The stimulation of adenosine A2A receptors ameliorates the pathological phenotype of fibroblasts from Niemann-Pick type C patients

Journal of Neuroscience

Volumn 33, Issue 39, 2013, Pages 15388-15393

  Visentin, Sergio ^a   De Nuccio, Chiara ^a   Bernardo, Antonietta ^a   Pepponi, Rita ^a   Ferrante, Antonella ^a   Minghetti, Luisa ^a   Popoli, Patrizia ^a  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

2 [4 (2 CARBOXYETHYL) PHENETHYLAMINO] ADENOSINE 5' (N ETHYLCARBOXAMIDE); 2 [4 (2 CARBOXYETHYL)PHENETHYLAMINO]ADENOSINE 5' (N ETHYLCARBOXAMIDE); 4 [2 [7 AMINO 2 (2 FURYL) 1, 2, 4 TRIAZOLO [2, 3 A] [1, 3, 5] TRIAZIN 5 YLAMINO] ETHYL] PHENOL; ADENOSINE A2A RECEPTOR; CALCIUM; CHOLESTEROL; FILIPIN; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 2; SPHINGOLIPID; UNCLASSIFIED DRUG; 2-(4-(2-CARBOXYETHYL)PHENETHYLAMINO)-5'-N-ETHYLCARBOXAMIDOADENOSINE; 4 [2 [7 AMINO 2 (2 FURYL) 1,2,4 TRIAZOLO[2,3 A][1,3,5]TRIAZIN 5 YLAMINO]ETHYL]PHENOL; ADENOSINE; ADENOSINE A2 RECEPTOR AGONIST; ADENOSINE A2 RECEPTOR ANTAGONIST; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYTOCHROME C OXIDASE; MITOGEN ACTIVATED PROTEIN KINASE; PHENETHYLAMINE DERIVATIVE; TRIAZINE DERIVATIVE; TRIAZOLE DERIVATIVE; 2 (4 (2 CARBOXYETHYL)PHENETHYLAMINO) 5' N ETHYLCARBOXAMIDOADENOSINE; DRUG DERIVATIVE;

ARTICLE; CALCIUM SIGNALING; CONTROLLED STUDY; FIBROBLAST; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; LYSOSOME; MITOCHONDRIAL MEMBRANE POTENTIAL; NIEMANN PICK DISEASE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RESPIRATORY CHAIN; WESTERN BLOTTING; ANALOGS AND DERIVATIVES; CASE CONTROL STUDY; CELL LINE; DRUG EFFECTS; FEMALE; MALE; METABOLISM; MITOCHONDRION; PATHOLOGY; DRUG EFFECT;

ADENOSINE; ADENOSINE A2 RECEPTOR AGONISTS; ADENOSINE A2 RECEPTOR ANTAGONISTS; CALCIUM; CASE-CONTROL STUDIES; CELL LINE; CHOLESTEROL; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; ELECTRON TRANSPORT COMPLEX IV; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; FIBROBLASTS; HUMANS; LYSOSOMES; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; NIEMANN-PICK DISEASE, TYPE C; PHENETHYLAMINES; PHENOTYPE; RECEPTOR, ADENOSINE A2A; TRIAZINES; TRIAZOLES;

EID: 84884574720     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.0558-13.2013     Document Type: Article

References (24)

1. Adler J, Parmryd I (2010) Quantifying colocalization by correlation: the Pearson correlation coefficient is superior to the Mander's overlap coefficient. Cytometry A 77:733-742. CrossRef Medline
2. Benarroch EE (2008) Brain cholesterol metabolism and neurologic disease. Neurology 71:1368-1373. CrossRef Medline
3. Burbulla LF, Krüger R (2012) The use of primary human fibroblasts for monitoring mitochondrial phenotypes in the field of Parkinson's disease. J Vis Exp 68:pii 4228. CrossRef Medline
4. Carini R, Castino R, De Cesaris MG, Splendore R, Démoz M, Albano E, Isidoro C (2004) Preconditioning-induced cytoprotection in hepatocytes requires Ca(2+)-dependent exocytosis of lysosomes. J Cell Sci 117: 1065-1077. CrossRef Medline
5. Chang TY, Reid PC, Sugii S, Ohgami N, Cruz JC, Chang CC (2005) Niemann-Pick type C disease and intracellular cholesterol trafficking. J Biol Chem 280:20917-20920. CrossRef Medline
6. 2A receptor revisited: evidence for physical separation of two signaling cascades. J Biol Chem 283:9276-9288. CrossRef Medline
7. 2A receptors and brain injury: broad spectrum of neuroprotection, multifaceted actions and "fine tuning" modulation. Prog Neurobiol 83:310-331. CrossRef Medline
8. Christensen KA, Myers JT, Swanson JA (2002) pH-dependent regulation of lysosomal calcium in macrophages. J Cell Sci 115:599-607. Medline
9. Duchen MR, Surin A, Jacobson J (2003) Imaging mitochondrial function in intact cells. Methods Enzymol 361:353-389. CrossRef Medline
10. Fredholm BB, IJzerman AP, Jacobson KA, Linden J, Mü ller CE (2011) International union of basic and clinical pharmacology. LXXXI. Nomenclature and classification of adenosine receptors-an update. Pharmacol Rev 63:1-34. CrossRef Medline
11. Gévry NY, Lalli E, Sassone-Corsi P, Murphy BD (2003) Regulation of Niemann-Pick C1 gene expression by the 3'5'-cyclic adenosine monophosphate pathway in steroidogenic cells. Mol Endocrinol 17:704-715. CrossRef Medline
12. Karten B, Peake KB, Vance JE (2009) Mechanisms and consequences of impaired lipid trafficking in Niemann-Pick type C1-deficient mammalian cells. Biochim Biophys Acta 1791:659-670. CrossRef Medline
13. Klinger M, Freissmuth M, Nanoff C (2002) Adenosine receptors:Gproteinmediated signalling and the role of accessory proteins. Cell Signal 14:99-108. CrossRef Medline
14. Liu J, Lu W, Reigada D, Nguyen J, Laties AM, Mitchell CH (2008) Restoration of lysosomal pH in RPE cells from cultured human and ABCA4(-/-) mice: pharmacologic approaches and functional recovery. Invest Ophthalmol Vis Sci 49:772-780. CrossRef Medline
15. Lloyd-Evans E, Morgan AJ, He X, Smith DA, Elliot-Smith E, Sillence DJ, Churchill GC, Schuchman EH, Galione A, Platt FM (2008) Niemann- Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium. Nat Med 14:1247-1255. CrossRef Medline
16. Manson ME, Corey DA, White NM, Kelley TJ (2008) cAMP-mediated regulation of cholesterol accumulation in cystic fibrosis and Niemann-Pick type C cells. Am J Physiol Lung Cell Mol Physiol 295:L809-L819. CrossRef Medline
17. Patterson MC, Hendriksz CJ, Walterfang M, Sedel F, Vanier MT, Wijburg F, NP-C Guidelines Working Group (2012) Recommendations for the diagnosis and management of Niemann-Pick disease type C: an update. Mol Genet Metab 106:330-344. CrossRef Medline
18. 2A receptors: implication for therapeutics. Curr Pharm Des 14:1466-1467. CrossRef Medline
19. 2A receptor reduces, through a presynaptic mechanism, quinolinic-acid induced excitotoxicity: a possible relevance to neuroprotective interventions in neurodegenerative diseases of the striatum. J Neurosci 22: 1967-1975. Medline
20. Seidel MG, Klinger M, Freissmuth M, Höller C (1999) Activation of mitogen-activated protein kinase by the A(2A)-adenosine receptor via a rap1-dependent and via a p21(ras)-dependent pathway. J Biol Chem 274: 25833-25841. CrossRef Medline
21. Sévin M, Lesca G, Baumann N, Millat G, Lyon-Caen O, Vanier MT, Sedel F (2007) The adult form of Niemann-Pick disease type C. Brain 130:120-133. CrossRef Medline
22. 2+ stores in bovine corneal endothelium. Invest Ophthalmol Vis Sci 43: 2341-2350. Medline
23. Vanier MT, Millat G (2003) Niemann-Pick disease type C. Clin Genet 64: 269-281. CrossRef Medline
24. Yu W, Gong JS, Ko M, Garver WS, Yanagisawa K, Michikawa M (2005) Altered cholesterol metabolism in Niemann-Pick type C1 mouse brains affects mitochondrial function. J Biol Chem 280:11731-11739. CrossRef Medline