In vitro study and semiempirical model for aerosol delivery control during mechanical ventilation

Intensive Care Medicine

Volumn 31, Issue 6, 2005, Pages 871-876

  Vecellio, Laurent ^a   Guérin, Claude ^b   Grimbert, Daniel ^a   De Monte, Michele ^a   Diot, Patrice ^a  

^a UNIVERSITÉ DE TOURS   (France)

^b CROIX ROUSSE HOSPITAL   (France)

Author keywords

Aerosol; Mechanical ventilation; Nebulizer; Terbutaline

Indexed keywords

TERBUTALINE;

AEROSOL; ARTICLE; ARTIFICIAL VENTILATION; CALCULATION; DIFFRACTION; ENDOTRACHEAL TUBE; LASER; LUNG; MATHEMATICAL MODEL; NEBULIZATION; POSITIVE END EXPIRATORY PRESSURE; RESPIRATORY AIRFLOW; STATISTICAL SIGNIFICANCE;

AEROSOLS; ANALYSIS OF VARIANCE; HUMANS; LINEAR MODELS; MODELS, THEORETICAL; NEBULIZERS AND VAPORIZERS; PARTICLE SIZE; POSITIVE-PRESSURE RESPIRATION; RESPIRATORY MECHANICS; STATISTICS, NONPARAMETRIC; TERBUTALINE;

EID: 21244459475     PISSN: 03424642     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00134-005-2594-4     Document Type: Article

References (12)

1. Harvey CJ, O'Doherty MJ, Page CJ, Thomas SH, Nunan TO, Treacher DF (1995) Effect of a spacer on pulmonary aerosol deposition from a jet nebuliser during mechanical ventilation. Thorax 50:50-53
2. O'Doherty MJ, Thomas SH, Page CJ, Treacher DF, Nunan TO (1992) Delivery of a nebulized aerosol to a lung model during mechanical ventilation. Effect of ventilator settings and nebulizer type, position, and volume of fill. Am Rev Respir Dis 146:383-388
3. Ahrens RC, Ries RA, Popendorf W, Wiese JA (1986) The delivery of therapeutic aerosols through endotracheal tubes. Pediatr Pulmonol 2:19-26
4. Pelkonen AS, Nikander K, Turpeinen M (1997) Jet nebulization of budesonide suspension into a neonatal ventilator circuit: synchronized versus continuous nebulizer flow. Pediatr Pulmonol 24:282-286
5. Dhand R, Tobin MJ (1997) Inhaled bronchodilator therapy in mechanically ventilated patients. Am J Respir Crit Care Med 156:3-10
6. Fink JB, Tobin MJ, Dhand R (1999) Bronchodilator therapy in mechanically ventilated patients. Respir Care 44:53-69
7. Fink JB, Dhand R, Grychowski J, Fahey PJ, Tobin MJ (1999) Reconciling in vitro and in vivo measurements of aerosol delivery from a metered-dose inhaler during mechanical ventilation and defining efficiency-enhancing factors. Am J Respir Crit Care Med 159:63-68
8. Hess DR, Dillman C, Kacmarek RM (2003) In vitro evaluation of aerosol bronchodilator delivery during mechanical ventilation: pressure-control vs volume control ventilation. Intensive Care Med 29:1145-1150
9. Diot P, Morra L, Smaldone GC (1995) Albuterol delivery in a model of mechanical ventilation. Comparison of metered-dose inhaler and nebulizer efficiency. Am J Respir Crit Care Med 152:1391-1394
10. O'Riordan TG, Greco MJ, Perry RJ, Smaldone GC (1992) Nebulizer function during mechanical ventilation. Am Rev Respir Dis 145:1117-1122
11. Williams L, Fletcher GC, Daniel M, Kinsella J (1999) A simple in vitro method for the evaluation of an ultrasonic nebulizer for drug delivery to intubated, ventilated patients and the effect of nebulizer and ventilator settings on the uptake of fluid from the nebulizer chamber. Eur J Anaesthesiol 16:479-484
12. Miller DD, Amin MM, Palmer LB, Shah AR, Smaldone GC (2003) Aerosol delivery and modern mechanical ventilation: in vitro/in vivo evaluation. Am J Respir Crit Care Med 168:1205-1209