Hypoxia-induced epithelial-mesenchymal transition is involved in bleomycin-induced lung fibrosis

BioMed Research International

Volumn 2015, Issue , 2015, Pages

  Guo, Liang ^a,b   Xu, Jun Mei ^b   Liu, Lei ^b   Liu, Su Mei ^b   Zhu, Rong ^b  

^a SHANDONG UNIVERSITY   (China)

^b CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; CALVASCULIN; FIBRONECTIN; GELATINASE A; HERMES ANTIGEN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MITOGEN ACTIVATED PROTEIN KINASE P38; NERVE CELL ADHESION MOLECULE; PROTEIN P42; PROTEIN P44; TRANSCRIPTION FACTOR ZEB1; UVOMORULIN; VIMENTIN; BLEOMYCIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLEOMYCIN-INDUCED PULMONARY FIBROSIS; CELL DIFFERENTIATION; CELL HYPOXIA; CELL INFILTRATION; CONTROLLED STUDY; ENZYME ACTIVATION; EPITHELIAL MESENCHYMAL TRANSITION; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPOXIA INDUCED EPITHELIAL MESENCHYMAL TRANSITION; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; LUNG FIBROBLAST; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TISSUE HOMOGENATE; WESTERN BLOTTING; ANIMAL; CELL LINE; CHEMICALLY INDUCED; DISEASE MODEL; DRUG EFFECTS; GENE EXPRESSION REGULATION; HYPOXIA; LUNG ALVEOLUS; LUNG FIBROSIS; METABOLISM; PATHOLOGY;

ANIMALS; BLEOMYCIN; CELL LINE; DISEASE MODELS, ANIMAL; EPITHELIAL-MESENCHYMAL TRANSITION; GENE EXPRESSION REGULATION; HUMANS; HYPOXIA; MALE; MICE; PULMONARY ALVEOLI; PULMONARY FIBROSIS;

EID: 84956962225     PISSN: 23146133     EISSN: 23146141     Source Type: Journal    
DOI: 10.1155/2015/232791     Document Type: Article

References (28)

1. J. Yarnold and M.-C. V. Brotons, "Pathogenetic mechanisms in radiation fibrosis, " Radiotherapy and Oncology, vol. 97, no. 1, pp. 149-161, 2010.
2. J. C. Lee and V. N. Ahya, "Lung transplantation in autoimmune diseases, " Clinics in Chest Medicine, vol. 31, no. 3, pp. 589-603, 2010.
3. R. A. C. Cohen, A. Patel, and F. H. Y. Green, "Lung disease caused by exposure to coal mine and silica dust, " Seminars in Respiratory and Critical Care Medicine, vol. 29, no. 6, pp. 651- 661, 2008.
4. N.-H. Ding, J. J. Li, and L.-Q. Sun, "Molecular mechanisms and treatment of radiation-induced lung fibrosis, " Current Drug Targets, vol. 14, no. 11, pp. 1347-1356, 2013.
5. M. H. Daba, K. E. El-Tahir, M. N. Al-Arifi, and O. A. Gubara, "Drug-induced pulmonary fibrosis, " Saudi Medical Journal, vol. 25, no. 6, pp. 700-706, 2004.
6. W. D. Hardie, T. D. Le Cras, K. Jiang, J. W. Tichelaar, M. Azhar, and T. R. Korfhagen, "Conditional expression of transforming growth factor-α in adultmouse lung causes pulmonary fibrosis, " American Journal of Physiology-Lung Cellular and Molecular Physiology, vol. 286, no. 4, pp. L741-L749, 2004.
7. N. Hirota and J. G. Martin, "Mechanisms of airway remodeling, " Chest, vol. 144, no. 3, pp. 1026-1032, 2013.
8. M. Corbel, S. Caulet-Maugendre, N. Germain, S. Molet, V. Lagente, and E. Boichot, "Inhibition of bleomycin-induced pulmonary fibrosis in mice by the matrix metalloproteinase inhibitor batimastat, " Journal of Pathology, vol. 193, no. 4, pp. 538-545, 2001.
9. J. Zhang, L. Chen, X. Liu, T. Kammertoens, T. Blankenstein, and Z. Qin, "Fibroblast-specific protein 1/S100A4-positive cells prevent carcinoma through collagen production and encapsulation of carcinogens, " Cancer Research, vol. 73, no. 9, pp. 2770-2781, 2013.
10. H.-Y. Zhang, M. Gharaee-Kermani, K. Zhang, S. Karmiol, and S. H. Phan, "Lung fibroblast α-smooth muscle actin expression and contractile phenotype in bleomycin-induced pulmonary fibrosis, " American Journal of Pathology, vol. 148, no. 2, pp. 527- 537, 1996.
11. T. A. Wynn, "Cellular and molecular mechanisms of fibrosis, " Journal of Pathology, vol. 214, no. 2, pp. 199-210, 2008.
12. A. E. Vaughan and H. A. Chapman, "Regenerative activity of the lung after epithelial injury, " Biochimica et Biophysica Acta, vol. 1832, no. 7, pp. 922-930, 2013.
13. H. Tanjore, X. C. Xu, V. V. Polosukhin et al., "Contribution of epithelial-derived fibroblasts to bleomycin-induced lung fibrosis, " American Journal of Respiratory and Critical Care Medicine, vol. 180, no. 7, pp. 657-665, 2009.
14. A. N. Lau, M. Goodwin, C. F. Kim, and D. J. Weiss, "Stem cells and regenerative medicine in lung biology and diseases, " Molecular Therapy, vol. 20, no. 6, pp. 1116-1130, 2012.
15. C.-Y. Lin, C.-Y. Peng, T.-T. Huang et al., "Exacerbation of oxidative stress-induced cell death and differentiation in induced pluripotent stem cells lacking heme oxygenase-1, " Stem Cells and Development, vol. 21, no. 10, pp. 1675-1687, 2012.
16. S. Park, J.-Y. Ahn, M.-J. Lim et al., "Sustained expression of NADPH oxidase 4 by p38 MAPK-AKT signaling potentiates radiation-induced differentiation of lung fibroblasts, " Journal of Molecular Medicine, vol. 88, no. 8, pp. 807-816, 2010.
17. R. M. Tuder, J. H. Yun, A. Bhunia, and I. Fijalkowska, "Hypoxia and chronic lung disease, " Journal of Molecular Medicine, vol. 85, no. 12, pp. 1317-1324, 2007.
18. G. Zhou, L. A. Dada, M. Wu et al., "Hypoxia-induced alveolar epithelial-mesenchymal transition requires mitochondrial ROS and hypoxia-inducible factor 1, " American Journal of Physiology-Lung Cellular and Molecular Physiology, vol. 297, no. 6, pp. L1120-L1130, 2009.
19. J. V. Joseph, S. Conroy, K. Pavlov et al., "Hypoxia enhances migration and invasion in glioblastoma by promoting a mesenchymal shift mediated by the HIF1α-ZEB1 axis, " Cancer Letters, vol. 359, no. 1, pp. 107-116, 2015.
20. W. Zhang, X. Shi, Y. Peng et al., "HIF-1α promotes epithelialmesenchymal transition and metastasis through direct regulation of ZEB1 in colorectal cancer, " PLOS ONE, vol. 10, no. 6, Article ID e0129603, 2015.
21. R.-H. Hübner, W. Gitter, N. E. ElMokhtari et al., "Standardized quantification of pulmonary fibrosis in histological samples, " BioTechniques, vol. 44, no. 4, pp. 507-517, 2008.
22. Y. Shi, Y. Tohyama, T. Kadono et al., "Protein-tyrosine kinase Syk is required for pathogen engulfment in complementmediated phagocytosis, " Blood, vol. 107, no. 11, pp. 4554-4562, 2006.
23. Y. Lu, N. Azad, L. Wang et al., "Phosphatidylinositol-3- kinase/Akt regulates bleomycin-induced fibroblast proliferation and collagen production, " American Journal of Respiratory Cell and Molecular Biology, vol. 42, no. 4, pp. 432-441, 2010.
24. A. L. Degryse, H. Tanjore, X. C. Xu et al., "Repetitive intratracheal bleomycin models several features of idiopathic pulmonary fibrosis, " American Journal of Physiology-Lung Cellular and Molecular Physiology, vol. 299, no. 4, pp. L442- L452, 2010.
25. F. Nurwidya, F. Takahashi, I. Kobayashi et al., "Treatment with insulin-like growth factor 1 receptor inhibitor reverses hypoxia-induced epithelial-mesenchymal transition in nonsmall cell lung cancer, " Biochemical and Biophysical Research Communications, vol. 455, no. 3-4, pp. 332-338, 2014.
26. B. C. Willis and Z. Borok, "TGF-β-induced EMT: mechanisms and implications for fibrotic lung disease, " American Journal of Physiology: Lung Cellular andMolecular Physiology, vol. 293, no. 3, pp. L525-L534, 2007.
27. B. C. Willis, J. M. Liebler, K. Luby-Phelps et al., "Induction of epithelial-mesenchymal transition in alveolar epithelial cells by transforming growth factor-β1: potential role in idiopathic pulmonary fibrosis, " The American Journal of Pathology, vol. 166, no. 5, pp. 1321-1332, 2005.
28. K. K. Kim, M. C. Kugler, P. J. Wolters et al., "Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix, " Proceedings of the National Academy of Sciences of the United States of America, vol. 103, no. 35, pp. 13180-13185, 2006.