HTLV-1 bZIP factor protein targets the Rb/E2F-1 pathway to promote proliferation and apoptosis of primary CD4+ T cells

Oncogene

Volumn 35, Issue 34, 2016, Pages 4509-4517

  Kawatsuki, A ^a   Yasunaga, J I ^a   Mitobe, Y ^a   Green, P L ^b   Matsuoka, M ^a  

^a KYOTO UNIVERSITY   (Japan)

^b OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE DEACETYLASE 3; HTLV 1 BZIP FACTOR PROTEIN; RETINOBLASTOMA PROTEIN; TAX PROTEIN; TRANSCRIPTION FACTOR E2F1; UNCLASSIFIED DRUG; VIRAL PROTEIN; BASIC LEUCINE ZIPPER TRANSCRIPTION FACTOR; E2F1 PROTEIN, HUMAN; HBZ PROTEIN, HUMAN T-CELL LEUKEMIA VIRUS TYPE I; HISTONE DEACETYLASE; PROTEIN P53;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER INHIBITION; CD4+ T LYMPHOCYTE; CELL CYCLE G1 PHASE; CELL CYCLE PROGRESSION; CELL CYCLE REGULATION; CELL CYCLE S PHASE; CELL LYSATE; COMPARATIVE STUDY; CONTROLLED STUDY; DELETION MUTANT; EX VIVO STUDY; GENETIC TRANSCRIPTION; HUMAN T-LYMPHOTROPIC VIRUS 1; IMMUNOPRECIPITATION; IN VITRO STUDY; LYMPHOCYTE PROLIFERATION; MEMORY T LYMPHOCYTE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; RNA STRUCTURE; SILENT MUTATION; SPLEEN CELL; UPREGULATION; ANIMAL; C57BL MOUSE; CELL CULTURE; CELL CYCLE; CELL PROLIFERATION; HUMAN; METABOLISM; PATHOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION; VIROLOGY;

ANIMALS; APOPTOSIS; BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTORS; CD4-POSITIVE T-LYMPHOCYTES; CELL CYCLE; CELL PROLIFERATION; CELLS, CULTURED; E2F1 TRANSCRIPTION FACTOR; HISTONE DEACETYLASES; HUMANS; MICE; MICE, INBRED C57BL; RETINOBLASTOMA PROTEIN; RETROVIRIDAE PROTEINS; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84955595129     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2015.510     Document Type: Article

References (40)

1. Matsuoka M, Jeang KT. Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation. Nat Rev Cancer 2007; 7: 270-280.
2. Matsuoka M, Yasunaga JI. Human T-cell leukemia virus type 1: replication, proliferation and propagation by Tax and HTLV-1 bZIP factor. Curr Opin Virol 2013; 3: 684-691.
3. Gillet NA, Malani N, Melamed A, Gormley N, Carter R, Bentley D et al. The host genomic environment of the provirus determines the abundance of HTLV-1-infected T-cell clones. Blood 2011; 117: 3113-3122.
4. Melamed A, Laydon DJ, Gillet NA, Tanaka Y, Taylor GP, Bangham CR. Genome-wide determinants of proviral targeting, clonal abundance and expression in natural HTLV-1 infection. PLoS Pathog 2013; 9: e1003271.
5. Philip S, Zahoor MA, Zhi H, Ho YK, Giam CZ. Regulation of human T-lymphotropic virus type I latency and reactivation by HBZ and Rex. PLoS Pathog 2014; 10: e1004040.
6. Yasunaga J, Matsuoka M. Molecular mechanisms of HTLV-1 infection and pathogenesis. Int J Hematol 2011; 94: 435-442.
7. Gaudray G, Gachon F, Basbous J, Biard-Piechaczyk M, Devaux C, Mesnard JM. The complementary strand of the human T-cell leukemia virus type 1 RNA genome encodes a bZIP transcription factor that down-regulates viral transcription. J Virol 2002; 76: 12813-12822.
8. Satou Y, Yasunaga J, Yoshida M, Matsuoka M. HTLV-I basic leucine zipper factor gene mRNA supports proliferation of adult T cell leukemia cells. Proc Natl Acad Sci USA 2006; 103: 720-725.
9. Fan J, Ma G, Nosaka K, Tanabe J, Satou Y, Koito A et al. APOBEC3G generates nonsense mutations in human T-cell leukemia virus type 1 proviral genomes in vivo. J Virol 2010; 84: 7278-7287.
10. Mitobe Y, Yasunaga J, Furuta R, Matsuoka M. HTLV-1 bZIP Factor RNA and Protein Impart Distinct Functions on T-cell Proliferation and Survival. Cancer Res 2015; 75: 4143-4152.
11. Satou Y, Matsuoka M. Molecular and cellular mechanism of leukemogenesis of ATL: emergent evidence of a significant role for HBZ in HTLV-1-induced pathogenesis. Leuk Res Treat 2012; 2012: 213653.
12. Classon M, Harlow E. The retinoblastoma tumour suppressor in development and cancer. Nat Rev Cancer 2002; 2: 910-917.
13. Dyson N. The regulation of E2F by pRB-family proteins. Genes Dev 1998; 12: 2245-2262.
14. Satou Y, Yasunaga J, Zhao T, Yoshida M, Miyazato P, Takai K et al. HTLV-1 bZIP factor induces T-cell lymphoma and systemic inflammation in vivo. PLoS Pathog 2011; 7: e1001274.
15. Dick FA, Rubin SM. Molecular mechanisms underlying RB protein function. Nat Rev Mol Cell Biol 2013; 14: 297-306.
16. Kehn K, Fuente Cde L, Strouss K, Berro R, Jiang H, Brady J et al. The HTLV-I Tax oncoprotein targets the retinoblastoma protein for proteasomal degradation. Oncogene 2005; 24: 525-540.
17. Trimarchi JM, Lees JA. Sibling rivalry in the E2F family. Nat Rev Mol Cell Biol 2002; 3: 11-20.
18. Polager S, Ginsberg D. p53 and E2f: partners in life and death. Nat Rev Cancer 2009; 9: 738-748.
19. Komarov PG, Komarova EA, Kondratov RV, Christov-Tselkov K, Coon JS, Chernov MV et al. A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy. Science 1999; 285: 1733-1737.
20. Davidson W, Ren Q, Kari G, Kashi O, Dicker AP, Rodeck U. Inhibition of p73 function by Pifithrin-alpha as revealed by studies in zebrafish embryos. Cell Cycle 2008; 7: 1224-1230.
21. Boyer SN, Wazer DE, Band V. E7 protein of human papilloma virus-16 induces degradation of retinoblastoma protein through the ubiquitin-proteasome pathway. Cancer Res 1996; 56: 4620-4624.
22. Munakata T, Liang Y, Kim S, McGivern DR, Huibregtse J, Nomoto A et al. Hepatitis C virus induces E6AP-dependent degradation of the retinoblastoma protein. PLoS Pathog 2007; 3: 1335-1347.
23. Knight JS, Sharma N, Robertson ES. Epstein-Barr virus latent antigen 3C can mediate the degradation of the retinoblastoma protein through an SCF cellular ubiquitin ligase. Proc Natl Acad Sci USA 2005; 102: 18562-18566.
24. Borchert S, Czech-Sioli M, Neumann F, Schmidt C, Wimmer P, Dobner T et al. High-affinity Rb binding, p53 inhibition, subcellular localization, and transformation by wild-type or tumor-derived shortened Merkel cell polyomavirus large T antigens. J Virol 2014; 88: 3144-3160.
25. Swaims AY, Khani F, Zhang Y, Roberts AI, Devadas S, Shi Y et al. Immune activation induces immortalization of HTLV-1 LTR-Tax transgenic CD4+ T cells. Blood 2010; 116: 2994-3003.
26. Arpin-Andre C, Laverdure S, Barbeau B, Gross A, Mesnard JM. Construction of a reporter vector for analysis of bidirectional transcriptional activity of retrovirus LTR. Plasmid 2014; 74: 45-51.
27. Yoshida M, Satou Y, Yasunaga J, Fujisawa J, Matsuoka M. Transcriptional control of spliced and unspliced human T-cell leukemia virus type 1 bZIP factor (HBZ) gene. J Virol 2008; 82: 9359-9368.
28. Wu X, Levine AJ. p53 and E2F-1 cooperate to mediate apoptosis. Proc Natl Acad Sci USA 1994; 91: 3602-3606.
29. Irwin M, Marin MC, Phillips AC, Seelan RS, Smith DI, Liu W et al. Role for the p53 homologue p73 in E2F-1-induced apoptosis. Nature 2000; 407: 645-648.
30. Bosco EE, Mayhew CN, Hennigan RF, Sage J, Jacks T, Knudsen ES. RB signaling prevents replication-dependent DNA double-strand breaks following genotoxic insult. Nucleic Acids Res 2004; 32: 25-34.
31. Lowe SW, Cepero E, Evan G. Intrinsic tumour suppression. Nature 2004; 432: 307-315.
32. Vernin C, Thenoz M, Pinatel C, Gessain A, Gout O, Delfau-Larue MH et al. HTLV-1 bZIP factor HBZ promotes cell proliferation and genetic instability by activating OncomiRs. Cancer Res 2014; 74: 6082-6093.
33. Zhao T, Satou Y, Sugata K, Miyazato P, Green PL, Imamura T et al. HTLV-1 bZIP factor enhances TGF-beta signaling through p300 coactivator. Blood 2011; 118: 1865-1876.
34. Yamamoto-Taguchi N, Satou Y, Miyazato P, Ohshima K, Nakagawa M, Katagiri K et al. HTLV-1 bZIP factor induces inflammation through labile Foxp3 expression. PLoS Pathog 2013; 9: e1003630.
35. Takeda S, Maeda M, Morikawa S, Taniguchi Y, Yasunaga J, Nosaka K et al. Genetic and epigenetic inactivation of tax gene in adult T-cell leukemia cells. Int J Cancer 2004; 109: 559-567.
36. Katoh T, Harada T, Morikawa S, Wakutani T. IL-2- and IL-2-R- independent proliferation of T-cell lines from adult T-cell leukemia/lymphoma patients. Int J Cancer 1986; 38: 265-274.
37. Zhao T, Yasunaga J, Satou Y, Nakao M, Takahashi M, Fujii M et al. Human T-cell leukemia virus type 1 bZIP factor selectively suppresses the classical pathway of NF-kappaB. Blood 2009; 113: 2755-2764.
38. Peloponese Jr JM, Yasunaga J, Kinjo T, Watashi K, Jeang KT. Peptidylproline cis-trans-isomerase Pin1 interacts with human T-cell leukemia virus type 1 tax and modulates its activation of NF-kappaB. J Virol 2009; 83: 3238-3248.
39. Sawada S, Gowrishankar K, Kitamura R, Suzuki M, Suzuki G, Tahara S et al. Disturbed CD4+ T cell homeostasis and in vitro HIV-1 susceptibility in transgenic mice expressing T cell line-tropic HIV-1 receptors. J Exp Med 1998; 187: 1439-1449.
40. Arnold J, Zimmerman B, Li M, Lairmore MD, Green PL. Human T-cell leukemia virus type-1 antisense-encoded gene, Hbz, promotes T-lymphocyte proliferation. Blood 2008; 112: 3788-3797.