A national common massive transfusion protocol (MTP) is a feasible and advantageous option for centralized blood services and hospitals

Vox Sanguinis

Volumn 110, Issue 1, 2016, Pages 36-50

  Chay, J ^a   Koh, M ^a   Tan, H H ^a   Ng, J ^b   Ng, H J ^b   Chia, N ^c   Kuperan, P ^d   Tan, J ^d   Lew, E ^e   Tan, L K ^f   Koh, P L ^f   Desouza, K A ^g   Bin Mohd Fathil, S ^h   Kyaw, P M ^a   Ang, A L ^a  

^a HEALTH SCIENCES AUTHORITY   (Singapore)

^b SINGAPORE GENERAL HOSPITAL   (Singapore)

^c KHOO TECK PUAT HOSPITAL   (Singapore)

^d TAN TOCK SENG HOSPITAL   (Singapore)

^e Department of Paediatrics   (Singapore)

^f NATIONAL UNIVERSITY HOSPITAL   (Singapore)

^g CHANGI GENERAL HOSPITAL   (Singapore)

^h Jurong Health Services   (Singapore)

Author keywords

Blood components; Massive transfusion; Plasma; Platelet transfusion; Transfusion trauma

Indexed keywords

FIBRINOGEN; FRESH FROZEN PLASMA;

APHERESIS; ARTICLE; BLOOD BANK; BLOOD CELL COUNT; BLOOD CLOTTING TEST; BLOOD COMPONENT; BLOOD TRANSFUSION; CLINICAL ASSESSMENT; CLINICAL PRACTICE; CLINICAL PROTOCOL; CRYOPRECIPITATE; EMERGENCY CARE; ERYTHROCYTE CONCENTRATE; ERYTHROCYTE TRANSFUSION; FIBRINOGEN BLOOD LEVEL; HEALTH CARE QUALITY; HEALTH CARE SYSTEM; HUMAN; MORBIDITY; OBSTETRIC PATIENT; PARTIAL THROMBOPLASTIN TIME; PATIENT CARE; PATIENT DECISION MAKING; PRIORITY JOURNAL; PROTHROMBIN TIME; THROMBOCYTE TRANSFUSION; VASCULARIZATION; WORKFLOW; ADULT; ADVERSE EFFECTS; HEMORRHAGE; HOSPITAL; PRACTICE GUIDELINE; PROCEDURES; SINGAPORE; STANDARDS; STATISTICS AND NUMERICAL DATA;

ADULT; BLOOD TRANSFUSION; CLINICAL PROTOCOLS; HEMORRHAGE; HOSPITALS; HUMANS; PRACTICE GUIDELINES AS TOPIC; SINGAPORE;

EID: 84956800561     PISSN: 00429007     EISSN: 14230410     Source Type: Journal    
DOI: 10.1111/vox.12311     Document Type: Article

References (63)

1. Devenport R, Khan S: Management of major trauma haemorrhage: treatment priorities and controversies. Br J Haematol 2011; 155:537-548
2. Bolliger D, Görlinger K, Tanaka KA: Pathophysiology and treatment of coagulopathy in massive hemorrhage and hemodilution. Anesthesiology 2010; 113:1205-1219
3. Frith D, Brohi K: The acute coagulopathy of trauma shock: clinical relevance. Surgeon 2010; 8:159-163
4. Hess JR, Brohi K, Dutton RP, et al.: The coagulopathy of trauma: a review of mechanisms. J Trauma 2008; 65:748-754
5. Bolliger D, Szlam F, Molinaro RJ, et al.: Finding the optimal fibrinogen concentration range for optimal fibrinogen replacement. Br J Anaesth 2009; 102:793-799
6. Fenger-Eriksen C, Lindberg-Larsen M, Christensen AQ, et al.: Fibrinogen concentrate substitution therapy in patients with massive haemorrhage and low plasma fibrinogen concentrates. Br J Anaesth 2008; 101:769-773
7. Brohi K: Acute traumatic coagulopathy: initiated by hypoperfusion: modulated through the protein c pathway? Ann Surg 2007; 245:812-818
8. Brohi K, Cohen MJ, Davenport RA: Acute coagulopathy of trauma: mechanism, identification and effect. Curr Opin Crit Care 2007; 13:680-685
9. Riskin DJ, Tsai TC, Riskin L, et al.: Massive transfusion protocols: the role of aggressive resuscitation versus product ratio in mortality reduction. J Am Coll Surg 2009; 000:198-205
10. Nascimento B, Callum J, Rubenfeld G, et al.: Clinical review: fresh frozen plasma in massive bleedings - more questions than answers. Crit Care 2010; 14:202
11. Curry N, Hopewell S, Doree C, et al.: The acute management of trauma haemorrhage; a systemic review of randomised controlled trials. Crit Care 2011; 15:R92
12. Spinella PC, Holcomb JB: Resusitation and transfusion principles for traumatic hemorrhagic shock. Blood Rev 2009; 23:231-240
13. Munro AR: Ferguson C: BET (Best Evidence Topic Report) 1: blood component therapy in trauma patients requiring massive transfusion. Emerg Med J 2010; 27:53-55
14. Kirkman E, Watts S, Hodgetts T, et al.: Proactive approach to the coagulopathy of trauma: the rationale and guidelines for treatment. J R Army Med Corps 2008; 153:302-306
15. Sperry JL, Ochoa JB, Gunn SR, et al.: An FFP:PRBC transfusion ratio >1:1.5 is associated with a lower risk of mortality after massive transfusion. J Trauma 2008; 65:986-993
16. Mitra B, Mori A, Cameron PA, et al.: Fresh frozen plasma (FFP) use during massive blood transfusion in trauma resuscitation. Injury 2010; 42:35-39
17. Maegele M, Paffrath T, Tjardes T, et al.: Red blood cell to plasma ratios transfused during massive transfusion are associated with mortality in severe multiple injury: a retrospective analysis from the Trauma Registry of the Deutsche Gesellschaft für Unfallchirurgie. Vox Sang 2008; 95:112-119
18. Teixeira PGR, Inaba K, Shulman I, et al.: The impact of plasma transfusion in massively transfused trauma patients. J Trauma 2009; 66:693-697
19. Kashuk JL, Moore EE, Johnson JL, et al.: Postinjury life threatening coagulopathy: is 1:1 fresh frozen plasma: packed red blood cells the answer? J Trauma 2008; 65:261-271
20. Scalea TM, Bochicchio KM, Lumpkins K, et al.: Early aggressive use of fresh frozen plasma does not improve outcome in critically injured trauma patients. Ann Surg 2008; Oct 248:578-584
21. Hallet J, Lauzier F, Mailloux O, et al.: The use of higher platelet: RBC transfusion ratio in the acute phase of trauma resuscitation: a systematic review. Crit Care Med 2013; 41:2800-2811
22. Holcomb JB, del Junco DJ, Fox EE, et al.: The prospective, observational, multicenter, major trauma transfusion (PROMMTT) study: comparative effectiveness of a time-varying treatment with competing risks. JAMA Surg 2013; 148:127-136
23. Holcomb JB, Tilley BC, Baraniuk S, et al.: Transfusion of plasma platelets, and red cells in a 1:1:1: vs !:1:2 ratio and mortality in patients with severe trauma. The PROPPR Randomized Clinical Trial. JAMA 2015; 313:471-482
24. Brown JB, Cohen MJ, Minei JP, et al.: Debunking the survival bias myth: characterization of mortality during the initial 24 hours for patients requiring massive transfusion. J Trauma Acute Care Surg 2012; 73:358-364; discussion 364.
25. Dente CJ, Shaz BH, Nicholas JM, et al.: Improvements in early mortality and coagulopathy are sustained better in patients with blunt trauma after institution of a massive transfusion protocol in a civilian level I trauma center. J Trauma 2009; 66:1616-1624
26. Cotton BA, Au BK, Nunez TC, et al.: Predefined massive transfusion protocols are associated with a reduction in organ failure and postinjury complications. J Trauma 2009; 66:41-49
27. Zaydfudim V, Dutton WD, Feurer ID, et al.: Exsanguination protocol improves survival after major hepatic trauma. Injury 2010; 41:30-34
28. Riskin DJ, Tsai TC, Riskin L, et al.: Massive Transfusion Protocols: the role of aggressive resuscitation versus product ratio in mortality reduction. J Am Coll Surg 2009; Aug 209:198-205
29. National Blood Authority, Australia. Patient Blood Management Guideline (2012) Module 1 - Critical Bleeding/Massive Transfusion. ISBN 978-0-9873687-9-9. Available at: www.blood.gov.au/pbm-module-1 [Last accessed 20 May 2015].
30. National Patient Safety Agency, UK (Oct 2010) - The transfusion of blood and blood components in an emergency. Rapid Response Report NPSA/2010/RRR017. Available at: http://www.nrls.npsa.nhs.uk/alerts/?entryid45=83659 [Last accessed 20 May 2010].
31. Department of Statistics, Singapore. Available at: http://www.singstat.gov.sg/statistics/latest_data.html. [Last accessed 24 September 2014]
32. Land Transport Authority: Singapore Land Transport Statistics 2013 in Brief. Singapore 2013. Available at: http://www.lta.gov.sg/ltaacademy/doc/J14May_p58-Spore_Statistics.pdf. [Last accessed 24 September 2014]
33. Health Information Division, Ministry of Health: Singapore Health Facts 2013. Singapore, 2013 Available at: https://www.moh.gov.sg/content/moh_web/home/statistics.html. [Last accessed 24 September 2014]
34. Bormanis J: Development of a massive transfusion protocol. Transfus Apher Sci 2008; 38:57-63
35. Phan HH, Wisner DH: Should we increase the ratio of plasma/platelets to red blood cells in massive transfusion: what is the evidence? Vox Sang 2010; 98(3 Pt 2):395-402
36. Zehtabchi S, Nishijima DK: Impact of transfusion of FFP and PCT in a 1:1 ratio on survival of emergency department patients with severe trauma. Acad Emerg Med 2009; 16:371-378
37. Malone DL, Hess JR, Fingerhut A: Massive transfusion practices around the globe and the suggestions for a common massive transfusion protocol. J Trauma 2006; 60(6 suppl):S91-S96
38. Baumann-Kreuziger LM, Morton CT, Sunramanian AT, et al.: Not only in trauma patients: hospital-wide implementation of a massive transfusion protocol. Transfus Med 2013; 24:162-168
39. McDaniel LM, Neal MD, Sprerry JL, et al.: Use of a massive transfusion protocol in non-trauma patients: activate away. J Am Coll Surg 2013; 216:1103-1109
40. Gehrie EA, Tormey CA: The development and implementation of, and first years' experience with, a massive/emergency transfusion protocol (damage control hematology protocol) in a veterans' affairs hospital. Mil Med 2014; 179:1099-1105
41. Nunez TC, Voskresensky IV, Dossett LA, et al.: Early prediction of massive transfusion in trauma: simple as ABC (assessment of blood consumption)? J Trauma 2009; 66:346-352
42. Cotton BA, Dossett LA, Haut ER, et al.: Multicenter validation of a simplified score to predict massive transfusion in trauma. J Trauma 2010; 69(Suppl 1):S33-S39
43. Koh BC, Chong LL, Goh LG, et al.: Ministry of health clinical practice guidelines: clinical blood transfusion. Singapore Med J 2011; 52:209-218
44. Stainsby D, MacLennan S, Thomas D, et al.: British Committee on Standards in Haematology (BCSH) Guidelines on the management of massive blood loss. Br J Haematol 2006; 135:634-641
45. ® provides early prediction of massive transfusion in trauma. Crit Care 2011; 15:R265
46. ®) on diagnosis of coagulopathy, transfusion guidance and mortality in trauma: descriptive systematic review. Crit Care 2014; 18:518
47. CRASH-2 trial collaborators, Shakur H, Roberts I, et al.: Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial. Lancet 2010; 376:23-32
48. Pampee P, Cotton BA, Goodnough LT: Massive transfusion protocols for patients with substantial haemorrhage. Transfus Med Rev 2011; 25:293-303
49. O'Keefe T, Refaai M, Tchorz K, et al.: A massive transfusion protocol to decrease blood component use and costs. Arch Surg 2008; 143:686-690
50. Morse BC, Dente CJ, Hodgman EI, et al.: Outcomes after massive transfusion in non-trauma patients in the era of damage control resuscitation. Am Surg 2012; Jun 78:679-684
51. Gutierrez MC, Goodnough LT, Druzin M, et al.: Postpartum hemorrhage treated with a massive transfusion protocol at a tertiary obstetric center: a retrospective study. Int J Obstet Anesth 2012; 21:230-235
52. Khan S, Allard S, Weaver A, et al.: A major haemorrhage protocol improves the delivery of blood component therapy and reduces waste in trauma massive transfusion. Injury 2013; 44:587-592
53. Burtelow M, Riley E, Druzin M, et al.: How we treat: management of life-threatening primary post-partum hemorrhage with a standard massive transfusion protocol. Transfusion 2007; 47:1564-1572
54. Levy JH, Welsby I, Goodnough LT: Fibrinogen as a therapeutic target for bleeding: a review of critical levels and replacement therapy. Transfusion 2014; 54:1389-1405
55. Leal-Noval SR, Casado M, Arellano-Orden V, et al.: Administration of fibrinogen concentrate for refractory bleeding in massively transfused, non-trauma patients with coagulopathy: a retrospective study with compactor group. BMC Anesthesiol 2014; 14:109
56. Rourke C, Curry N, Khan S, et al.: Fibrinogen levels during trauma haemorrhage, response to replacement therapy, and association with patient outcomes. J Thromb Haemost 2012; 10:1342-1351
57. McQuilten ZK, Crighton G, Engelbrecht S, et al.: Transfusion interventions in critical bleeding requiring massive transfusion: a systematic review. Transfus Med Rev 2015; 29:127-137
58. Dente CJ, Shaz BH, Nicholas JM, et al.: Early predictors of massive transfusion in patients sustaining torso gunshot wounds in a civilian level I trauma center. J Trauma 2010; Feb 68:298-304
59. Subramaniam A, Albert V, Sharma S, et al.: Assessing the efficiency of scoring systems for predicting the probability of massive transfusion in trauma patients. J Haematol Thrombo Dis 2014; 2:1000161
60. Inaba K, Branco BC, Rhee P, et al.: Impact of plasma transfusion in trauma patients who do not require massive transfusion. J Am Coll Surg 2010; 210:957-965
61. Perel P, Clayton T, Altman DG, et al.: Red blood cell transfusion and mortality in trauma patients: risk-stratified analysis of an observational study. PLoS Med 2014; 11:e1001664
62. Sambasivan CN, Kunio NR, Nair PV, et al.: High ratios of plasma and platelets to packed red blood cells do not affect mortality in non massively transfused patients. J Trauma 2011; 71:S329-S336
63. Sariani B, Dunkman WJ, Dean L, et al.: Transfusion of fresh frozen plasma in critically ill surgical patients is associated with an increased risk of infection. Crit Care Med 2008; 36:1114-1118