Aerosol therapy in intensive and intermediate care units: prospective observation of 2808 critically ill patients

Intensive Care Medicine

Volumn 42, Issue 2, 2016, Pages 192-201

  Ehrmann, Stephan ^a,b,c   Roche Campo, Ferran ^d   Bodet Contentin, Laetitia ^b,e   Razazi, Keyvan ^f   Dugernier, Jonathan ^g   Trenado Alvarez, Josep ^h   Donzeau, Alexis ⁱ   Vermeulen, François ^j   Thévoz, David ^k   Papanikolaou, Metaxia ^l   Edelson, Antoine ^m   León Yoshido, Héctor ⁿ   Piquilloud, Lise ^i,k   Lakhal, Karim ^o   Lopes, Carlos ^p   Vicent, Carlos ^q   Desachy, Arnaud ^r   Apiou Sbirlea, Gabriela ^a,s   Isabey, Daniel ^a   Brochard, Laurent ^t,u  

^a UNIVERSITÉ PARIS EST CRÉTEIL   (France)

^b UNIVERSITY HOSPITAL OF TOURS   (France)

^c UNIVERSITÉ DE TOURS   (France)

^d HOSPITAL VERGE DE LA CINTA   (Spain)

^e Université Paris Descartes ^*  (France)

^f HENRI MONDOR HOSPITAL   (France)

^g CLINIQUES UNIVERSITAIRES SAINT LUC   (Belgium)

^h UNIVERSITY OF BARCELONA   (Spain)

ⁱ ANGERS UNIVERSITY HOSPITAL   (France)

^j GENEVA UNIVERSITY HOSPITALS   (Switzerland)

^k LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^l HIPPOKRATION HOSPITAL   (Greece)

^m Centre hospitalier du Taaone   (French Polynesia)

ⁿ HOSPITAL NACIONAL EDGARDO REBAGLIATI MARTINS   (Peru)

^o CHU de Nantes   (France)

^p HOSPITAL DE SANTA MARIA   (Portugal)

^q HOSPITAL LLUÍS ALCANYÍS   (Spain)

^r centre hospitalier d'Angoulême   (France)

^s MASSACHUSETTS GENERAL HOSPITAL   (United States)

^t ST MICHAEL'S HOSPITAL   (Canada)

^u UNIVERSITY OF TORONTO   (Canada)

^v NONE   (France)

more..

Author keywords

Administration, inhalation MeSH ; Anti bacterial agents MeSH ; Bronchodilator agents MeSH ; Metered dose inhalers MeSH ; Nebulizers and vaporizers MeSH ; Respiration, artificial MeSH

Indexed keywords

ANTIINFECTIVE AGENT; BRONCHODILATING AGENT; COLISTIN; CORTICOSTEROID; AEROSOL;

ADULT; ARTICLE; BRONCHOSPASM; CHRONIC RESPIRATORY TRACT DISEASE; CLINICAL PRACTICE; COUGHING; CRITICALLY ILL PATIENT; CROSS-SECTIONAL STUDY; FEMALE; HEALTH CARE DELIVERY; HOSPITAL INFECTION; HUMAN; HYPERTENSION; HYPOTENSION; HYPOXEMIA; INHALATIONAL DRUG ADMINISTRATION; INTENSIVE CARE UNIT; MAJOR CLINICAL STUDY; MALE; MEDICAL DEVICE COMPLICATION; METERED DOSE INHALER; NEBULIZER; NURSING HOME; OBSERVATIONAL STUDY; PREVALENCE; RESPIRATORY TRACT INTUBATION; TACHYCARDIA; ADMINISTRATION AND DOSAGE; AEROSOL; AGED; BACTERIAL INFECTIONS; COMPARATIVE STUDY; INTENSIVE CARE; MIDDLE AGED; PROCEDURES; PROSPECTIVE STUDY; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; VERY ELDERLY;

ADMINISTRATION, INHALATION; ADULT; AEROSOLS; AGED; AGED, 80 AND OVER; ANTI-BACTERIAL AGENTS; BACTERIAL INFECTIONS; BRONCHODILATOR AGENTS; CRITICAL CARE; CROSS-SECTIONAL STUDIES; FEMALE; HUMANS; MALE; MIDDLE AGED; NEBULIZERS AND VAPORIZERS; PROSPECTIVE STUDIES; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE;

EID: 84955678659     PISSN: 03424642     EISSN: 14321238     Source Type: Journal    
DOI: 10.1007/s00134-015-4114-5     Document Type: Article

References (36)

1. Dolovich MB, Dhand R (2011) Aerosol drug delivery: developments in device design and clinical use. Lancet 377:1032–1045
2. Global Initiative for Chronic Obstructive Lung Disease (GOLD) (2014) Global strategy for the diagnosis, management and prevention of COPD. http://www.goldcopd.org/. Accessed 27 July 2015
3. Global Initiative for Asthma (GINA) (2014) Global strategy for asthma management and prevention. http://www.ginasthma.org/. Accessed 27 July 2015
4. Mogayzl PJ, Naureckas ET, Robinson KA, Mueller G, Hadjiliadis D, Hoag JB, Lubsch L, Hazle L, Sabadosa K, Marshall B, Committee Pulmonary Clinical Practice Guidelines (2013) Cystic fibrosis pulmonary guidelines. Chronic medications for maintenance of lung health. Am J Respir Crit Care Med 187:680–689
5. O’Doherty MJ, Thomas SH (1997) Nebuliser therapy in the intensive care unit. Thorax 52:S56–S59
6. Ari A, Fink JB, Dhand R (2012) Inhalation therapy in patients receiving mechanical ventilation: an update. J Aerosol Med Pulm Drug Deliv 25:319–332
7. Vecellio L, Guérin C, Grimbert D, De Monte M, Diot P (2005) In vitro study and semiempirical model for aerosol delivery control during mechanical ventilation. Intensive Care Med 31:871–876
8. Diot P, Morra L, Smaldone GC (1995) Albuterol delivery in a model of mechanical ventilation. Comparison of metered-dose inhaler and nebulizer efficiency. Am J Respir Crit Care Med 152:1391–1394
9. Miller DD, Amin MM, Palmer LB, Shah AR, Smaldone GC (2003) Aerosol delivery and modern mechanical ventilation: in vitro/in vivo evaluation. Am J Respir Crit Care Med 168:1205–1209
10. Mojoli F, Iotti GA, Imberti R, Braschi A (2013) The importance of protecting the mechanical ventilator during colistin methanesulfonate nebulization. Intensive Care Med 39:535–536
11. Laube BL, Janssens HM, de Jongh FHC, Devadason SG, Dhand R, Diot P, Everard ML, Horvath I, Navalesi P, Voshaar T, Chrystyn H (2011) What the pulmonary specialist should know about the new inhalation therapies. Eur Respir J 37:1308–1331
12. Mancebo J, Amaro P, Lorino H, Lemaire F, Harf A, Brochard L (1991) Effects of albuterol inhalation on the work of breathing during weaning from mechanical ventilation. Am Rev Respir Dis 144:95–100
13. Mouloudi E, Prinianakis G, Kondili E, Georgopoulos D (2001) Effect of inspiratory flow rate on beta2-agonist induced bronchodilation in mechanically ventilated COPD patients. Intensive Care Med 27:42–46
14. Lu Q, Yang J, Liu Z, Gutierrez C, Aymard G, Rouby JJ (2011) Nebulized ceftazidime and amikacin in ventilator-associated pneumonia caused by Pseudomonas aeruginosa. Am J Respir Crit Care Med 184:106–115
15. Lu Q, Luo R, Bodin L, Yang J, Zahr N, Aubry A, Golmard JL, Rouby JJ (2012) Efficacy of high-dose nebulized colistin in ventilator-associated pneumonia caused by multidrug-resistant Pseudomonas aerugiosa and Acinetobacter baumannii. Anesthesiology 117:1335–1347
16. Palmer LB, Smaldone GC, Chen JJ, Baram D, Duan T, Monteforte M, Varela M, Tempone AK, O’Riordan T, Daroowalla F, Richman P (2008) Aerosolized antibiotics and ventilator-associated tracheobronchitis in the intensive care unit. Crit Care Med 36:2008–2013
17. Palmer LB, Smaldone GC (2014) Reduction of bacterial resistance with inhaled antibiotics in the intensive care unit. Am J Respir Crit Care Med 189:1225–1233
18. Esteban A, Ferguson ND, Meade MO, Frutos-Vivar F, Apezteguia C, Brochard L, Raymondos K, Nin N, Hurtado J, Tomicic V, Gonzalez M, Elizalde J, Nightingale P, Abroug F, Pelosi P, Arabi Y, Moreno R, Jibaja M, D’Empaire G, Sandi F, Matamis D, Montanez AM, Anzueto A, VENTILA Group (2008) Evolution of mechanical ventilation in response to clinical research. Am J Respir Crit Car Med 177:170–177
19. Esteban A, Frutos-Vivar F, Muriel A, Ferguson ND, Penuelas O, Abraira V, Raymondos K, Rios F, Nin N, Apezteguia C, Violi DA, Thille AW, Brochard L, Gonzalez M, Villagomez AJ, Hurtado J, Davies AR, Du B, Maggiore SM, Belosi P, Soto L, Tomicic V, D’Empaire G, Matamis D, Abroug F, Moreno RP, Soares MA, Arabi Y, Sandi F, Jibaja M, Amin P, Koh Y, Kuiper MA, Bülow HH, Zeggwagh AA, Anzueto A (2013) Evolution of mortality over time in patients receiving mechanical ventilation. Am J Respir Crit Care Med 188:220–230
20. Ehrmann S, Roche-Campo F, Sferrazza Papa GF, Isabey D, Brochard L, Apiou-Sbirlea G, Reva Research Network (2013) Aerosol therapy during mechanical ventilation: an international survey. Intensive Care Med 39:1048–1056
21. Grivans C, Lindgren S, Aneman A, Stengwist O, Lundin S (2009) A Scandinavian survey of drug administration through inhalation, suctioning and recruitment maneuvers in mechanically ventilated patients. Acta Anaesthesiol Scand 53:710–716
22. Le Gall JR, Lemeshow S, Saulnier F (1993) A New Simplified Acute Physiology Score (SAPS II) Based on a European/North American Multicenter Study. JAMA 270:2957–2963
23. Fauroux B, Jtti E, Pigeot J, Isabey D, Meignan M, Ferry G, Lofaso F, Willemot JM, Clément A, Harf A (2000) Optimization of aerosol deposition by pressure support in children with cystic fibrosis: an experimental and clinical study. Am J Respir Crit Care Med 162:2265–2271
24. Nava S, Karakurt S, Rampulla C, Braschi A, Fanfulla F (2001) Salbutamol delivery during non-invasive mechanical ventilation in patients with chronic obstructive pulmonary disease: a randomized, controlled study. Intensive Care Med 27:1627–1635
25. Galindo-Filho VC, Brandao DC, Ferreira RC, Menezes MJ, Ameida-Filho P, Parreira VF, Silva TN, Rodrigues-Machado MG, Dean E, Dornelas de Andrade A (2013) Non invasive ventilation coupled with nebulization during asthma crises: a randomized controlled trial. Respir Care 58:241–249
26. Hess DR (2015) Aerosol therapy during noninvasive ventilation or high-flow nasal cannula. Respir Care 60:880–893
27. Ehrmann S, Lyazidi A, Louis B, Isabey D, Le Pennec D, Brochard L, Apiou-Sbirlea G (2014) Ventilator-integrated jet nebulization systems: tidal volume control and efficiency of synchronization. Respir Care 59:1508–1516
28. Kiatboonsri S, Kiatboonsri C, Theerawit P (2010) Fatal respiratory events caused by zanamivir nebulization. Clin Infect Dis 50:620
29. Davies JB, Bromilow J (2011) Bacterial filter obstruction with the use of ultrasonic nebulisation. Anaesthesia 66:394–395
30. Tonnelier A, Lellouche F, Bouchard PA, L’Her E (2013) Impact of humidification and nebulization during expiratory limb protection: an experimental bench study. Respir Care 58:1315–1322
31. Rouby JJ, Bouhemad B, Monsel A, Brisson H, Arbelot C, Lu Q, the Nebulized Antibiotics Study Group (2012) Aerosolized antibiotics for ventilator-associated pneumonia: lessons from experimental studies. Anesthesiology 117:1364–1380
32. Elman M, Goldstein I, Marquett CH, Wallet F, Lenaour G, Rouby JJ, Experimental ICU Study Group (2002) Influence of lung aeration on pulmonary concentrations of nebulized and intravenous amikacin in ventilated piglets with severe bronchopneumonia. Anesthesiology 97:199–206
33. Palmer LB, Smaldone GC, Simon SR, O’Riordan TG, Cuccia A (1998) Aerosolized antibiotics in mechanically ventilated patients: delivery and response. Crit Care Med 26:31–39
34. Valachis A, Samonis G, Kofteridis DP (2015) The role of aerosolized colistin in the treatment of ventilator-associated pneumonia: a systematic review and metaanalysis. Crit Care Med 43:527–533
35. Nava S, Compagnoni ML (2000) Controlled short-term trial of fluticasone propionate in ventilator-dependent patients with COPD. Chest 118:990–999
36. 2-agonists and ventilator-associated pneumonia: a cohort study. Crit Care Med 39:725–730