메뉴 건너뛰기




Volumn 17, Issue 1, 2016, Pages 27-40

Current treatment options for hereditary angioedema due to C1 inhibitor deficiency

Author keywords

angioedema; bradykinin; C1 inhibitor; ecallantide; icatibant; kallikrein

Indexed keywords

AMINOCAPROIC ACID; COMPLEMENT COMPONENT C1S INHIBITOR; CREATINE KINASE; DANAZOL; ECALLANTIDE; FRESH FROZEN PLASMA; HIGH DENSITY LIPOPROTEIN; ICATIBANT; LOW DENSITY LIPOPROTEIN CHOLESTEROL; METHYLTESTOSTERONE; STANOZOLOL; TRANEXAMIC ACID; ANTIFIBRINOLYTIC AGENT; BRADYKININ B2 RECEPTOR ANTAGONIST; PLASMA KALLIKREIN; RECOMBINANT PROTEIN; SERPING1 PROTEIN, HUMAN;

EID: 84955628881     PISSN: 14656566     EISSN: 17447666     Source Type: Journal    
DOI: 10.1517/14656566.2016.1104300     Document Type: Review
Times cited : (21)

References (96)
  • 1
    • 84898045718 scopus 로고    scopus 로고
    • Classification, diagnosis, and approach to treatment for angioedema: Consensus report from the Hereditary Angioedema International Working Group
    • Cicardi M, Aberer W, Banerji A, et al. Classification, diagnosis, and approach to treatment for angioedema: Consensus report from the Hereditary Angioedema International Working Group. Allergy. 2014;69:602-616.
    • (2014) Allergy. , vol.69 , pp. 602-616
    • Cicardi, M.1    Aberer, W.2    Banerji, A.3
  • 2
    • 84924213383 scopus 로고    scopus 로고
    • A nationwide survey of hereditary angioedema due to C1 inhibitor deficiency in Italy
    • Zanichelli A, Arcoleo F, Barca M, et al. A nationwide survey of hereditary angioedema due to C1 inhibitor deficiency in Italy. Orphanet J Rare Dis. 2015;10:11.
    • (2015) Orphanet J Rare Dis. , vol.10 , pp. 11
    • Zanichelli, A.1    Arcoleo, F.2    Barca, M.3
  • 3
    • 84856654320 scopus 로고    scopus 로고
    • Hereditary angio-oedema
    • Longhurst H, Cicardi M. Hereditary angio-oedema. Lancet. 2012;379:474-481.
    • (2012) Lancet. , vol.379 , pp. 474-481
    • Longhurst, H.1    Cicardi, M.2
  • 4
    • 84894364029 scopus 로고    scopus 로고
    • Mutational spectrum of the c1 inhibitor gene in a cohort of Italian patients with hereditary angioedema: Description of nine novel mutations
    • Bafunno V, Bova M, Loffredo S, et al. Mutational spectrum of the c1 inhibitor gene in a cohort of Italian patients with hereditary angioedema: Description of nine novel mutations. Ann Hum Genet. 2014;78:73-82.
    • (2014) Ann Hum Genet. , vol.78 , pp. 73-82
    • Bafunno, V.1    Bova, M.2    Loffredo, S.3
  • 6
    • 84987657462 scopus 로고    scopus 로고
    • The humanistic burden of hereditary angioedema: Results from the Burden of Illness Study in Europe
    • Caballero T, Aygoren-Pursun E, Bygum A, et al. The humanistic burden of hereditary angioedema: Results from the Burden of Illness Study in Europe. Allergy Asthma Proc. 2014;35:47-53.
    • (2014) Allergy Asthma Proc. , vol.35 , pp. 47-53
    • Caballero, T.1    Aygoren-Pursun, E.2    Bygum, A.3
  • 7
    • 0022556870 scopus 로고
    • Human C1 inhibitor: Primary structure, cDNA cloning, and chromosomal localization
    • Bock SC, Skriver K, Nielsen E, et al. Human C1 inhibitor: Primary structure, cDNA cloning, and chromosomal localization. Biochemistry. 1986;25:4292-4301.
    • (1986) Biochemistry. , vol.25 , pp. 4292-4301
    • Bock, S.C.1    Skriver, K.2    Nielsen, E.3
  • 8
    • 0023928192 scopus 로고
    • Genomic and cDNA cloning of the human C1 inhibitor. Intron-exon junctions and comparison with other serpins
    • Carter PE, Dunbar B, Fothergill JE. Genomic and cDNA cloning of the human C1 inhibitor. Intron-exon junctions and comparison with other serpins. Eur J Biochem. 1988;173:163-169.
    • (1988) Eur J Biochem. , vol.173 , pp. 163-169
    • Carter, P.E.1    Dunbar, B.2    Fothergill, J.E.3
  • 9
    • 0011210621 scopus 로고
    • Human inhibitor of the first component of complement C1: Characterization of cDNA clones and localization of the gene to chromosome 11
    • Davis AE 3rd, Whitehead AS, Harrison RA, et al. Human inhibitor of the first component of complement, C1: Characterization of cDNA clones and localization of the gene to chromosome 11. Proc Natl Acad Sci USA. 1986;83:3161-3165.
    • (1986) Proc Natl Acad Sci USA. , vol.83 , pp. 3161-3165
    • Davis, A.E.1    Whitehead, A.S.2    Harrison, R.A.3
  • 10
    • 55949106824 scopus 로고    scopus 로고
    • Biological activities of C1 inhibitor
    • Davis AE 3rd, Mejia P, Lu F. Biological activities of C1 inhibitor. Mol Immunol. 2008;45:4057-4063.
    • (2008) Mol Immunol. , vol.45 , pp. 4057-4063
    • Davis, A.E.1    Mejia, P.2    Lu, F.3
  • 11
    • 77649144033 scopus 로고    scopus 로고
    • The bradykininforming cascade and its role in hereditary angioedema
    • Kaplan AP, Joseph K. The bradykininforming cascade and its role in hereditary angioedema. Ann Allergy Asthma Immunol. 2010;104:193-204.
    • (2010) Ann Allergy Asthma Immunol. , vol.104 , pp. 193-204
    • Kaplan, A.P.1    Joseph, K.2
  • 12
    • 0020520854 scopus 로고
    • Kinin formation in hereditary angioedema plasma: Evidence against kinin derivation from C2 and in support of "spontaneous" formation of bradykinin
    • Fields T, Ghebrehiwet B, Kaplan AP. Kinin formation in hereditary angioedema plasma: Evidence against kinin derivation from C2 and in support of "spontaneous" formation of bradykinin. J Allergy Clin Immunol. 1983;72:54-60.
    • (1983) J Allergy Clin Immunol. , vol.72 , pp. 54-60
    • Fields, T.1    Ghebrehiwet, B.2    Kaplan, A.P.3
  • 13
    • 0032490360 scopus 로고    scopus 로고
    • Plasma bradykinin in angio-oedema
    • Nussberger J, Cugno M, Amstutz C, et al. Plasma bradykinin in angio-oedema. Lancet. 1998;351:1693-1697.
    • (1998) Lancet. , vol.351 , pp. 1693-1697
    • Nussberger, J.1    Cugno, M.2    Amstutz, C.3
  • 14
    • 84898677514 scopus 로고    scopus 로고
    • Tracking down contact activation-from coagulation in vitro to inflammation in vivo
    • De Maat S, Tersteeg C, Herczenik E, et al. Tracking down contact activation-from coagulation in vitro to inflammation in vivo. Int J Lab Hematol. 2014;36:374-381.
    • (2014) Int J Lab Hematol. , vol.36 , pp. 374-381
    • De Maat, S.1    Tersteeg, C.2    Herczenik, E.3
  • 15
    • 0036122075 scopus 로고    scopus 로고
    • Increased vascular permeability in C1 inhibitor-deficient mice mediated by the bradykinin type 2 receptor
    • Han ED, MacFarlane RC, Mulligan AN, et al. Increased vascular permeability in C1 inhibitor-deficient mice mediated by the bradykinin type 2 receptor. J Clin Invest. 2002;109:1057-1063.
    • (2002) J Clin Invest. , vol.109 , pp. 1057-1063
    • Han, E.D.1    MacFarlane, R.C.2    Mulligan, A.N.3
  • 16
    • 34249801766 scopus 로고    scopus 로고
    • Treatment of acute edema attacks in hereditary angioedema with a bradykinin receptor-2 antagonist (Icatibant)
    • Bork K, Frank J, Grundt B, et al. Treatment of acute edema attacks in hereditary angioedema with a bradykinin receptor-2 antagonist (Icatibant). J Allergy Clin Immunol. 2007;119:1497-1503.
    • (2007) J Allergy Clin Immunol. , vol.119 , pp. 1497-1503
    • Bork, K.1    Frank, J.2    Grundt, B.3
  • 17
    • 71249105731 scopus 로고    scopus 로고
    • Novel pathogenic mechanism and therapeutic approaches to angioedema associated with C1 inhibitor deficiency
    • Bossi F, Fischetti F, Regoli D, et al. Novel pathogenic mechanism and therapeutic approaches to angioedema associated with C1 inhibitor deficiency. J Allergy Clin Immunol. 2009;124:1303-10.e1304.
    • (2009) J Allergy Clin Immunol. , vol.124 , pp. 1303-10e1304
    • Bossi, F.1    Fischetti, F.2    Regoli, D.3
  • 18
    • 84894412583 scopus 로고    scopus 로고
    • Bradykinin in health and disease: Proceedings of the bradykinin symposium 2012 Berlin 23-24 August 2012
    • Magerl M, Bader M, Gompel A, et al. Bradykinin in health and disease: Proceedings of the Bradykinin Symposium 2012 Berlin 23-24 August 2012. Inflamm Res. 2014;63(3):173-178.
    • (2014) Inflamm Res. , vol.63 , Issue.3 , pp. 173-178
    • Magerl, M.1    Bader, M.2    Gompel, A.3
  • 19
    • 60949104520 scopus 로고    scopus 로고
    • C1-inhibitor deficiency and angioedema: Molecular mechanisms and clinical progress
    • Cugno M, Zanichelli A, Foieni F, et al. C1-inhibitor deficiency and angioedema: Molecular mechanisms and clinical progress. Trends Mol Med. 2009;15:69-78. DOI:10.1016/j.molmed.2008.12.001.
    • (2009) Trends Mol Med. , vol.15 , pp. 69-78
    • Cugno, M.1    Zanichelli, A.2    Foieni, F.3
  • 21
    • 84855779242 scopus 로고    scopus 로고
    • Evidence-based recommendations for the therapeutic management of angioedema owing to hereditary C1 inhibitor deficiency: Consensus report of an International Working Group
    • Cicardi M, Bork K, Caballero T, et al. Evidence-based recommendations for the therapeutic management of angioedema owing to hereditary C1 inhibitor deficiency: Consensus report of an International Working Group. Allergy. 2012;67:147-157.
    • (2012) Allergy. , vol.67 , pp. 147-157
    • Cicardi, M.1    Bork, K.2    Caballero, T.3
  • 22
    • 84865676871 scopus 로고    scopus 로고
    • Fatal laryngeal attacks and mortality in hereditary angioedema due to C1-INH deficiency
    • Bork K, Hardt J, Witzke G. Fatal laryngeal attacks and mortality in hereditary angioedema due to C1-INH deficiency. J Allergy Clin Immunol. 2012;130:692-697.
    • (2012) J Allergy Clin Immunol. , vol.130 , pp. 692-697
    • Bork, K.1    Hardt, J.2    Witzke, G.3
  • 23
    • 0014675828 scopus 로고
    • Replacement therapy in hereditary angioedema. Successful treatment of two patients with fresh frozen plasma
    • Pickering RJ, Good RA, Kelly JR, et al. Replacement therapy in hereditary angioedema. Successful treatment of two patients with fresh frozen plasma. Lancet. 1969;1:326-330.
    • (1969) Lancet. , vol.1 , pp. 326-330
    • Pickering, R.J.1    Good, R.A.2    Kelly, J.R.3
  • 24
    • 0016365132 scopus 로고
    • Contributions to the optimal use of human blood. 3. Large-scale preparation of human c1 esterase inhibitor concentrate for clinical use
    • Vogelaar EF, Brummelhuis HG, Krijnen HW. Contributions to the optimal use of human blood. 3. Large-scale preparation of human c1 esterase inhibitor concentrate for clinical use. Vox Sang. 1974;26:118-127.
    • (1974) Vox Sang. , vol.26 , pp. 118-127
    • Vogelaar, E.F.1    Brummelhuis, H.G.2    Krijnen, H.W.3
  • 25
    • 0021287489 scopus 로고
    • Pasteurization of C1 inactivator in the presence of citrate salts
    • Williams C, Wickerhauser M, Busby TF, et al. Pasteurization of C1 inactivator in the presence of citrate salts. Vox Sang. 1984;46:260-269.
    • (1984) Vox Sang. , vol.46 , pp. 260-269
    • Williams, C.1    Wickerhauser, M.2    Busby, T.F.3
  • 26
    • 55249106917 scopus 로고    scopus 로고
    • Pathogen safety of intravenous Rh immunoglobulin liquid and other immune globulin products: Enhanced nanofiltration and manufacturing process overview
    • Soluk L, Price H, Sinclair C, et al. Pathogen safety of intravenous Rh immunoglobulin liquid and other immune globulin products: Enhanced nanofiltration and manufacturing process overview. Am J Ther. 2008;15:435-443.
    • (2008) Am J Ther. , vol.15 , pp. 435-443
    • Soluk, L.1    Price, H.2    Sinclair, C.3
  • 27
    • 70449727672 scopus 로고    scopus 로고
    • Efficacy of human C1 esterase inhibitor concentrate compared with placebo in acute hereditary angioedema attacks
    • Craig TJ, Levy RJ, Wasserman RL, et al. Efficacy of human C1 esterase inhibitor concentrate compared with placebo in acute hereditary angioedema attacks. J Allergy Clin Immunol. 2009;124:801-808.
    • (2009) J Allergy Clin Immunol. , vol.124 , pp. 801-808
    • Craig, T.J.1    Levy, R.J.2    Wasserman, R.L.3
  • 28
    • 77955299623 scopus 로고    scopus 로고
    • Nanofiltered C1 inhibitor concentrate for treatment of hereditary angioedema
    • Zuraw BL, Busse PJ, White M, et al. Nanofiltered C1 inhibitor concentrate for treatment of hereditary angioedema. N Engl J Med. 2010;363:513-522.
    • (2010) N Engl J Med. , vol.363 , pp. 513-522
    • Zuraw, B.L.1    Busse, P.J.2    White, M.3
  • 29
    • 82955243866 scopus 로고    scopus 로고
    • C1 esterase inhibitor concentrate in 1085 Hereditary Angioedema attacks-final results of the I.M.P.A.C.T.2 study
    • Craig TJ, Bewtra AK, Bahna SL, et al. C1 esterase inhibitor concentrate in 1085 Hereditary Angioedema attacks-final results of the I.M.P.A.C.T.2 study. Allergy. 2011;66:1604-1611.
    • (2011) Allergy. , vol.66 , pp. 1604-1611
    • Craig, T.J.1    Bewtra, A.K.2    Bahna, S.L.3
  • 30
    • 84355162811 scopus 로고    scopus 로고
    • Nanofiltered C1 esterase inhibitor (human) for the treatment of acute attacks of hereditary angioedema: An open-label trial
    • Riedl MA, Hurewitz DS, Levy R, et al. Nanofiltered C1 esterase inhibitor (human) for the treatment of acute attacks of hereditary angioedema: An open-label trial. Ann Allergy Asthma Immunol. 2012;108:49-53.
    • (2012) Ann Allergy Asthma Immunol. , vol.108 , pp. 49-53
    • Riedl, M.A.1    Hurewitz, D.S.2    Levy, R.3
  • 31
    • 84856500063 scopus 로고    scopus 로고
    • International consensus and practical guidelines on the gynecologic and obstetric management of female patients with hereditary angioedema caused by C1 inhibitor deficiency
    • Caballero T, Farkas H, Bouillet L, et al. International consensus and practical guidelines on the gynecologic and obstetric management of female patients with hereditary angioedema caused by C1 inhibitor deficiency. J Allergy Clin Immunol. 2012;129:308-320.
    • (2012) J Allergy Clin Immunol. , vol.129 , pp. 308-320
    • Caballero, T.1    Farkas, H.2    Bouillet, L.3
  • 32
    • 60849102075 scopus 로고    scopus 로고
    • A patient with hereditary angioedema who experienced anaphylaxis in response to C1 esterase inhibitor is successfully treated with DX-88 (Ecallantide), a potent human plasma kallikrein inhibitor: A case study
    • Cicardi M, Zingale LC, Zanichelli A. A patient with hereditary angioedema who experienced anaphylaxis in response to C1 esterase inhibitor is successfully treated with DX-88 (Ecallantide), a potent human plasma kallikrein inhibitor: A case study. Mol Immunol. 2007;44:160-161.
    • (2007) Mol Immunol. , vol.44 , pp. 160-161
    • Cicardi, M.1    Zingale, L.C.2    Zanichelli, A.3
  • 33
    • 0028832055 scopus 로고
    • Reduction in transmission of hepatitis C after the introduction of a heattreatment step in the production of C1-inhibitor concentrate
    • Cicardi M, Mannucci PM, Castelli R, et al. Reduction in transmission of hepatitis C after the introduction of a heattreatment step in the production of C1-inhibitor concentrate. Transfusion. 1995;35:209-212.
    • (1995) Transfusion. , vol.35 , pp. 209-212
    • Cicardi, M.1    Mannucci, P.M.2    Castelli, R.3
  • 34
    • 0142245455 scopus 로고    scopus 로고
    • Safety and efficacy of pasteurized C1 inhibitor concentrate (Berinert P) in hereditary angioedema: A review
    • De Serres J, Groner A, Lindner J. Safety and efficacy of pasteurized C1 inhibitor concentrate (Berinert P) in hereditary angioedema: A review. Transfus Apher Sci. 2003;29:247-254.
    • (2003) Transfus Apher Sci. , vol.29 , pp. 247-254
    • De Serres, J.1    Groner, A.2    Lindner, J.3
  • 35
    • 84868303782 scopus 로고    scopus 로고
    • Pathogen safety of human C1 esterase inhibitor concentrate
    • Groner A, Nowak T, Schafer W. Pathogen safety of human C1 esterase inhibitor concentrate. Transfusion. 2012;52:2104-2112.
    • (2012) Transfusion. , vol.52 , pp. 2104-2112
    • Groner, A.1    Nowak, T.2    Schafer, W.3
  • 36
    • 84877700550 scopus 로고    scopus 로고
    • Evidence for the transmission of parvovirus B19 in patients with bleeding disorders treated with plasma-derived factor concentrates in the era of nucleic acid test screening
    • Soucie JM, De Staercke C, Monahan PE, et al. Evidence for the transmission of parvovirus B19 in patients with bleeding disorders treated with plasma-derived factor concentrates in the era of nucleic acid test screening. Transfusion. 2013;53:1217-1225.
    • (2013) Transfusion. , vol.53 , pp. 1217-1225
    • Soucie, J.M.1    De Staercke, C.2    Monahan, P.E.3
  • 37
    • 84910604258 scopus 로고    scopus 로고
    • The thrombogenicity of C1 esterase inhibitor (human): Review of the evidence
    • Crowther M, Bauer KA, Kaplan AP. The thrombogenicity of C1 esterase inhibitor (human): Review of the evidence. Allergy Asthma Proc. 2014;35(6):444-453.
    • (2014) Allergy Asthma Proc. , vol.35 , Issue.6 , pp. 444-453
    • Crowther, M.1    Bauer, K.A.2    Kaplan, A.P.3
  • 38
    • 25844432828 scopus 로고    scopus 로고
    • A phase i study of recombinant human C1 inhibitor in asymptomatic patients with hereditary angioedema
    • Van Doorn MB, Burggraaf J, Van Dam T, et al. A phase I study of recombinant human C1 inhibitor in asymptomatic patients with hereditary angioedema. J Allergy Clin Immunol. 2005;116:876-883.
    • (2005) J Allergy Clin Immunol. , vol.116 , pp. 876-883
    • Van Doorn, M.B.1    Burggraaf, J.2    Van Dam, T.3
  • 39
    • 77957792655 scopus 로고    scopus 로고
    • Recombinant human C1-inhibitor for the treatment of acute angioedema attacks in patients with hereditary angioedema
    • Zuraw B, Cicardi M, Levy RJ, et al. Recombinant human C1-inhibitor for the treatment of acute angioedema attacks in patients with hereditary angioedema. J Allergy Clin Immunol. 2010;126:821-7. e814.
    • (2010) J Allergy Clin Immunol. , vol.126 , pp. 821-7e814
    • Zuraw, B.1    Cicardi, M.2    Levy, R.J.3
  • 40
    • 84865173076 scopus 로고    scopus 로고
    • Efficacy and safety of recombinant human C1-inhibitor for the treatment of attacks of hereditary angioedema: European openlabel extension study
    • Moldovan D, Reshef A, Fabiani J, et al. Efficacy and safety of recombinant human C1-inhibitor for the treatment of attacks of hereditary angioedema: European openlabel extension study. Clin Exp Allergy. 2012;42:929-935.
    • (2012) Clin Exp Allergy. , vol.42 , pp. 929-935
    • Moldovan, D.1    Reshef, A.2    Fabiani, J.3
  • 41
    • 84875436177 scopus 로고    scopus 로고
    • Efficacy and safety of recombinant C1 inhibitor for the treatment of hereditary angioedema attacks: A North American open-label study
    • Riedl MA, Levy RJ, Suez D, et al. Efficacy and safety of recombinant C1 inhibitor for the treatment of hereditary angioedema attacks: A North American open-label study. Ann Allergy Asthma Immunol. 2013;110:295-299.
    • (2013) Ann Allergy Asthma Immunol. , vol.110 , pp. 295-299
    • Riedl, M.A.1    Levy, R.J.2    Suez, D.3
  • 42
    • 84893684243 scopus 로고    scopus 로고
    • Recombinant human C1-esterase inhibitor relieves symptoms of hereditary angioedema attacks: Phase 3, randomized, placebo-controlled trial
    • Riedl MA, Bernstein JA, Li H, et al. Recombinant human C1-esterase inhibitor relieves symptoms of hereditary angioedema attacks: Phase 3, randomized, placebo-controlled trial. Ann Allergy Asthma Immunol. 2014;112:163-9.e161.
    • (2014) Ann Allergy Asthma Immunol. , vol.112 , pp. 163-163e161
    • Riedl, M.A.1    Bernstein, J.A.2    Li, H.3
  • 43
    • 84886728753 scopus 로고    scopus 로고
    • Population pharmacokinetics of recombinant human C1 inhibitor in patients with hereditary angioedema
    • Farrell C, Hayes S, Relan A, et al. Population pharmacokinetics of recombinant human C1 inhibitor in patients with hereditary angioedema. Br J Clin Pharmacol. 2013;76:897-907.
    • (2013) Br J Clin Pharmacol. , vol.76 , pp. 897-907
    • Farrell, C.1    Hayes, S.2    Relan, A.3
  • 44
    • 83555161732 scopus 로고    scopus 로고
    • Target levels of functional C1-inhibitor in hereditary angioedema
    • Hack CE, Relan A, Van Amersfoort ES, et al. Target levels of functional C1-inhibitor in hereditary angioedema. Allergy. 2012;67:123-130.
    • (2012) Allergy. , vol.67 , pp. 123-130
    • Hack, C.E.1    Relan, A.2    Van Amersfoort, E.S.3
  • 45
    • 77955295556 scopus 로고    scopus 로고
    • Icatibant, a new bradykinin-receptor antagonist, in hereditary angioedema
    • Cicardi M, Banerji A, Bracho F, et al. Icatibant, a new bradykinin-receptor antagonist, in hereditary angioedema. N Engl J Med. 2010;363:532-541.
    • (2010) N Engl J Med. , vol.363 , pp. 532-541
    • Cicardi, M.1    Banerji, A.2    Bracho, F.3
  • 46
    • 84903976159 scopus 로고    scopus 로고
    • Repeat treatment of acute hereditary angioedema attacks with open-label icatibant in the FAST-1 trial
    • Malbran A, Riedl M, Ritchie B, et al. Repeat treatment of acute hereditary angioedema attacks with open-label icatibant in the FAST-1 trial. Clin Exp Immunol. 2014;177:544-553.
    • (2014) Clin Exp Immunol. , vol.177 , pp. 544-553
    • Malbran, A.1    Riedl, M.2    Ritchie, B.3
  • 47
    • 82955233701 scopus 로고    scopus 로고
    • Randomized placebo-controlled trial of the bradykinin B' receptor antagonist icatibant for the treatment of acute attacks of hereditary angioedema: The FAST-3 trial
    • Lumry WR, Li HH, Levy RJ, et al. Randomized placebo-controlled trial of the bradykinin B? receptor antagonist icatibant for the treatment of acute attacks of hereditary angioedema: The FAST-3 trial. Ann Allergy Asthma Immunol. 2011;107(6):529-537.
    • (2011) Ann Allergy Asthma Immunol. , vol.107 , Issue.6 , pp. 529-537
    • Lumry, W.R.1    Li, H.H.2    Levy, R.J.3
  • 48
    • 73349134740 scopus 로고    scopus 로고
    • Successful treatment of 103 attacks of hereditary angioedema (HAE) with bradykinin B2 receptor antagonist icatibant
    • Malbran A. Successful treatment of 103 attacks of hereditary angioedema (HAE) with bradykinin B2 receptor antagonist icatibant. J Allergy Clin Immunol. 2008;121:S102.
    • (2008) J Allergy Clin Immunol. , vol.121 , pp. 102
    • Malbran, A.1
  • 49
    • 79959818300 scopus 로고    scopus 로고
    • Ecallantide (DX-88) for acute hereditary angioedema attacks: Integrated analysis of 2 double-blind, phase 3 studies
    • Sheffer AL, Campion M, Levy RJ, et al. Ecallantide (DX-88) for acute hereditary angioedema attacks: Integrated analysis of 2 double-blind, phase 3 studies. J Allergy Clin Immunol. 2011;128:153-9 e154.
    • (2011) J Allergy Clin Immunol. , vol.128 , pp. 153-9e154
    • Sheffer, A.L.1    Campion, M.2    Levy, R.J.3
  • 50
    • 77953172116 scopus 로고    scopus 로고
    • EDEMA4: A phase 3, double-blind study of subcutaneous ecallantide treatment for acute attacks of hereditary angioedema
    • Levy RJ, Lumry WR, McNeil DL, et al. EDEMA4: A phase 3, double-blind study of subcutaneous ecallantide treatment for acute attacks of hereditary angioedema. Ann Allergy Asthma Immunol. 2010;104:523-529.
    • (2010) Ann Allergy Asthma Immunol. , vol.104 , pp. 523-529
    • Levy, R.J.1    Lumry, W.R.2    McNeil, D.L.3
  • 51
    • 77955296289 scopus 로고    scopus 로고
    • Ecallantide for the treatment of acute attacks in hereditary angioedema
    • Cicardi M, Levy RJ, McNeil DL, et al. Ecallantide for the treatment of acute attacks in hereditary angioedema. N Engl J Med. 2010;363:523-531.
    • (2010) N Engl J Med. , vol.363 , pp. 523-531
    • Cicardi, M.1    Levy, R.J.2    McNeil, D.L.3
  • 52
    • 84924204714 scopus 로고    scopus 로고
    • Characterization of anaphylaxis after ecallantide treatment of hereditary angioedema attacks
    • Craig TJ, Li HH, Riedl M, et al. Characterization of anaphylaxis after ecallantide treatment of hereditary angioedema attacks. J Allergy Clin Immunol Pract. 2015;3:206-12.e4.
    • (2015) J Allergy Clin Immunol Pract. , vol.3 , pp. 206-206e4
    • Craig, T.J.1    Li, H.H.2    Riedl, M.3
  • 53
    • 34147199441 scopus 로고    scopus 로고
    • Fresh frozen plasma for the treatment of hereditary angioedema
    • Prematta M, Gibbs JG, Pratt EL, et al. Fresh frozen plasma for the treatment of hereditary angioedema. Ann Allergy Asthma Immunol. 2007;98:383-388.
    • (2007) Ann Allergy Asthma Immunol. , vol.98 , pp. 383-388
    • Prematta, M.1    Gibbs, J.G.2    Pratt, E.L.3
  • 54
    • 84899866192 scopus 로고    scopus 로고
    • Barriers to self-administered therapy for hereditary angioedema
    • Tuong LA, Olivieri K, Craig TJ. Barriers to self-administered therapy for hereditary angioedema. Allergy Asthma Proc. 2014;35:250-254.
    • (2014) Allergy Asthma Proc. , vol.35 , pp. 250-254
    • Tuong, L.A.1    Olivieri, K.2    Craig, T.J.3
  • 55
    • 84864767139 scopus 로고    scopus 로고
    • Preprocedural administration of nanofiltered C1 esterase inhibitor to prevent hereditary angioedema attacks
    • Grant JA, White MV, Lee HH, et al. Preprocedural administration of nanofiltered C1 esterase inhibitor to prevent hereditary angioedema attacks. Allergy Asthma Proc. 2012;33:348-353.
    • (2012) Allergy Asthma Proc. , vol.33 , pp. 348-353
    • Grant, J.A.1    White, M.V.2    Lee, H.H.3
  • 56
    • 84862565650 scopus 로고    scopus 로고
    • Current options for prophylactic treatment of hereditary angioedema in the United States: Patient-based considerations
    • Gower RG, Lumry WR, Davis-Lorton MA, et al. Current options for prophylactic treatment of hereditary angioedema in the United States: Patient-based considerations. Allergy Asthma Proc. 2012;33:235-240.
    • (2012) Allergy Asthma Proc. , vol.33 , pp. 235-240
    • Gower, R.G.1    Lumry, W.R.2    Davis-Lorton, M.A.3
  • 57
    • 79958768045 scopus 로고    scopus 로고
    • Risk of laryngeal edema and facial swellings after tooth extraction in patients with hereditary angioedema with and without prophylaxis with C1 inhibitor concentrate: A retrospective study
    • Bork K, Hardt J, Staubach-Renz P, et al. Risk of laryngeal edema and facial swellings after tooth extraction in patients with hereditary angioedema with and without prophylaxis with C1 inhibitor concentrate: A retrospective study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011;112:58-64.
    • (2011) Oral Surg Oral Med Oral Pathol Oral Radiol Endod. , vol.112 , pp. 58-64
    • Bork, K.1    Hardt, J.2    Staubach-Renz, P.3
  • 58
    • 68249140424 scopus 로고    scopus 로고
    • Modern preoperative and intraoperative management of hereditary angioedema
    • Szema AM, Paz G, Merriam L, et al. Modern preoperative and intraoperative management of hereditary angioedema. Allergy Asthma Proc. 2009;30:338-342.
    • (2009) Allergy Asthma Proc. , vol.30 , pp. 338-342
    • Szema, A.M.1    Paz, G.2    Merriam, L.3
  • 59
    • 77955191013 scopus 로고    scopus 로고
    • Population pharmacokinetics of plasmaderived C1 esterase inhibitor concentrate used to treat acute hereditary angioedema attacks
    • Bernstein JA, Ritchie B, Levy RJ, et al. Population pharmacokinetics of plasmaderived C1 esterase inhibitor concentrate used to treat acute hereditary angioedema attacks. Ann Allergy Asthma Immunol. 2010;105:149-154.
    • (2010) Ann Allergy Asthma Immunol. , vol.105 , pp. 149-154
    • Bernstein, J.A.1    Ritchie, B.2    Levy, R.J.3
  • 60
    • 75749126152 scopus 로고    scopus 로고
    • Pharmacokinetic analysis of human plasma-derived pasteurized C1-inhibitor concentrate in adults and children with hereditary angioedema: A prospective study
    • Martinez-Saguer I, Rusicke E, Aygoren-Pursun E, et al. Pharmacokinetic analysis of human plasma-derived pasteurized C1-inhibitor concentrate in adults and children with hereditary angioedema: A prospective study. Transfusion. 2010;50:354-360.
    • (2010) Transfusion. , vol.50 , pp. 354-360
    • Martinez-Saguer, I.1    Rusicke, E.2    Aygoren-Pursun, E.3
  • 61
    • 84872302853 scopus 로고    scopus 로고
    • WAO guideline for the management of hereditary angioedema
    • Craig T, Aygoren-Pursun E, Bork K, et al. WAO guideline for the management of hereditary angioedema. World Allergy Organ J. 2012;5:182-199.
    • (2012) World Allergy Organ J. , vol.5 , pp. 182-199
    • Craig, T.1    Aygoren-Pursun, E.2    Bork, K.3
  • 63
    • 0017053432 scopus 로고
    • Treatment of hereditary angioedema with danazol. Reversal of clinical and biochemical abnormalities
    • Gelfand JA, Sherins RJ, Alling DW, et al. Treatment of hereditary angioedema with danazol. Reversal of clinical and biochemical abnormalities. N Engl J Med. 1976;295:1444-1448.
    • (1976) N Engl J Med. , vol.295 , pp. 1444-1448
    • Gelfand, J.A.1    Sherins, R.J.2    Alling, D.W.3
  • 64
    • 0017355707 scopus 로고
    • Methyltestosterone therapy in hereditary angioedema
    • Sheffer AL, Fearon DT, Austen KF. Methyltestosterone therapy in hereditary angioedema. Ann Intern Med. 1977;86:306-308.
    • (1977) Ann Intern Med. , vol.86 , pp. 306-308
    • Sheffer, A.L.1    Fearon, D.T.2    Austen, K.F.3
  • 65
    • 0019406629 scopus 로고
    • Clinical and biochemical effects of stanozolol therapy for hereditary angioedema
    • Sheffer AL, Fearon DT, Austen KF. Clinical and biochemical effects of stanozolol therapy for hereditary angioedema. J Allergy Clin Immunol. 1981;68:181-187.
    • (1981) J Allergy Clin Immunol. , vol.68 , pp. 181-187
    • Sheffer, A.L.1    Fearon, D.T.2    Austen, K.F.3
  • 66
    • 1642328285 scopus 로고    scopus 로고
    • Oxandrolone treatment of childhood hereditary angioedema
    • Church JA. Oxandrolone treatment of childhood hereditary angioedema. Ann Allergy Asthma Immunol. 2004;92:377-378.
    • (2004) Ann Allergy Asthma Immunol. , vol.92 , pp. 377-378
    • Church, J.A.1
  • 67
    • 0016358085 scopus 로고
    • Longterm therapy of hereditary angioedema (HAE). Preventive management with fluoxymesterone and oxymetholone in severely affected males and females
    • Davis PJ, Davis FB, Charache P. Longterm therapy of hereditary angioedema (HAE). Preventive management with fluoxymesterone and oxymetholone in severely affected males and females. Johns Hopkins Med J. 1974;135:391-398.
    • (1974) Johns Hopkins Med J. , vol.135 , pp. 391-398
    • Davis, P.J.1    Davis, F.B.2    Charache, P.3
  • 68
    • 0018665126 scopus 로고
    • Clinical and biochemical effects of impeded androgen (oxymetholone) therapy of hereditary angioedema
    • Sheffer AL, Fearon DT, Austen KF. Clinical and biochemical effects of impeded androgen (oxymetholone) therapy of hereditary angioedema. J Allergy Clin Immunol. 1979;64:275-280.
    • (1979) J Allergy Clin Immunol. , vol.64 , pp. 275-280
    • Sheffer, A.L.1    Fearon, D.T.2    Austen, K.F.3
  • 69
    • 33846257234 scopus 로고    scopus 로고
    • Treatment of hereditary angioneurotic oedema (HANE) with tibolone
    • (Oxf
    • Ott HW, Mattle V, Hadziomerovic D, et al. Treatment of hereditary angioneurotic oedema (HANE) with tibolone. Clin Endocrinol (Oxf). 2007;66:180-184.
    • (2007) Clin Endocrinol , vol.66 , pp. 180-184
    • Ott, H.W.1    Mattle, V.2    Hadziomerovic, D.3
  • 70
    • 0019277560 scopus 로고
    • Danazol and stanozolol in long-term prophylactic treatment of hereditary angioedema
    • Agostoni A, Cicardi M, Martignoni GC, et al. Danazol and stanozolol in long-term prophylactic treatment of hereditary angioedema. J Allergy Clin Immunol. 1980;65:75-79.
    • (1980) J Allergy Clin Immunol. , vol.65 , pp. 75-79
    • Agostoni, A.1    Cicardi, M.2    Martignoni, G.C.3
  • 71
    • 39149132433 scopus 로고    scopus 로고
    • Metallopeptidase activities in hereditary angioedema: Effect of androgen prophylaxis on plasma aminopeptidase P
    • Drouet C, Desormeaux A, Robillard J, et al. Metallopeptidase activities in hereditary angioedema: Effect of androgen prophylaxis on plasma aminopeptidase P. J Allergy Clin Immunol. 2008;121:429-433.
    • (2008) J Allergy Clin Immunol. , vol.121 , pp. 429-433
    • Drouet, C.1    Desormeaux, A.2    Robillard, J.3
  • 72
    • 39049122335 scopus 로고    scopus 로고
    • Benefits and risks of danazol in hereditary angioedema: A long-term survey of 118 patients
    • Bork K, Bygum A, Hardt J. Benefits and risks of danazol in hereditary angioedema: A long-term survey of 118 patients. Ann Allergy Asthma Immunol. 2008;100:153-161.
    • (2008) Ann Allergy Asthma Immunol. , vol.100 , pp. 153-161
    • Bork, K.1    Bygum, A.2    Hardt, J.3
  • 73
    • 84926421779 scopus 로고    scopus 로고
    • Critical appraisal of androgen use in hereditary angioedema: A systematic review
    • Riedl MA. Critical appraisal of androgen use in hereditary angioedema: A systematic review. Ann Allergy Asthma Immunol. 2015;114:281-8.e7.
    • (2015) Ann Allergy Asthma Immunol. , vol.114 , pp. 281-281e7
    • Riedl, M.A.1
  • 74
    • 0025874826 scopus 로고
    • Long-term treatment of hereditary angioedema with attenuated androgens: A survey of a 13-year experience
    • Cicardi M, Bergamaschini L, Cugno M, et al. Long-term treatment of hereditary angioedema with attenuated androgens: A survey of a 13-year experience. J Allergy Clin Immunol. 1991;87:768-773.
    • (1991) J Allergy Clin Immunol. , vol.87 , pp. 768-773
    • Cicardi, M.1    Bergamaschini, L.2    Cugno, M.3
  • 75
    • 40949141935 scopus 로고    scopus 로고
    • Long-term danazol prophylaxis does not lead to increased carotid intima-media thickness in hereditary angioedema patients
    • Szegedi R, Szeplaki G, Varga L, et al. Long-term danazol prophylaxis does not lead to increased carotid intima-media thickness in hereditary angioedema patients. Atherosclerosis. 2008;198:184-191.
    • (2008) Atherosclerosis. , vol.198 , pp. 184-191
    • Szegedi, R.1    Szeplaki, G.2    Varga, L.3
  • 76
    • 38049016296 scopus 로고    scopus 로고
    • Hereditary angioedema: A current stateof-the-art review V: Attenuated androgens for the treatment of hereditary angioedema
    • Banerji A, Sloane DE, Sheffer AL. Hereditary angioedema: A current stateof-the-art review, V: Attenuated androgens for the treatment of hereditary angioedema. Ann Allergy Asthma Immunol. 2008;100:S19-22.
    • (2008) Ann Allergy Asthma Immunol. , vol.100 , pp. 19-22
    • Banerji, A.1    Sloane, D.E.2    Sheffer, A.L.3
  • 77
    • 0031741820 scopus 로고    scopus 로고
    • Danazol therapy: An unusual aetiology of hepatocellular carcinoma [letter]
    • Crampon D, Barnoud R, Durand M, et al. Danazol therapy: An unusual aetiology of hepatocellular carcinoma [letter]. J Hepatol. 1998;29:1035-1036.
    • (1998) J Hepatol. , vol.29 , pp. 1035-1036
    • Crampon, D.1    Barnoud, R.2    Durand, M.3
  • 78
    • 0036261401 scopus 로고    scopus 로고
    • Danazol-induced hepatocellular adenoma in patients with hereditary angio-oedema
    • Bork K, Schneiders V. Danazol-induced hepatocellular adenoma in patients with hereditary angio-oedema. J Hepatol. 2002;36:707-709.
    • (2002) J Hepatol. , vol.36 , pp. 707-709
    • Bork, K.1    Schneiders, V.2
  • 79
    • 77953923858 scopus 로고    scopus 로고
    • The effect of long-term danazol prophylaxis on liver function in hereditary angioedema-a longitudinal study
    • Farkas H, Czaller I, Csuka D, et al. The effect of long-term danazol prophylaxis on liver function in hereditary angioedema-a longitudinal study. Eur J Clin Pharmacol. 2010;66:419-426.
    • (2010) Eur J Clin Pharmacol. , vol.66 , pp. 419-426
    • Farkas, H.1    Czaller, I.2    Csuka, D.3
  • 80
    • 84927131195 scopus 로고    scopus 로고
    • Hepatocellular carcinoma in a noncirrhotic liver after long-term use of danazol for hereditary angioedema
    • Rahal S, Gilabert M, Ries P, et al. Hepatocellular carcinoma in a noncirrhotic liver after long-term use of danazol for hereditary angioedema. Case Rep Oncol. 2014;7:825-827.
    • (2014) Case Rep Oncol. , vol.7 , pp. 825-827
    • Rahal, S.1    Gilabert, M.2    Ries, P.3
  • 81
    • 0029973831 scopus 로고    scopus 로고
    • Treatment of hereditary angioedema with a vapor-heated C1 inhibitor concentrate
    • Waytes AT, Rosen FS, Frank MM. Treatment of hereditary angioedema with a vapor-heated C1 inhibitor concentrate. N Engl J Med. 1996;334:1630-1634.
    • (1996) N Engl J Med. , vol.334 , pp. 1630-1634
    • Waytes, A.T.1    Rosen, F.S.2    Frank, M.M.3
  • 82
    • 84865693626 scopus 로고    scopus 로고
    • Safety and efficacy of prophylactic nanofiltered C1-inhibitor in hereditary angioedema
    • Zuraw BL, Kalfus I. Safety and efficacy of prophylactic nanofiltered C1-inhibitor in hereditary angioedema. Am J Med. 2012;125:938.e1-7.
    • (2012) Am J Med. , vol.125 , pp. 938e1-9387
    • Zuraw, B.L.1    Kalfus, I.2
  • 83
    • 84867289618 scopus 로고    scopus 로고
    • Thrombotic events associated with C1 esterase inhibitor products in patients with hereditary angioedema: Investigation from the United States Food and Drug Administration adverse event reporting system database
    • Gandhi PK, Gentry WM, Bottorff MB. Thrombotic events associated with C1 esterase inhibitor products in patients with hereditary angioedema: Investigation from the United States Food and Drug Administration adverse event reporting system database. Pharmacotherapy. 2012;32:902-909.
    • (2012) Pharmacotherapy. , vol.32 , pp. 902-909
    • Gandhi, P.K.1    Gentry, W.M.2    Bottorff, M.B.3
  • 84
    • 0015504576 scopus 로고
    • Epsilon aminocaproic acid therapy of hereditary angioneurotic edema. A doubleblind study
    • Frank MM, Sergent JS, Kane MA, et al. Epsilon aminocaproic acid therapy of hereditary angioneurotic edema. A doubleblind study. N Engl J Med. 1972;286:808-812.
    • (1972) N Engl J Med. , vol.286 , pp. 808-812
    • Frank, M.M.1    Sergent, J.S.2    Kane, M.A.3
  • 85
    • 0015531064 scopus 로고
    • Tranexamic acid therapy in hereditary angioneurotic edema
    • Sheffer AL, Austen KF, Rosen FS. Tranexamic acid therapy in hereditary angioneurotic edema. N Engl J Med. 1972;287:452-454.
    • (1972) N Engl J Med. , vol.287 , pp. 452-454
    • Sheffer, A.L.1    Austen, K.F.2    Rosen, F.S.3
  • 86
    • 0026749660 scopus 로고
    • Mechanism of enhanced kinin release from high molecular weight kininogen by plasma kallikrein after its exposure to plasmin
    • Kleniewski J, Blankenship DT, Cardin AD, et al. Mechanism of enhanced kinin release from high molecular weight kininogen by plasma kallikrein after its exposure to plasmin. J Lab Clin Med. 1992;120:129-139.
    • (1992) J Lab Clin Med. , vol.120 , pp. 129-139
    • Kleniewski, J.1    Blankenship, D.T.2    Cardin, A.D.3
  • 87
    • 0034903952 scopus 로고    scopus 로고
    • No increased risk of venous thrombosis in women taking tranexamic acid
    • Berntorp E, Follrud C, Lethagen S. No increased risk of venous thrombosis in women taking tranexamic acid. Thromb Haemost. 2001;86:714-715.
    • (2001) Thromb Haemost. , vol.86 , pp. 714-715
    • Berntorp, E.1    Follrud, C.2    Lethagen, S.3
  • 88
    • 0024826263 scopus 로고
    • Massive pulmonary thromboembolism after tranexamic acid antifibrinolytic therapy
    • Woo KS, Tse LK, Woo JL, et al. Massive pulmonary thromboembolism after tranexamic acid antifibrinolytic therapy. Br J Clin Pract. 1989;43:465-466.
    • (1989) Br J Clin Pract. , vol.43 , pp. 465-466
    • Woo, K.S.1    Tse, L.K.2    Woo, J.L.3
  • 89
    • 84876678134 scopus 로고    scopus 로고
    • Nanofiltered C1-esterase inhibitor for the acute management and prevention of hereditary angioedema attacks due to C1-inhibitor deficiency in children
    • Lumry W, Manning ME, Hurewitz DS, et al. Nanofiltered C1-esterase inhibitor for the acute management and prevention of hereditary angioedema attacks due to C1-inhibitor deficiency in children. J Pediatr. 2013;162:1017-22.e1-2.
    • (2013) J Pediatr. , vol.162 , pp. 1017-22e12
    • Lumry, W.1    Manning, M.E.2    Hurewitz, D.S.3
  • 90
    • 84855352471 scopus 로고    scopus 로고
    • Home therapy with intravenous human C1-inhibitor in children and adolescents with hereditary angioedema
    • Kreuz W, Rusicke E, Martinez-Saguer I, et al. Home therapy with intravenous human C1-inhibitor in children and adolescents with hereditary angioedema. Transfusion. 2012;52:100-107.
    • (2012) Transfusion. , vol.52 , pp. 100-107
    • Kreuz, W.1    Rusicke, E.2    Martinez-Saguer, I.3
  • 91
    • 84911999719 scopus 로고    scopus 로고
    • Hereditary angioedema: Children should be considered for training in self-administration
    • Abdel-Karim O, Dizdarevic A, Bygum A. Hereditary angioedema: Children should be considered for training in self-administration. Pediatr Dermatol. 2014;31:e132-e135.
    • (2014) Pediatr Dermatol. , vol.31 , pp. e132-e135
    • Abdel-Karim, O.1    Dizdarevic, A.2    Bygum, A.3
  • 92
    • 34548445562 scopus 로고    scopus 로고
    • Management of hereditary angioedema in pediatric patients
    • Farkas H, Varga L, Szeplaki G, et al. Management of hereditary angioedema in pediatric patients. Pediatrics. 2007;120: E713-e722.
    • (2007) Pediatrics. , vol.120 , pp. e713-e722
    • Farkas, H.1    Varga, L.2    Szeplaki, G.3
  • 93
    • 4444347650 scopus 로고    scopus 로고
    • Canadian 2003 international consensus algorithm for the diagnosis, therapy, and management of hereditary angioedema
    • Bowen T, Cicardi M, Farkas H, et al. Canadian 2003 international consensus algorithm for the diagnosis, therapy, and management of hereditary angioedema. J Allergy Clin Immunol. 2004;114:629-637.
    • (2004) J Allergy Clin Immunol. , vol.114 , pp. 629-637
    • Bowen, T.1    Cicardi, M.2    Farkas, H.3
  • 94
    • 20044384875 scopus 로고    scopus 로고
    • C1 inhibitor deficiency: Consensus document
    • Gompels MM, Lock RJ, Abinun M, et al. C1 inhibitor deficiency: Consensus document. Clin Exp Immunol. 2005;139:379-394.
    • (2005) Clin Exp Immunol. , vol.139 , pp. 379-394
    • Gompels, M.M.1    Lock, R.J.2    Abinun, M.3
  • 95
    • 84911374174 scopus 로고    scopus 로고
    • High-molecular-weight kininogen cleavage correlates with disease states in the bradykinin-mediated angioedema due to hereditary C1-inhibitor deficiency
    • Suffritti C, Zanichelli A, Maggioni L, et al. High-molecular-weight kininogen cleavage correlates with disease states in the bradykinin-mediated angioedema due to hereditary C1-inhibitor deficiency. Clin Exp Allergy. 2014;44:1503-1514.
    • (2014) Clin Exp Allergy. , vol.44 , pp. 1503-1514
    • Suffritti, C.1    Zanichelli, A.2    Maggioni, L.3
  • 96
    • 84881095783 scopus 로고    scopus 로고
    • Enzymatic assays for the diagnosis of bradykinin-dependent angioedema
    • Defendi F, Charignon D, Ghannam A, et al. Enzymatic assays for the diagnosis of bradykinin-dependent angioedema. PLoS One. 2013;8(8):e70140.
    • (2013) PLoS One. , vol.8 , Issue.8 , pp. e70140
    • Defendi, F.1    Charignon, D.2    Ghannam, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.