High-resolution accurate mass LC-MS in clinical toxicology

Applications of High-Resolution Mass Spectrometry in Drug Discovery and Development

Volumn , Issue , 2014, Pages 42-57

  Chindarkar, Nandkishor S ^a   Stone, Judy ^a   Warren, Eric C ^a   Fitzgerald, Robert L ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACCURATE MASS; CLINICAL TOXICOLOGIES; DRUG SCREENING; HIGH RESOLUTION; LC-MS/MS;

EID: 84957004282     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.4155/EBO.13.423     Document Type: Chapter

References (22)

1. Ojanpera I, Kolmonen M, Pelander A. Current use of high-resolution mass spectrometry in drug screening relevant to clinical and forensic toxicology and doping control. Anal. Bioanal. Chem. 403, 1203-1220 (2012).
2. Wu AH, Gerona R, Armenian P et al. Role of liquid chromatography-high- resolution mass spectrometry (LC-HR/MS) in clinical toxicology. Clin. Toxicol. (Phila.) 50, 733-742 (2012).
3. Pelander A, Decker P, Baessmann C et al. Evaluation of a high resolving power time- of-flight mass spectrometer for drug analysis in terms of resolving power and acquisition rate. J. Am. Soc. Mass Spectrom. 22, 379-385 (2011).
4. Dawson JH, Guilhaust M. Orthogonal-acceleration time-of-flight mass spectrometer. Rapid Commun. Mass Spectrom. 3, 155-159 (1989).
5. Hu Q, Noll RJ, Li H et al. The Orbitrap: a new mass spectrometer. J. Mass Spectrom. 40, 430-443 (2005).
6. Gergov M, Boucher B, Ojanpera I et al. Toxicological screening of urine for drugs by liquid chromatography/ time-of-flight mass spectrometry with automated target library search based on elemental formulas. Rapid Commun. Mass Spectrom. 15, 521-526 (2001).
7. Mortier KA, Maudens KE, Lambert WE et al. Simultaneous, quantitative determination of opiates, amphetamines, cocaine and benzoylecgonine in oral fluid by liquid chromatography quadrupole-time-of-flight mass spectrometry. J. Chromatogr. B Anal. Technol. Biomed. Life Sci. 779, 321-330 (2002).
8. Pelander A, Ojanpera I, Laks S et al. Toxicological screening with formula-based metabolite identification by liquid chromatography/time- of-flight mass spectrometry. Anal. Chem. 75, 5710-5718 (2003).
9. Zhang H, Heinig K, Henion J. Atmospheric pressure ionization time-of-flight mass spectrometry coupled with fast liquid chromatography for quantitation and accurate mass measurement of five pharmaceutical drugs in human plasma. J. Mass Spectrom. 35, 423-431 (2000).
10. Zhang H, Henion J. Comparison between liquid chromatography-time of- flight mass spectrometry and selected reaction monitoring liquid chromatography-mass spectrometry for quantitative determination of idoxifene in human plasma. J. Chromatogr. B Biomed. Sci. App. 757, 151-159 (2001).
11. Ojanpera S, Pelander A, Pelzing M et al. Isotopic pattern and accurate mass determination in urine drug screening by liquid chromatography/time-of- flight mass spectrometry. Rapid Commun. Mass Spectrom. 20, 1161-1167 (2006).
12. Dominguez-Romero JC, Garcia-Reyes JF, Molina- Diaz A. Screening and quantitation of multiclass drugs of abuse and pharmaceuticals in hair by fast liquid chromatography electrospray time-of-flight mass spectrometry. Chromatogr. B Anal. Technol. Biomed. Life Sci. 879, 2034-2042 (2011).
13. Marin SJ, Hughes JM, Lawlor BG et al. Rapid screening for 67 drugs and metabolites in serum or plasma by accurate-mass LC-TOF-MS. J. Anal. Toxicol. 36, 477-486 (2012).
14. Crews BO, Pesce AJ, West R et al. Evaluation of high- resolution mass spectrometry for urine toxicology screening in a pain management setting. Anal. Toxicol. 36, 601-607 (2012).
15. Decaestecker TN, Vande Casteele SR, Wallemacq PE et al. Information-dependent acquisition-mediated LC-MS/ MS screening procedure with semiquantitative potential. Anal. Chem. 76, 6365-6373 (2004).
16. Broecker S, Herre S, Wust B et al. Development and practical application of a library of CID accurate mass spectra of more than 2,500 toxic compounds for systematic toxicological analysis by LC-QTOF-MS with data-dependent acquisition. Anal. Bioanal. Chem. 400, 101-117 (2011).
17. Bateman KP, Castro-Perez J, Wrona M et al. MSE with mass defect filtering for in vitro and in vivo metabolite identification. Rapid Commun. Mass Spectrom. 21, 1485-1496 (2007).
18. Lee HK, Ho CS, Iu YP et al. Development of a broad toxicological screening technique for urine using ultra-performance liquid chromatography and time-of- flight mass spectrometry. Anal. Chim. Acta 649, 80-90 (2009).
19. Kaufmann A, Butcher P, Maden K et al. Quantitative and confirmative performance of liquid chromatography coupled to high-resolution mass spectrometry compared to tandem mass spectrometry. Rapid Commun. Mass Spectrom. 25, 979-992 (2011).
20. Henry H, Sobhi HR, Scheibner O et al. Comparison between a high-resolution single-stage Orbitrap and a triple quadrupole mass spectrometer for quantitative analyses of drugs. Rapid Commun. Mass Spectrom. 26, 499-509 (2012).
21. Wu L, Vogt FG. A review of recent advances in mass spectrometric methods for gas-phase chiral analysis of pharmaceutical and biological compounds. J. Pharm. Biomed. Anal. 69, 133-147 (2012).
22. Croley TR, White KD, Callahan JH et al. The chromatographic role in high resolution mass spectrometry for non- targeted analysis. J. Am. Soc. Mass Spectrom. 23, 1569-1578 (2012).