A Single-Photon Avalanche Camera for Fluorescence Lifetime Imaging Microscopy and Correlation Spectroscopy

IEEE Journal of Selected Topics in Quantum Electronics

Volumn 20, Issue 6, 2014, Pages 344-353

  Vitali, Marco ^a   Bronzi, Danilo ^c   Krmpot, Aleksandar J ^e   Nikolić, Stanko N ^e   Schmitt, Franz Josef ^b   Junghans, Cornelia ^b   Tisa, Simone ^d   Friedrich, Thomas ^b   Vukojević, Vladana ^f   Terenius, Lars ^f   Zappa, Franco ^c   Rigler, Rudolf ^f  

^a Omicron Energy Solutions GmbH   (Germany)

^b TECHNISCHE UNIVERSITÄT BERLIN   (Germany)

^c POLITECNICO DI MILANO   (Italy)

^d Micro Photon Devices   (Italy)

^e UNIVERSITY OF BELGRADE   (Serbia)

^f KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Fluorescence Correlation Spectroscopy; Multifocal microscopy; Single Photon Avalanche Diode array

Indexed keywords

AVALANCHE DIODES; CAMERAS; EXCITED STATES; FLUORESCENCE IMAGING; FLUORESCENCE SPECTROSCOPY; MOLECULES; PARTICLE BEAMS; PHOTOBLEACHING; PHOTONS; PROTEINS; SEMICONDUCTOR QUANTUM DOTS; SPECTROSCOPIC ANALYSIS;

CONFOCAL LASER SCANNING MICROSCOPY; ENHANCED GREEN FLUORESCENT PROTEIN; FLUORESCENCE CORRELATION SPECTROSCOPY; FLUORESCENCE INTENSITIES; FLUORESCENCE LIFETIME IMAGING MICROSCOPY; MULTIFOCAL MICROSCOPY; SINGLE PHOTON AVALANCHE DIODE; SINGLE-PHOTON AVALANCHE DIODE ARRAYS;

PHOTON CORRELATION SPECTROSCOPY;

EID: 84956976817     PISSN: 1077260X     EISSN: 15584542     Source Type: Journal    
DOI: 10.1109/JSTQE.2014.2333238     Document Type: Article

References (39)

1. J. Pawley, Handbook of Biological Confocal Microscopy, 3rd ed. New York, NY, USA: Plenum Press, 2006.
2. G. Y. Fan, H. Fujisaki, A. Miyawaki, R. K. Tsay, R. Y. Tsien, and M. H. Ellisman, "Video-rate scanning two-photon excitation fluorescence microscopy and ratio imaging with Cameleons," Biophys. J, vol. 76, no. 5, pp. 2412-2420, 1999.
3. L. Greenbaum, C. Rothmann, R. Lavie, and Z. Malik, "Green fluorescent protein photobleaching: A model for protein damage by endogenous and exogenous singlet oxygen," Biol. Chem., vol. 381, no. 12, pp. 1251-1258, Dec. 2000.
4. E. Wang, C. M. Babbey, and K. W. Dunn, "Performance comparison between the high-speed Yokogawa spinning disc confocal system and single-point scanning confocal systems," J. Microsc., vol. 218, no. 2, pp. 148-159, 2005.
5. R. Rigler, FCS in Single Molecule Analysis. Nobel Symposium on Single Molecule Spectroscopy in Chemistry, Physics and Biology. New York, NY, USA: Springer, 2010.
6. A. Rochas, M. Gosch, A. Serov, P. Besse, R. Popovic, T. Lasser, and R. Rigler, "First fully integrated 2-D array of single-photon detectors in standard CMOS technology," IEEE Photon. Technol. Lett., vol. 15, no. 7, pp. 963-965, Jul. 2003.
7. F. Guerrieri, S. Tisa, A. Tosi, and F. Zappa, "Two-dimensional SPAD imaging camera for photon counting," IEEE Photon. J., vol. 2, no. 5, pp. 759-774, Oct. 2010.
8. M. Gersbach, J. Richardson, E. Mazaleyrat, S. Hardillier, C. Niclass, R. Henderson, L. Grant, and E. Charbon, "A low-noise single-photon detector implemented in a 130 nm CMOS imaging process," Solid-State Electron., vol. 53, no. 7, pp. 803-808, 2009.
9. H. Blom, M. Johansson, A.-S. Hedman, L. Lundberg, A. Hanning, S. Hård, and R. Rigler, "Parallel fluorescence detection of single biomolecules in microarrays by a diffractive-optical-designed 2 x 2 fan-out element," Appl. Opt., vol. 41, no. 16, pp. 3336-3342, 2002.
10. H. Blom, M. Johansson, M. Gösch, T. Sigmundsson, J. Holm, S. Hård, and R. Rigler, "Parallel flow measurements in microstructures by use of a multifocal 4 x 1 diffractive optical fan-out element," Appl. Opt., vol. 41, no. 31, pp. 6614-6620, 2002.
11. M. Gösch, A. Serov, T. Anhut, T. Lasser, A. Rochas, R. S. Popovic, H. Blom, and R. Rigler, "Parallel single molecule detection with a fully integrated single-photon 2 x 2 CMOS detector array," J. Biomed. Opt., vol. 9, no. 5, pp. 913-921, 2004.
12. X. Michalet, R. A. Colyer, G. Scalia, T. Kim, M. Levi, D. Aharoni, A. Cheng, F. Guerrieri, K. Arisaka, J. Millaud, I. Rech, D. Resnati, S. Marangoni, A. Gulinatti, M. Ghioni, S. Tisa, F. Zappa, S. Cova, and S. Weiss, "High-throughput single-molecule fluorescence spectroscopy using parallel detection," presented at the SPIE Photon. West Conf. Proc., San Jose, CA, USA, vol. 7608, no. 76082D, 2010.
13. J. Buchholz, J. W. Krieger, G. Mocsár, B. Kreith, E. Charbon, G. Vámosi, U. Kebschull, and J. Langowski, "FPGA implementation of a 32 x 32 autocorrelator array for analysis of fast image series," Opt. Exp., vol. 20, no. 16 pp. 17 767-17 782, 2012.
14. X. Michalet, R. A. Colyer, G. Scalia, A. Ingargiola, R. Lin, J. E. Millaud, S. Weiss, O. H. W. Siegmund, A. S. Tremsin, J. V. Vallerga, A. Cheng, M. Levi, D. Aharoni, K. Arisaka, F. Villa, F. Guerrieri, F. Panzeri, I. Rech, A. Gulinatti, F. Zappa, M. Ghioni, and S. Cova, "Development of new photon-counting detectors for single-molecule fluorescence microscopy," Philos. Trans. Royal Soc. Lond. B Biol. Sci., vol. 368, no. 1611, p. 20120035, 2013.
15. M. Kloster-Landsberg, D. Tyndall, I. Wang, R. Walker, J. Richardson, R. Henderson, and A. Delon, "Note: Multi-confocal fluorescence correlation spectroscopy in living cells using a complementary metal oxide semiconductor-single photon avalanche diode array," Rev. Sci. Instrum., vol. 84, no. 7, p. 076105, 2013.
16. A. Draaijer, R. Sanders, and H. C. Gerritsen, "Fluorescence lifetime imaging, a new tool in confocal microscopy," in Handbook of Biological Confocal Microscopy. New York, NY, USA: Springer, 1995, pp. 491-505.
17. C. J. de Grauw and H. C. Gerritsen, "Multiple time-gate module for fluorescence lifetime imaging," Appl. Spectrosc., vol. 55, no. 6, pp. 670-678, Jun. 2001.
18. T. W. J. Gadella, Ed., FRET and FLIM Techniques, vol. 33. Amsterdam, The Netherlands: Elsevier Science, 2008.
19. S. Tisa, A. Tosi, and F. Zappa, "Fully-integrated CMOS single photon counter," Opt. Exp., vol. 15, no. 6, pp. 2873-2887, 2007.
20. F. Guerrieri, S. Tisa, and F. Zappa, "Fast single-photon imager acquires 1024 pixels at 100 kframe/s," Proc. SPIE, vol. 7249, p. 72490U, Jan. 27, 2009.
21. S. Cova, M. Ghioni, A. Lacaita, C. Samori, and F. Zappa, "Avalanche photodiodes and quenching circuits for single-photon detection," Appl. Opt., vol. 35, no. 12, pp. 1956-1976, 1996.
22. S. Tisa, F. Guerrieri, and F. Zappa, "Variable-load quenching circuit for single-photon avalanche diodes," Opt. Exp., vol. 16, no. 3, pp. 2232-2244, 2008.
23. S. P. Chan, Z. J. Fuller, J. N. Demas, and B. A. DeGraff, "Optimized gating scheme for rapid lifetime determinations of single-exponential luminescence lifetimes," Anal. Chem., vol. 73, no. 18, pp. 4486-4490, 2001.
24. D. D.-U. Li, S. Ameer-Beg, J. Arlt, D. Tyndall, R. Walker, D. R. Matthews, V. Visitkul, J. Richardson, and R. K. Henderson, "Time-domain fluorescence lifetime imaging techniques suitable for solid-state imaging sensor arrays," Sensors, vol. 12, no. 5, pp. 5650-5669, 2012.
25. P. Hall and B. Selinger, "Better estimates of exponential decay parameters," J. Phys. Chem., vol. 85, no. 20, pp. 2941-2946, 1981.
26. J. Tellinghuisen and C. W. Wilkerson, "Bias and precision in the estimation of exponential decay parameters from sparse data," Anal. Chem., vol. 65, no. 9, pp. 1240-1246, 1993.
27. M. Maus, M. Cotlet, J. Hofkens, T. Gensch, F. C. de Schryver, J. Schaffer, and C. A. Seidel, "An experimental comparison of the maximum likelihood estimation and nonlinear least-squares fluorescence lifetime analysis of single molecules," Anal. Chem., vol. 73, no. 9, pp. 2078-2086, 2001.
28. K. Schätzel, M. Drewel, and S. Stimac, "Photon correlation measurements at large lag times: Improving statistical accuracy," J. Mod. Opt., vol. 35, no. 4, pp. 711-718, 1988.
29. T. Wohland, R. Rigler, and H. Vogel, "The standard deviation in fluorescence correlation spectroscopy," Biophys. J., vol. 80, no. 6, pp. 2987-2999, 2001.
30. J. R. Lakowicz, Principles of Fluorescence Spectroscopy., 3rd ed. New York, NY, USA: Springer, 2006.
31. S. R. Aragon and R. Pecora, "Fluorescence correlation spectroscopy as a probe of molecular dynamics," J. Chem. Phys., vol. 64, no. 4, pp. 1791-1803, 1976.
32. D.-U. Li, E. Bonnist, D. Renshaw, and R. Henderson, "On-chip, time-correlated, fluorescence lifetime extraction algorithms and error analysis," J. Opt. Soc. Amer. A Opt. Image Sci. Vis., vol. 25, no. 5, pp. 1190-1198, 2008.
33. D.-U. Li, J. Arlt, J. Richardson, R. Walker, A. Buts, D. Stoppa, E. Charbon, and R. Henderson, "Real-time fluorescence lifetime imaging system with a 32 x 32 0.13 μm CMOS low dark-count single-photon avalanche diode array," Opt. Exp., vol. 18, no. 10 pp. 10 257-10 269, 2010.
34. R. Reisfeld, R. Zusman, Y. Cohen, and M. Eyal, "The spectroscopic behaviour of rhodamine 6G in polar and non-polar solvents and in thin glass and PMMA films," Chem. Phys. Lett., vol. 147, no. 2, pp. 142-147, 1988.
35. G. Zhang, V. Gurtu, and S. R. Kain, "An enhanced green fluorescent protein allows sensitive detection of gene transfer in mammalian cells," Biochem. Biophys. Res. Commun., vol. 227, no. 3, pp. 707-711, 1996.
36. M. Cotlet, J. Hofkens, M. Maus, T. Gensch, M. van der Auweraer, J. Michiels, G. Dirix, M. van Guyse, J. Vanderleyden, A. J. W. G. Visser, and F. de Schryver, "Excited-state dynamics in the enhanced green fluorescent protein mutant probed by picosecond time-resolved single photon counting spectroscopy," J. Phys. Chem. B, vol. 105, no. 21, pp. 4999-5006, 2001.
37. M. Vitali, F. Picazo, Y. Prokazov, A. Duci, E. Turbin, C. Götze, J. Llopis, R. Hartig, A. J. W. G. Visser, and W. Zuschratter, "Wide-field multiparameter FLIM: Long-term minimal invasive observation of proteins in living cells," PloS One, vol. 6, no. 2, pp. e15820, 2011.
38. H. C. Gerritsen, M. A. H. Asselbergs, A. V. Agronskaia, and W. G. J. H. M. van Sark, "Fluorescence lifetime imaging in scanning microscopes: acquisition speed, photon economy and lifetime resolution," J. Microsc., vol. 206, no. 3, pp. 218-224, 2002.
39. Y. Han, J. Lee, Y. Lee, and S. W. Kim, "Measurement of the diffusion coefficients of fluorescence beads and quantum dots by using fluorescence correlation spectroscopy," J. Korean Phys. Soc., vol. 59, no. 5, pp. 3177-3181, 2011.