Increased Interleukin-1α and Prostaglandin E2 expression in the spinal cord at 1 day after painful facet joint injury: Evidence of early spinal inflammation

Spine

Volumn 39, Issue 3, 2014, Pages 207-212

  Kras, Jeffrey V ^a   Dong, Ling ^a   Winkelstein, Beth A ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

facet; IL 1; inflammation; joint; pain; PGE 2; spinal cord

Indexed keywords

ANIMALS; CERVICAL VERTEBRAE; DINOPROSTONE; GENE EXPRESSION REGULATION; INTERLEUKIN-1ALPHA; MALE; MYELITIS; PAIN; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, PROSTAGLANDIN E; SPINAL CORD; TIME FACTORS; ZYGAPOPHYSEAL JOINT;

EID: 84894069865     PISSN: 03622436     EISSN: 15281159     Source Type: Journal    
DOI: 10.1097/BRS.0000000000000107     Document Type: Article

References (49)

1. Côté P, Cassidy JD, Carroll L. The Saskatchewan health and back pain survey: the prevalence of neck pain and related disability in Saskatchewan adults. Spine 1998; 23: 1689-98. (Pubitemid 28433869)
2. Freeman MD, Croft AC, Rossignol AM, et al. A review and methodologic critique of the literature refuting whiplash syndrome. Spine 1999; 24: 86-98.
3. Cavanaugh JM, Lu Y, Chen C, et al. Pain generation in lumbar and cervical facet joints. J Bone Joint Surg Am 2006; 88: 63-7.
4. Chen C, Lu Y, Kallakuri S, et al. Distribution of A-δ and C-fi ber receptors in the cervical facet joint capsule and their response to stretch. J Bone Joint Surg Am 2006; 88: 1807-16. (Pubitemid 44200222)
5. Deng B, Begeman PC, Yang KH, et al. Kinematics of human cadaver cervical spine during low speed rear-end impacts. Stapp Car Crash J 2000; 44: 171-88.
6. Kras JV, Dong L, Winkelstein BA. The prostaglandin E2 receptor, EP2, is upregulated in the dorsal root ganglion after painful cervical facet joint injury in the rat. Spine 2013; 38: 217-22.
7. Lee KE, Davis MB, Winkelstein BA. Capsular ligament involvement in the development of mechanical hyperalgesia after facet joint loading: behavioral and infl ammatory outcomes in a rodent model of pain. J Neurotrauma 2008; 25: 1383-93.
8. Tachihara H, Kikuchi S, Konno S, et al. Does facet joint infl ammation induce radiculopathy? An investigation using a rat model of lumbar facet joint infl ammation. Spine 2007; 32: 406-12.
9. Dong L, Smith JR, Winkelstein BA. Ketorolac reduces spinal astrocytic activation and PAR1 expression associated with attenuation of pain after facet joint injury. J Neurotrauma 2013; 30: 818-25.
10. Rothman SM, Huang Z, Lee KE, et al. Cytokine mRNA expression in painful radiculopathy. J Pain 2009; 10: 90-9.
11. Rothman SM, Winkelstein BA. Cytokine antagonism reduces pain and modulates spinal astrocytic reactivity after cervical nerve root compression. Ann Biomed Eng 2010; 38: 2563-76.
12. Winkelstein BA, Rutkowski MD, Sweitzer SM, et al. Nerve injury proximal or distal to the DRG induces similar spinal glial activation and selective cytokine expression but differential behavioral responses to pharmacologic treatment. J Comp Neurol 2001; 439: 127-39. (Pubitemid 32906017)
13. DeLeo JA, Colburn RW, Nichols M, et al. Interleukin-6-mediated hyperalgesia/allodynia and increased spinal IL-6 expression in a rat mononeuropathy model. J Interferon Cytokine Res 1996; 16: 695-700. (Pubitemid 26330415)
14. Hashizume H, DeLeo JA, Colburn RW, et al. Spinal glial activation and cytokine expression after lumbar root injury in the rat. Spine 2000; 25: 1206-17. (Pubitemid 30322310)
15. Lindenlaub T, Teuteberg P, Hartung T, et al. Effects of neutralizing antibodies to TNF-alpha on pain-related behavior and nerve regeneration in mice with chronic constriction injury. Brain Res 2000; 866: 15-22. (Pubitemid 30313003)
16. Sweitzer SM, Colburn RW, Rutkowski M, et al. Acute peripheral infl ammation induces moderate glial activation and spinal IL-1 β expression that correlates with pain behavior in the rat. Brain Res 1999; 829: 209-21. (Pubitemid 29251705)
17. Watkins LR, Maier SF, Goehler LE. Immune activation: the role of pro-infl ammatory cytokines in infl ammation, illness responses and pathological pain states. Pain 1995; 63: 289-302.
18. Ebersberger A, Grubb BD, Willingale HL, et al. The intraspinal release of prostaglandin E 2 in a model of acute arthritis is accompanied by an up-regulation of cyclo-oxygenase-2 in the spinal cord. Neuroscience 1999; 93: 775-81. (Pubitemid 29329481)
19. Ferreira SH, Lorenzetti BB, Bristow AF, et al. Interleukin-1 β as a potent hyperalgesic agent antagonized by a tripeptide analogue. Nature 1988; 334: 698-700.
20. Fiorentino PM, Tallents RH, Miller JH, et al. Spinal interleukin-1 β in a mouse model of arthritis and joint pain. Arthritis Rheum 2008; 58: 3100-9.
21. Li X, Kim J, van Wijnen AJ, et al. Osteoarthritic tissues modulate functional properties of sensory neurons associated with symptomatic OA pain. Mol Biol Rep 2011; 38: 5335-9.
22. O'Byrne EM, Blancuzzi V, Wilson DE, et al. Elevated substance P and accelerated cartilage degradation in rabbit knees injected with interleukin-1 and tumor necrosis factor. Arthritis Rheum 1990; 33: 1023-8. (Pubitemid 20226357)
23. Quinn JH, Bazan NG. Identifi cation of prostaglandin E 2 and leukotriene B 4 in the synovial fl uid of painful, dysfunctional temporomandibular joints. J Oral Maxillofac Surg 1990; 48: 968-71. (Pubitemid 20282051)
24. Smith MD, Riantafi llou S, Parker A, et al. Synovial membrane infl ammation and cytokine production in patients with early osteoarthritis. J Rheumatol 1997; 24: 365-71. (Pubitemid 27104104)
25. Mika J, Korostynski M, Kaminska D, et al. Interleukin-1 alpha has antiallodynic and antihyperalgesic activities in a rat neuropathic pain model. Pain 2008; 138: 587-97.
26. Samad TA, Moore KA, Sapirstein A, et al. Interleukin-1 β-mediated induction of Cox-2 in the CNS contributes to infl ammatory pain hypersensitivity. Nature 2001; 410: 471-5. (Pubitemid 32240046)
27. Ferreira SH, Lorenzetti BB. Intrathecal administration of prostaglandin E2 causes sensitization of the primary afferent neuron via the spinal release of glutamate. Inflamm Res 1996; 45: 499-502. (Pubitemid 26360008)
28. Kras JV, Weisshaar CL, Quindlen J, et al. Brain-derived neurotrophic factor is upregulated in the cervical DRG & spinal cord and contributes to the maintenance of pain from facet joint injury in the rat. J Neurosci Res 2013;91:1312-21.
29. Zimmermann M. Ethical guidelines for investigations of experimental pain in conscious animals. Pain 1983; 16: 109-10. (Pubitemid 13058546)
30. Dong L, Winkelstein BA. Simulated whiplash modulates expression of the glutamatergic system in the spinal cord suggesting spinal plasticity is associated with painful dynamic cervical facet loading. J Neurotrauma 2010; 27: 163-74.
31. Lee KE, Davis MB, Mejilla RM, et al. In vivo cervical facet capsule distraction: mechanical implications for whiplash & neck pain. Stapp Car Crash J 2004; 48: 373-95.
32. Schaible HG, Grubb BD. Afferent and spinal mechanisms of joint pain. Pain 1993; 55: 5-54. (Pubitemid 23300815)
33. Vanegas H, Schaible HG,. Prostaglandins and cyclooxygenases in the spinal cord. Prog Neurobiol 2001; 64: 327-63.
34. Vasquez E, Bär K, Ebersberger A, et al. Spinal prostaglandins are involved in the development but not the maintenance of infl ammationinduced spinal hyperexcitability. J Neurosci 2001; 21: 9001-8. (Pubitemid 33054861)
35. Dinarello CA. Interleukin-1 and interleukin-1 antagonism. Blood 1991; 77: 1627-52.
36. Lee SC, Liu W, Dickson DW, et al. Cytokine production by human fetal microglia and astrocytes: differential induction by lipopolysaccharide and IL-1 β. J Immunol 1993; 150: 2659-67. (Pubitemid 23127515)
37. Skoff AM, Zhao C, Adler JE. Interleukin-1 α regulates substance P expression and release in adult sensory neurons. Exp Neurol 2009; 217: 395-400.
38. Bileviciute I, Lundeberg T, Ekblom A, et al. The effect of a single intraperitoneal dose of hrIL-1 α on substance P-, neurokinin A-, calcitonin gene-related peptide-and neuropeptide Y-like immunoreactivity in cerebrospinal fl uid, plasma and knee joint synovial fl uid in the rat. Regul Pept 1994; 53: 71-6.
39. Lee KE, Winkelstein BA. Joint distraction magnitude is associated with different behavioral outcomes and substance P levels for cervical facet joint loading in the rat. J Pain 2009; 10: 436-45.
40. DeLeo JA, Colburn RW, Rickman AJ. Cytokine and growth factor immunohistochemical spinal profi les in two animal models of mononeuropathy. Brain Res 1997; 759: 50-7. (Pubitemid 27286343)
41. Crosby ND, Weisshaar CL, Winkelstein BA. Spinal neuronal plasticity is evident within 1 day after a painful cervical facet joint injury. Neurosci Lett 2013; 542: 102-6.
42. Cruz Duarte P, St-Jacques B, Ma W. Prostaglandin E2 contributes to the synthesis of brain-derived neurotrophic factor in primary sensory neuron in ganglion explant cultures and in a neuropathic pain model. Exp Neurol 2012; 234: 466-81.
43. Dong L, Guarino BB, Jordan-Sciutto KL, et al. Activating transcription factor 4, a mediator of the integrated stress response, is increased in the dorsal root ganglia following painful facet joint distraction. Neuroscience 2011; 193: 377-86.
44. Schaible HG, Ebersberger A, Von Banchet GS. Mechanisms of pain in arthritis. Ann N Y Acad Sci 2002; 966: 343-54. (Pubitemid 34729193)
45. Bar KJ, Natura G, Telleria-Diaz A, et al. Changes in the effect of spinal prostaglandin E 2 during infl ammation: prostaglandin E (EP1-EP4) receptors in spinal nociceptive processing of input from the normal or infl amed knee joint. J Neurosci 2004; 24: 642-51. (Pubitemid 38166490)
46. Nakayama Y, Omote K, Kawamata T, et al. Role of prostaglandin receptor subtype EP 1 in prostaglandin E 2-induced nociceptive transmission in the rat spinal dorsal horn. Brain Res 2004; 1010: 62-8. (Pubitemid 38569853)
47. Sterling M, Jull G, Vicenzino B, et al. Sensory hypersensitivity occurs soon after whiplash injury and is associated with poor recovery. Pain 2003; 104: 509-17. (Pubitemid 37289050)
48. Hill R. NK1 (substance P) receptor antagonists-why are they not analgesic in humans ? Trends Pharmacol Sci 2000; 21: 244-6. (Pubitemid 30445249)
49. Mogil JS. Animal models of pain: progress and challenges. Nat Rev Neurosci 2009; 10: 283-94.