An audit of sample sizes for pilot and feasibility trials being undertaken in the United Kingdom registered in the United Kingdom Clinical Research Network database

BMC Medical Research Methodology

Volumn 13, Issue 1, 2013, Pages

  Billingham, Sophie Am ^a   Whitehead, Amy L ^b   Julious, Steven A ^b  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

Feasibility; Pilot; Sample size; UK

Indexed keywords

FACTUAL DATABASE; FEASIBILITY STUDY; HUMAN; MEDICAL RESEARCH; PILOT STUDY; RANDOMIZED CONTROLLED TRIAL (TOPIC); SAMPLE SIZE; UNITED KINGDOM; ARTICLE;

BIOMEDICAL RESEARCH; DATABASES, FACTUAL; FEASIBILITY STUDIES; GREAT BRITAIN; HUMANS; PILOT PROJECTS; RANDOMIZED CONTROLLED TRIALS AS TOPIC; SAMPLE SIZE;

EID: 84883288869     PISSN: None     EISSN: 14712288     Source Type: Journal    
DOI: 10.1186/1471-2288-13-104     Document Type: Article

References (18)

1. NETSCC definition of pilot and feasibility studies [ http://www.netscc. ac.uk/glossary/ (date last accessed, 16 August 2013)]
2. What is a pilot or feasibility study? a review of current practice and editorial policy. Arain M, Campbell MJ, Cooper CL, Lancaster GA, BMC Med Res Methodol 2010 10 67 http://www.biomedcentral.com/1471-2288/10/67 (date last accessed 19 August 2013) 10.1186/1471-2288-10-67 20637084
3. Optimal sample sizes for phase II clinical trials and pilot studies. Stallard N, Stat Med 2012 31 1031 1042 10.1002/sim.4357 22052407
4. A tutorial on pilot studies: the what, why and how. Thabane L, Ma J, Chu R, Cheng J, Ismaila A, Rios LP, et al. BMC Med Res Methodol 2010 10 1 http://www.biomedcentral.com/1471-2288/10/1 (date last accessed 19 August 2013) 10.1186/1471-2288-10-1 20053272
5. The potential uses of pilot work. Prescott PA, Soeken KL, Nurs Res 1989 38 60 62 10.1097/00006199-198901000-00015 2911515
6. Considerations in determining sample size for pilot studies. Hertzog MA, Res Nurs Health 2008 31 180 191 10.1002/nur.20247 18183564
7. Sample sizes for estimation in clinical research. Julious SA, Patterson SD, Pharm Stat 2004 3 213 215 10.1002/pst.125 (Pubitemid 39654842)
8. On the use of a pilot sample for sample size determination. Browne RH, Stat Med 1995 14 1933 1940 10.1002/sim.4780141709 8532986
9. Sample size of 12 per group rule of thumb for a pilot study. Julious SA, Pharm Stat 2005 4 287 291 10.1002/pst.185 (Pubitemid 43013602)
10. The size of a pilot study for a clinical trial should be calculated in relation to considerations of precision and efficiency. Sim J, Lewis M, J Clin Epidemiol 2012 65 301 308 10.1016/j.jclinepi.2011.07.011 22169081
11. Statistics and ethics in medical research lll: How large a sample? Altman DG, Br Med J 1980 281 1336 1338 10.1136/bmj.281.6251.1336 7437789 (Pubitemid 10029868)
12. Design and analysis of pilot studies: recommendations for good practice. Lancaster GA, Dodd S, Williamson PR, J Eval Clin Pract 2002 10 2 307 312
13. UKCRN, http://public.ukcrn.org.uk/search/ (date last accessed, 20 March 2013)
14. NIHR, NIHR clinical research network portfolio 2013 [cited 2013 15 March]; Available from: http://www.crncc.nihr.ac.uk/about-us/processes/ portfolio/portfolio, [date last accessed 20th March 2013]
15. SPSS Inc, Released 2009. PASW statistics for windows, version 18.0 Chicago: SPSS Inc 2009
16. Recommendations for planning pilot studies in clinical and translational research. Moore CG, Carter RE, Nietert PJ, Stewart PW, Clin Transl Sci 2011 4 5 332 337 10.1111/j.1752-8062.2011.00347.x 22029804
17. Outcome reporting among drug trials registered in ClinicalTrials.gov. Bourgeois FT, Murthy S, Mandl KD, Ann Intern Med 2010 153 158 166 10.7326/0003-4819-153-3-201008030-00006 20679560
18. Sample sizes for dichotomous, ordered categorical and continuous outcomes in two group comparisons. Campbell MJ, Julious SA, Altman DG, Br Med J 1995 311 1145 1148 With Erratrum 1996, 312, 96 10.1136/bmj.311.7013.1145