Phages Fight Back: Inactivation of the CRISPR-Cas Bacterial Immune System by Anti-CRISPR Proteins

PLoS Pathogens

Volumn 12, Issue 1, 2016, Pages

  Maxwell, Karen L ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CRISPR ASSOCIATED PROTEIN;

BACTERIAL INFECTION; BACTERIAL SURVIVAL; CRISPR CAS SYSTEM; DNA BINDING; DNA DEGRADATION; DNA SEQUENCE; DNA TRANSFER; GENE DELETION; GENE EXPRESSION; GENE INACTIVATION; NONHUMAN; PROTEIN EXPRESSION; REVIEW; ANIMAL; BACTERIOPHAGE; BACTERIUM; HUMAN; IMMUNOLOGY; VIROLOGY;

ANIMALS; BACTERIA; BACTERIOPHAGES; CRISPR-CAS SYSTEMS; HUMANS;

EID: 84956842046     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1005282     Document Type: Review

References (15)

1. Barrangou R, Fremaux C, Deveau H, Richards M, Boyaval P, Moineau S, et al. CRISPR provides acquired resistance against viruses in prokaryotes. Science. 2007;315(5819):1709–12. doi: 10.1126/science.1138140 17379808.
2. Makarova KS, Haft DH, Barrangou R, Brouns SJ, Charpentier E, Horvath P, et al. Evolution and classification of the CRISPR-Cas systems. Nature reviews Microbiology. 2011;9(6):467–77. doi: 10.1038/nrmicro2577 21552286; PubMed Central PMCID: PMC3380444.
3. Ishino Y, Shinagawa H, Makino K, Amemura M, Nakata A, Nucleotide sequence of the iap gene, responsible for alkaline phosphatase isozyme conversion in Escherichia coli, and identification of the gene product. Journal of bacteriology. 1987;169(12):5429–33. 3316184; PubMed Central PMCID: PMC213968.
4. Jore MM, Brouns SJ, van der Oost J, RNA in defense: CRISPRs protect prokaryotes against mobile genetic elements. Cold Spring Harb Perspect Biol. 2012;4(6). doi: 10.1101/cshperspect.a003657 21441598; PubMed Central PMCID: PMC3367551.
5. Bondy-Denomy J, Pawluk A, Maxwell KL, Davidson AR, Bacteriophage genes that inactivate the CRISPR/Cas bacterial immune system. Nature. 2013;493(7432):429–32. doi: 10.1038/nature11723 23242138.
6. Pawluk A, Bondy-Denomy J, Cheung VH, Maxwell KL, Davidson AR, A new group of phage anti-CRISPR genes inhibits the type I-E CRISPR-Cas system of Pseudomonas aeruginosa. mBio. 2014;5(2):e00896. doi: 10.1128/mBio.00896-14 24736222; PubMed Central PMCID: PMC3993853.
7. Haurwitz RE, Jinek M, Wiedenheft B, Zhou K, Doudna JA, Sequence- and structure-specific RNA processing by a CRISPR endonuclease. Science. 2010;329(5997):1355–8. doi: 10.1126/science.1192272 20829488; PubMed Central PMCID: PMC3133607.
8. Wiedenheft B, van Duijn E, Bultema JB, Waghmare SP, Zhou K, Barendregt A, et al. RNA-guided complex from a bacterial immune system enhances target recognition through seed sequence interactions. Proceedings of the National Academy of Sciences of the United States of America. 2011;108(25):10092–7. doi: 10.1073/pnas.1102716108 21536913; PubMed Central PMCID: PMC3121849.
9. Westra ER, van Erp PB, Kunne T, Wong SP, Staals RH, Seegers CL, et al. CRISPR immunity relies on the consecutive binding and degradation of negatively supercoiled invader DNA by Cascade and Cas3. Mol Cell. 2012;46(5):595–605. doi: 10.1016/j.molcel.2012.03.018 22521689; PubMed Central PMCID: PMC3372689.
10. Huo Y, Nam KH, Ding F, Lee H, Wu L, Xiao Y, et al. Structures of CRISPR Cas3 offer mechanistic insights into Cascade-activated DNA unwinding and degradation. Nat Struct Mol Biol. 2014;21(9):771–7. doi: 10.1038/nsmb.2875 25132177; PubMed Central PMCID: PMC4156918.
11. Bondy-Denomy J, Garcia B, Strum S, Du M, Rollins MF, Hidalgo-Reyes Y, et al. Multiple mechanisms for CRISPR–Cas inhibition by anti-CRISPR proteins. Nature. 2015;526(7571):136–9. doi: 10.1038/nature15254 26416740
12. van Duijn E, Barbu IM, Barendregt A, Jore MM, Wiedenheft B, Lundgren M, et al. Native tandem and ion mobility mass spectrometry highlight structural and modular similarities in clustered-regularly-interspaced shot-palindromic-repeats (CRISPR)-associated protein complexes from Escherichia coli and Pseudomonas aeruginosa. Mol Cell Proteomics. 2012;11(11):1430–41. doi: 10.1074/mcp.M112.020263 22918228; PubMed Central PMCID: PMC3494201.
13. Luo ML, Mullis AS, Leenay RT, Beisel CL, Repurposing endogenous type I CRISPR-Cas systems for programmable gene repression. Nucleic acids research. 2015;43(1):674–81. doi: 10.1093/nar/gku971 25326321; PubMed Central PMCID: PMC4288209.
14. Battle SE, Meyer F, Rello J, Kung VL, Hauser AR, Hybrid pathogenicity island PAGI-5 contributes to the highly virulent phenotype of a Pseudomonas aeruginosa isolate in mammals. Journal of bacteriology. 2008;190(21):7130–40. doi: 10.1128/JB.00785-08 18757543; PubMed Central PMCID: PMC2580712.
15. Semenova E, Jore MM, Datsenko KA, Semenova A, Westra ER, Wanner B, et al. Interference by clustered regularly interspaced short palindromic repeat (CRISPR) RNA is governed by a seed sequence. Proceedings of the National Academy of Sciences of the United States of America. 2011;108(25):10098–103. doi: 10.1073/pnas.1104144108 21646539; PubMed Central PMCID: PMC3121866.