Tissue strain reorganizes collagen with a switchlike response that regulates neuronal extracellular signal-regulated kinase phosphorylation in vitro: Implications for ligamentous injury and mechanotransduction

Journal of Biomechanical Engineering

Volumn 138, Issue 2, 2016, Pages

  Zhang, Sijia ^a   Cao, Xuan ^a   Stablow, Alec M ^a   Shenoy, Vivek B ^a   Winkelstein, Beth A ^a,b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Biomechanics; Collagen; Discrete fiber network model; Ligament; Mechanotransduction; Pain

Indexed keywords

ASPECT RATIO; BIOMECHANICS; COLLAGEN; ENZYME ACTIVITY; ENZYMES; FIBERS; FINITE ELEMENT METHOD; LIGAMENTS; PHOSPHORYLATION; STRAIN; TISSUE; TRANSITION FLOW;

COLLAGEN CONSTRUCTS; COLLAGEN FIBER RE ALIGNMENTS; EXTRACELLULAR SIGNAL-REGULATED KINASE; FIBER NETWORK MODELS; MACROSCOPIC DEFORMATIONS; MECHANOTRANSDUCTION; PAIN; STRAIN-INDUCED CHANGE;

NEURONS;

COLLAGEN; MITOGEN ACTIVATED PROTEIN KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOMECHANICS; COLLAGEN FIBER; COMPRESSIVE STRENGTH; CONTROLLED STUDY; EMBRYO; FEMALE; FINITE ELEMENT ANALYSIS; IN VITRO STUDY; KINEMATICS; LIGAMENT INJURY; MECHANOTRANSDUCTION; NERVE CELL; NERVE CELL PLASTICITY; NONHUMAN; PROTEIN PHOSPHORYLATION; RAT; STRESS STRAIN RELATIONSHIP; TENSILE STRENGTH; TENSION; TISSUE LEVEL; VOLUME; ANIMAL; CYTOLOGY; INJURIES; LIGAMENT; MECHANICAL STRESS; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; SPRAGUE DAWLEY RAT; WEIGHT BEARING;

ANIMALS; BIOMECHANICAL PHENOMENA; COLLAGEN; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; LIGAMENTS; MECHANOTRANSDUCTION, CELLULAR; NEURONS; PHOSPHORYLATION; RATS; RATS, SPRAGUE-DAWLEY; STRESS, MECHANICAL; WEIGHT-BEARING;

EID: 84956977477     PISSN: 01480731     EISSN: 15288951     Source Type: Journal    
DOI: 10.1115/1.4031975     Document Type: Article

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