Randomized controlled trial of daily interruption of sedatives in critically ill children

Paediatric Anaesthesia

Volumn 24, Issue 2, 2014, Pages 151-156

  Verlaat, Carin W M ^a   Heesen, Ger P ^a   Vet, Nienke J ^b   De Hoog, Matthijs ^b   Van Der Hoeven, Johannes G ^a   Kox, Matthijs ^a   Pickkers, Peter ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b SOPHIA CHILDREN S HOSPITAL   (Netherlands)

Author keywords

children; COMFORT score; critical illness; interruption; sedatives

Indexed keywords

MIDAZOLAM; MORPHINE; HYPNOTIC SEDATIVE AGENT; NARCOTIC ANALGESIC AGENT;

ARTICLE; ARTIFICIAL VENTILATION; BOLUS INJECTION; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; CRITICAL ILLNESS; CRITICALLY ILL PATIENT; DRUG USE; EXTUBATION; FEASIBILITY STUDY; FEMALE; HOSPITALIZED CHILD; HUMAN; INFANT; INTENSIVE CARE; INTENSIVE CARE UNIT; LENGTH OF STAY; MALE; NEWBORN; OPEN STUDY; PEDIATRIC ANESTHESIA; PRESCHOOL CHILD; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; SEDATION; TEACHING HOSPITAL; TERTIARY HEALTH CARE; TREATMENT DURATION; TREATMENT WITHDRAWAL; BIOASSAY; DRUG UTILIZATION; KAPLAN MEIER METHOD; RESPIRATION CONTROL; SURVIVAL;

AIRWAY EXTUBATION; AIRWAY MANAGEMENT; ANALGESICS, OPIOID; CHILD; CHILD, PRESCHOOL; CRITICAL ILLNESS; DRUG UTILIZATION; ENDPOINT DETERMINATION; FEASIBILITY STUDIES; FEMALE; HUMANS; HYPNOTICS AND SEDATIVES; INFANT; INFANT, NEWBORN; KAPLAN-MEIER ESTIMATE; LENGTH OF STAY; MALE; MIDAZOLAM; MORPHINE; PROSPECTIVE STUDIES; RESPIRATION, ARTIFICIAL; SURVIVAL ANALYSIS;

EID: 84891827944     PISSN: 11555645     EISSN: 14609592     Source Type: Journal    
DOI: 10.1111/pan.12245     Document Type: Article

References (19)

1. Hartman ME, McCrory DC, Schulman SR,. Efficacy of sedation regimens to facilitate mechanical ventilation in the pediatric intensive care unit: a systematic review. Pediatr Crit Care Med 2009; 10: 246-255.
2. Katz R, Kelly HW,. Pharmacokinetics of continuous infusions of fentanyl in critically ill children. Crit Care Med 1993; 21: 995-1000.
3. Hughes J, Gill AM, Mulhearn H, et al,. Steady-state plasma concentrations of midazolam in critically ill infants and children. Ann Pharmacother 1996; 30: 27-30.
4. Tobias JD,. Tolerance, withdrawal, and physical dependency after long-term sedation and analgesia of children in the pediatric intensive care unit. Crit Care Med 2000; 28: 2122-2132.
5. Kress JP, Pohlman AS, O'Connor MF, et al,. Daily interruption of sedative infusions in critically ill patients undergoing mechanical ventilation. N Engl J Med 2000; 342: 1471-1477.
6. Schweickert WD, Gehlbach BK, Pohlman AS, et al,. Daily interruption of sedative infusions and complications of critical illness in mechanically ventilated patients. Crit Care Med 2004; 32: 1272-1276.
7. Kress JP, Gehlbach B, Lacy M, et al,. The long-term psychological effects of daily sedative interruption on critically ill patients. Am J Respir Crit Care Med 2003; 168: 1457-1461.
8. Little LA, Koenig JC Jr, Newth CJ,. Factors affecting accidental extubations in neonatal and pediatric intensive care patients. Crit Care Med 1990; 18: 163-165.
9. de Wildt SN, de Hoog M, Vinks AA, et al,. Population pharmacokinetics and metabolism of midazolam in pediatric intensive care patients. Crit Care Med 2003; 31: 1952-1958.
10. Gupta K, Gupta VK, Jayashree M, et al,. Randomized controlled trial of interrupted versus continuous sedative infusions in ventilated children. Pediatr Crit Care Med 2012; 13: 131-135.
11. Vet NJ, Verlaat CW, de Wildt SN, et al,. Daily interruption of sedation in critically ill children. Pediatr Crit Care Med 2012; 13: 122. author reply 122-123.
12. Ambuel B, Hamlett KW, Marx CM, et al,. Assessing distress in pediatric intensive care environments: the COMFORT scale. J Pediatr Psychol 1992; 17: 95-109.
13. Carnevale FA, Razack S,. An item analysis of the COMFORT scale in a pediatric intensive care unit. Pediatr Crit Care Med 2002; 3: 177-180.
14. Ista E, van Dijk M, Tibboel D, et al,. Assessment of sedation levels in pediatric intensive care patients can be improved by using the COMFORT "behavior" scale. Pediatr Crit Care Med 2005; 6: 58-63.
15. Playfor S, Jenkins I, Boyles C, et al,. Consensus guidelines on sedation and analgesia in critically ill children. Intensive Care Med 2006; 32: 1125-1136.
16. Mehta S, Burry L, Cook D, et al,. Daily sedation interruption in mechanically ventilated critically ill patients cared for with a sedation protocol: a randomized controlled trial. JAMA 2012; 308: 1985-1992.
17. Wildschut ED, Hanekamp MN, Vet NJ, et al,. Feasibility of sedation and analgesia interruption following cannulation in neonates on extracorporeal membrane oxygenation. Intensive Care Med 2010; 36: 1587-1591.
18. de Wildt SN, de Hoog M, Vinks AA, et al,. Pharmacodynamics of midazolam in pediatric intensive care patients. Ther Drug Monit 2005; 27: 98-102.
19. Vet NJ, de Hoog M, Tibboel D, et al,. The effect of critical illness and inflammation on midazolam therapy in children. Pediatr Crit Care Med 2012; 13: e48-e50.