Keep calm and carry on: MiR-1298 prevents up-regulation of Cx43 and secures a quiescent vascular smooth muscle cell

Cardiovascular Research

Volumn 107, Issue 4, 2015, Pages 407-409

  Schmidt, Kjestine ^a,b   De Wit, Cor ^a,b  

^a UNIVERSITY OF LÜBECK   (Germany)

^b DZHK GERMAN CENTRE FOR CARDIOVASCULAR RESEARCH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CONNEXIN 43; KI 67 ANTIGEN; MICRORNA; MICRORNA 1298; MITOGEN ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

CELL CYCLE PROGRESSION; CELL CYCLE S PHASE; CELL FUNCTION; CELL MIGRATION; CELL PROLIFERATION; DNA METHYLATION; DOWN REGULATION; GENE SILENCING; HUMAN; INTRACELLULAR SIGNALING; NEOINTIMA; NONHUMAN; PRIORITY JOURNAL; REVIEW; UPREGULATION; VASCULAR SMOOTH MUSCLE CELL; CELL MOTION; GENETICS; METABOLISM; PHYSIOLOGY; SMOOTH MUSCLE CELL; VASCULAR SMOOTH MUSCLE;

CELL MOVEMENT; CONNEXIN 43; HUMANS; MICRORNAS; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE;

EID: 84948135745     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvv200     Document Type: Review

References (21)

1. Schroen B, Heymans S. Small but smart-microRNAs in the centre of inflammatory processes during cardiovascular diseases, the metabolic syndrome, and ageing. Cardiovasc Res 2012;93:605-613
2. Dangwal S, Bang C, Thum T. Novel techniques and targets in cardiovascular microRNA research. Cardiovasc Res 2012;93:545-554
3. Cheng Y, Liu X, Yang J, Lin Y, Xu DZ, Lu Q, Deitch EA, Huo Y, Delphin ES, Zhang C. MicroRNA-145, a novel smooth muscle cell phenotypic marker and modulator, controls vascular neointimal lesion formation. Circ Res 2009;105:158-166
4. Neth P, Nazari-Jahantigh M, Schober A, Weber C. MicroRNAs in flow-dependent vascular remodelling. Cardiovasc Res 2013;99:294-303
5. Liu X, Cheng Y, Zhang S, Lin Y, Yang J, Zhang C. A necessary role of miR-221 and miR-222 in vascular smooth muscle cell proliferation and neointimal hyperplasia. Circ Res 2009;104:476-487
6. Wei Y, Schober A, Weber C. Pathogenic arterial remodeling: the good and bad of microRNAs. Am J Physiol Heart Circ Physiol 2013;304:H1050-H1059
7. Li P, Zhu N, Yi B, Wang N, Chen M, You X, Zhao X, Solomides CC, Qin Y, Sun J. MicroRNA-663 regulates human vascular smooth muscle cell phenotypic switch and vascular neointimal formation. Circ Res 2013;113:1117-1127
8. Choe N, Kwon JS, Kim YS, Eom GH, Ahn YK, Baik YH, Park HY, Kook H. The micro-RNA miR-34c inhibits vascular smooth muscle cell proliferation and neointimal hyperplasia by targeting stem cell factor. Cell Signal 2015;27:1056-1065
9. Wang YS, Wang HYJ, Liao YC, Tsai PC, Chen KC, Cheng HY, Lin RT, Juo SH. MicroRNA-195 regulates vascular smooth muscle cell phenotype and prevents neointimal formation. Cardiovasc Res 2012;95:517-526
10. McDonald RA, Hata A, MacLean MR, Morrell NW, Baker AH. MicroRNA and vascular remodelling in acute vascular injury and pulmonary vascular remodelling. Cardiovasc Res 2012;93:594-604
11. Hu W, Wang M, Yin H, Yao C, He Q, Yin L, Zhang C, Li W, Chang G, Wang S. MicroRNA-1298 is regulated by DNA methylation and affects vascular smooth muscle cell function by targeting connexin 43. Cardiovasc Res 2015;107:534-545
12. Chadjichristos CE, Morel S, Derouette JP, Sutter E, Roth I, Brisset AC, Bochaton-Piallat ML, Kwak BR. Targeting connexin 43 prevents platelet-derived growth factor-BB-induced phenotypic change in porcine coronary artery smooth muscle cells. Circ Res 2008;102:653-660
13. Oyamada M, Takebe K, Oyamada Y. Regulation of connexin expression by transcription factors and epigenetic mechanisms. Biochim Biophys Acta 2013;1828:118-133
14. Yang B, Lin H, Xiao J, Lu Y, Luo X, Li B, Zhang Y, Xu C, Bai Y,Wang H, Chen G,Wang Z. The muscle-specific microRNA miR-1 regulates cardiac arrhythmogenic potential by targeting GJA1 and KCNJ2. Nat Med 2007;13:486-491
15. Danielson LS, Park DS, Rotllan N, Chamorro-Jorganes A, Guijarro MV, Fernandez-Hernando C, Fishman GI, Phoon CK, Hernando E. Cardiovascular dysregulation of miR-17-92 causes a lethal hypertrophic cardiomyopathy and arrhythmogenesis. FASEB J 2013;27:1460-1467
16. Jin Z, Xu S, Yu H, Yang B, Zhao H, Zhao G. miR-125b inhibits Connexin43 and promotes glioma growth. Cell Mol Neurobiol 2013;33:1143-1148
17. Klotz LO. Posttranscriptional regulation of connexin-43 expression. Arch Biochem Biophys 2012;524:23-29
18. Lujambio A, Calin GA, Villanueva A, Ropero S, Sanchez-Cespedes M, Blanco D, Montuenga LM, Rossi S, Nicoloso MS, Faller WJ, Gallagher WM, Eccles SA, Croce CM, Esteller M. A microRNA DNA methylation signature for human cancer metastasis. Proc Natl Acad Sci USA 2008;105:13556-13561
19. Lopez-Serra P, Esteller M. DNA methylation-Associated silencing of tumor-suppressor microRNAs in cancer. Oncogene 2012;31:1609-1622
20. Suzuki H, Maruyama R, Yamamoto E, Kai M. Epigenetic alteration and microRNA dysregulation in cancer. Front Genet 2013;4:258
21. Pfenniger A, Chanson M, Kwak BR. Connexins in atherosclerosis. Biochim Biophys Acta 2013;1828:157-166