICS; PILOT STUDY; PRIORITY JOURNAL; PUBLICATION; PULMONARY HYPERTENSION; RANDOMIZED CONTROLLED TRIAL (TOPIC); RESPIRATORY FAILURE; REVIEW; SEDATION; SEPTIC SHOCK; SHOCK; SYSTEMATIC REVIEW; TRAUMATIC BRAIN INJURY; VENTILATOR ASSOCIATED PNEUMONIA; PROCEDURES;

CHILD; CRITICAL CARE; HUMANS; PEDIATRICS; PILOT PROJECTS; RANDOMIZED CONTROLLED TRIALS AS TOPIC;

EID: 84957083998     PISSN: 15297535     EISSN: 19473893     Source Type: Journal    
DOI: 10.1097/PCC.0000000000000475     Document Type: Review

References (16)

1. Thabane L, Ma J, Chu R, A tutorial on pilot studies: The what, why and how. BMC Med Res Methodol 2010 10 1
2. Arnold DM, Burns KE, Adhikari NK, McMaster Critical Care Interest Group The design and interpretation of pilot trials in clinical research in critical care. Crit Care Med 2009 37 S69 S74
3. Lancaster GA, Dodd S, Williamson PR, Design and analysis of pilot studies: Recommendations for good practice. J Eval Clin Pract 2004 10 307 312
4. Craig P, Dieppe P, Macintyre S, Medical Research Council Guidance Developing and evaluating complex interventions: The new Medical Research Council guidance. BMJ 2008 337 a1655
5. Duffett M, Choong K, Hartling L, Randomized controlled trials in pediatric critical care: A scoping review. Crit Care 2013 17 R256
6. Arain M, Campbell MJ, Cooper CL, What is a pilot or feasibility study? A review of current practice and editorial policy. BMC Med Res Methodol 2010 10 67
7. Shanyinde M, Pickering RM, Weatherall M, Questions asked and answered in pilot and feasibility randomized controlled trials. BMC Med Res Methodol 2011 11 117
8. Higgins J, Altman DG, Higgins J, Green S, The Cochrane Collaboration Assessing risk of bias in included studies. Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 2011 187 241. In
9. Adelson PD, Ragheb J, Kanev P, Phase II clinical trial of moderate hypothermia after severe traumatic brain injury in children. Neurosurgery 2005 56 740 754
10. Pemberton VL, Browning B, Webster A, Therapeutic hypothermia after pediatric cardiac arrest trials: The vanguard phase experience and implications for other trials. Pediatr Crit Care Med 2013 14 19 26
11. Luchetti M, Casiraghi G, Valsecchi R, Porcine-derived surfactant treatment of severe bronchiolitis. Acta Anaesthesiol Scand 1998 42 805 810
12. Verlaat CW, Heesen GP, Vet NJ, Randomized controlled trial of daily interruption of sedatives in critically ill children. Paediatr Anaesth 2014 24 151 156
13. Adelson PD, Wisniewski SR, Beca J, Paediatric Traumatic Brain Injury Consortium Comparison of hypothermia and normothermia after severe traumatic brain injury in children (Cool Kids): A phase 3, randomised controlled trial. Lancet Neurol 2013 12 546 553
14. Luchetti M, Ferrero F, Gallini C, Multicenter, randomized, controlled study of porcine surfactant in severe respiratory syncytial virus-induced respiratory failure. Pediatr Crit Care Med 2002 3 261 268
15. Moore CG, Carter RE, Nietert PJ, Recommendations for planning pilot studies in clinical and translational research. Clin Transl Sci 2011 4 332 337
16. Billingham SA, Whitehead AL, Julious SA, An audit of sample sizes for pilot and feasibility trials being undertaken in the United Kingdom registered in the United Kingdom Clinical Research Network database. BMC Med Res Methodol 2013 13 104