Role of hypoxia-induced VEGF in blood-spinal cord barrier disruption in chronic spinal cord injury

Chinese Journal of Traumatology - English Edition

Volumn 18, Issue 5, 2015, Pages 293-295

  Long, Hou Qing ^a   Li, Guang Sheng ^a   Cheng, Xing ^a   Xu, Jing Hui ^a   Li, Fo Bao ^a  

^a THE FIRST AFFILIATED HOSPITAL OF SUN YAT SEN UNIVERSITY   (China)

Author keywords

Blood spinal cord barrier; Chronic spinal cord lesions; VEGF

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1; VASCULOTROPIN; VASCULOTROPIN A;

ANGIOGENESIS; BLOOD SPINAL CORD BARRIER; CHRONIC DISEASE; HUMAN; HYPOXIA; NERVOUS SYSTEM DEVELOPMENT; PERMEABILITY BARRIER; REVIEW; SPINAL CORD INJURY; ANIMAL; PATHOPHYSIOLOGY; PHYSIOLOGY; SPINAL CORD;

ANIMALS; CHRONIC DISEASE; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1; NEOVASCULARIZATION, PHYSIOLOGIC; NEUROGENESIS; SPINAL CORD; SPINAL CORD INJURIES; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84955654374     PISSN: 10081275     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cjtee.2015.08.004     Document Type: Review

References (21)

1. H.R. Sandrow-Feinberg, and J.D. Houlé Exercise after spinal cord injury as an agent for neuroprotection, regeneration and rehabilitation Brain Res 1619 2015 12 21
2. H.Q. Long, G.S. Li, Y. Hu, C.Y. Wen, and W.H. Xie HIF-1α/VEGF signaling pathway may play a dual role in secondary pathogenesis of cervical myelopathy Med Hypotheses 79 2012 82 84
3. V. Bartanusz, D. Jezova, B. Alajajian, and M. Digicaylioglu The blood-spinal cord barrier: morphology and clinical implications Ann Neurol 70 2011 194 206
4. T.S. Reese, and M.J. Karnovsky Fine structural localization of a blood-brain barrier to exogenous peroxidase J Cell Biol 34 1967 207 217
5. J.W. Lee, S.H. Bae, J.W. Jeong, S.H. Kim, and K.W. Kim Hypoxia-inducible factor (HIF-1)alpha: its protein stability and biological functions Exp Mol Med 36 2004 1 12
6. Y.Q. Li, J.R. Ballinger, R.A. Nordal, Z.F. Su, and C.S. Wong Hypoxia in radiation-induced blood-spinal cord barrier breakdown Cancer Res 61 2001 3348 3354
7. C.B. Patel, D.M. Cohen, P. Ahobila-Vajjula, L.M. Sundberg, T. Chacko, and P.A. Narayana Effect of VEGF treatment on the blood-spinal cord barrier permeability in experimental spinal cord injury: dynamic contrast-enhanced magnetic resonance imaging J Neurotrauma 26 2009 1005 1016
8. S.J. Hemley, J. Tu, and M.A. Stoodley Role of the blood-spinal cord barrier in posttraumatic syringomyelia J Neurosurg Spine 11 2009 696 704
9. R.K. Bruick, and S.L. McKnight A conserved family of prolyl-4-hydroxylases that modify HIF Science 294 2001 1337 1340
10. M.H. Chen, Q.X. Ren, W.F. Yang, X.L. Chen, C. Lu, and J. Sun Influences of HIF-lαon Bax/Bcl-2 and VEGF expressions in rats with spinal cord injury Int J Clin Exp Pathol 6 2013 2312 2322
11. J. Fang, L. Yan, Y. Shing, and M.A. Moses HIF-1alpha-mediated up-regulation of vascular endothelial growth factor, independent of basic fibroblast growth factor, is important in the switch to the angiogenic phenotype during early tumorigenesis Cancer Res 61 2001 5731 5735
12. J. Provias, K. Claffey, L. delAguila, N. Lau, M. Feldkamp, and A. Guha Meningiomas: role of vascular endothelial growth factor/vascular permeability factor in angiogenesis and peritumoral edema Neurosurgery 40 1997 1016 1026
13. A.V. Leonard, and R. Vink The effect of an NK1 receptor antagonist on blood spinal cord barrier permeability following balloon compression-induced spinal cord injury Acta Neurochir Suppl 118 2013 303 306
14. J.J. Herrera, L.M. Sundberg, L. Zentilin, M. Giacca, and P.A. Narayana Sustained expression of vascular endothelial growth factor and angiopoietin-1 improves blood-spinal cord barrier integrity and functional recovery after spinal cord injury J Neurotrauma 27 2010 2067 2076
15. S. Engelhardt, A.J. Al-Ahmad, M. Gassmann, and O.O. Ogunshola Hypoxia selectively disrupts brain microvascular endothelial tight junction complexes through a hypoxia-inducible factor-1 (HIF-1) dependent mechanism J Cell Physiol 229 2014 1096 1105
16. J. Stone, A. Itin, T. Alon, and et al. Development of retinal vasculature is mediated by hypoxia-induced vascular endothelial growth factor (VEGF) expression by neuroglia J Neurosci 15 1995 4738 4747
17. S. Ma, and Z. Huang Neural regulation of CNS angiogenesis during development Front Biol (Beijing) 10 2015 61 73
18. C. Lutton, Y.W. Young, R. Williams, A.C. Meedeniya, A. Mackay-Sim, and B. Goss Combined VEGF and PDGF treatment reduces secondary degeneration after spinal cord injury J Neurotrauma 29 2012 957 970
19. J.M. Rosenstein, and J.M. Krum New roles for VEGF in nervous tissue-beyond blood vessels Exp Neurol 187 2004 246 253
20. A. Chen, L.J. Xiong, Y. Tong, and M. Mao Neuroprotective effect of brain-derived neurotrophic factor mediated by autophagy through the PI3K/Akt/mTOR pathway Mol Med Rep 8 2013 1011 1016
21. J. Wang, W. Rong, X. Hu, and et al. Hyaluronan tetrasaccharide in the cerebrospinal fluid is associated with self-repair of rats after chronic spinal cord compression Neuroscience 210 2012 467 480