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Volumn 113, Issue 5, 2016, Pages E548-E557

Transcription factor 7-like 1 is involved in hypothalamo-pituitary axis development in mice and humans

(27)  Gaston Massuet, Carles a,b   McCabe, Mark J a,i,j   Scagliotti, Valeria b   Young, Rodrigo M c   Carreno, Gabriela a   Gregory, Louise C a   Jayakody, Sujatha A a   Pozzi, Sara a   Gualtieri, Angelica b   Basu, Basudha d   Koniordou, Markela a   Wu, Chun I e   Bancalari, Rodrigo E a   Rahikkala, Elisa f,g   Veijola, Riitta g   Lopponen, Tuija h   Graziola, Federica b   Turton, James a   Signore, Massimo a   Gharavy, Seyedeh Neda Mousavy a   more..


Author keywords

Hypopituitarism; Pituitary; Septooptic dysplasia; TCF7L1; Wnt pathway

Indexed keywords

BETA CATENIN; TRANSCRIPTION FACTOR 7 LIKE 1; TCF7L1 PROTEIN, HUMAN; TCF7L1 PROTEIN, MOUSE;

EID: 84956677665     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1503346113     Document Type: Article
Times cited : (45)

References (66)
  • 1
    • 84923868222 scopus 로고    scopus 로고
    • Combined pituitary hormone deficiency: Current and future status
    • Castinetti F, et al. (2014) Combined pituitary hormone deficiency: Current and future status. J Endocrinol Invest 38(1):1-12.
    • (2014) J Endocrinol Invest , vol.38 , Issue.1 , pp. 1-12
    • Castinetti, F.1
  • 3
    • 77956916684 scopus 로고    scopus 로고
    • Genetic causes and treatment of isolated growth hormone deficiency-An update
    • Alatzoglou KS, Dattani MT (2010) Genetic causes and treatment of isolated growth hormone deficiency-An update. Nat Rev Endocrinol 6(10):562-576.
    • (2010) Nat Rev Endocrinol , vol.6 , Issue.10 , pp. 562-576
    • Alatzoglou, K.S.1    Dattani, M.T.2
  • 5
    • 77952884443 scopus 로고    scopus 로고
    • Molecular mechanisms of pituitary organogenesis: In search of novel regulatory genes
    • Davis SW, et al. (2010) Molecular mechanisms of pituitary organogenesis: In search of novel regulatory genes. Mol Cell Endocrinol 323(1):4-19.
    • (2010) Mol Cell Endocrinol , vol.323 , Issue.1 , pp. 4-19
    • Davis, S.W.1
  • 7
    • 63049131393 scopus 로고    scopus 로고
    • Distinct developmental roles of cell cycle inhibitors p57Kip2 and p27Kip1 distinguish pituitary progenitor cell cycle exit from cell cycle reentry of differentiated cells
    • Bilodeau S, Roussel-Gervais A, Drouin J (2009) Distinct developmental roles of cell cycle inhibitors p57Kip2 and p27Kip1 distinguish pituitary progenitor cell cycle exit from cell cycle reentry of differentiated cells. Mol Cell Biol 29(7):1895-1908.
    • (2009) Mol Cell Biol , vol.29 , Issue.7 , pp. 1895-1908
    • Bilodeau, S.1    Roussel-Gervais, A.2    Drouin, J.3
  • 8
    • 79953024515 scopus 로고    scopus 로고
    • Birthdating studies reshape models for pituitary gland cell specification
    • Davis SW, Mortensen AH, Camper SA (2011) Birthdating studies reshape models for pituitary gland cell specification. Dev Biol 352(2):215-227.
    • (2011) Dev Biol , vol.352 , Issue.2 , pp. 215-227
    • Davis, S.W.1    Mortensen, A.H.2    Camper, S.A.3
  • 9
    • 82155173540 scopus 로고    scopus 로고
    • The role of homeodomain transcription factors in heritable pituitary disease
    • Prince KL, Walvoord EC, Rhodes SJ (2011) The role of homeodomain transcription factors in heritable pituitary disease. Nat Rev Endocrinol 7(12):727-737.
    • (2011) Nat Rev Endocrinol , vol.7 , Issue.12 , pp. 727-737
    • Prince, K.L.1    Walvoord, E.C.2    Rhodes, S.J.3
  • 10
    • 79961006122 scopus 로고    scopus 로고
    • Pituitary stem cell update and potential implications for treating hypopituitarism
    • Castinetti F, Davis SW, Brue T, Camper SA (2011) Pituitary stem cell update and potential implications for treating hypopituitarism. Endocr Rev 32(4):453-471.
    • (2011) Endocr Rev , vol.32 , Issue.4 , pp. 453-471
    • Castinetti, F.1    Davis, S.W.2    Brue, T.3    Camper, S.A.4
  • 11
    • 84885133119 scopus 로고    scopus 로고
    • Sox2 (+) stem/progenitor cells in the adult mouse pituitary support organ homeostasis and have tumor-inducing potential
    • Andoniadou CL, et al. (2013) Sox2(+) stem/progenitor cells in the adult mouse pituitary support organ homeostasis and have tumor-inducing potential. Cell Stem Cell 13(4):433-445.
    • (2013) Cell Stem Cell , vol.13 , Issue.4 , pp. 433-445
    • Andoniadou, C.L.1
  • 12
    • 84885155429 scopus 로고    scopus 로고
    • Mobilized adult pituitary stem cells contribute to endocrine regeneration in response to physiological demand
    • Rizzoti K, Akiyama H, Lovell-Badge R (2013) Mobilized adult pituitary stem cells contribute to endocrine regeneration in response to physiological demand. Cell Stem Cell 13(4):419-432.
    • (2013) Cell Stem Cell , vol.13 , Issue.4 , pp. 419-432
    • Rizzoti, K.1    Akiyama, H.2    Lovell-Badge, R.3
  • 13
    • 0035692012 scopus 로고    scopus 로고
    • Molecular effects of novel mutations in Hesx1/HESX1 associated with human pituitary disorders
    • Brickman JM, et al. (2001) Molecular effects of novel mutations in Hesx1/HESX1 associated with human pituitary disorders. Development 128(24):5189-5199.
    • (2001) Development , vol.128 , Issue.24 , pp. 5189-5199
    • Brickman, J.M.1
  • 14
    • 0035576879 scopus 로고    scopus 로고
    • Temporal regulation of a paired-like homeodomain repressor/TLE corepressor complex and a related activator is required for pituitary organogenesis
    • Dasen JS, et al. (2001) Temporal regulation of a paired-like homeodomain repressor/TLE corepressor complex and a related activator is required for pituitary organogenesis. Genes Dev 15(23):3193-3207.
    • (2001) Genes Dev , vol.15 , Issue.23 , pp. 3193-3207
    • Dasen, J.S.1
  • 15
    • 84861986053 scopus 로고    scopus 로고
    • Wnt/β-catenin signaling and disease
    • Clevers H, Nusse R (2012) Wnt/β-catenin signaling and disease. Cell 149(6):1192-1205.
    • (2012) Cell , vol.149 , Issue.6 , pp. 1192-1205
    • Clevers, H.1    Nusse, R.2
  • 16
    • 0037205007 scopus 로고    scopus 로고
    • The promise and perils of Wnt signaling through beta-catenin
    • Moon RT, Bowerman B, Boutros M, Perrimon N (2002) The promise and perils of Wnt signaling through beta-catenin. Science 296(5573):1644-1646.
    • (2002) Science , vol.296 , Issue.5573 , pp. 1644-1646
    • Moon, R.T.1    Bowerman, B.2    Boutros, M.3    Perrimon, N.4
  • 17
    • 67650230896 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling: Components, mechanisms, and diseases
    • MacDonald BT, Tamai K, He X (2009) Wnt/beta-catenin signaling: Components, mechanisms, and diseases. Dev Cell 17(1):9-26.
    • (2009) Dev Cell , vol.17 , Issue.1 , pp. 9-26
    • MacDonald, B.T.1    Tamai, K.2    He, X.3
  • 18
    • 0030978351 scopus 로고    scopus 로고
    • Beta-catenin is a target for the ubiquitin-proteasome pathway
    • Aberle H, Bauer A, Stappert J, Kispert A, Kemler R (1997) beta-catenin is a target for the ubiquitin-proteasome pathway. EMBO J 16(13):3797-3804.
    • (1997) EMBO J , vol.16 , Issue.13 , pp. 3797-3804
    • Aberle, H.1    Bauer, A.2    Stappert, J.3    Kispert, A.4    Kemler, R.5
  • 19
    • 0037155691 scopus 로고    scopus 로고
    • Control of beta-catenin phosphorylation/degradation by a dualkinase mechanism
    • Liu C, et al. (2002) Control of beta-catenin phosphorylation/degradation by a dualkinase mechanism. Cell 108(6):837-847.
    • (2002) Cell , vol.108 , Issue.6 , pp. 837-847
    • Liu, C.1
  • 20
    • 0032562603 scopus 로고    scopus 로고
    • Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta
    • Behrens J, et al. (1998) Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta. Science 280(5363):596-599.
    • (1998) Science , vol.280 , Issue.5363 , pp. 596-599
    • Behrens, J.1
  • 21
    • 0032473355 scopus 로고    scopus 로고
    • Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin
    • Ikeda S, et al. (1998) Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin. EMBO J 17(5):1371-1384.
    • (1998) EMBO J , vol.17 , Issue.5 , pp. 1371-1384
    • Ikeda, S.1
  • 22
    • 0035071348 scopus 로고    scopus 로고
    • Wnt signalling: A theme with nuclear variations
    • Sharpe C, Lawrence N, Martinez Arias A (2001) Wnt signalling: A theme with nuclear variations. BioEssays 23(4):311-318.
    • (2001) BioEssays , vol.23 , Issue.4 , pp. 311-318
    • Sharpe, C.1    Lawrence, N.2    Martinez Arias, A.3
  • 23
    • 0032497485 scopus 로고    scopus 로고
    • The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors
    • Roose J, et al. (1998) The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors. Nature 395(6702):608-612.
    • (1998) Nature , vol.395 , Issue.6702 , pp. 608-612
    • Roose, J.1
  • 24
    • 0034282678 scopus 로고    scopus 로고
    • Sequence-specific high mobility group box factors recognize 10-12-base pair minor groove motifs
    • van Beest M, et al. (2000) Sequence-specific high mobility group box factors recognize 10-12-base pair minor groove motifs. J Biol Chem 275(35):27266-27273.
    • (2000) J Biol Chem , vol.275 , Issue.35 , pp. 27266-27273
    • Van Beest, M.1
  • 25
    • 0026696874 scopus 로고
    • Sequence-specific interaction of the HMG box proteins TCF-1 and SRY occurs within the minor groove of a Watson-Crick double helix
    • van de Wetering M, Clevers H (1992) Sequence-specific interaction of the HMG box proteins TCF-1 and SRY occurs within the minor groove of a Watson-Crick double helix. EMBO J 11(8):3039-3044.
    • (1992) EMBO J , vol.11 , Issue.8 , pp. 3039-3044
    • Van De Wetering, M.1    Clevers, H.2
  • 26
    • 0035312290 scopus 로고    scopus 로고
    • All Tcf HMG box transcription factors interact with Groucho-related co-repressors
    • Brantjes H, Roose J, van De Wetering M, Clevers H (2001) All Tcf HMG box transcription factors interact with Groucho-related co-repressors. Nucleic Acids Res 29(7):1410-1419.
    • (2001) Nucleic Acids Res , vol.29 , Issue.7 , pp. 1410-1419
    • Brantjes, H.1    Roose, J.2    Van De Wetering, M.3    Clevers, H.4
  • 27
    • 0032941717 scopus 로고    scopus 로고
    • Regulation of LEF-1/TCF transcription factors by Wnt and other signals
    • Eastman Q, Grosschedl R (1999) Regulation of LEF-1/TCF transcription factors by Wnt and other signals. Curr Opin Cell Biol 11(2):233-240.
    • (1999) Curr Opin Cell Biol , vol.11 , Issue.2 , pp. 233-240
    • Eastman, Q.1    Grosschedl, R.2
  • 28
    • 0027945654 scopus 로고
    • Development of several organs that require inductive epithelial-mesenchymal interactions is impaired in LEF-1-deficient mice
    • van Genderen C, et al. (1994) Development of several organs that require inductive epithelial-mesenchymal interactions is impaired in LEF-1-deficient mice. Genes Dev 8(22):2691-2703.
    • (1994) Genes Dev , vol.8 , Issue.22 , pp. 2691-2703
    • Van Genderen, C.1
  • 29
    • 0028935955 scopus 로고
    • Lymphoid enhancer factor 1 directs hair follicle patterning and epithelial cell fate
    • Zhou P, Byrne C, Jacobs J, Fuchs E (1995) Lymphoid enhancer factor 1 directs hair follicle patterning and epithelial cell fate. Genes Dev 9(6):700-713.
    • (1995) Genes Dev , vol.9 , Issue.6 , pp. 700-713
    • Zhou, P.1    Byrne, C.2    Jacobs, J.3    Fuchs, E.4
  • 30
    • 0038635932 scopus 로고    scopus 로고
    • Two tcf3 genes cooperate to pattern the zebrafish brain
    • Dorsky RI, Itoh M, Moon RT, Chitnis A (2003) Two tcf3 genes cooperate to pattern the zebrafish brain. Development 130(9):1937-1947.
    • (2003) Development , vol.130 , Issue.9 , pp. 1937-1947
    • Dorsky, R.I.1    Itoh, M.2    Moon, R.T.3    Chitnis, A.4
  • 31
    • 0034687424 scopus 로고    scopus 로고
    • Repressor activity of Headless/Tcf3 is essential for vertebrate head formation
    • Kim CH, et al. (2000) Repressor activity of Headless/Tcf3 is essential for vertebrate head formation. Nature 407(6806):913-916.
    • (2000) Nature , vol.407 , Issue.6806 , pp. 913-916
    • Kim, C.H.1
  • 32
    • 0036713055 scopus 로고    scopus 로고
    • Repression of organizer genes in dorsal and ventral Xenopus cells mediated by maternal XTcf3
    • Houston DW, et al. (2002) Repression of organizer genes in dorsal and ventral Xenopus cells mediated by maternal XTcf3. Development 129(17):4015-4025.
    • (2002) Development , vol.129 , Issue.17 , pp. 4015-4025
    • Houston, D.W.1
  • 33
    • 84861362271 scopus 로고    scopus 로고
    • Function of Wnt/β-catenin in counteracting Tcf3 repression through the Tcf3-β-catenin interaction
    • Wu CI, et al. (2012) Function of Wnt/β-catenin in counteracting Tcf3 repression through the Tcf3-β-catenin interaction. Development 139(12):2118-2129.
    • (2012) Development , vol.139 , Issue.12 , pp. 2118-2129
    • Wu, C.I.1
  • 34
    • 17944373656 scopus 로고    scopus 로고
    • Identification of members of the Wnt signaling pathway in the embryonic pituitary gland
    • Douglas KR, et al. (2001) Identification of members of the Wnt signaling pathway in the embryonic pituitary gland. Mamm Genome 12(11):843-851.
    • (2001) Mamm Genome , vol.12 , Issue.11 , pp. 843-851
    • Douglas, K.R.1
  • 35
    • 65349134145 scopus 로고    scopus 로고
    • Identification of Wnt-responsive cells in the zebrafish hypothalamus
    • Wang X, Lee JE, Dorsky RI (2009) Identification of Wnt-responsive cells in the zebrafish hypothalamus. Zebrafish 6(1):49-58.
    • (2009) Zebrafish , vol.6 , Issue.1 , pp. 49-58
    • Wang, X.1    Lee, J.E.2    Dorsky, R.I.3
  • 36
    • 0442278332 scopus 로고    scopus 로고
    • Early steps in the development of the forebrain
    • Wilson SW, Houart C (2004) Early steps in the development of the forebrain. Dev Cell 6(2):167-181.
    • (2004) Dev Cell , vol.6 , Issue.2 , pp. 167-181
    • Wilson, S.W.1    Houart, C.2
  • 37
    • 33646134106 scopus 로고    scopus 로고
    • Homeodomain-mediated beta-catenin-dependent switching events dictate cell-lineage determination
    • Olson LE, et al. (2006) Homeodomain-mediated beta-catenin-dependent switching events dictate cell-lineage determination. Cell 125(3):593-605.
    • (2006) Cell , vol.125 , Issue.3 , pp. 593-605
    • Olson, L.E.1
  • 38
    • 1642355291 scopus 로고    scopus 로고
    • WNT5A signaling affects pituitary gland shape
    • Cha KB, et al. (2004) WNT5A signaling affects pituitary gland shape. Mech Dev 121(2):183-194.
    • (2004) Mech Dev , vol.121 , Issue.2 , pp. 183-194
    • Cha, K.B.1
  • 39
    • 42149180590 scopus 로고    scopus 로고
    • WNT signaling affects gene expression in the ventral diencephalon and pituitary gland growth
    • Potok MA, et al. (2008) WNT signaling affects gene expression in the ventral diencephalon and pituitary gland growth. Dev Dyn 237(4):1006-1020.
    • (2008) Dev Dyn , vol.237 , Issue.4 , pp. 1006-1020
    • Potok, M.A.1
  • 40
    • 0242298721 scopus 로고    scopus 로고
    • TCF and Groucho-related genes influence pituitary growth and development
    • Brinkmeier ML, et al. (2003) TCF and Groucho-related genes influence pituitary growth and development. Mol Endocrinol 17(11):2152-2161.
    • (2003) Mol Endocrinol , vol.17 , Issue.11 , pp. 2152-2161
    • Brinkmeier, M.L.1
  • 41
    • 35948993820 scopus 로고    scopus 로고
    • TCF4 deficiency expands ventral diencephalon signaling and increases induction of pituitary progenitors
    • Brinkmeier ML, Potok MA, Davis SW, Camper SA (2007) TCF4 deficiency expands ventral diencephalon signaling and increases induction of pituitary progenitors. Dev Biol 311(2):396-407.
    • (2007) Dev Biol , vol.311 , Issue.2 , pp. 396-407
    • Brinkmeier, M.L.1    Potok, M.A.2    Davis, S.W.3    Camper, S.A.4
  • 42
    • 79959963618 scopus 로고    scopus 로고
    • Opposing effects of Tcf3 and Tcf1 control Wnt stimulation of embryonic stem cell self-renewal
    • Yi F, et al. (2011) Opposing effects of Tcf3 and Tcf1 control Wnt stimulation of embryonic stem cell self-renewal. Nat Cell Biol 13(7):762-770.
    • (2011) Nat Cell Biol , vol.13 , Issue.7 , pp. 762-770
    • Yi, F.1
  • 43
    • 48449105489 scopus 로고    scopus 로고
    • Tcf3 functions as a steady-state limiter of transcriptional programs of mouse embryonic stem cell self-renewal
    • Yi F, Pereira L, Merrill BJ (2008) Tcf3 functions as a steady-state limiter of transcriptional programs of mouse embryonic stem cell self-renewal. Stem Cells 26(8):1951-1960.
    • (2008) Stem Cells , vol.26 , Issue.8 , pp. 1951-1960
    • Yi, F.1    Pereira, L.2    Merrill, B.J.3
  • 44
    • 70349554461 scopus 로고    scopus 로고
    • Tcf3 and Tcf4 are essential for long-term homeostasis of skin epithelia
    • Nguyen H, et al. (2009) Tcf3 and Tcf4 are essential for long-term homeostasis of skin epithelia. Nat Genet 41(10):1068-1075.
    • (2009) Nat Genet , vol.41 , Issue.10 , pp. 1068-1075
    • Nguyen, H.1
  • 45
    • 0842344619 scopus 로고    scopus 로고
    • Tcf3: A transcriptional regulator of axis induction in the early embryo
    • Merrill BJ, et al. (2004) Tcf3: A transcriptional regulator of axis induction in the early embryo. Development 131(2):263-274.
    • (2004) Development , vol.131 , Issue.2 , pp. 263-274
    • Merrill, B.J.1
  • 46
    • 84875461910 scopus 로고    scopus 로고
    • Tcf7l1 prepares epiblast cells in the gastrulating mouse embryo for lineage specification
    • Hoffman JA, Wu CI, Merrill BJ (2013) Tcf7l1 prepares epiblast cells in the gastrulating mouse embryo for lineage specification. Development 140(8):1665-1675.
    • (2013) Development , vol.140 , Issue.8 , pp. 1665-1675
    • Hoffman, J.A.1    Wu, C.I.2    Merrill, B.J.3
  • 47
    • 80054960278 scopus 로고    scopus 로고
    • HESX1- and TCF3-mediated repression of Wnt/β-catenin targets is required for normal development of the anterior forebrain
    • Andoniadou CL, et al. (2011) HESX1- and TCF3-mediated repression of Wnt/β-catenin targets is required for normal development of the anterior forebrain. Development 138(22):4931-4942.
    • (2011) Development , vol.138 , Issue.22 , pp. 4931-4942
    • Andoniadou, C.L.1
  • 48
    • 84884906952 scopus 로고    scopus 로고
    • Developmental mechanisms directing early anterior forebrain specification in vertebrates
    • Andoniadou CL, Martinez-Barbera JP (2013) Developmental mechanisms directing early anterior forebrain specification in vertebrates. Cell Mol Life Sci 70(20):3739-3752.
    • (2013) Cell Mol Life Sci , vol.70 , Issue.20 , pp. 3739-3752
    • Andoniadou, C.L.1    Martinez-Barbera, J.P.2
  • 49
    • 34248545437 scopus 로고    scopus 로고
    • Lack of the murine homeobox gene Hesx1 leads to a posterior transformation of the anterior forebrain
    • Andoniadou CL, et al. (2007) Lack of the murine homeobox gene Hesx1 leads to a posterior transformation of the anterior forebrain. Development 134(8):1499-1508.
    • (2007) Development , vol.134 , Issue.8 , pp. 1499-1508
    • Andoniadou, C.L.1
  • 50
    • 79960973767 scopus 로고    scopus 로고
    • Increased Wingless (Wnt) signaling in pituitary progenitor/stem cells gives rise to pituitary tumors in mice and humans
    • Gaston-Massuet C, et al. (2011) Increased Wingless (Wnt) signaling in pituitary progenitor/stem cells gives rise to pituitary tumors in mice and humans. Proc Natl Acad Sci USA 108(28):11482-11487.
    • (2011) Proc Natl Acad Sci USA , vol.108 , Issue.28 , pp. 11482-11487
    • Gaston-Massuet, C.1
  • 51
    • 84867145497 scopus 로고    scopus 로고
    • SOX2 regulates the hypothalamic-pituitary axis at multiple levels
    • Jayakody SA, et al. (2012) SOX2 regulates the hypothalamic-pituitary axis at multiple levels. J Clin Invest 122(10):3635-3646.
    • (2012) J Clin Invest , vol.122 , Issue.10 , pp. 3635-3646
    • Jayakody, S.A.1
  • 52
    • 0031916557 scopus 로고    scopus 로고
    • An Fgf8 mutant allelic series generated by Cre- and Flp-mediated recombination
    • Meyers EN, Lewandoski M, Martin GR (1998) An Fgf8 mutant allelic series generated by Cre- and Flp-mediated recombination. Nat Genet 18(2):136-141.
    • (1998) Nat Genet , vol.18 , Issue.2 , pp. 136-141
    • Meyers, E.N.1    Lewandoski, M.2    Martin, G.R.3
  • 53
    • 56449105561 scopus 로고    scopus 로고
    • Genetic interaction between the homeobox transcription factors HESX1 and SIX3 is required for normal pituitary development
    • Gaston-Massuet C, et al. (2008) Genetic interaction between the homeobox transcription factors HESX1 and SIX3 is required for normal pituitary development. Dev Biol 324(2):322-333.
    • (2008) Dev Biol , vol.324 , Issue.2 , pp. 322-333
    • Gaston-Massuet, C.1
  • 54
    • 64249164439 scopus 로고    scopus 로고
    • Analysis of mouse models carrying the I26T and R160C substitutions in the transcriptional repressor HESX1 as models for septo-optic dysplasia and hypopituitarism
    • Sajedi E, et al. (2008) Analysis of mouse models carrying the I26T and R160C substitutions in the transcriptional repressor HESX1 as models for septo-optic dysplasia and hypopituitarism. Dis Model Mech 1(4-5):241-254.
    • (2008) Dis Model Mech , vol.1 , Issue.4-5 , pp. 241-254
    • Sajedi, E.1
  • 55
    • 84877789292 scopus 로고    scopus 로고
    • Inhibition of Sox2-dependent activation of Shh in the ventral diencephalon by Tbx3 is required for formation of the neurohypophysis
    • Trowe MO, et al. (2013) Inhibition of Sox2-dependent activation of Shh in the ventral diencephalon by Tbx3 is required for formation of the neurohypophysis. Development 140(11):2299-2309.
    • (2013) Development , vol.140 , Issue.11 , pp. 2299-2309
    • Trowe, M.O.1
  • 56
    • 65549155393 scopus 로고    scopus 로고
    • Tcf3 inhibits spinal cord neurogenesis by regulating sox4a expression
    • Gribble SL, Kim HS, Bonner J, Wang X, Dorsky RI (2009) Tcf3 inhibits spinal cord neurogenesis by regulating sox4a expression. Development 136(5):781-789.
    • (2009) Development , vol.136 , Issue.5 , pp. 781-789
    • Gribble, S.L.1    Kim, H.S.2    Bonner, J.3    Wang, X.4    Dorsky, R.I.5
  • 58
    • 0035123270 scopus 로고    scopus 로고
    • Hedgehog signaling is required for pituitary gland development
    • Treier M, et al. (2001) Hedgehog signaling is required for pituitary gland development. Development 128(3):377-386.
    • (2001) Development , vol.128 , Issue.3 , pp. 377-386
    • Treier, M.1
  • 59
    • 84863393632 scopus 로고    scopus 로고
    • Disruption of SoxB1-dependent Sonic hedgehog expression in the hypothalamus causes septo-optic dysplasia
    • Zhao L, et al. (2012) Disruption of SoxB1-dependent Sonic hedgehog expression in the hypothalamus causes septo-optic dysplasia. Dev Cell 22(3):585-596.
    • (2012) Dev Cell , vol.22 , Issue.3 , pp. 585-596
    • Zhao, L.1
  • 60
    • 79952524771 scopus 로고    scopus 로고
    • Septo-optic dysplasia and other midline defects: The role of transcription factors: HESX1 and beyond
    • McCabe MJ, Alatzoglou KS, Dattani MT (2011) Septo-optic dysplasia and other midline defects: The role of transcription factors: HESX1 and beyond. Best Pract Res Clin Endocrinol Metab 25(1):115-124.
    • (2011) Best Pract Res Clin Endocrinol Metab , vol.25 , Issue.1 , pp. 115-124
    • McCabe, M.J.1    Alatzoglou, K.S.2    Dattani, M.T.3
  • 61
    • 17344362762 scopus 로고    scopus 로고
    • Mutations in the homeobox gene HESX1/Hesx1 associated with septo-optic dysplasia in human and mouse
    • Dattani MT, et al. (1998) Mutations in the homeobox gene HESX1/Hesx1 associated with septo-optic dysplasia in human and mouse. Nat Genet 19(2):125-133.
    • (1998) Nat Genet , vol.19 , Issue.2 , pp. 125-133
    • Dattani, M.T.1
  • 62
    • 77957001039 scopus 로고    scopus 로고
    • Oligogenic basis of isolated gonadotropin-releasing hormone deficiency
    • Sykiotis GP, et al. (2010) Oligogenic basis of isolated gonadotropin-releasing hormone deficiency. Proc Natl Acad Sci USA 107(34):15140-15144.
    • (2010) Proc Natl Acad Sci USA , vol.107 , Issue.34 , pp. 15140-15144
    • Sykiotis, G.P.1
  • 63
    • 84927087291 scopus 로고    scopus 로고
    • The role of the sonic hedgehog signalling pathway in patients with midline defects and congenital hypopituitarism
    • Gregory LC, et al. (2014) The role of the sonic hedgehog signalling pathway in patients with midline defects and congenital hypopituitarism. Clin Endocrinol (Oxf) 82(5):728-738.
    • (2014) Clin Endocrinol (Oxf) , vol.82 , Issue.5 , pp. 728-738
    • Gregory, L.C.1
  • 64
    • 40849095909 scopus 로고    scopus 로고
    • Three novel missense mutations within the LHX4 gene are associated with variable pituitary hormone deficiencies
    • Pfaeffle RW, et al. (2008) Three novel missense mutations within the LHX4 gene are associated with variable pituitary hormone deficiencies. J Clin Endocrinol Metab 93(3):1062-1071.
    • (2008) J Clin Endocrinol Metab , vol.93 , Issue.3 , pp. 1062-1071
    • Pfaeffle, R.W.1
  • 65
    • 77957876629 scopus 로고    scopus 로고
    • Regulation of TCF3 by Wnt-dependent phosphorylation during vertebrate axis specification
    • Hikasa H, et al. (2010) Regulation of TCF3 by Wnt-dependent phosphorylation during vertebrate axis specification. Dev Cell 19(4):521-532.
    • (2010) Dev Cell , vol.19 , Issue.4 , pp. 521-532
    • Hikasa, H.1
  • 66
    • 79953305300 scopus 로고    scopus 로고
    • Phosphorylation of TCF proteins by homeodomain-interacting protein kinase 2
    • Hikasa H, Sokol SY (2011) Phosphorylation of TCF proteins by homeodomain-interacting protein kinase 2. J Biol Chem 286(14):12093-12100.
    • (2011) J Biol Chem , vol.286 , Issue.14 , pp. 12093-12100
    • Hikasa, H.1    Sokol, S.Y.2


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