Influence of granulocyte-macrophage colony-stimulating factor or influenza vaccination on HLA-DR, infection and delirium days in immunosuppressed surgical patients: Double blind, randomised controlled trial

PLoS ONE

Volumn 10, Issue 12, 2015, Pages

  Spies, Claudia ^a   Luetz, Alawi ^a   Lachmann, Gunnar ^a   Renius, Markus ^a   Von Haefen, Clarissa ^a   Wernecke, Klaus Dieter ^b   Bahra, Marcus ^a   Schiemann, Alexander ^a   Paupers, Marco ^a   Meisel, Christian ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b SOSTANA GMBH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

HLA DR ANTIGEN; INFLUENZA VACCINE; PLACEBO; SARGRAMOSTIM; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; ESOPHAGUS RESECTION; FEMALE; HUMAN; IMMUNOCOMPETENCE; IMMUNOREACTIVITY; IMMUNOSUPPRESSIVE TREATMENT; MAJOR CLINICAL STUDY; MALE; MONOCYTE; OUTCOME ASSESSMENT; PANCREAS RESECTION; POSTOPERATIVE DELIRIUM; POSTOPERATIVE INFECTION; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; SURGICAL PATIENT; UNIVERSITY HOSPITAL; CLINICAL TRIAL; DELIRIUM; ESOPHAGUS; IMMUNOCOMPROMISED PATIENT; INFLUENZA, HUMAN; METABOLISM; MIDDLE AGED; MULTICENTER STUDY; PANCREAS; PATHOPHYSIOLOGY; SURGERY; VACCINATION;

AGED; DELIRIUM; DOUBLE-BLIND METHOD; ESOPHAGUS; FEMALE; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HLA-DR ANTIGENS; HUMANS; IMMUNOCOMPROMISED HOST; INFLUENZA VACCINES; INFLUENZA, HUMAN; MALE; MIDDLE AGED; MONOCYTES; PANCREAS; VACCINATION;

EID: 84955571855     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0144003     Document Type: Article

References (54)

1. Geffers C, Sohr D, Gastmeier P. Mortality attributable to hospital-acquired infections among surgical patients. Infection control and hospital epidemiology: The official Journal of the Society of Hospital Epidemiologists of America. 2008; 29(12): 1167-70. Epub 2008/11/19. doi: 10.1086/592410 PMID: 19014317.
2. Angus DC, Linde-Zwirble WT, Lidicker J, Clermont G, Carcillo J, Pinsky MR. Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care. Critical Care Medicine. 2001; 29(7): 1303-10. PMID: 11445675.
3. Dasgupta M, Dumbrell AC. Preoperative risk assessment for delirium after noncardiac surgery: A systematic review. Journal of the American Geriatrics Society. 2006; 54(10): 1578-89. doi: 10.1111/j.1532-5415.2006.00893.x PMID: 17038078.
4. Radtke FM, Franck M, Schneider M, Luetz A, Seeling M, Heinz A, et al. Comparison of three scores to screen for delirium in the recovery room. British Journal of anaesthesia. 2008; 101(3): 338-43. Epub 2008/07/08. doi: 10.1093/bja/aen193 PMID: 18603528.
5. Radtke FM, Franck M, Schust S, Boehme L, Pascher A, Bail HJ, et al. A comparison of three scores to screen for delirium on the surgical ward. World Journal of Surgery. 2010; 34(3): 487-94. Epub 2010/01/13. doi: 10.1007/s00268-009-0376-9 PMID: 20066416.
6. Luetz A, Heymann A, Radtke FM, Chenitir C, Neuhaus U, Nachtigall I, et al. Different assessment tools for intensive care unit delirium: Which score to use? Critical Care Medicine. 2010; 38(2): 409-18. doi: 10.1097/CCM.0b013e3181cabb42 PMID: 20029345.
7. Delgado-Rodriguez M, Gomez-Ortega A, Llorca J, Lecuona M, Dierssen T, Sillero-Arenas M, et al. Nosocomial infection, indices of intrinsic infection risk, and in-hospital mortality in general Surgery. The Journal of hospital infection. 1999; 41(3): 203-11. Epub 1999/04/16. PMID: 10204122.
8. Hensler T, Hecker H, Heeg K, Heidecke CD, Bartels H, Barthlen W, et al. Distinct mechanisms of immunosuppression as a consequence of major Surgery. Infection and Immunity. 1997; 65(6): 2283-91. PMID: 9169765; PubMed Central PMCID: PMC175317.
9. Wakefield CH, Carey PD, Foulds S, Monson JR, Guillou PJ. Changes in major histocompatibility complex class II expression in monocytes and T cells of patients developing infection after Surgery. The British Journal of Surgery. 1993; 80(2): 205-9. PMID: 8443652.
10. Weimann K, Zimmermann M, Spies CD, Wernecke KD, Vicherek O, Nachtigall I, et al. Intensive Care Infection Score-A new approach to distinguish between infectious and noninfectious processes in intensive care and medicosurgical patients. The Journal of international medical research. 2015. doi: 10.1177/0300060514557711 PMID: 25850686.
11. Spies CD, von Dossow V, Eggers V, Jetschmann G, El-Hilali R, Egert J, et al. Altered cell-mediated immunity and increased postoperative infection rate in long-term alcoholic patients. Anesthesiology. 2004; 100(5): 1088-100. Epub 2004/04/29. PMID: 15114205.
12. Docke WD, Hoflich C, Davis KA, Rottgers K, Meisel C, Kiefer P, et al. Monitoring temporary immunodepression by flow cytometric measurement of monocytic HLA-DR expression: A multicenter standardized study. Clinical chemistry. 2005; 51(12): 2341-7. doi: 10.1373/clinchem.2005.052639 PMID: 16214828.
13. Heymann A, Radtke F, Schiemann A, Lutz A, MacGuill M, Wernecke KD, et al. Delayed treatment of delirium increases mortality rate in intensive care unit patients. The Journal of international medical research. 2010; 38(5): 1584-95. Epub 2011/02/12. PMID: 21309472.
14. Spies CD, Kern H, Schroder T, Sander M, Sepold H, Lang P, et al. Myocardial ischemia and cytokine response are associated with subsequent onset of infections after noncardiac Surgery. Anesthesia and analgesia. 2002; 95(1): 9-18, table of contents. Epub 2002/06/29. PMID: 12088935.
15. Haupt W, Riese J, Mehler C, Weber K, Zowe M, Hohenberger W. Monocyte function before and after surgical trauma. Digestive Surgery. 1998; 15(2): 102-4. Epub 1998/12/09. PMID: 9845570.
16. Wu JF, Ma J, Chen J, Ou-Yang B, Chen MY, Li LF, et al. Changes of monocyte human leukocyte antigen-DR expression as a reliable predictor of mortality in severe sepsis. Crit Care. 2011; 15(5): R220. doi: 10.1186/cc10457 PMID: 21933399; PubMed Central PMCID: PMC3334765.
17. Lukaszewicz AC, Grienay M, Resche-Rigon M, Pirracchio R, Faivre V, Boval B, et al. Monocytic HLADR expression in intensive care patients: Interest for prognosis and secondary infection prediction. Critical Care Medicine. 2009; 37(10): 2746-52. doi: 10.1097/CCM.0b013e3181ab858a PMID: 19707128.
18. Landelle C, Lepape A, Voirin N, Tognet E, Venet F, Bohe J, et al. Low monocyte human leukocyte antigen-DR is independently associated with nosocomial infections after septic shock. Intensive Care Medicine. 2010; 36(11): 1859-66. doi: 10.1007/s00134-010-1962-x PMID: 20652682.
19. Schinkel C, Sendtner R, Zimmer S, Faist E. Functional analysis of monocyte subsets in surgical sepsis. The Journal of trauma. 1998; 44(5): 743-8; discussion 8-9. PMID: 9603073.
20. Haining WN, Evans JW, Seth NP, Callaway GD, Wucherpfennig KW, Nadler LM, et al. Measuring T cell immunity to influenza vaccination in children after haemopoietic stem cell transplantation. British Journal of haematology. 2004; 127(3): 322-5. doi: 10.1111/j.1365-2141.2004.05204.x PMID: 15491293.
21. Blazevic V, Trubey CM, Shearer GM. Comparison of in vitro immunostimulatory potential of live and inactivated influenza viruses. Human Immunology. 2000; 61(9): 845-9. Epub 2000/10/29. PMID: 11053627.
22. Gorse GJ, Patel GB, Belshe RB, National Institute of A, Infectious Diseases HIVVTN. HIV type 1 vaccine-induced T cell memory and cytotoxic T lymphocyte responses in HIV type 1-uninfected volunteers. AIDS research and human retroviruses. 2001; 17(12): 1175-89. doi: 10.1089/088922201316912781 PMID: 11522187.
23. Spies CD, Kip M, Lau A, Sander M, Breuer JP, Meyerhoefer J, et al. Influence of vaccination and surgery on HLA-DR expression in patients with upper aerodigestive tract cancer. The Journal of international medical research. 2008; 36(2): 296-307. PMID: 18380940.
24. Meisel C, Schefold JC, Pschowski R, Baumann T, Hetzger K, Gregor J, et al. Granulocyte-macrophage colony-stimulating factor to reverse sepsis-associated immunosuppression: A double-blind, randomized, placebo-controlled multicenter trial. American Journal of respiratory and critical Care Medicine. 2009; 180(7): 640-8. Epub 2009/07/11. doi: 10.1164/rccm.200903-0363OC PMID: 19590022.
25. Borgermann J, Friedrich I, Scheubel R, Kuss O, Lendemans S, Silber RE, et al. Granulocyte-macrophage colony-stimulating factor (GM-CSF) restores decreased monocyte HLA-DR expression after cardiopulmonary bypass. The Thoracic and cardiovascular surgeon. 2007; 55(1): 24-31. PMID: 17285470.
26. Nierhaus A, Montag B, Timmler N, Frings DP, Gutensohn K, Jung R, et al. Reversal of immunoparalysis by recombinant human granulocyte-macrophage colony-stimulating factor in patients with severe sepsis. Intensive Care Medicine. 2003; 29(4): 646-51. Epub 2003/02/22. PMID: 12595977.
27. Bilgin K, Yaramis A, Haspolat K, Tas MA, Gunbey S, Derman O. A randomized trial of granulocyte-macrophage colony-stimulating factor in neonates with sepsis and neutropenia. Pediatrics. 2001; 107 (1): 36-41. Epub 2001/01/03. PMID: 11134431.
28. Goldmann A, Renius M, Zachmann C, Kleinwaechter R, von Haefen C, Wernecke KD, et al. Influence of preoperative vaccination on monocytic HLA-DR expression and postoperative infection rate of patients with upper aerodigestive tract cancer: A randomised trial. European Journal of anaesthesiology. 2015. doi: 10.1097/EJA.0000000000000171 PMID: 25564783.
29. Semenenko TA, Selkova EP, Gotvianskaia TP, Gaidarenko AD, Polezhaeva NA, Evseeva LF, et al. [Characteristics of the immune status in specific and nonspecific prophylaxis of influenza in elderly persons]. Zhurnal mikrobiologii, epidemiologii, i immunobiologii. 2005;( 6): 24-8. PMID: 16438370.
30. Spies C KW, Kastrup M, Melzer-Gartzke C, Zielke H. SOPs in Intensivmedizin und Notfallmedizin: Alle relevanten Standards und Techniken für die Klinik. Stuttgart, Georg Thieme Verlag. 2013.
31. Horan TC, Gaynes RP, Martone WJ, Jarvis WR, Emori TG. CDC definitions of nosocomial surgical site infections, 1992: A modification of CDC definitions of surgical wound infections. American Journal of infection control. 1992; 20(5): 271-4. Epub 1992/10/01. PMID: 1332552.
32. American Thoracic S, Infectious Diseases Society of A. Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia. American Journal of respiratory and critical Care Medicine. 2005; 171(4): 388-416. PMID: 15699079.
33. Lendemans S, Kreuzfelder E, Waydhas C, Schade FU, Flohe S. Differential immunostimulating effect of granulocyte-macrophage colony-stimulating factor (GM-CSF), granulocyte colony-stimulating factor (G-CSF) and interferon gamma (IFNgamma) after severe trauma. Inflammation research: Official Journal of the European Histamine Research Society [et al]. 2007; 56(1): 38-44. PMID: 17334669.
34. Hall MW, Knatz NL, Vetterly C, Tomarello S, Wewers MD, Volk HD, et al. Immunoparalysis and nosocomial infection in children with multiple organ dysfunction syndrome. Intensive Care Medicine. 2011; 37 (3): 525-32. doi: 10.1007/s00134-010-2088-x PMID: 21153402.
35. Hornell TM, Beresford GW, Bushey A, Boss JM, Mellins ED. Regulation of the class II MHC pathway in primary human monocytes by granulocyte-macrophage colony-stimulating factor. Journal of Immunology. 2003; 171(5): 2374-83. Epub 2003/08/21. PMID: 12928384.
36. Egli A, Humar A, Widmer LA, Lisboa LF, Santer DM, Mueller T, et al. Effect of Immunosuppression on T-Helper 2 and B-Cell Responses to Influenza Vaccination. The Journal of infectious diseases. 2015; 212(1): 137-46. doi: 10.1093/infdis/jiv015 PMID: 25589334.
37. Hughes CG, Patel MB, Pandharipande PP. Pathophysiology of acute brain dysfunction: What's the cause of all this confusion? Current opinion in critical care. 2012; 18(5): 518-26. doi: 10.1097/MCC. 0b013e328357effa PMID: 22941208.
38. Bo L, Wang F, Zhu J, Li J, Deng X. Granulocyte-colony stimulating factor (G-CSF) and granulocytemacrophage colony stimulating factor (GM-CSF) for sepsis: A meta-analysis. Crit Care. 2011; 15(1): R58. doi: 10.1186/cc10031 PMID: 21310070; PubMed Central PMCID: PMC3221991.
39. Pisani MA, Kong SY, Kasl SV, Murphy TE, Araujo KL, Van Ness PH. Days of delirium are associated with 1-year mortality in an older intensive care unit population. American Journal of respiratory and critical Care Medicine. 2009; 180(11): 1092-7. doi: 10.1164/rccm.200904-0537OC PMID: 19745202; PubMed Central PMCID: PMC2784414.
40. Patel SB, Poston JT, Pohlman A, Hall JB, Kress JP. Rapidly reversible, sedation-related delirium versus persistent delirium in the intensive care unit. American Journal of respiratory and critical Care Medicine. 2014; 189(6): 658-65. doi: 10.1164/rccm.201310-1815OC PMID: 24423152.
41. Greenberg DP, Robertson CA, Noss MJ, Blatter MM, Biedenbender R, Decker MD. Safety and immunogenicity of a quadrivalent inactivated influenza vaccine compared to licensed trivalent inactivated influenza vaccines in adults. Vaccine. 2013; 31(5): 770-6. doi: 10.1016/j.vaccine.2012.11.074 PMID: 23228813.
42. Forrest BD, Steele AD, Hiemstra L, Rappaport R, Ambrose CS, Gruber WC. A prospective, randomized, open-label trial comparing the safety and efficacy of trivalent live attenuated and inactivated influenza vaccines in adults 60 years of age and older. Vaccine. 2011; 29(20): 3633-9. Epub 2011/03/29. doi: 10.1016/j.vaccine.2011.03.029 PMID: 21440036.
43. Vellozzi C, Burwen DR, Dobardzic A, Ball R, Walton K, Haber P. Safety of trivalent inactivated influenza vaccines in adults: Background for pandemic influenza vaccine safety monitoring. Vaccine. 2009; 27 (15): 2114-20. Epub 2009/04/10. doi: 10.1016/j.vaccine.2009.01.125 PMID: 19356614.
44. Boutros N, Keck BP. Delirium following influenza vaccination. The American Journal of Psychiatry. 1993; 150(12): 1899. PMID: 8238653.
45. Cerejeira J, Nogueira V, Luis P, Vaz-Serra A, Mukaetova-Ladinska EB. The cholinergic system and inflammation: Common pathways in delirium pathophysiology. Journal of the American Geriatrics Society. 2012; 60(4): 669-75. doi: 10.1111/j.1532-5415.2011.03883.x PMID: 22316182.
46. Hala M. Pathophysiology of postoperative delirium: Systemic inflammation as a response to surgical trauma causes diffuse microcirculatory impairment. Medical hypotheses. 2007; 68(1): 194-6. PMID: 16979300.
47. Murray C, Sanderson DJ, Barkus C, Deacon RM, Rawlins JN, Bannerman DM, et al. Systemic inflammation induces acute working memory deficits in the primed brain: Relevance for delirium. Neurobiology of aging. 2012; 33(3): 603-16 e3. doi: 10.1016/j.neurobiolaging.2010.04.002 PMID: 20471138; PubMed Central PMCID: PMC3200140.
48. Hingorani AD, Cross J, Kharbanda RK, Mullen MJ, Bhagat K, Taylor M, et al. Acute systemic inflammation impairs endothelium-dependent dilatation in humans. Circulation. 2000; 102(9): 994-9. PMID: 10961963.
49. Clapp BR, Hingorani AD, Kharbanda RK, Mohamed-Ali V, Stephens JW, Vallance P, et al. Inflammation-induced endothelial dysfunction involves reduced nitric oxide bioavailability and increased oxidant stress. Cardiovascular research. 2004; 64(1): 172-8. doi: 10.1016/j.cardiores.2004.06.020 PMID: 15364625.
50. van Gool WA, van de Beek D, Eikelenboom P. Systemic infection and delirium: When cytokines and acetylcholine collide. Lancet. 2010; 375(9716): 773-5. doi: 10.1016/S0140-6736(09)61158-2 PMID: 20189029.
51. Terrando N, Eriksson LI, Ryu JK, Yang T, Monaco C, Feldmann M, et al. Resolving postoperative neuroinflammation and cognitive decline. Annals of neurology. 2011; 70(6): 986-95. doi: 10.1002/ana. 22664 PMID: 22190370.
52. Cheron A, Floccard B, Allaouchiche B, Guignant C, Poitevin F, Malcus C, et al. Lack of recovery in monocyte human leukocyte antigen-DR expression is independently associated with the development of sepsis after major trauma. Crit Care. 2010; 14(6): R208. Epub 2010/11/26. doi: 10.1186/cc9331 PMID: 21092108; PubMed Central PMCID: PMC3220028.
53. Harms H, Prass K, Meisel C, Klehmet J, Rogge W, Drenckhahn C, et al. Preventive antibacterial therapy in acute ischemic stroke: A randomized controlled trial. PloS one. 2008; 3(5): E2158. doi: 10.1371/Journal.pone.0002158 PMID: 18478129; PubMed Central PMCID: PMC2373885.
54. Evans TG, Hasan M, Galibert L, Caron D. The use of Flt3 ligand as an adjuvant for hepatitis B vaccination of healthy adults. Vaccine. 2002; 21(3-4): 322-9. PMID: 12450708.