Pathomorphological study on small nodular lesions in hepatitis C virus-related cirrhosis

Oncology Reports

Volumn 14, Issue 6, 2005, Pages 1469-1474

  Miyaaki, Hisamitsu ^a,b   Fujimoto, Masaru ^a   Kurogi, Mina ^a   Nakashima, Osamu ^a   Eguchi, Katsumi ^b   Kojiro, Masamichi ^a  

^a KURUME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b NAGASAKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Hepatocellular carcinoma; High grade dysplastic nodule; Large regenerative nodule; Low grade dysplastic nodule; Sinusoidal capillarization; Unpaired artery

Indexed keywords

ACTIN; CD34 ANTIGEN; CD68 ANTIGEN, HUMAN; DIFFERENTIATION ANTIGEN; LEUKOCYTE ANTIGEN;

AGED; ARTICLE; CHEMISTRY; FEMALE; HEPATITIS C; HUMAN; IMMUNOHISTOCHEMISTRY; KUPFFER CELL; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; LIVER TUMOR; MALE; METABOLISM; MIDDLE AGED; PATHOLOGY; SMOOTH MUSCLE;

ACTINS; AGED; ANTIGENS, CD; ANTIGENS, CD34; ANTIGENS, DIFFERENTIATION, MYELOMONOCYTIC; CARCINOMA, HEPATOCELLULAR; FEMALE; HEPATITIS C; HUMANS; IMMUNOHISTOCHEMISTRY; KUPFFER CELLS; LIVER CIRRHOSIS; LIVER NEOPLASMS; MALE; MIDDLE AGED; MUSCLE, SMOOTH;

EID: 33644678566     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.14.6.1469     Document Type: Article

References (30)

1. International Working Party: Terminology of nodular hepatocellular lesion. Hepatology 22: 983-993, 1995.
2. Kondo F, Ebara M, Sugiura N, Wada K, Kita K, Hirooka N, Nagato Y, Kondo Y, Ohto M and Okuda K: Histological features and clinical course of large regenerative nodules: evaluation of their precancerous potentiality. Hepatology 12: 592-598, 1990.
3. Ochiai T, Urata Y, Yamano T, Yamagishi H and Ashihara T: Clonal expansion in evolution of chronic hepatitis to hepatocellular carcinoma as seen at an X-chromosome locus. Hepatology 31: 615-621, 2000. (Pubitemid 30118629)
4. Paradis V, Laurendeau I, Vidaus M and Bedossa P: Clonal analysis of macronodules in cirrhosis. Hepatology 28: 953-958, 1998. (Pubitemid 28450255)
5. Tsuda H, Hirohashi Y, Shimasato Y, Terada M and Hasegawa H: Clonal origin of atypical adenomatous hyperplasia of the liver and clonal identity with hepatocellular carcinoma. Gastroenterology 95: 1664-1666, 1998.
6. Terasaki S, Kaneko S, Kobayashi K, Nonomura A and Nakanuma Y: Histological features predicting malignant transformation of nonmalignant hepatocellular nodules: A prospective study. Gastroenterology 115: 1216-1222,1998. (Pubitemid 28485613)
7. Borzio M, Fargion S, Borzio F, Fracanzani AL, Croce AM, Stroffolini T, Oldani S, et al:. Impact of large regenerative, low grade and high grade dysplastic nodules in hepatocellular carcinoma development. J Hepatol 39: 208-214, 2003. (Pubitemid 36920556)
8. Arakawa M, Kage M, Sugihara S, Nakashima T, Suenaga M and Okuda K: Emergence of malignant lesions with an adenomatous hyperplastic nodule in a cirrhotic liver-observations in five cases. Gastroenterology 91: 198-208, 1986. (Pubitemid 16086674)
9. Takakyama T, Makuuchi M, Horohashi S, Sakamoto M, Okazaki N, Takayasu K, Kosuge T, Motoo Y, Susumu Y and Hasegawa H: Malignant transformation of adenomatous hyperplasia to hepatocellular carcinoma. Lancet 336: 1150-1153, 1990. (Pubitemid 20362906)
10. Shimamatsu K, Kage M, Nakashima O and Kojiro M: Pathomorphological study of HCV antibody-positive liver cirrhosis. J Gastroenterol Hepatol 9: 624-630, 1994. (Pubitemid 24364615)
11. Maggioni M, Goggi G, Cassani B, Biachi P, Romagnoli S, Mandelli A, Borzio M, Colombo P and Rocalli M: Molecular chage in hepatocellular dysplastic nodules on microdisected liver biopsies. Hepatology 32: 942-946, 2000.
12. Sun M, Eshleman JR, Ferrell LD, Jacobs G, Sudilovsky EC, Tuthill R, Hussein RM and Sudilovsky O: An early lesion in hepatic carcinogenesis: loss of heterozygosity in human cirrhotic livers and dysplastic nodules at the 1p36-p34 region. Hepatology 33: 1415-1424, 2001. (Pubitemid 32496978)
13. Furuya K, Nakamura M, Yamamoto Y, Togei K and Otsuka H: Macroregenerative nodule of the liver: A clinicopathological study of 345 autopsy cases of chronic liver disease. Cancer 61: 99-105, 1988. (Pubitemid 18023117)
14. Theise ND, Schwartz M, Miller C and Thung SN: Macro-regenerative nodules and hepatocellular carcinoma in forty-four sequential adult liver explants with cirrhosis. Hepatology 16: 949-955, 1992.
15. Hytiroglou P, Theise ND, Schwartz M, Mor E, Miller C and Thung SN: Macroregenerative nodules in a series of adult cirrhotic liver explants: issue of classification and nomenclature. Hepatology 21: 703-708, 1995.
16. Eguchi A, Nakashima O, Okudaira S, Sugihara S and Kojiro M: Adenomatous hyperplasia in the vicinity of small hepatocellular carcinoma. Hepatology 15: 843-848, 1992.
17. Bail LB, Belleannee G, Bernard P, Saric J, Balabaud C and Bioulac-Sage P: Adenomatous hyperplasia in cirrhotic livers. Hum Pathol 26: 897-906, 1995.
18. Sakamoto M, Hirohashi S and Shimosato Y: Early stages of multistep hepatocarcinogenesis. Hum Pathol 22: 172-178, 1991.
19. Kutami R, Nakashima Y, Nakshima O, Shiota K and Kojiro M: Pathomorphological study on the mechanism of fatty change in small hepatocellular carcinoma of humans. J Hepatol 33: 282-289, 2000. (Pubitemid 30485232)
20. Edamitsu O: Pathomorphologic study on tumor vessels of hepatocellular carcinoma (Japanese). Kanzo 33: 15-20, 1992.
21. Conn HO: Portacaval anastomosis and hepatic hemosiderin deposition: a prospective, controlled investigation. Gastroenterology 62: 61-72, 1972.
22. Kadoya M, Matsui O, Kitagawa K, Kawamori Y, Yoshikawa J, Gabata T, Miyayama S and Takashima T: Segmental iron deposition in the liver due to decreased intrahepatic portal perfusion: findings at MR imaging. Radiology 193: 671-676, 1994. (Pubitemid 24366933)
23. Matsui O, Kadoya M, Kameyama T, Yoshikawa J, Takashima T, Nakanuma Y, Unoura M, Kobayashi K, Izumi R, Ida M and Kitagawa K: Benign and malignant nodules in cirrhotic livers: distinction based on blood supply. Radiology 178: 493-497, 1991.
24. Deuginer YM, Charalambous P, Le Quileuic D, Turlin B, Searle J, Brissot P, Powell LW and Halliday JW: Preneoplastic significance of hepatic iron-free foci in genetic hemochromatosis: A study of 185 patients. Hepatology 18: 1363-1369, 1993. (Pubitemid 23348423)
25. Terada T, Kadoya M, Nakanuma Y and Matsui O: Iron-accumulating adenomatous hyperplastic nodule with malignant foci in the cirrhotic liver. Histopathologic, quantitative iron, and magnetic resonance imaging in vitro studies. Cancer 65: 1994-2000, 1990. (Pubitemid 20147639)
26. Tanaka M, Nakashima O, Wada Y, Kage M and Kojiro M: Pathomorphological study of Kupffer cells in hepatocellular carcinoma and hyperplastic nodular lesions in the liver. Hepatology 24: 807-812, 1996. (Pubitemid 26334277)
27. Imai Y, Murakami T, Yoshida S, Nishikawa M, Ohsawa M, Tokunaga K, Murata M, Shibata K, Zushi S, et al: Super-paramagnetic iron oxide-enhanced magnetic resonance images of hepatocellular carcinoma: Correlation with histological grading. Hepatology 32: 205-212, 2000. (Pubitemid 30614651)
28. Schaffner F and Popper H: Capillarization of hepatic sinusoids in man. Gatroenterology 44: 239-241, 1963.
29. Couvelard A, Scoazeac JY and Feldmann G: Expression of cell-cell and cell-matrix adhesion proteins by sinusoidal endothelial cells in the normal and cirrhotic human liver. Am J Pathol 143: 738-752, 1993. (Pubitemid 24058230)
30. Cui S, Hano H, Sakata A, Harada T, Liu T, Takai S and Ushigome S: Enhanced CD34 expression of sinusoid-like vascular endothelial cells in hepatocellular carcinoma. Pathol Int 46: 751-756, 1996. (Pubitemid 26353225)