Microvessel density in hepatocellular carcinoma: Prognostic significance and review of the previous published work

Hepatology Research

Volumn 45, Issue 12, 2015, Pages 1185-1194

  Murakami, Keigo ^a   Kasajima, Atsuko ^a   Kawagishi, Naoki ^b   Ohuchi, Noriaki ^b   Sasano, Hironobu ^a  

^a Department of Pathology ^*  (Japan)

^b TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Angiogenesis; CD34 antigen; Hepatocellular carcinoma; Microvessel density; Prognostic factor

Indexed keywords

ALPHA FETOPROTEIN; CD34 ANTIGEN; CYTOKERATIN 19; KI 67 ANTIGEN;

ADULT; AGED; ANGIOGENESIS; ARTICLE; CANCER STAGING; CANCER SURVIVAL; CAPILLARY DENSITY; CONTROLLED STUDY; DISEASE FREE SURVIVAL; FEMALE; HEPATITIS B; HEPATITIS C; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; JAPANESE (PEOPLE); LIVER CELL CARCINOMA; LYMPH VESSEL METASTASIS; MAJOR CLINICAL STUDY; OVERALL SURVIVAL; PRIORITY JOURNAL; PROGNOSIS; PROGNOSTIC ASSESSMENT; RECEIVER OPERATING CHARACTERISTIC; RETROSPECTIVE STUDY; TUMOR DIFFERENTIATION; TUMOR VOLUME; VERY ELDERLY;

EID: 84955693994     PISSN: 13866346     EISSN: 1872034X     Source Type: Journal    
DOI: 10.1111/hepr.12487     Document Type: Article

References (35)

1. Kin M, Torimura T, Ueno T, Inuzuka S, Tanikawa K. Sinusoidal capillarization in small hepatocellular carcinoma. Pathol Int 1994; 44: 771-8.
2. Folkman J. What is the evidence that tumors are angiogenesis dependent? J Natl Cancer Inst 1990; 82: 4-6.
3. Mann CD, Neal CP, Garcea G, Manson MM, Dennison AR, Berry DP. Prognostic molecular markers in hepatocellular carcinoma: a systematic review. Eur J Cancer 2007; 43: 979-92.
4. Poon RT, Ng IO, Lau C et al. Tumor microvessel density as a predictor of recurrence after resection of hepatocellular carcinoma: a prospective study. J Clin Oncol 2002; 20: 1775-85.
5. Messerini L, Novelli L, Comin CE. Microvessel density and clinicopathological characteristics in hepatitis C virus and hepatitis B virus related hepatocellular carcinoma. J Clin Pathol 2004; 57: 867-71.
6. Ruck P, Xiao JC, Kaiserling E. Immunoreactivity of sinusoids in hepatocellular carcinoma. An immunohistochemical study using lectin UEA-1 and antibodies against endothelial markers, including CD34. Arch Pathol Lab Med 1995; 119: 173-8.
7. Tanigawa N, Lu C, Mitsui T, Miura S. Quantitation of sinusoid-like vessels in hepatocellular carcinoma: its clinical and prognostic significance. Hepatology 1997; 26: 1216-23.
8. Sun HC, Tang ZY, Li XM, Zhou YN, Sun BR, Ma ZC. Microvessel density of hepatocellular carcinoma: its relationship with prognosis. J Cancer Res Clin Oncol 1999; 125: 419-26.
9. Ng IO, Poon RT, Lee JM, Fan ST, Ng M, Tso WK. Microvessel density, vascular endothelial growth factor and its receptors Flt-1 and Flk-1/KDR in hepatocellular carcinoma. Am J Clin Pathol 2001; 116: 838-45.
10. Ho JW, Poon RT, Sun CK, Xue WC, Fan ST. Clinicopathological and prognostic implications of endoglin (CD105) expression in hepatocellular carcinoma and its adjacent non-tumorous liver. World J Gastroenterol 2005; 11: 176-81.
11. Llovet JM, Ricci S, Mazzaferro V et al. Sorafenib in advanced hepatocellular carcinoma. N Engl J Med 2008; 359: 378-90.
12. Chen ZY, Wei W, Guo ZX, Lin JR, Shi M, Guo RP. Morphologic classification of microvessels in hepatocellular carcinoma is associated with the prognosis after resection. J Gastroenterol Hepatol 2011; 26: 866-74.
13. Sobin LH, Gospodarowicz MK, Wittekind CH. International Union Against Cancer (UICC). TNM Classification of Malignant Tumours. 7th edn. New York: Wiley-Blackwell, 2009; 110-3.
14. Liver Cancer Study Group of Japan. General rules for the clinical and pathological study of primary liver cancer, 3rd English edn. Tokyo: Kanehara & Co., Ltd, 2010.
15. Asayama Y, Yoshimitsu K, Nishihara Y et al. Arterial blood supply of hepatocellular carcinoma and histologic grading: radiologic-pathologic correlation. AJR Am J Roentgenol 2008; 190: W28-34.
16. Weidner N, Semple JP, Welch WR, Folkman J. Tumor angiogenesis and metastasis--correlation in invasive breast carcinoma. N Engl J Med 1991; 324: 1-8.
17. Terada T, Nakanuma Y. Multiple occurrence of borderline hepatocellular nodules in human cirrhotic livers: possible multicentric origin of hepatocellular carcinoma. Virchows Arch 1995; 427: 379-83.
18. Kobayashi M, Ikeda K, Hosaka T et al. Dysplastic nodules frequently develop into hepatocellular carcinoma in patients with chronic viral hepatitis and cirrhosis. Cancer 2006; 106: 636-47.
19. Hayashi M, Matsui O, Ueda K et al. Correlation between the blood supply and grade of malignancy of hepatocellular nodules associated with liver cirrhosis: evaluation by CT during intraarterial injection of contrast medium. AJR Am J Roentgenol 1999; 172: 969-76.
20. Kitao A, Zen Y, Matsui O, Gabata T, Nakanuma Y. Hepatocarcinogenesis: multistep changes of drainage vessels at CT during arterial portography and hepatic arteriography--radiologic-pathologic correlation. Radiology 2009; 252: 605-14.
21. Okamoto D, Yoshimitsu K, Nishie A et al. Enhancement pattern analysis of hypervascular hepatocellular carcinoma on dynamic MR imaging with histopathological correlation: validity of portal phase imaging for predicting tumor grade. Eur J Radiol 2012; 81: 1116-21.
22. Nishie A, Yoshimitsu K, Okamoto D et al. CT prediction of histological grade of hypervascular hepatocellular carcinoma: utility of the portal phase. Jpn J Radiol 2013; 31: 89-98.
23. Jang HJ, Kim TK, Burns PN, Wilson SR. Enhancement patterns of hepatocellular carcinoma at contrast-enhanced US: comparison with histologic differentiation. Radiology 2007; 244: 898-906.
24. Hawighorst H, Knapstein PG, Weikel W et al. Angiogenesis of uterine cervical carcinoma: characterization by pharmacokinetic magnetic resonance parameters and histological microvessel density with correlation to lymphatic involvement. Cancer Res 1997; 57: 4777-86.
25. El-Assal ON, Yamanoi A, Soda Y et al. Clinical significance of microvessel density and vascular endothelial growth factor expression in hepatocellular carcinoma and surrounding liver: possible involvement of vascular endothelial growth factor in the angiogenesis of cirrhotic liver. Hepatology 1998; 27: 1554-62.
26. Yamamoto A, Dhar DK, El-Assal ON, Igarashi M, Tabara H, Nagasue N. Thymidine phosphorylase (platelet-derived endothelial cell growth factor), microvessel density and clinical outcome in hepatocellular carcinoma. J Hepatol 1998; 29: 290-9.
27. Kimura H, Nakajima T, Kagawa K et al. Angiogenesis in hepatocellular carcinoma as evaluated by CD34 immunohistochemistry. Liver 1998; 18: 14-9.
28. Chebib I, Shabani-Rad MT, Chow MS, Zhang J, Gao ZH. Microvessel density and clinicopathologic characteristics in hepatocellular carcinoma with and without cirrhosis. Biomarker insights 2007; 2: 59-68.
29. Miyaaki H, Fujimoto M, Kurogi M, Nakashima O, Eguchi K, Kojiro M. Pathomorphological study on small nodular lesions in hepatitis C virus-related cirrhosis. Oncol Rep 2005; 14: 1469-74.
30. Ueda K, Terada T, Nakanuma Y, Matsui O. Vascular supply in adenomatous hyperplasia of the liver and hepatocellular carcinoma: a morphometric study. Hum Pathol 1992; 23: 619-26.
31. Kinoshita H, Umezawa T, Omine Y et al. Distribution of elastic fibers in the head and neck: a histological study using late-stage human fetuses. Anat Cell Biol 2013; 46: 39-48.
32. Uematsu S, Higashi T, Nouso K et al. Altered expression of vascular endothelial growth factor, fibroblast growth factor-2 and endostatin in patients with hepatocellular carcinoma. J Gastroenterol Hepatol 2005; 20: 583-8.
33. Yamaguchi R, Yano H, Iemura A, Ogasawara S, Haramaki M, Kojiro M. Expression of vascular endothelial growth factor in human hepatocellular carcinoma. Hepatology 1998; 28: 68-77.
34. Grigioni WF, D'Errico A, Bacci F et al. Primary liver neoplasms: evaluation of proliferative index using MoAb Ki67. J Pathol 1989; 158: 23-9.
35. Chan AWH, Tong JHM, Chan SL et al. Expression of stemness markers (CD133 and EpCAM) in prognostication of hepatocellular carcinoma. Histopathol 2014; 64: 935-50.