Stimulation of adenosine A2A receptors reduces intracellular cholesterol accumulation and rescues mitochondrial abnormalities in human neural cell models of Niemann-Pick C1

Neuropharmacology

Volumn 103, Issue , 2016, Pages 155-162

  Ferrante, A ^a   De Nuccio, C ^a   Pepponi, R ^a   Visentin, S ^a   Martire, A ^a   Bernardo, A ^a   Minghetti, L ^a   Popoli, P ^a  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

Author keywords

Adenosine A2A receptor; Cholesterol; Mitochondrial membrane potential; Neuroblastoma cell line; Niemann Pick C; Oligodendroglial cell line

Indexed keywords

2 [4 (2 CARBOXYETHYL)PHENETHYLAMINO]ADENOSINE 5' (N ETHYLCARBOXAMIDE); 4 [2 [7 AMINO 2 (2 FURYL) 1,2,4 TRIAZOLO[2,3 A][1,3,5]TRIAZIN 5 YLAMINO]ETHYL]PHENOL; ADENOSINE A2A RECEPTOR; CALCIUM; CHOLESTEROL; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID; KT 5720; SMALL INTERFERING RNA; 2-(4-(2-CARBOXYETHYL)PHENETHYLAMINO)-5'-N-ETHYLCARBOXAMIDOADENOSINE; ADENOSINE; ADENOSINE A2 RECEPTOR AGONIST; CARRIER PROTEIN; MEMBRANE PROTEIN; NPC1 PROTEIN, HUMAN; PHENETHYLAMINE DERIVATIVE;

ARTICLE; CELL LEVEL; CELL LINE; CHOLESTEROL CELL LEVEL; DOWN REGULATION; DRUG EFFECT; EXCITATION AND STIMULATION; FIBROBLAST; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; NERVE CELL; NIEMANN PICK DISEASE; NPC1 CELL LINE; OLIGODENDROGLIA; PHENOTYPE; PRIORITY JOURNAL; RECEPTOR STIMULATION; SIGNAL TRANSDUCTION; ANALOGS AND DERIVATIVES; CELL MEMBRANE; GENETICS; METABOLISM; MITOCHONDRION; TUMOR CELL LINE;

ADENOSINE; ADENOSINE A2 RECEPTOR AGONISTS; CALCIUM; CARRIER PROTEINS; CELL LINE, TUMOR; CELL MEMBRANE; CHOLESTEROL; CYCLIC AMP-DEPENDENT PROTEIN KINASES; HUMANS; MEMBRANE GLYCOPROTEINS; MITOCHONDRIA; NEURONS; NIEMANN-PICK DISEASE, TYPE C; OLIGODENDROGLIA; PHENETHYLAMINES; RECEPTOR, ADENOSINE A2A;

EID: 84957071756     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2015.11.022     Document Type: Article

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