Inflammation-induced endothelial dysfunction involves reduced nitric oxide bioavailability and increased oxidant stress

Cardiovascular Research

Volumn 64, Issue 1, 2004, Pages 172-178

  Clapp, Brian R ^a   Hingorani, Aroon D ^a   Kharbanda, Rajesh K ^a   Mohamed Ali, Vidya ^a   Stephens, Jeffrey W ^a   Vallance, Patrick ^a   MacAllister, Raymond J ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Coronary disease; Endothelium; Inflammation; Nitric oxide; Reactive oxygen species

Indexed keywords

ALBUMIN; ARGININE; ASCORBIC ACID; BRADYKININ; CYTOKINE; GLYCERYL TRINITRATE; N(G) METHYLARGININE; NITRIC OXIDE; NORADRENALIN; PROTEIN; SALMONELLOSIS VACCINE; TYPHOID VACCINE;

ADULT; ARTICLE; BIOAVAILABILITY; BLOOD FLOW; CLINICAL ARTICLE; CONTROLLED STUDY; ENDOTHELIUM INJURY; FEMALE; FOREARM; HUMAN; INFLAMMATION; MALE; MEASUREMENT; OXIDATIVE STRESS; PLETHYSMOGRAPHY; PRIORITY JOURNAL; PROTEIN URINE LEVEL; SIDE EFFECT; VACCINATION;

ADULT; ALBUMINURIA; ANALYSIS OF VARIANCE; ARGININE; ASCORBIC ACID; BIOLOGICAL AVAILABILITY; BRADYKININ; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; FEMALE; FOREARM; HUMANS; MALE; NITRIC OXIDE; NITROGLYCERIN; NOREPINEPHRINE; OMEGA-N-METHYLARGININE; OXIDATIVE STRESS; PLETHYSMOGRAPHY; REGIONAL BLOOD FLOW; STATISTICS, NONPARAMETRIC; TYPHOID-PARATYPHOID VACCINES; VASOCONSTRICTOR AGENTS; VASODILATOR AGENTS;

EID: 4444324584     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cardiores.2004.06.020     Document Type: Article

References (36)

1. M.A. Creager, J.P. Cooke, and M.E. Mendelsohn Impaired vasodilation of forearm resistance vessels in hypercholesterolemic humans J. Clin. Invest. 86 1990 228 234
2. H.O. Steinberg, B. Bayazeed, G. Hook, A. Johnson, J. Cronin, and A.D. Baron Endothelial dysfunction is associated with cholesterol levels in the high normal range in humans Circulation 96 1997 3287 3293
3. I.R. Goldsmith, A.D. Blann, R.L. Patel, and G.Y. Lip Plasma fibrinogen, soluble P-selectin, and von Willebrand factor in aortic valve disease: evidence for abnormal haemorheology, platelet activation, and endothelial dysfunction[letter] Heart 83 2000 577 578
4. T. Bombeli, M. Mueller, and A. Haeberli Anticoagulant properties of the vascular endothelium Thromb. Haemost. 77 1997 408 423
5. R. Ross Atherosclerosis - an inflammatory disease N. Engl. J. Med. 340 1999 115 126
6. P. Libby, D. Egan, and S. Skarlatos Roles of infectious agents in atherosclerosis and restenosis: an assessment of the evidence and need for future research Circulation 96 1997 4095 4103
7. D.H. Thom, J.T. Grayston, D.S. Siscovick, S.P. Wang, N.S. Weiss, and J.R. Daling Association of prior infection with Chlamydia pneumoniae and angiographically demonstrated coronary artery disease JAMA 268 1992 68 72
8. A.A. Quartin, R.M. Schein, D.H. Kett, and P.N. Peduzzi Magnitude and duration of the effect of sepsis on survival. Department of Veterans Affairs Systemic Sepsis Cooperative Studies Group JAMA 277 1997 1058 1063
9. N. Mamode, S. Cobbe, and J.G. Pollock Infarcts after surgery BMJ 310 1995 1215 1216
10. C.R. Meier, S.S. Jick, L.E. Derby, C. Vasilakis, and H. Jick Acute respiratory-tract infections and risk of first-time acute myocardial infarction Lancet 351 1998 1467 1471
11. F. Ohkawa, U. Ikeda, T. Kanbe, K. Kawasaki, and K. Shimada Effects of inflammatory cytokines on vascular tone Cardiovasc. Res. 30 1995 711 715
12. K. Bhagat, and P. Vallance Inflammatory cytokines impair endothelium-dependent dilatation in human veins in vivo Circulation 96 1997 3042 3047
13. A.D. Hingorani, J. Cross, and R.K. Kharbanda Acute systemic inflammation impairs endothelium-dependent dilatation in humans Circulation 102 2000 994 999
14. D.W. Laight, P.T. Gunnarsson, A.V. Kaw, E.E. Anggard, and M.J. Carrier Physiological microassay of plasma total antioxidant status in a model of endothelial dysfunction in the rat following oxidant stress in vivo ETAP 7 1999 27 31
15. M.J. Sampson, N. Gopaul, I.R. Davies, D.A. Hughes, and M.J. Carrier Plasma F2 isoprostanes: direct evidence of increased free radical damage during acute hyperglycemia in type 2 diabetes Diabetes Care 25 2002 537 541
16. N. Benjamin, A. Calver, J. Collier, B. Robinson, P. Vallance, and D. Webb Measuring forearm blood flow and interpreting the responses to drugs and mediators [see comments] Hypertension 25 1995 918 923
17. J.P. Chin-Dusting, J.D. Cameron, A.M. Dart, and G.L. Jennings Human forearm venous occlusion plethysmography: methodology, presentation and analysis Clin. Sci. (Colch) 96 1999 439 440
18. S. Taddei, L. Ghiadoni, A. Virdis, S. Buralli, and A. Salvetti Vasodilation to bradykinin is mediated by an ouabain-sensitive pathway as a compensatory mechanism for impaired nitric oxide availability in essential hypertensive patients Circulation 100 1999 1400 1405
19. M.L. Honing, P. Smits, P.J. Morrison, and T.J. Rabelink Bradykinin-induced vasodilation of human forearm resistance vessels is primarily mediated by endothelium-dependent hyperpolarization Hypertension 35 2000 1314 1318
20. R.K. Kharbanda, B. Walton, and M. Allen Prevention of inflammation-induced endothelial dysfunction: a novel vasculo-protective action of aspirin Circulation 105 2002 2600 2604
21. K. Kauser, V. da Cunha, R. Fitch, C. Mallari, and G.M. Rubanyi Role of endogenous nitric oxide in progression of atherosclerosis in apolipoprotein E-deficient mice Am. J. Physiol., Heart Circ. Physiol. 278 2000 H1679 H1685
22. J. Chen, P.J. Kuhlencordt, J. Astern, R. Gyurko, and P.L. Huang Hypertension does not account for the accelerated atherosclerosis and development of aneurysms in male apolipoprotein E/endothelial nitric oxide synthase double knockout mice Circulation 104 2001 2391 2394
23. J.M. Cross, A.E. Donald, R. Kharbanda, J.E. Deanfield, R.G. Woolfson, and R.J. MacAllister Acute administration of l-arginine does not improve arterial endothelial function in chronic renal failure Kidney Int. 60 2001 2318 2323
24. F. Nappo, N. De Rosa, and R. Marfella Impairment of endothelial functions by acute hyperhomocysteinemia and reversal by antioxidant vitamins JAMA 281 1999 2113 2118
25. M.A. Creager, S.J. Gallagher, X.J. Girerd, S.M. Coleman, V.J. Dzau, and J.P. Cooke l-Arginine improves endothelium-dependent vasodilation in hypercholesterolemic humans J. Clin. Invest. 90 1992 1248 1253
26. Y. Hirooka, T. Imaizumi, and T. Tagawa Effects of l-arginine on impaired acetylcholine-induced and ischemic vasodilation of the forearm in patients with heart failure Circulation 90 1994 658 668
27. A. Huang, J.A. Vita, R.C. Venema, and J.F. Keaney Jr. Ascorbic acid enhances endothelial nitric-oxide synthase activity by increasing intracellular tetrahydrobiopterin J. Biol. Chem. 275 2000 17399 17406
28. R. Heller, A. Unbehaun, B. Schellenberg, B. Mayer, G. Werner-Felmayer, and E.R. Werner l-Ascorbic acid potentiates endothelial nitric oxide synthesis via a chemical stabilization of tetrahydrobiopterin J. Biol. Chem. 276 2001 40 47
29. Z.S. Katusic Vascular endothelial dysfunction: does tetrahydrobiopterin play a role? J. Am. Physiol., Heart Circ. Physiol. 281 2001 H981 H986
30. C.D. Stehouwer, J.J. Nauta, G.C. Zeldenrust, W.H. Hackeng, A.J. Donker, and G.J. de Ottolander Urinary albumin excretion, cardiovascular disease, and endothelial dysfunction in non-insulin-dependent diabetes mellitus Lancet 340 1992 319 323
31. R. Pedrinelli, G. Dell'Omo, V. Di Bello, R. Pontremoli, and M. Mariani Microalbuminuria, an integrated marker of cardiovascular risk in essential hypertension J. Hum. Hypertens. 16 2002 79 89
32. G.M. Tsang, S. Allen, D. Pagano, C. Wong, T.R. Graham, and R.S. Bonser von Willebrand factor and urinary albumin excretion are possible indicators of endothelial dysfunction in cardiopulmonary bypass J. Eur. Cardiothorac. Surg. 13 1998 385 391
33. O. Abid, Q. Sun, K. Sugimoto, D. Mercan, and J.L. Vincent Predictive value of microalbuminuria in medical ICU patients: results of a pilot study Chest 120 2001 1984 1988
34. K.E. Paisley, M. Beaman, J.E. Tooke, V. Mohamed-Ali, G.D. Lowe, and A.C. Shore Endothelial dysfunction and inflammation in asymptomatic proteinuria Kidney Int. 63 2003 624 633
35. P. Clausen, J.S. Jensen, G. Jensen, K. Borch-Johnsen, and B. Feldt-Rasmussen Elevated urinary albumin excretion is associated with impaired arterial dilatory capacity in clinically healthy subjects Circulation 103 2001 1869 1874
36. G.F. Diercks, E.S. Stroes, and A.J. van Boven Urinary albumin excretion is related to cardiovascular risk indicators, not to flow-mediated vasodilation, in apparently healthy subjects Atherosclerosis 163 2002 121 126